CA2351885A1 - Ensemble de test et procede permettant de diagnostiquer une pancreatite aigue severe - Google Patents

Ensemble de test et procede permettant de diagnostiquer une pancreatite aigue severe Download PDF

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Publication number
CA2351885A1
CA2351885A1 CA002351885A CA2351885A CA2351885A1 CA 2351885 A1 CA2351885 A1 CA 2351885A1 CA 002351885 A CA002351885 A CA 002351885A CA 2351885 A CA2351885 A CA 2351885A CA 2351885 A1 CA2351885 A1 CA 2351885A1
Authority
CA
Canada
Prior art keywords
capap
antibody
amino acid
acid sequence
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002351885A
Other languages
English (en)
Inventor
Anders Borgstrom
Stefan Appelros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EURODIAGNOSTICA AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2351885A1 publication Critical patent/CA2351885A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé permettant de diagnostiquer in vitro une pancréatite aiguë sévère, des anticorps monoclonaux se fixant sur les peptides d'activation de la carboxypeptidase B (CAPAP) présentant la séquence SEQ ID NO:1 (aa 1 81) ou des fragments de ces derniers, et un ensemble de test, se présentant de préférence sous forme d'une bandelette réactive. Ce procédé comprend les étapes suivantes: A) on met en contact un échantillon de fluide corporel avec a) un premier anticorps se fixant sur les peptides CAPAP présentant la SEQ ID NO:1, et b) un second anticorps se fixant sur les CAPAP présentant la SEQ ID NO:1, en un site différent de a), ou c) un CAPAP présentant la SEQ ID NO:1 ou des fragments de celui-ci, fixés sur un support solide, un des anticorps a) et b) ou le peptide c) étant marqué au moyen d'un marqueur non radioactif, et au moins un des anticorps a) et b) étant monospécifique de CAPAP; et B) on mesure la concentration de complexe anticorps-antigène-anticorps formé ou la concentration d'un composant excédentaire dans la réaction compétitive antigène-anticorps et C) on utilise les valeurs correspondant à la concentration de CAPAP dans l'échantillon pour diagnostiquer une pancréatite aiguë sévère chez le patient.
CA002351885A 1998-11-26 1999-11-16 Ensemble de test et procede permettant de diagnostiquer une pancreatite aigue severe Abandoned CA2351885A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9804069-4 1998-11-26
SE9804069A SE9804069D0 (sv) 1998-11-26 1998-11-26 Test kit and method of diagnosing acute pancreatitis
PCT/SE1999/002094 WO2000031533A1 (fr) 1998-11-26 1999-11-16 Ensemble de test et procede permettant de diagnostiquer une pancreatite aigue severe

Publications (1)

Publication Number Publication Date
CA2351885A1 true CA2351885A1 (fr) 2000-06-02

Family

ID=20413434

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002351885A Abandoned CA2351885A1 (fr) 1998-11-26 1999-11-16 Ensemble de test et procede permettant de diagnostiquer une pancreatite aigue severe

Country Status (6)

Country Link
EP (1) EP1133693A1 (fr)
JP (1) JP2002530675A (fr)
AU (1) AU2008500A (fr)
CA (1) CA2351885A1 (fr)
SE (1) SE9804069D0 (fr)
WO (1) WO2000031533A1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356781A (en) * 1986-07-28 1994-10-18 Bioscience International, Inc. Zymogen activation peptides (ZAP) in the diagnosis of disease

Also Published As

Publication number Publication date
WO2000031533A1 (fr) 2000-06-02
EP1133693A1 (fr) 2001-09-19
AU2008500A (en) 2000-06-13
JP2002530675A (ja) 2002-09-17
SE9804069D0 (sv) 1998-11-26

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Legal Events

Date Code Title Description
FZDE Discontinued