CA2221341C - Submicron liposome suspensions obtained from preliposome lyophilizates - Google Patents

Submicron liposome suspensions obtained from preliposome lyophilizates Download PDF

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Publication number
CA2221341C
CA2221341C CA002221341A CA2221341A CA2221341C CA 2221341 C CA2221341 C CA 2221341C CA 002221341 A CA002221341 A CA 002221341A CA 2221341 A CA2221341 A CA 2221341A CA 2221341 C CA2221341 C CA 2221341C
Authority
CA
Canada
Prior art keywords
preliposome
lyophilate
liposomes
surfactant
annamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002221341A
Other languages
English (en)
French (fr)
Other versions
CA2221341A1 (en
Inventor
Yiyu Zou
Waldemar Priebe
Roman Perez-Soler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The University of Texas System
Original Assignee
The University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University of Texas System filed Critical The University of Texas System
Publication of CA2221341A1 publication Critical patent/CA2221341A1/en
Application granted granted Critical
Publication of CA2221341C publication Critical patent/CA2221341C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002221341A 1995-06-06 1996-06-06 Submicron liposome suspensions obtained from preliposome lyophilizates Expired - Fee Related CA2221341C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/468,791 1995-06-06
US08/468,791 US5902604A (en) 1995-06-06 1995-06-06 Submicron liposome suspensions obtained from preliposome lyophilizates
PCT/US1996/009830 WO1996039121A1 (en) 1995-06-06 1996-06-06 Submicron liposome suspensions obtained from preliposome lyophilizates

Publications (2)

Publication Number Publication Date
CA2221341A1 CA2221341A1 (en) 1996-12-12
CA2221341C true CA2221341C (en) 2009-04-21

Family

ID=23861262

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221341A Expired - Fee Related CA2221341C (en) 1995-06-06 1996-06-06 Submicron liposome suspensions obtained from preliposome lyophilizates

Country Status (6)

Country Link
US (2) US5902604A (2)
EP (2) EP0831781A1 (2)
JP (1) JPH11507369A (2)
AU (1) AU710113B2 (2)
CA (1) CA2221341C (2)
WO (1) WO1996039121A1 (2)

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WO2001032145A1 (en) * 1999-10-29 2001-05-10 Board Of Regents, The University Of Texas System Method of cancer treatment
EP1138312A1 (de) * 2000-03-28 2001-10-04 Primacare S.A. Pro-liposomen
US6761901B1 (en) 2000-05-02 2004-07-13 Enzrel Inc. Liposome drug delivery
US20020007055A1 (en) * 2000-05-15 2002-01-17 Hirotaka Uchiyama Compositions comprising cyclodextrin
US8658202B2 (en) * 2001-04-25 2014-02-25 Western University Of Health Sciences Coated drug delivery formulations
CN1245153C (zh) * 2002-06-06 2006-03-15 上海家化联合股份有限公司 一种维生素a脂质体及其制备方法
WO2004022100A1 (en) * 2002-08-15 2004-03-18 Yunqing Liu Soild nano pharmaceutical formulation and preparation method thereof
AU2004235781A1 (en) * 2003-05-02 2004-11-18 Aronex Pharmaceuticals, Inc. Lipid platinum complexes and methods of use thereof
CA2525973A1 (en) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising capecitabine and a liposomal platinum complex
CA2526289A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex
CA2525952A1 (en) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising gemcitabine and a liposomal platinum complex
EP1663153A4 (en) * 2003-05-20 2011-01-05 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH A LIPOSOMAL PLATINUM COMPLEX
EP1643972A4 (en) * 2003-06-27 2010-01-20 Smithkline Beecham Corp STABILIZED LIPOSOMAL TOPOTECAN COMPOSITION AND METHOD
US20060002994A1 (en) * 2004-03-23 2006-01-05 Thomas James L Responsive liposomes for ultrasonic drug delivery
RU2542449C2 (ru) * 2007-11-30 2015-02-20 Эндо Фармасьютикалз Солюшнз Инк. Композиции и способы лечения рака мочевого пузыря
JP2012528846A (ja) * 2009-06-03 2012-11-15 マヨ、ジョン、チャールズ 深部組織の痛みを治療するための製剤
CA3044884A1 (en) * 2009-12-07 2011-06-16 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
GB201205642D0 (en) 2012-03-29 2012-05-16 Sequessome Technology Holdings Ltd Vesicular formulations
MX2016005232A (es) * 2013-10-22 2017-01-19 Aradigm Corp Formulaciones liposomicas para inhalacion, modificadas con agente tensoactivo, que proveen un perfil de liberacion tanto inmediata como sostenida.
US20160120806A1 (en) * 2014-04-08 2016-05-05 Aradigm Corporation Nanocrystals formed in a microenvironment
RU2016143591A (ru) * 2014-04-08 2018-05-08 Арадайм Корпорейшн Липосомы, в которых образуются нанокристаллы лекарственного вещества после замораживания-оттаивания
RU2016143590A (ru) * 2014-04-08 2018-05-11 Арадайм Корпорейшн Липосомальные композиции ципрофлоксацина, обладающие активностью против нетуберкулезных микробактерий
US10744090B2 (en) 2015-06-30 2020-08-18 Sequessome Technology Holdings Limited Multiphasic compositions
PH12022550592A1 (en) * 2016-01-07 2023-07-17 Tesorx Pharma Llc Formulations for treating bladder cancer
AU2017382281B2 (en) 2016-12-22 2024-07-11 Genentech, Inc. Methods and formulations for reducing reconstitution time of lyophilized polypeptides
US20200188298A1 (en) * 2018-12-14 2020-06-18 NuVessl, Inc. Method For Using Composition With Enhanced Passenger Molecule Loading
CN114641296B (zh) * 2019-06-28 2025-05-27 德州大学系统董事会 制备安那霉素脂质体前体冻干物
BR112021026480A2 (pt) * 2019-06-28 2022-02-08 Univ Texas Método para reconstituir anamicina, método para preparar uma dose eficaz de uma formulação lipossômica reconstituída de anamicina e método para tratar câncer
EP4061810A4 (en) 2019-11-21 2023-12-20 Board of Regents, The University of Texas System Lung targeted anticancer therapies with liposomal annamycin

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Also Published As

Publication number Publication date
AU6108796A (en) 1996-12-24
WO1996039121A1 (en) 1996-12-12
JPH11507369A (ja) 1999-06-29
AU710113B2 (en) 1999-09-16
US7238366B1 (en) 2007-07-03
EP1800665A3 (en) 2008-06-04
US5902604A (en) 1999-05-11
EP0831781A1 (en) 1998-04-01
EP1800665A2 (en) 2007-06-27
CA2221341A1 (en) 1996-12-12

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20150608