CA2563302C - Combinaisons de glycopyrrolate et d'agonistes de recepteur beta2-adrenergique - Google Patents

Combinaisons de glycopyrrolate et d'agonistes de recepteur beta2-adrenergique Download PDF

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Publication number
CA2563302C
CA2563302C CA2563302A CA2563302A CA2563302C CA 2563302 C CA2563302 C CA 2563302C CA 2563302 A CA2563302 A CA 2563302A CA 2563302 A CA2563302 A CA 2563302A CA 2563302 C CA2563302 C CA 2563302C
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Canada
Prior art keywords
hydroxy
clo
alkyl
glycopyrrolate
medicament
Prior art date
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Expired - Lifetime
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CA2563302A
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CA2563302A1 (fr
Inventor
Stephen Paul Collingwood
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Novartis AG
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Novartis AG
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Publication of CA2563302A1 publication Critical patent/CA2563302A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention concerne un médicament comprenant, séparément ou conjointement, (A) un glycopyrrolate; et (B) soit un composé de formule (I) sous forme libre, sous forme de sel ou sous forme de solvate, dans laquelle W, R?x¿, R?y¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et R?7¿ ont les notations indiquées dans les pièces descriptives de la demande, soit un composé de formule (II) sous forme libre, sous forme de sel ou sous forme de solvate, dans laquelle X possède la notation indiquée dans les pièces descriptives de la demande, en vue d'une administration simultanée, séquentielle ou séparée dans le traitement des maladies inflammatoires ou obstructives des voies respiratoires. Cette invention concerne également des compositions pharmaceutiques qui contiennent (A) et (B).
CA2563302A 2004-05-18 2005-05-17 Combinaisons de glycopyrrolate et d'agonistes de recepteur beta2-adrenergique Expired - Lifetime CA2563302C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0411056.5A GB0411056D0 (en) 2004-05-18 2004-05-18 Organic compounds
GB0411056.5 2004-05-18
PCT/EP2005/005354 WO2005110402A1 (fr) 2004-05-18 2005-05-17 Combinaisons de glycopyrrolate et d'agonistes de recepteur beta2-adrenergique

Publications (2)

Publication Number Publication Date
CA2563302A1 CA2563302A1 (fr) 2005-11-24
CA2563302C true CA2563302C (fr) 2012-08-28

Family

ID=32607514

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2563302A Expired - Lifetime CA2563302C (fr) 2004-05-18 2005-05-17 Combinaisons de glycopyrrolate et d'agonistes de recepteur beta2-adrenergique

Country Status (33)

Country Link
US (6) US20080267886A1 (fr)
EP (3) EP1755590B1 (fr)
JP (2) JP5567252B2 (fr)
KR (2) KR101360556B1 (fr)
CN (1) CN1953745A (fr)
AT (1) ATE521348T1 (fr)
AU (1) AU2005244439C1 (fr)
BE (1) BE2020C517I2 (fr)
BR (1) BRPI0511327B8 (fr)
CA (1) CA2563302C (fr)
CY (4) CY1112086T1 (fr)
DK (2) DK2228064T3 (fr)
EC (1) ECSP066950A (fr)
ES (2) ES2370647T3 (fr)
FR (1) FR20C1018I2 (fr)
GB (1) GB0411056D0 (fr)
HU (3) HUE048936T2 (fr)
IL (1) IL179013A (fr)
LT (3) LT2228064T (fr)
LU (1) LUC00155I2 (fr)
MA (1) MA28598B1 (fr)
MX (1) MXPA06013382A (fr)
NO (2) NO334760B1 (fr)
NZ (1) NZ550369A (fr)
PL (2) PL1755590T3 (fr)
PT (2) PT2228064T (fr)
RU (1) RU2388465C2 (fr)
SE (1) SE1755590T5 (fr)
SG (1) SG153836A1 (fr)
SI (2) SI1755590T1 (fr)
TN (1) TNSN06377A1 (fr)
WO (1) WO2005110402A1 (fr)
ZA (1) ZA200608123B (fr)

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GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
EP1863476B1 (fr) * 2005-03-16 2016-02-03 MEDA Pharma GmbH & Co. KG Combinaison d'anticholinergiques et d'antagonistes de recepteur de leukotriene permettant de traiter les maladies respiratoires
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GB0511065D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0523656D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
GB0523655D0 (en) * 2005-11-21 2005-12-28 Novartis Ag Organic compounds
PT2044025E (pt) * 2006-06-30 2012-12-17 Novartis Ag Derivados de quinolinona e suas composições farmacêuticas
EP1878722A1 (fr) * 2006-07-13 2008-01-16 Novartis AG Dérivés de quinolinone et leur compositions pharmaceutiques
EP1938822A1 (fr) * 2006-12-21 2008-07-02 Novartis AG Thérapie combinée pour le traitement des maladies des voies respiratoires
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