CA2303365A1 - Hydrogels de poly(ethylene glycol) degradables a demi-vie regulee et leurs precurseurs - Google Patents

Hydrogels de poly(ethylene glycol) degradables a demi-vie regulee et leurs precurseurs Download PDF

Info

Publication number
CA2303365A1
CA2303365A1 CA002303365A CA2303365A CA2303365A1 CA 2303365 A1 CA2303365 A1 CA 2303365A1 CA 002303365 A CA002303365 A CA 002303365A CA 2303365 A CA2303365 A CA 2303365A CA 2303365 A1 CA2303365 A1 CA 2303365A1
Authority
CA
Canada
Prior art keywords
hydrogels
peg
hydrolytically degradable
crosslinked
life
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002303365A
Other languages
English (en)
Other versions
CA2303365C (fr
Inventor
J. Milton Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25455637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2303365(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2303365A1 publication Critical patent/CA2303365A1/fr
Application granted granted Critical
Publication of CA2303365C publication Critical patent/CA2303365C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CA002303365A 1997-09-12 1998-01-23 Hydrogels de poly(ethylene glycol) degradables a demi-vie regulee et leurs precurseurs Expired - Fee Related CA2303365C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/928,049 1997-09-12
US08/928,049 US20020064546A1 (en) 1996-09-13 1997-09-12 Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
PCT/US1998/000920 WO1999014259A1 (fr) 1997-09-12 1998-01-23 Hydrogels de poly(ethylene glycol) degradables a demi-vie regulee et leurs precurseurs

Publications (2)

Publication Number Publication Date
CA2303365A1 true CA2303365A1 (fr) 1999-03-25
CA2303365C CA2303365C (fr) 2007-08-21

Family

ID=25455637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002303365A Expired - Fee Related CA2303365C (fr) 1997-09-12 1998-01-23 Hydrogels de poly(ethylene glycol) degradables a demi-vie regulee et leurs precurseurs

Country Status (11)

Country Link
US (2) US20020064546A1 (fr)
EP (1) EP1019446B2 (fr)
JP (1) JP4083384B2 (fr)
AT (1) ATE358150T1 (fr)
AU (1) AU6029398A (fr)
CA (1) CA2303365C (fr)
DE (1) DE69837443T3 (fr)
DK (1) DK1019446T4 (fr)
ES (1) ES2281925T5 (fr)
PT (1) PT1019446E (fr)
WO (1) WO1999014259A1 (fr)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
WO1998012274A1 (fr) 1996-09-23 1998-03-26 Chandrashekar Pathak Procedes et dispositifs pour preparer des concentres de proteines
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US20030191496A1 (en) 1997-03-12 2003-10-09 Neomend, Inc. Vascular sealing device with microwave antenna
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US7642323B2 (en) 1997-11-06 2010-01-05 Nektar Therapeutics Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6458147B1 (en) 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
US6994686B2 (en) 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US7279001B2 (en) 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US8802146B2 (en) * 1998-11-06 2014-08-12 Neomend, Inc. Systems, methods, and compositions for prevention of tissue adhesion
US6949114B2 (en) 1998-11-06 2005-09-27 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6830756B2 (en) 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
JP2002531217A (ja) 1998-12-04 2002-09-24 チャンドラシェカー ピー． パサック， 生体適合性架橋ポリマー
DK1181323T3 (da) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7008635B1 (en) 1999-09-10 2006-03-07 Genzyme Corporation Hydrogels for orthopedic repair
DK1455839T3 (da) * 1999-10-08 2013-05-06 Nektar Therapeutics Heterobifunktioneller poly(ethylenglycol)-derivater og fremgangsmåder til fremstilling heraf
US6413507B1 (en) * 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
AU2458501A (en) * 2000-01-05 2001-07-16 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7291673B2 (en) 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
WO2002055185A2 (fr) 2000-10-19 2002-07-18 Eidgenoess Tech Hochschule Copolymeres blocs pour systemes auto-assembles multifonctionnels
US7829074B2 (en) 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
EP1421216A4 (fr) * 2001-09-01 2006-05-17 Samsung Electronics Co Ltd Procede pour fabriquer une biopuce en hydrogel au moyen d'un derive de polyethyleneglycol etoile comportant un groupe epoxy
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
ES2411007T3 (es) 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
CA2822457C (fr) 2001-12-14 2016-03-08 The University Of Wyoming Methodes et compositions de liberation controlee de medicaments
ATE412684T1 (de) * 2002-09-09 2008-11-15 Nektar Therapeutics Al Corp Verfahren zur herstellung von wasserlöslichen polymerderivaten mit terminalen carboxylgruppen
US7045552B2 (en) * 2002-09-27 2006-05-16 Trimeris, Inc. Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy
NZ542094A (en) 2003-03-14 2008-12-24 Neose Technologies Inc Branched polymer conjugates comprising a peptide and water-soluble polymer chains
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
JP2007523630A (ja) 2003-05-09 2007-08-23 ネオス テクノロジーズ インコーポレイテッド ヒト成長ホルモングリコシル化突然変異体の組成と調合法
US6787443B1 (en) * 2003-05-20 2004-09-07 Intel Corporation PCB design and method for providing vented blind vias
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7842661B2 (en) 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
AU2004313242A1 (en) * 2004-01-07 2005-07-28 Trimeris, Inc. HIV gp41 HR2-derived synthetic peptides, and their use in therapy to inhibit transmission of human immunodeficiency virus
NZ548123A (en) 2004-01-08 2010-05-28 Novo Nordisk As O-linked glycosylation of peptides
DE602004011660T2 (de) 2004-06-16 2009-01-29 Straumann Holding Ag Abdeckmembran
US7282584B2 (en) 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
WO2006031811A2 (fr) 2004-09-10 2006-03-23 Neose Technologies, Inc. Interferon alpha glycopegyle
WO2006050247A2 (fr) 2004-10-29 2006-05-11 Neose Technologies, Inc. Remodelage et glycopegylation du facteur de croissance des fibroblastes (fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US9707252B2 (en) 2005-02-09 2017-07-18 Covidien Lp Synthetic sealants
US7517914B2 (en) 2005-04-04 2009-04-14 Boston Scientificscimed, Inc. Controlled degradation materials for therapeutic agent delivery
WO2006121569A2 (fr) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions et methodes utilisees pour la preparation de mutants par glycosylation de l'hormone de croissance humaine resistant a la protease
EP2975135A1 (fr) 2005-05-25 2016-01-20 Novo Nordisk A/S Facteur IX glycopégylé
WO2007008300A2 (fr) 2005-05-31 2007-01-18 ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE Copolymeres triblocs pour l'administration cytoplasmique de medicaments a base de genes
US8367096B2 (en) 2005-07-19 2013-02-05 Boston Scientific Scimed, Inc. Polymers having covalently bound therapeutic agents
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (fr) 2005-11-03 2007-05-18 Neose Technologies, Inc. Purification de sucre de nucleotide en utilisant des membranes
CA2630327C (fr) 2005-12-08 2015-05-26 Tyco Healthcare Group Lp Compositions chirurgicales biocompatibles
TWI341844B (en) 2006-02-02 2011-05-11 Trimeris Inc Hiv fusion inhibitor peptides with improved biological properties
AU2007243483B2 (en) 2006-04-24 2012-07-26 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
US7960498B2 (en) * 2006-06-30 2011-06-14 Actamax Surgical Materials, Llc Tissue adhesives with modified elasticity
EP2049144B8 (fr) 2006-07-21 2015-02-18 ratiopharm GmbH Glycosylation de peptides par l'intermédiaire de séquences de glycosylation à liaison o
EP2054521A4 (fr) 2006-10-03 2012-12-19 Novo Nordisk As Méthodes de purification de conjugués de polypeptides
ES2655734T3 (es) 2006-10-04 2018-02-21 Novo Nordisk A/S Glicopéptidos y azúcares pegilados unidos a glicerol
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
JP5052919B2 (ja) * 2007-03-08 2012-10-17 成均▲館▼大學校 産學協力團 Ｐｈ及び温度敏感性のブロック共重合体ヒドロゲル
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
CA2682848A1 (fr) * 2007-04-03 2008-10-16 Trimeris, Inc. Nouvelles formulations destinees a l'application de therapies peptidiques antivirales
HRP20130382T1 (hr) 2007-04-03 2013-05-31 Biogenerix Ag Postupci lijeäśenja pomoä†u glikopegiliranog g-csf
CA2690611C (fr) 2007-06-12 2015-12-08 Novo Nordisk A/S Procede ameliore pour la production de sucres de nucleotide
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
CN101874038A (zh) * 2007-09-25 2010-10-27 特里梅里斯公司 治疗性抗-hiv肽的合成方法
CN101855669A (zh) * 2007-11-08 2010-10-06 皇家飞利浦电子股份有限公司 用于管理内容的方法和电子设备
AU2009214615B2 (en) * 2008-02-13 2014-06-12 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
JP5150297B2 (ja) * 2008-02-14 2013-02-20 ネクター セラピューティックス エイエル，コーポレイション ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
PL2257311T3 (pl) 2008-02-27 2014-09-30 Novo Nordisk As Koniugaty cząsteczek czynnika VIII
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US9271929B2 (en) 2008-11-25 2016-03-01 École Polytechnique Fédérale De Lausanne (Epfl) Block copolymers and uses thereof
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP5890182B2 (ja) 2009-02-12 2016-03-22 インセプト エルエルシー ヒドロゲルプラグによる薬物送達
NO2440239T3 (fr) 2009-06-09 2018-02-10
NZ597964A (en) 2009-07-31 2014-04-30 Sanofi Aventis Deutschland Long acting insulin composition
CA2769162C (fr) * 2009-07-31 2017-12-05 Ascendis Pharma As Hydrogels insolubles dans l?eau a base de polyethylene glycol biodegradable
US9138462B2 (en) 2009-07-31 2015-09-22 Sanofi-Aventis Deutschland Gmbh Prodrugs comprising an insulin linker conjugate
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
JP5893566B2 (ja) 2009-10-29 2016-03-23 アセンディス ファーマ エー／エス 生分解性ヒドロゲルの滅菌
CA3149284A1 (fr) 2009-12-15 2011-07-14 Incept, Llc Implants et marqueurs de reference biodegradables
US8524215B2 (en) * 2010-08-02 2013-09-03 Janssen Biotech, Inc. Absorbable PEG-based hydrogels
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
EP2438930A1 (fr) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Promédicaments comprenant un conjugué de liaison d'exendine
CA2817568A1 (fr) 2010-11-12 2012-05-18 The Salk Institute For Biological Studies Intellectual Property And Tech Nology Transfer Therapies et diagnostics du cancer
US8440309B2 (en) 2011-01-31 2013-05-14 Confluent Surgical, Inc. Crosslinked polymers with the crosslinker as therapeutic for sustained release
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
ES2762405T3 (es) 2011-11-03 2020-05-25 Univ Columbia Composición con actividad antimicrobiana sostenida
JP6199883B2 (ja) 2011-12-05 2017-09-20 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ 医療用オルガノゲルプロセス及び組成物
CA2862391C (fr) 2011-12-29 2023-10-10 Loren D. Walensky Helices hybrides stabilisees antivirales
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
EP2819688A4 (fr) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Macrocycles peptidomimétiques réticulés par triazole et par thioéther
JP5953459B2 (ja) * 2012-03-27 2016-07-20 ネクター セラピューティクス ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2014039245A1 (fr) * 2012-09-07 2014-03-13 The Regents Of The University Of California Procédé d'élaboration d'hydrogels grâce à la formation de liaisons oximes
WO2014052647A2 (fr) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Peptides agrafés bloqués par la proline et leurs utilisations
KR101450859B1 (ko) * 2012-10-10 2014-10-15 한국과학기술연구원 염증 억제용 약물을 구비한 신경 전극 및 그 제조 방법
CA2883833C (fr) 2012-10-11 2020-10-27 Ascendis Pharma A/S Promedicaments sous forme d'hydrogel
WO2014071241A1 (fr) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
EP3391898A3 (fr) 2013-03-13 2019-02-13 President and Fellows of Harvard College Polypeptides piqués et agrafés et leurs utilisations
AU2014227824B2 (en) 2013-03-15 2018-09-27 Dana-Farber Cancer Institute, Inc. Stabilized SOS1 peptides
EP2970417B1 (fr) 2013-03-15 2019-06-19 Dana-Farber Cancer Institute, Inc. Peptides bh4 stabilisés et leurs utilisations
EP2970418A4 (fr) 2013-03-15 2016-08-17 Dana Farber Cancer Inst Inc Peptide d'ezh2 stabilisé
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
WO2015013510A1 (fr) 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl Matériaux en nanofibrilles à rapport d'aspect élevé
AU2014348502B2 (en) 2013-11-15 2019-08-15 Tangible Science, Inc. Contact lens with a hydrophilic layer
CA2949535C (fr) 2014-05-21 2023-09-12 President And Fellows Of Harvard College Peptides inhibiteurs de ras et leurs utilisations
CN106714854B (zh) 2014-07-17 2020-09-04 加利福尼亚大学董事会 用于生物医学应用的可控的自退火微凝胶颗粒
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
EP3197478A4 (fr) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
CN107206119B (zh) 2014-12-09 2021-01-29 实体科学公司 具有生物相容性层的医疗设备涂层
CA2979999A1 (fr) 2015-03-18 2016-09-22 Massachusetts Institute Of Technology Peptides de liaison a mcl-1 selectifs
WO2016154058A1 (fr) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
EP4279064A3 (fr) 2015-05-12 2024-02-28 Incept, LLC Administration de médicament à partir d'hydrogels
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP3317294B1 (fr) 2015-07-02 2023-03-15 Dana-Farber Cancer Institute, Inc. Peptides stabilisés anti-microbiens
US20190002506A1 (en) 2015-08-28 2019-01-03 Dana-Farber Cancer Institute, Inc. Stabilized peptides for covalent binding to target protein
CA2995479A1 (fr) 2015-08-28 2017-03-09 Dana-Farber Cancer Institute, Inc. Peptides se liant a bfl -1
WO2017044633A1 (fr) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques en tant que modulateurs de mcl-1
JP6184462B2 (ja) * 2015-10-28 2017-08-23 ウェルズ ファーゴ バンク ナショナル アソシエイション ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
WO2017142879A1 (fr) 2016-02-16 2017-08-24 The Regents Of The University Of California Procédé de modulation du système immunitaire avec des gels de particules hybridées microporeuses
CA3014442A1 (fr) 2016-02-29 2017-09-08 Dana-Farber Cancer Institute, Inc. Peptides antimicrobiens agrafes a ciblage intracellulaire pour traiter une infection
JP6925579B2 (ja) 2016-03-31 2021-08-25 日油株式会社 環状ベンジリデンアセタール構造を有する生分解性ヒドロゲル
US20190133126A1 (en) * 2016-05-16 2019-05-09 The Trustees Of Columbia University In The City Of New York Coatings and methods for infection-resistant medical devices
WO2018017922A2 (fr) 2016-07-22 2018-01-25 Massachusetts Institute Of Technology Peptides bfl-1 sélectifs
US11466064B2 (en) 2016-08-26 2022-10-11 Dana-Farber Cancer Institute, Inc. Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss
WO2018066692A1 (fr) 2016-10-07 2018-04-12 国立大学法人東京工業大学 Polyéthylène glycol monodispersé de type hétéro ramifié, procédé de production et conjugué associés
WO2018106937A1 (fr) 2016-12-07 2018-06-14 The University Of Chicago Compositions et procédés d'inhibition de fox3
CN110446508A (zh) 2016-12-29 2019-11-12 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
WO2018170299A1 (fr) 2017-03-15 2018-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteurs de transcription de gène procaryote et leurs utilisations
JP6361083B2 (ja) * 2017-06-27 2018-07-25 ウェルズ ファーゴ バンク ナショナル アソシエイション ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
AU2018304230A1 (en) 2017-07-19 2020-02-06 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections
EP3724216A1 (fr) 2017-12-15 2020-10-21 Dana Farber Cancer Institute, Inc. Dégradation de protéine ciblée médiée par un peptide stabilisé
EP3737404A1 (fr) 2017-12-15 2020-11-18 Dana Farber Cancer Institute, Inc. Ciblage sélectif des protéines d'apoptose par des peptides noxa structuralement stabilisés et/ou réactifs à la cystéine
US11952432B2 (en) 2018-02-07 2024-04-09 Dana-Farber Cancer Institute, Inc. Cell-permeable stapled peptide modules for cellular delivery
WO2019178313A1 (fr) 2018-03-14 2019-09-19 Dana-Farber Cancer Institute, Inc. Peptides stabilisés de détection de biomarqueurs
JP6500318B2 (ja) * 2018-04-04 2019-04-17 ウェルズ ファーゴ バンク ナショナル アソシエイション ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
CN109939065B (zh) * 2018-08-10 2021-08-03 上海瑞凝生物科技有限公司 医用水凝胶
WO2020060975A1 (fr) 2018-09-17 2020-03-26 Massachusetts Institute Of Technology Peptides sélectifs pour des protéines de la famille bcl-2
JP7167336B2 (ja) * 2018-11-02 2022-11-08 バイオナット ラブス リミテッド 小型化されたデバイスからのペイロード放出の磁気機械的トリガー
AU2020258482B2 (en) 2019-04-18 2026-02-12 Dana-Farber Cancer Institute, Inc. Selective targeting of ubiquitin- and ubiquitin-like E1-activating enzymes by structurally-stabilized peptides
AU2020340441A1 (en) * 2019-08-29 2022-03-24 Paul Douglas Godfrin Hydrogels as oral delivery dosage forms, methods of making and using same
WO2021071927A1 (fr) * 2019-10-08 2021-04-15 Incube Labs, Llc Dispositif de distribution pour une formulation à libération contrôlée
US20230116760A1 (en) 2019-12-16 2023-04-13 Dana-Farber Cancer Institute, Inc. Structurally-stabilized oncolytic peptides and uses thereof
AU2020408070A1 (en) 2019-12-20 2022-06-09 Dana-Farber Cancer Institute, Inc. Structurally-stabilized glucagon-like peptide 1 peptides and uses thereof
WO2021178714A2 (fr) 2020-03-04 2021-09-10 Dana-Farber Cancer Institute, Inc. Peptides antiviraux dirigés contre le sars-cov-2 structuralement stabilisés et leurs utilisations
CA3179872A1 (fr) 2020-04-22 2021-10-28 Dana-Farber Cancer Institute, Inc. Peptides de type helice 1 d'ace2 antiviraux structuralement stabilises et leurs utilisations
AU2021262752A1 (en) 2020-04-27 2022-10-13 Dana-Farber Cancer Institute, Inc. Structurally-stabilized and HDMX-selective p53 peptides and uses thereof
EP4182377A1 (fr) 2020-07-16 2023-05-24 3M Innovative Properties Company Copolymères contenant du phosphate permettant la suppression de la virulence
CN116801908A (zh) 2020-10-14 2023-09-22 丹娜法伯癌症研究院 用于降解病毒和宿主蛋白的嵌合缀合物和使用方法
US20240002450A1 (en) 2020-11-05 2024-01-04 Dana-Farber Cancer Institute, Inc. Antiviral structurally-stabilized ebolavirus peptides and uses thereof
US12552834B2 (en) 2021-01-25 2026-02-17 Massachusetts Institute Of Technology Selective MENA binding peptides
CN114907580B (zh) * 2021-02-09 2024-11-29 上海瓴就医疗科技有限公司 一种可降解的双组份水凝胶及其制备方法与应用
WO2023039474A1 (fr) 2021-09-08 2023-03-16 Dana-Farber Cancer Institute, Inc. Conjugués peptide-cholestérol de sars-cov-2 antiviraux structurellement insérés et leurs utilisations
EP4518900A1 (fr) 2022-05-04 2025-03-12 Dana-Farber Cancer Institute, Inc. Peptides de glycoprotéines de surface d'ebolavirus, conjugués et utilisations de ceux-ci
CN114767920B (zh) * 2022-05-13 2023-08-29 中国科学院长春应用化学研究所 一种聚乙二醇基粘合剂及其制备方法以及应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149006A (en) 1963-01-31 1964-09-15 William T Abel Prevention of embrittlement of metals
US3419006A (en) * 1966-08-08 1968-12-31 Union Carbide Corp Novel dressing and use thereof
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3963805A (en) 1974-10-30 1976-06-15 Union Carbide Corporation Water swellable poly(alkylene oxide)
NZ193221A (en) 1979-03-21 1984-08-24 M P Embrey Controlled release composition
JPS585320A (ja) 1981-07-01 1983-01-12 Toray Ind Inc グラフト共重合体
EP0206448B1 (fr) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hémoglobine liée à un poly(oxyde d'alkylène)
WO1992000748A1 (fr) 1990-07-06 1992-01-23 Enzon, Inc. Copolymeres d'aminoacides et de poly(oxydes d'alkylene), vehicules de medicament et copolymeres charges bases sur lesdits vehicules
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
AU4899093A (en) 1992-10-13 1994-04-28 Pacesetter Ab Compound and method of applying anti-fouling coatings on medical devices
US5321095A (en) * 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
DE4342154A1 (de) * 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
US5618528A (en) * 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
US5730968A (en) * 1994-03-31 1998-03-24 Sterling Winthrop Inc. Segmented chelating polymers as imaging and therapeutic agents
EP0802787A4 (fr) * 1994-06-17 1998-09-02 Univ Nebraska VECTEUR D'APPORT DE SUBSTANCES BIO-EFFICACES A GELIFICATION -i(IN SITU) ET METHODE D'UTILISATION
WO1996020012A2 (fr) 1994-12-23 1996-07-04 Middlesex Sciences, Inc. Procedes de preparation et de purification de conjugues macromoleculaires
US5962023A (en) * 1995-03-06 1999-10-05 Ethicon, Inc. Hydrogels containing absorbable polyoxaamides
US5698213A (en) * 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5597579A (en) 1995-03-06 1997-01-28 Ethicon, Inc. Blends of absorbable polyoxaamides
US5648088A (en) * 1995-03-06 1997-07-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amide groups
US5607687A (en) * 1995-03-06 1997-03-04 Ethicon, Inc. Polymer blends containing absorbable polyoxaesters
WO1997022371A1 (fr) * 1995-12-18 1997-06-26 Collagen Corporation Composition a base de polymeres reticules et leur procede d'utilisation
US5610241A (en) * 1996-05-07 1997-03-11 Cornell Research Foundation, Inc. Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6214966B1 (en) * 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
PT1053019E (pt) * 1998-01-07 2004-04-30 Debio Rech Pharma Sa Acrilatos de poli(etileno-glicol) heterobifuncional degradaveis e geles e conjugados derivados dos mesmos
US6348558B1 (en) * 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom

Also Published As

Publication number Publication date
EP1019446A1 (fr) 2000-07-19
DE69837443D1 (de) 2007-05-10
WO1999014259A1 (fr) 1999-03-25
AU6029398A (en) 1999-04-05
PT1019446E (pt) 2007-06-25
ES2281925T3 (es) 2007-10-01
DK1019446T4 (da) 2012-03-19
EP1019446B1 (fr) 2007-03-28
CA2303365C (fr) 2007-08-21
ES2281925T5 (es) 2012-04-13
US7964217B2 (en) 2011-06-21
DK1019446T3 (da) 2007-07-30
ATE358150T1 (de) 2007-04-15
JP2001518528A (ja) 2001-10-16
JP4083384B2 (ja) 2008-04-30
DE69837443T3 (de) 2012-05-24
DE69837443T2 (de) 2008-04-17
US20040076602A1 (en) 2004-04-22
EP1019446B2 (fr) 2011-11-30
US20020064546A1 (en) 2002-05-30

Similar Documents

Publication Publication Date Title
CA2303365A1 (fr) Hydrogels de poly(ethylene glycol) degradables a demi-vie regulee et leurs precurseurs
MXPA02006220A (es) Derivados carbamato de poli(etilenglicol) hidroliticamente degradables.
EP1374908A2 (fr) Conjugués de polymère - médicament comprenant des groupes de liaison hydrazide
CA2304976A1 (fr) Administration de molecules conjuguees a du polyethylene glycol a partir d'hydrogels degradables
Bhattarai et al. PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release
ES2294134T3 (es) Modificadores de superficies bilogicamente activas para polimeros y articulos preparados a partir de ellos.
WO1997005185A3 (fr) Hydrogels multiblocs biodegradables destines a etre utilises comme agents de liberation regulee pour l'administration de medicaments et le traitement de tissus
WO2000064486A3 (fr) Conjugues de medicaments polymeres actives par voie enzymatique
US5962520A (en) Hydrolytically unstable, biocompatible polymer
US6150472A (en) Multi-functional site containing polymers, and applications thereof
DE60038010D1 (de) Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
Nazeri et al. 5-aminopyrazole-conjugated gelatin hydrogel: A controlled 5-fluorouracil delivery system for rectal administration
WO2006039276A3 (fr) Derives polymeres de lactam
SI0973819T1 (sl) Neantigenski razvejeni polimerni konjugati
AU2001266033A1 (en) Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base
WO2001000246A3 (fr) Hydrogels derives du chitosane et du poly(ethylene glycol) ou de polymeres apparentes
CA2243649A1 (fr) Polymeres ayant un effet therapeutique, activables biologiquement, et articles realises avec ces polymeres
NO954434L (no) Bioaktive og/eller målsökende dendrimer-konjugater
CA2323048A1 (fr) Derives de poly(ethylene glycol) avec groupes reactifs proximaux
Gerrits et al. Semiflexible polymer scaffolds: an overview of conjugation strategies
EP0780419A1 (fr) Polymères contenant des sites multi-fonctions et leurs applications
Kim et al. In vitro release behavior of dextran-methacrylate hydrogels using doxorubicin and other model compounds
CA2283648A1 (fr) Excipient polymere
WO1998002189A3 (fr) Procede de preparation de polymeres bioactifs
WO2002094324A1 (fr) Systemes d'administration de medicaments par injection avec hydrogels a base de cyclodextrine-polymere

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150123