CA2196200A1 - Nouveaux composes - Google Patents

Nouveaux composes

Info

Publication number
CA2196200A1
CA2196200A1 CA002196200A CA2196200A CA2196200A1 CA 2196200 A1 CA2196200 A1 CA 2196200A1 CA 002196200 A CA002196200 A CA 002196200A CA 2196200 A CA2196200 A CA 2196200A CA 2196200 A1 CA2196200 A1 CA 2196200A1
Authority
CA
Canada
Prior art keywords
dna
compound according
seq
compound
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002196200A
Other languages
English (en)
Inventor
Michael Joseph Browne
Kay Elizabeth Murphy
Helen Elizabeth Clinkenbeard
Peter Ronald Young
Allan Richard Shatzman
Conrad Gerald Chapman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415379A external-priority patent/GB9415379D0/en
Application filed by Individual filed Critical Individual
Publication of CA2196200A1 publication Critical patent/CA2196200A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5406IL-4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Protéine soluble ayant une activité antagoniste complète ou partielle de IL4 (interleukine 4) et/ou de IL13, qui comprend un variant ou mutant de IL4 fusionné avec au moins un domaine constant d'immunoglobuline humaine ou fragment dudit domaine.
CA002196200A 1994-07-29 1995-07-28 Nouveaux composes Abandoned CA2196200A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9415379.8 1994-07-29
GB9415379A GB9415379D0 (en) 1994-07-29 1994-07-29 Novel compounds
US46829795A 1995-06-06 1995-06-06
US08/468,297 1995-06-06

Publications (1)

Publication Number Publication Date
CA2196200A1 true CA2196200A1 (fr) 1996-02-15

Family

ID=26305369

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002196200A Abandoned CA2196200A1 (fr) 1994-07-29 1995-07-28 Nouveaux composes

Country Status (13)

Country Link
EP (1) EP0770135A1 (fr)
JP (1) JPH10503371A (fr)
CN (1) CN1117155C (fr)
AU (1) AU3382595A (fr)
BR (1) BR9508469A (fr)
CA (1) CA2196200A1 (fr)
CZ (1) CZ25697A3 (fr)
HU (1) HUT76369A (fr)
MX (1) MX9700764A (fr)
NO (1) NO970374L (fr)
NZ (1) NZ292124A (fr)
PL (1) PL182665B1 (fr)
WO (1) WO1996004388A1 (fr)

Families Citing this family (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US7597886B2 (en) 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7429646B1 (en) 1995-06-05 2008-09-30 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like 2
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US6664227B1 (en) 1996-03-01 2003-12-16 Genetics Institute, Llc Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
EP0812913A3 (fr) * 1996-06-12 1999-08-04 Smithkline Beecham Corporation Récepteur HR-1 appartenant la famille des récepteurs de cytokin
US5986059A (en) * 1996-06-14 1999-11-16 Bayer Corporation T-cell selective interleukin-4 agonists
US6335426B1 (en) 1996-06-14 2002-01-01 Bayer Corporation T-cell selective interleukin-4 agonists
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
US6287801B1 (en) * 1996-07-22 2001-09-11 Smithkline Beecham Corporation Nucleic acids encoding the G-protein coupled receptor HNFDS78
CA2275183A1 (fr) * 1996-12-20 1998-07-02 Amgen Inc. Procedes et compositions de proteines de fusion ob
US6852508B1 (en) 1997-02-28 2005-02-08 Genetics Institute, Llc Chemokine with amino-terminal modifications
US6100387A (en) * 1997-02-28 2000-08-08 Genetics Institute, Inc. Chimeric polypeptides containing chemokine domains
PT1037927E (pt) 1997-12-08 2004-10-29 Emd Lexigen Res Ct Corp Proteinas de fusao heterodimericas uteis para imunoterapia de abordagem selectiva e estimulacao imunologica geral
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
EP1093457B8 (fr) 1998-03-19 2011-02-02 Human Genome Sciences, Inc. Analogue de chaine gamma commune de recepteur de cytokine
EP2357192A1 (fr) 1999-02-26 2011-08-17 Human Genome Sciences, Inc. Endokine alpha humain et methodes d'utilisation
US20010021380A1 (en) * 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
BR0013231A (pt) 1999-08-09 2002-07-23 Lexigen Pharm Corp Complexos citocina-anticorpo múltiplos
EP1228214A2 (fr) 1999-11-12 2002-08-07 MERCK PATENT GmbH Formes d'erythropoietine dotees de proprietes ameliorees
JP5179689B2 (ja) 2000-02-11 2013-04-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗体ベース融合タンパク質の循環系内半減期の増強
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
WO2001096528A2 (fr) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Facteur de necrose tumorale humain delta et epsilon
AU2001268427B2 (en) 2000-06-16 2007-03-29 Glaxosmithkline Intellectual Property Limited Antibodies that immunospecifically bind to blys
JP5390055B2 (ja) 2000-06-29 2014-01-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 免疫サイトカインの取り込み増強剤との併用治療による抗体−サイトカイン融合タンパク質媒介免疫応答の増強
AU1994402A (en) 2000-11-28 2002-06-11 Mediummune Inc Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment
JP4336498B2 (ja) 2000-12-12 2009-09-30 メディミューン,エルエルシー 延長した半減期を有する分子ならびにその組成物および用途
EP1683865A3 (fr) 2001-02-02 2006-10-25 Eli Lilly & Company Protéines de mammifères en particulier CD200
EP1377826B1 (fr) * 2001-02-22 2010-06-09 The Research Foundation Of State University Of New York Recepteurs d'opiaces
GB0105360D0 (en) * 2001-03-03 2001-04-18 Glaxo Group Ltd Chimaeric immunogens
HUP0303428A2 (hu) 2001-03-07 2004-01-28 Merck Patent Gmbh. Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez
WO2002079415A2 (fr) 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reduction de l'immunogenicite de proteines de fusion
DE60236646D1 (de) 2001-04-13 2010-07-22 Human Genome Sciences Inc Anti-VEGF-2 Antikörper
KR100900166B1 (ko) 2001-05-03 2009-06-02 메르크 파텐트 게엠베하 재조합 종양 특이적 항체 및 이들의 용도
CN100594935C (zh) 2001-05-25 2010-03-24 人体基因组科学有限公司 免疫特异性结合trail受体的抗体
US6867189B2 (en) 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
ATE542137T1 (de) 2001-12-04 2012-02-15 Merck Patent Gmbh Immunocytokine mit modulierter selektivität
JP2005535572A (ja) 2002-04-12 2005-11-24 メディミューン,インコーポレーテッド 組換え抗インターロイキン−9抗体
EP1575509B1 (fr) 2002-05-10 2011-10-26 Purdue Research Foundation Anticorps monoclonaux agonistes de la epha2 et utilisations de ceux-ci
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
WO2004016750A2 (fr) 2002-08-14 2004-02-26 Macrogenics, Inc. Anticorps specifiques du recepteur fc$g(g)riib et procedes d'utilisation de ces anticorps
CN100432105C (zh) 2002-12-17 2008-11-12 默克专利有限公司 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
BRPI0406776A (pt) * 2003-01-18 2005-12-27 Childrens Hosp Medical Center Composição farmacêutica, método de avaliação fisiológica e uso de pelo menos um dentre um inibidor de uma molécula semelhante a resistina (alfa) (relm(alfa)), uma molécula semelhante a resistina ß (relmß), um regulador de expressão de relm(alfa) ou um regulador de expressão de relmß
MXPA05007615A (es) 2003-01-21 2005-09-30 Bristol Myers Squibb Co Polinucleotido que codifica una novedosa acil coenzima a, monoacilglicerol aciltransferasa-3 (mgat3), y usos del mismo.
EP1444989A1 (fr) 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensibilisation de cellules à l'apoptose par bloquage selective de cytokines
DK1594542T3 (da) 2003-02-20 2010-10-11 Seattle Genetics Inc Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer
DE602004025332D1 (de) 2003-03-14 2010-03-18 Wyeth Corp Antikörper gegen il21-rezeptor und deren verwendung
KR20110094361A (ko) 2003-04-11 2011-08-23 메디뮨 엘엘씨 재조합 il­9 항체 및 그의 용도
PT1641483E (pt) * 2003-06-12 2008-04-29 Lilly Co Eli Proteínas de fusão
JP4629047B2 (ja) * 2003-06-12 2011-02-09 イーライ リリー アンド カンパニー Glp−1アナログ複合タンパク質
US20050048617A1 (en) 2003-08-18 2005-03-03 Medimmune, Inc. Humanization of antibodies
WO2005058961A2 (fr) 2003-12-12 2005-06-30 Amgen Inc. Anticorps anti-galanine et leurs utilisations
PT1699822E (pt) 2003-12-30 2008-07-30 Merck Patent Gmbh Proteínas de fusão de il-7
BRPI0417916A (pt) 2003-12-31 2007-04-10 Merck Patent Gmbh proteìna de fusão de fc-eritropoietina com farmacocinética melhorada
AU2005203962C1 (en) 2004-01-05 2012-11-08 Antisoma Research Limited Interleukin-12 targeted to oncofoetal fibronectin
EP1786463A4 (fr) 2004-03-26 2009-05-20 Human Genome Sciences Inc Anticorps contre le recepteur nogo
PL1751184T3 (pl) 2004-05-13 2010-02-26 Lilly Co Eli Białka fuzyjne FGF-21
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
AU2005286770A1 (en) 2004-09-21 2006-03-30 Medimmune, Llc Antibodies against and methods for producing vaccines for respiratory syncytial virus
US7635754B2 (en) * 2004-09-22 2009-12-22 Aerovance, Inc. Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same
WO2006047639A2 (fr) 2004-10-27 2006-05-04 Medimmune, Inc. Modulation d'une specificite d'anticorps par adaptation sur mesure de son affinite a un antigene apparente
JP2008520684A (ja) 2004-11-17 2008-06-19 アブジェニックス・インコーポレーテッド Il−13に対する完全ヒトモノクローナル抗体
RU2437893C2 (ru) 2004-12-09 2011-12-27 Мерк Патент Гмбх Варианты il-7 со сниженной иммуногенностью
PT1831252E (pt) * 2004-12-22 2009-09-17 Lilly Co Eli Formulações de proteínas de fusão de análogos de glp-1
EP1869192B1 (fr) 2005-03-18 2016-01-20 MedImmune, LLC Rearrangement de l'infrastructure d'anticorps
EP1871418B1 (fr) 2005-04-19 2014-03-19 Seattle Genetics, Inc. Agents de liaison anti-cd70 humanises et utilisations
BRPI0611069A2 (pt) 2005-05-06 2010-11-09 Zymogenetics Inc anticorpo monoclonal, anticorpo humanizado, fragmento de anticorpo, uso de um antagonista, e, hibridoma
KR20080025174A (ko) 2005-06-23 2008-03-19 메디뮨 인코포레이티드 응집 및 단편화 프로파일이 최적화된 항체 제제
EP1904652A2 (fr) 2005-07-08 2008-04-02 Brystol-Myers Squibb Company Polymorphismes de nucleotides simples associes a l'oedeme dose-dependant, et leurs procedes d'utilisation
ZA200804082B (en) 2005-11-07 2010-02-24 Scripps Research Inst Compositions and methods for controlling tissue factor signaling specificity
WO2007127936A2 (fr) 2006-04-27 2007-11-08 Pikamab, Inc. Procédés et compositions pour la thérapie par anticorps
EP2041576B1 (fr) 2006-06-21 2011-08-10 Apogenix GmbH Expression différentielle de la cytokine dans les cancers chez l'homme
AU2007281876B2 (en) 2006-06-26 2013-09-05 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
EA021255B1 (ru) 2006-08-28 2015-05-29 Киова Хакко Кирин Ко., Лимитед Антагонистические моноклональные антитела человека, специфичные в отношении light человека
CN103044550A (zh) 2006-09-01 2013-04-17 津莫吉尼蒂克斯公司 Il-31单克隆抗体的可变区序列和使用方法
EP2064335A4 (fr) 2006-10-16 2011-03-30 Medimmune Llc Molécules ayant des demi-vies réduites, compositions et leurs utilisations
DK2099823T4 (da) 2006-12-01 2022-05-09 Seagen Inc Målbindingsmiddelvarianter og anvendelser deraf
US20100209434A1 (en) 2007-03-30 2010-08-19 Medimmune, Llc Antibody formulation
EP2164868B1 (fr) 2007-05-04 2015-03-25 Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA Domaines variables transgéniques d'anticorps de lapin et leurs utilisations
DK3072525T3 (en) 2007-05-14 2018-04-30 Astrazeneca Ab PROCEDURES FOR REDUCING BASOFILE CELL LEVELS
KR101603109B1 (ko) 2007-12-07 2016-03-25 지모제넥틱스, 인코포레이티드 Il-31에 특이적인 인간화된 항체 분자
ES2613963T3 (es) 2008-01-18 2017-05-29 Medimmune, Llc Anticuerpos manipulados con cisteína para conjugación específica de sitio
CN102076865B (zh) 2008-05-02 2016-03-16 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
KR101030978B1 (ko) * 2008-07-10 2011-04-28 (주) 에이프로젠 동물세포용 재조합 발현벡터
PY09026846A (es) 2008-08-05 2015-09-01 Novartis Ag Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
WO2010087927A2 (fr) 2009-02-02 2010-08-05 Medimmune, Llc Anticorps contre le virus respiratoire syncytial et procédés permettant de produire des vaccins contre le virus respirateur syncytial
WO2010093993A2 (fr) 2009-02-12 2010-08-19 Human Genome Sciences, Inc. Utilisation d'antagonistes de la protéine stimulant les lymphocytes b afin de favoriser la tolérance aux greffes
SG175233A1 (en) 2009-04-22 2011-11-28 Merck Patent Gmbh Antibody fusion proteins with modified fcrn binding sites
WO2010141329A1 (fr) 2009-06-01 2010-12-09 Medimmune, Llc Molecules a demi-vie prolongee et utilisations associees
CA2766405A1 (fr) 2009-06-22 2011-01-13 Medimmune, Llc Regions fc de synthese pour une conjugaison specifique a un site
LT2769737T (lt) 2009-07-20 2017-06-26 Bristol-Myers Squibb Company Anti-ctla4 antikūno derinys su etopozidu, skirtas sinerginiam proliferacinių ligų gydymui
US9133500B2 (en) 2009-08-10 2015-09-15 MorphoSys A6 Screening strategies for the identification of binders
AU2010282340B2 (en) 2009-08-13 2016-12-22 The Johns Hopkins University Methods of modulating immune function
DK2464664T3 (da) 2009-08-13 2016-01-18 Crucell Holland Bv Antistoffer mod humant respiratorisk syncytialvirus (rsv) og fremgangsmåder til anvendelse deraf
US20110189183A1 (en) 2009-09-18 2011-08-04 Robert Anthony Williamson Antibodies against candida, collections thereof and methods of use
CA2798432A1 (fr) 2010-05-06 2011-11-10 Novartis Ag Compositions et procedes d'utilisation d'anticorps therapeutiques diriges contre la proteine 6 liee a la lipoproteine de basse densite (lrp6)
EA201291181A1 (ru) 2010-05-06 2013-05-30 Новартис Аг Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6)
EP2591000B1 (fr) 2010-07-09 2017-05-17 Janssen Vaccines & Prevention B.V. Anticorps anti-virus respiratoire syncytial (rsv) humain et procédés d'utilisation
PT3552619T (pt) 2010-07-09 2025-10-23 Bioverativ Therapeutics Inc Polipéptidos de fator ix e métodos de uso dos mesmos
WO2012019061A2 (fr) 2010-08-05 2012-02-09 Stem Centrx, Inc. Nouveaux effecteurs et leurs procédés d'utilisation
SG187908A1 (en) 2010-08-20 2013-03-28 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
US20130224191A1 (en) 2010-08-27 2013-08-29 Robert A. Stull Notum protein modulators and methods of use
WO2012031273A2 (fr) 2010-09-03 2012-03-08 Stem Centrx, Inc. Nouveaux modulateurs et leurs procédés d'utilisation
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
US20130245233A1 (en) 2010-11-24 2013-09-19 Ming Lei Multispecific Molecules
TWI655210B (zh) 2010-12-08 2019-04-01 艾伯維史坦森特瑞斯有限責任公司 新穎調節劑及其使用方法
EP3763740A1 (fr) 2011-01-26 2021-01-13 Celldex Therapeutics, Inc. Anticorps anti-kit et leurs utilisations
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
US9244074B2 (en) 2011-06-07 2016-01-26 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
WO2012170742A2 (fr) 2011-06-07 2012-12-13 University Of Hawaii Traitement et prévention du cancer avec des antagonistes du hmgb1
WO2012172495A1 (fr) 2011-06-14 2012-12-20 Novartis Ag Compositions et procédés de ciblage du tem8 par des anticorps
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
EP2758422A1 (fr) 2011-09-23 2014-07-30 Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA Domaines de liaison à l'albumine modifiés et utilisations de ceux-ci pour améliorer la pharmacocinétique
EP2773373B1 (fr) 2011-11-01 2018-08-22 Bionomics, Inc. Procédés de blocage de la croissance des cellules souches cancéreuses
EP2773664A1 (fr) 2011-11-01 2014-09-10 Bionomics, Inc. Anticorps anti-gpr49
AU2012332593B2 (en) 2011-11-01 2016-11-17 Bionomics, Inc. Anti-GPR49 antibodies
JP2014533247A (ja) 2011-11-01 2014-12-11 バイオノミクス インコーポレイテッド 抗体および癌を治療する方法
PL2773671T3 (pl) 2011-11-04 2022-01-24 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerycznego z mutacjami w domenie fc
KR20140091031A (ko) 2011-11-04 2014-07-18 노파르티스 아게 저밀도 지단백질-관련 단백질 6 (lrp6) - 반감기 연장제 구축물
US9453073B2 (en) 2011-12-02 2016-09-27 Eli Lilly And Company Anti-glucagon antibodies and uses thereof
KR102083957B1 (ko) 2011-12-05 2020-03-04 노파르티스 아게 표피 성장 인자 수용체 3 (her3)에 대한 항체
JP2015500829A (ja) 2011-12-05 2015-01-08 ノバルティス アーゲー 上皮細胞増殖因子受容体3(her3)のドメインiiに対するher3の抗体
ES2728278T3 (es) 2011-12-21 2019-10-23 Novartis Ag Composiciones que comprenden anticuerpos dirigidos al factor P y C5
EP3539982B1 (fr) 2011-12-23 2025-02-19 Pfizer Inc. Régions constantes d'anticorps modifiés pour conjugaison spécifique à un site, et leurs procédés et utilisations
SG10201801444WA (en) 2012-02-24 2018-04-27 Abbvie Stemcentrx Llc Anti sez6 antibodies and methods of use
RU2014138474A (ru) 2012-02-24 2016-04-10 СтемСентРкс, Инк. Новые модуляторы и способы применения
JP6351572B2 (ja) 2012-05-10 2018-07-04 ザイムワークス,インコーポレイテッド Fcドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物
CN104812775B (zh) 2012-07-25 2019-05-03 塞尔德克斯医疗公司 抗kit抗体及其用途
JP2015533832A (ja) 2012-10-09 2015-11-26 アイジェニカ バイオセラピューティクス インコーポレイテッド 抗C16orf54抗体およびその使用方法
WO2014084859A1 (fr) 2012-11-30 2014-06-05 Novartis Ag Molécules et procédés pour la modulation d'activités de tmem16a
WO2014089111A1 (fr) 2012-12-05 2014-06-12 Novartis Ag Compositions et procédés pour des anticorps ciblant epo
CA2891686A1 (fr) 2012-12-18 2014-06-26 Novartis Ag Compositions et procedes qui utilisent une etiquette peptidique qui se lie au hyaluronane
MX2015010682A (es) 2013-02-22 2016-05-31 Stemcentrx Inc Nuevos conjugados de anticuerpos y usos de los mismos.
JP2016514130A (ja) 2013-03-14 2016-05-19 ノバルティス アーゲー Notch3に対する抗体
PT2970473T (pt) 2013-03-14 2017-10-26 Bristol Myers Squibb Co Combinação de agonista de dr5 e antagonista anti-pd-1 e métodos de utilização
CN103265637B (zh) * 2013-06-04 2015-10-21 江苏众红生物工程创药研究院有限公司 一种重组猪白细胞介素4-Fc融合蛋白及其编码基因和表达方法
SG10201708143QA (en) 2013-06-06 2017-11-29 Pf Medicament Anti-c10orf54 antibodies and uses thereof
UY35620A (es) 2013-06-21 2015-01-30 Novartis Ag Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
AR096601A1 (es) 2013-06-21 2016-01-20 Novartis Ag Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
WO2015053871A2 (fr) 2013-08-26 2015-04-16 MabVax Therapeutics, Inc. Acides nucléiques codant des anticorps humains contre sialyl-lewisa
PE20160674A1 (es) 2013-08-28 2016-07-21 Stemcentrx Inc Metodos de conjugacion de anticuerpos especificos de sitio y composiciones
CA2922529A1 (fr) 2013-08-28 2015-03-05 Stemcentrx, Inc. Nouveaux modulateurs sez6 et procedes d'utilisation
BR112016010051A2 (pt) 2013-11-04 2017-12-05 Pfizer ?conjugados de anticorpo-fármaco anti-efna4?
PL3097122T3 (pl) 2014-01-24 2020-10-19 Ngm Biopharmaceuticals, Inc. Przeciwciała wiążące domenę 2 beta klotho oraz sposoby ich stosowania
WO2015127407A1 (fr) 2014-02-21 2015-08-27 Stemcentrx, Inc. Anticorps anti-dll3 et conjugués de médicaments destinés à être utilisés dans un mélanome
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
AU2015240599B2 (en) 2014-04-04 2020-11-19 Bionomics, Inc. Humanized antibodies that bind LGR5
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
EP3142700B1 (fr) 2014-05-16 2021-03-03 Medimmune, LLC Molécules présentant une altération de liaison de récepteur fc néonatal ayant des propriétés thérapeutiques et diagnostiques améliorées
KR102226248B1 (ko) 2014-06-04 2021-03-12 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 강글리오사이드 gd2에 대한 사람 단클론 항체
US20170291939A1 (en) 2014-06-25 2017-10-12 Novartis Ag Antibodies specific for il-17a fused to hyaluronan binding peptide tags
US20170327553A1 (en) 2014-06-25 2017-11-16 Novartis Ag Compositions and methods for long acting proteins
EP3160990A2 (fr) 2014-06-25 2017-05-03 Novartis AG Compositions et procédés pour protéines à action longue
SG10201805646WA (en) 2014-08-07 2018-08-30 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
WO2016020882A2 (fr) 2014-08-07 2016-02-11 Novartis Ag Anticorps de type angiopoétine 4 (angptl4) et procédés d'utilisation
EP3189152A4 (fr) 2014-09-03 2018-04-04 BioAtla LLC Découverte et production de protéines biologiques conditionnellement actives dans les mêmes cellules hôtes eucaryotes de production
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
WO2016094837A2 (fr) 2014-12-11 2016-06-16 Igenica Biotherapeutics, Inc. Anticorps anti-c10orf54 et leurs utilisations
UY36449A (es) 2014-12-19 2016-07-29 Novartis Ag Composiciones y métodos para anticuerpos dirigidos a bmp6
CA2977687C (fr) 2015-02-24 2024-02-13 Hwai Wen Chang Proteines conditionnellement actives
KR102740384B1 (ko) 2015-03-03 2024-12-06 키맵 리미티드 항체, 용도 및 방법
EA201792561A1 (ru) 2015-06-05 2018-04-30 Новартис Аг Антитела, нацеленные на морфогенетический белок кости 9 (bmp9), и способы их применения
UY36751A (es) 2015-06-26 2017-01-31 Novartis Ag Anticuerpos de factor xi y métodos de uso
WO2017021893A1 (fr) 2015-08-03 2017-02-09 Novartis Ag Méthode de traitement des troubles associés au fgf21
US10000561B2 (en) 2015-09-09 2018-06-19 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding molecules and methods of using the molecules
KR20180042433A (ko) 2015-09-09 2018-04-25 노파르티스 아게 흉선 기질 림포포이에틴 (tslp)-결합 항체 및 항체의 사용 방법
EP3355920A4 (fr) 2015-09-29 2019-05-15 Celgene Corporation Protéines de liaison à pd-1 et leurs méthodes d'utilisation
EP3371349A4 (fr) 2015-11-02 2018-09-12 Bioatla, LLC Polypeptides conditionnellement actifs
AU2016362777B2 (en) 2015-12-04 2020-01-30 Novartis Ag Antibody cytokine engrafted compositions and methods of use for immunoregulation
CA3008102A1 (fr) 2015-12-18 2017-06-22 Novartis Ag Anticorps ciblant cd32b et leurs procedes d'utilisation associes
EP3405492B1 (fr) 2016-01-21 2020-10-21 Novartis AG Molécules multispécifiques ciblant cll-1
KR20180138205A (ko) 2016-03-22 2018-12-28 바이오노믹스 리미티드 항-lgr5 단클론성 항체의 투여
CN109071647B (zh) 2016-04-27 2022-11-22 诺华股份有限公司 抗生长分化因子15的抗体及其用途
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
CA3027651A1 (fr) 2016-06-15 2017-12-21 Novartis Ag Methodes de traitement de maladie a l'aide d'inhibiteurs de la proteine morphogenetique osseuse 6 (bmp6)
ES2992868T3 (en) 2016-07-06 2024-12-19 Bristol Myers Squibb Co Combination of tim-4 antagonist and pd-1 antagonist and methods of use
EP3515943A4 (fr) 2016-09-19 2020-05-06 Celgene Corporation Méthodes de traitement du vitiligo au moyen de protéines de liaison à pd-1
WO2018053405A1 (fr) 2016-09-19 2018-03-22 Celgene Corporation Procédés de traitement de troubles immunitaires à l'aide de protéines de liaison à pd-1
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
US20200231701A1 (en) 2016-12-23 2020-07-23 Novartis Ag Methods of treatment with anti-factor xi/xia antibodies
BR112019012667A2 (pt) 2016-12-23 2020-02-11 Novartis Ag Anticorpos do fator xi e métodos de uso
EP3580237B1 (fr) 2017-02-08 2025-05-14 Novartis AG Anticorps mimétiques du fgf21 et leurs utilisations
JOP20190271A1 (ar) 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
JP2020520671A (ja) 2017-05-24 2020-07-16 ノバルティス アーゲー 抗体−サイトカイングラフト化タンパク質及び使用方法
CN110662762A (zh) 2017-05-24 2020-01-07 诺华股份有限公司 抗体细胞因子移植蛋白和用于治疗癌症的方法
WO2018215937A1 (fr) 2017-05-24 2018-11-29 Novartis Ag Protéines à greffe de cytokine-anticorps anti-interleukine-7 et procédés d'utilisation dans le traitement du cancer
WO2018229715A1 (fr) 2017-06-16 2018-12-20 Novartis Ag Compositions comprenant des anticorps anti-cd32b et procédés d'utilisation correspondants
CN111630069B (zh) 2017-10-13 2024-05-31 勃林格殷格翰国际有限公司 针对Thomsen-nouvelle(Tn)抗原的人抗体
WO2019081983A1 (fr) 2017-10-25 2019-05-02 Novartis Ag Anticorps ciblant cd32b et leurs procédés d'utilisation
EP3773739A1 (fr) 2018-04-12 2021-02-17 MediaPharma S.r.l. Conjugué anticorps de lgals3bp-médicament et son utilisation pour le traitement du cancer
UY38247A (es) 2018-05-30 2019-12-31 Novartis Ag Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
AU2019277029C1 (en) 2018-06-01 2024-01-04 Novartis Ag Binding molecules against BCMA and uses thereof
IL280199B2 (en) 2018-07-20 2025-08-01 Pf Medicament Receptor for vista
TW202028237A (zh) 2018-09-27 2020-08-01 美商西建公司 SIRPα結合蛋白及其使用方法
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
US20220169706A1 (en) 2019-03-28 2022-06-02 Danisco Us Inc Engineered antibodies
WO2020236797A1 (fr) 2019-05-21 2020-11-26 Novartis Ag Domaines de cd58 variants et leurs utilisations
UY38701A (es) 2019-05-21 2020-12-31 Novartis Ag Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas
JP2022548881A (ja) 2019-09-18 2022-11-22 ノバルティス アーゲー Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與entpd2抗體之組合療法
TWI877278B (zh) 2019-12-30 2025-03-21 美商思進公司 以非海藻糖苷化抗-cd70抗體治療癌症之方法
US20230203191A1 (en) 2020-03-30 2023-06-29 Danisco Us Inc Engineered antibodies
US20230167193A1 (en) 2020-05-01 2023-06-01 Novartis Ag Immunoglobulin variants
US20230242647A1 (en) 2020-05-01 2023-08-03 Novartis Ag Engineered immunoglobulins
WO2022012680A1 (fr) 2020-07-16 2022-01-20 Nanjing Legend Biotech Co., Ltd. Molécules de liaison à cd20 et leurs utilisations
WO2022031576A1 (fr) 2020-08-03 2022-02-10 Janssen Biotech, Inc. Matériaux et procédés pour le biotransport multidirectionnel dans des agents virothérapeutiques
EP4240491A1 (fr) 2020-11-06 2023-09-13 Novartis AG Molécules de liaison à cd19 et utilisations associées
JP2024502832A (ja) 2020-12-31 2024-01-23 アラマー バイオサイエンシーズ, インコーポレイテッド 高親和性及び/または特異性を有する結合剤分子ならびにその製造及び使用方法
EP4362977A1 (fr) 2021-06-29 2024-05-08 Seagen Inc. Méthodes de traitement du cancer au moyen d'une combinaison d'un anticorps anti-cd70 non fucosylé et d'un antagoniste de cd47
UY40097A (es) 2022-01-07 2023-07-14 Johnson & Johnson Entpr Innovation Inc Materiales y métodos de proteínas de unión a il-1b
WO2023209568A1 (fr) 2022-04-26 2023-11-02 Novartis Ag Anticorps multispécifiques ciblant il-13 et il-18
CN119546339A (zh) 2022-07-15 2025-02-28 丹尼斯科美国公司 用于产生单克隆抗体的方法
EP4554969A1 (fr) 2022-07-15 2025-05-21 Janssen Biotech, Inc. Matériau et procédés d'appariement amélioré par génie biologique de régions variables de liaison à l'antigène
EP4612165A1 (fr) * 2022-11-02 2025-09-10 Synerkine Pharma B.V. Immunocytokines modifiées, polypeptides de fusion et polypeptides il10
WO2024130158A1 (fr) 2022-12-16 2024-06-20 Modernatx, Inc. Nanoparticules lipidiques et polynucléotides codant l'interleukine-22 à demi-vie sérique étendue pour le traitement d'une maladie métabolique
WO2025104604A1 (fr) 2023-11-14 2025-05-22 Janssen Pharmaceuticals, Inc. Anticorps anti-virus respiratoire syncytial et leurs utilisations
WO2026058155A1 (fr) 2024-09-11 2026-03-19 Novartis Ag Anticorps ciblant il-31

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307434B2 (fr) * 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Anticorps alteres
KR900005995A (ko) * 1988-10-31 1990-05-07 우메모또 요시마사 변형 인터류킨-2 및 그의 제조방법
ATE169030T1 (de) * 1990-06-28 1998-08-15 Hoechst Ag Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung
DE4137333A1 (de) * 1991-11-13 1993-05-19 W Prof Dr Sebald Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung

Also Published As

Publication number Publication date
PL182665B1 (pl) 2002-02-28
NO970374L (no) 1997-02-19
MX9700764A (es) 1997-05-31
BR9508469A (pt) 1997-09-16
AU3382595A (en) 1996-03-04
WO1996004388A1 (fr) 1996-02-15
CN1164872A (zh) 1997-11-12
JPH10503371A (ja) 1998-03-31
NO970374D0 (no) 1997-01-28
HUT76369A (en) 1997-08-28
EP0770135A1 (fr) 1997-05-02
NZ292124A (en) 1998-10-28
CZ25697A3 (en) 1997-09-17
CN1117155C (zh) 2003-08-06
PL318380A1 (en) 1997-06-09

Similar Documents

Publication Publication Date Title
US5783181A (en) Therapeutic uses of fusion proteins between mutant IL 4/IL13 antagonists and immunoglobulins
EP0770135A1 (fr) Nouveaux composes
EP0939121B2 (fr) Protéines liant le TNF
DE3650538T2 (de) Interleukin-4 protein mit bcgf- und tcgf-aktivität gegenüber menschlichen zellen (menschliches interleukin-4)
US5231176A (en) Distinct family DNA encoding of human leukocyte interferons
JP2644794B2 (ja) 新規な型のコロニー刺激因子―1
US6610830B1 (en) Microbial production of mature human leukocyte interferons
DE3855523T2 (de) Proteine mit Faktor-VIII-Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende pharmazeutische Zusammensetzungen
US6433142B1 (en) Megakaryocyte stimulating factors
HU194305B (en) Process for production of dns sequences, recombinated dns molecules and human interferon-type polipeptides
US5120832A (en) Distinct family of human leukocyte interferons
US20070104680A1 (en) Antibodies to natural killer stimulatory factor
EP0287075B2 (fr) Procédé de construction d'une lignée cellulaire animale pour la préparation de bêta-interféron humain
CA2087494C (fr) Recepteur soluble ldl, fabrication et utilisation de celui-ci
US5496926A (en) Process of preparing a soluble LDL receptor
EP0174143A1 (fr) Famille distincte d'interférons de leucocytes humains, compositions les contenant, méthodes pour leur production et ADN et hôtes transfectés pour ces méthodes
CN102382850A (zh) 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
AU2140699A (en) Novel compounds
AU1196402A (en) Novel compounds
CA1341299C (fr) Interleukine-4 de mammifere
KR930009084B1 (ko) 포유동물의 인터로이킨-4, 이를 포함하는 조성물 및 이의 제조방법
US7026291B1 (en) Epithelial cell specific growth factor, keratinocyte growth factor (KGF)

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued