CA2589514E - Formulations de poudre seche pour inhalateur comprenant des particules modifiees en surface avec des additifs anti-adherants - Google Patents

Formulations de poudre seche pour inhalateur comprenant des particules modifiees en surface avec des additifs anti-adherants

Info

Publication number
CA2589514E
CA2589514E CA2589514A CA2589514A CA2589514E CA 2589514 E CA2589514 E CA 2589514E CA 2589514 A CA2589514 A CA 2589514A CA 2589514 A CA2589514 A CA 2589514A CA 2589514 E CA2589514 E CA 2589514E
Authority
CA
Canada
Prior art keywords
particles
active
milled
powder
additive material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2589514A
Other languages
English (en)
Other versions
CA2589514A1 (fr
CA2589514C (fr
Inventor
David Morton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0425758.0A external-priority patent/GB0425758D0/en
Application filed by Vectura Ltd filed Critical Vectura Ltd
Publication of CA2589514A1 publication Critical patent/CA2589514A1/fr
Application granted granted Critical
Publication of CA2589514E publication Critical patent/CA2589514E/fr
Publication of CA2589514C publication Critical patent/CA2589514C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

La présente invention concerne une amélioration du traitement de particules destinées à former une formulation en poudre sèche à administrer aux poumons à l'aide d'un dispositif inhalateur de poudre sèche (DPI). L'invention concerne notamment le traitement de particules de matière active et de particules de matière porteuse en la présence d'une matière d'additif pour produire une composition en poudre présentant d'excellentes propriétés de poudre et économique à produire.
CA2589514A 2004-11-23 2005-11-23 Formulations de poudre seche pour inhalateur comprenant des particules modifiees en surface avec des additifs anti-adherants Expired - Lifetime CA2589514C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0425758.0 2004-11-23
GBGB0425758.0A GB0425758D0 (en) 2004-11-23 2004-11-23 Preparation of pharmaceutical compositions
PCT/GB2005/050211 WO2006056812A1 (fr) 2004-11-23 2005-11-23 Formulations de poudre seche pour inhalateur comprenant des particules modifiees en surface avec des additifs anti-adherants

Publications (3)

Publication Number Publication Date
CA2589514A1 CA2589514A1 (fr) 2006-06-01
CA2589514E true CA2589514E (fr) 2014-07-22
CA2589514C CA2589514C (fr) 2014-07-22

Family

ID=33548732

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2589514A Expired - Lifetime CA2589514C (fr) 2004-11-23 2005-11-23 Formulations de poudre seche pour inhalateur comprenant des particules modifiees en surface avec des additifs anti-adherants

Country Status (16)

Country Link
US (4) US20080127972A1 (fr)
EP (4) EP1814521B1 (fr)
JP (2) JP5339401B2 (fr)
CN (2) CN101106975A (fr)
AT (1) ATE456363T1 (fr)
CA (1) CA2589514C (fr)
DE (1) DE602005019192D1 (fr)
DK (2) DK2311434T3 (fr)
ES (3) ES2548884T3 (fr)
GB (1) GB0425758D0 (fr)
HU (1) HUE027465T2 (fr)
IN (1) IN2014CN04336A (fr)
PL (3) PL2174653T3 (fr)
PT (3) PT2311434E (fr)
SI (2) SI2311434T1 (fr)
WO (1) WO2006056812A1 (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2283818B1 (fr) 2000-11-30 2017-08-02 Vectura Limited Procede de preparation de particules destinees a etre utilisees dans une composition pharmaceutique
WO2004073729A1 (fr) 2003-02-21 2004-09-02 Translational Research Ltd. Compositions destinees a l'administration nasale d'un medicament
CA2519287A1 (fr) 2003-03-27 2004-10-14 Bioactis Limited Applicateur de medicament en poudre pour cavite nasale
US20120321717A1 (en) * 2003-04-14 2012-12-20 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
WO2006016530A1 (fr) * 2004-08-10 2006-02-16 Translational Research, Ltd. Composition transnasale dont l’action est immédiate et l’absorbabilité est élevée
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0621957D0 (en) * 2006-11-03 2006-12-13 Vectura Group Plc Inhaler devices and bespoke pharmaceutical compositions
CN101668544B (zh) 2006-12-26 2013-04-24 株式会社新日本科学 经鼻投用制剂
US11241420B2 (en) 2007-04-11 2022-02-08 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
US20160331729A9 (en) 2007-04-11 2016-11-17 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
EP3788877B1 (fr) * 2007-04-11 2024-08-07 Omeros Corporation Compositions et procédés pour la prophylaxie et le traitement de la toxicomanie
GB0712316D0 (en) * 2007-06-26 2007-08-01 Entripneur Ltd A novel powder and its method of manufacture
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
JP5936353B2 (ja) 2008-07-18 2016-06-22 プロソニックス リミテッドＰｒｏｓｏｎｉｘ Ｌｉｍｉｔｅｄ フルチカゾン粒子の結晶化度を改善する方法
CA2754691C (fr) * 2009-03-26 2019-07-30 Pulmatrix, Inc. Formulations de poudre seche et methodes pour traiter des maladies pulmonaires
GB0905840D0 (en) * 2009-04-06 2009-05-20 Sagentia Ltd Apparatus and methods
US20120101077A1 (en) * 2009-04-24 2012-04-26 Schering Corporation Agglomerate formulations useful in dry powder inhalers
US9101539B2 (en) * 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
GB0918431D0 (en) 2009-10-21 2009-12-09 Prosonix Ltd Process for improving crystallinity
BR112012024059B1 (pt) * 2010-04-01 2021-06-01 Chiesi Farmaceutici S.P.A. Processo de preparo de um excipiente para composições farmacêuticas em pó para inalação, partículas carreadoras para uma formulação farmacêutica de pó seco, composição farmacêutica em forma de pó seco para inalação e inalador de pó seco
WO2011131663A1 (fr) * 2010-04-21 2011-10-27 Chiesi Farmaceutici S.P.A. Procédé de préparation de particules ayant des charges électrostatiques réduites
CN102309456B (zh) * 2010-07-02 2013-05-01 北京化工大学 一种厄贝沙坦纳微复合粉体与片剂及其制备方法
EP2464346A1 (fr) 2010-08-30 2012-06-20 Pulmatrix, Inc. Méthodes de traitement de la mucoviscidose
AU2011296343B2 (en) * 2010-08-30 2015-12-10 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
RU2017144619A (ru) 2010-09-29 2019-02-20 Пулмэтрикс, Инк. Катионы одновалентных металлов сухих порошков для ингаляций
EP3470057B1 (fr) 2010-09-29 2021-11-03 Pulmatrix Operating Company, Inc. Poudres sèches cationiques contenants un sel de magnésium
UY33337A (es) 2010-10-18 2011-10-31 Respivert Ltd DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
ITMI20120092A1 (it) * 2012-01-26 2013-07-27 Micro Macinazione S A Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
NZ628072A (en) 2012-03-13 2015-08-28 Respivert Ltd Crystalline pi3 kinase inhibitors
RU2666963C2 (ru) 2012-04-13 2018-09-13 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Агрегированные частицы
CN103570610B (zh) * 2012-07-18 2017-08-11 重庆华邦制药有限公司 一种罗氟司特微粒的制备方法
CN103588846B (zh) * 2012-08-15 2016-08-03 重庆华邦制药有限公司 一种丙酸氟替卡松微粒的制备方法及其用途
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
JP6116206B2 (ja) * 2012-11-26 2017-04-19 クリニプロ株式会社 吸入用パウダーの製造方法
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
JP6473738B2 (ja) 2013-04-01 2019-02-20 パルマトリックス，インコーポレイテッド チオトロピウム乾燥粉末
ITMI20130572A1 (it) * 2013-04-10 2014-10-11 Eratech Srl Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione
HK1218720A1 (zh) 2013-04-30 2017-03-10 欧缇托匹克公司 干粉制剂及使用方法
HUE053957T2 (hu) * 2013-07-11 2021-08-30 Chiesi Farm Spa Antikolinerg, kortikoszteroid és béta-adrenerg anyagot tartalmazó száraz porkészítmény inhalálással történõ beadásra
US10307370B2 (en) 2013-10-08 2019-06-04 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
US10307371B2 (en) 2014-02-11 2019-06-04 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
ES2922206T3 (es) 2014-02-20 2022-09-09 Otitopic Inc Formulaciones de polvo seco para la inhalación
DK3125875T3 (da) 2014-04-04 2023-07-24 Ai Therapeutics Inc Inhalerbar rapamycinformulering til behandling af aldersrelaterede tilstande
ES2701525T3 (es) 2014-07-09 2019-02-22 Arven Ilac Sanayi Ve Ticaret As Un procedimiento para la preparación de formulaciones para inhalación
ES2942297T3 (es) * 2014-07-31 2023-05-31 Vectura Inc Formulaciones de polvo seco para inhalación
SMT202000280T1 (it) 2014-09-09 2020-07-08 Vectura Ltd Formulazione comprendente glicopirrolato, metodo ed apparecchiatura
KR20170095807A (ko) 2014-10-07 2017-08-23 램 테라퓨틱스, 인코포레이티드 폐 고혈압의 치료를 위한 흡입가능 라파마이신 제제
US20160119692A1 (en) * 2014-10-24 2016-04-28 Sunshine Partners LLC Interactive system and method for viewer selection of objects in context while viewing television
WO2016067252A1 (fr) 2014-10-31 2016-05-06 Glaxosmithkline Intellectual Property Development Limited Formulation de poudre
PE20180690A1 (es) 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
US9585835B1 (en) * 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
US10149844B2 (en) 2015-09-16 2018-12-11 Philip Morris Products S.A. Inhalable nicotine formulations, and methods of making and using thereof
CA3067011A1 (fr) 2016-06-17 2017-12-21 Axon Enterprise, Inc. Systemes et procedes d'alignement de donnees d'evenement
RU2741309C2 (ru) 2016-06-30 2021-01-25 Филип Моррис Продактс С.А. Никотиносодержащие частицы
KR102523677B1 (ko) * 2016-06-30 2023-04-20 필립모리스 프로덕츠 에스.에이. 니코틴 입자 및 조성물
EP3525759A1 (fr) * 2016-10-14 2019-08-21 Pulmatrix Operating Company, Inc. Poudres sèches antifongiques
KR20190126772A (ko) * 2017-03-07 2019-11-12 필립모리스 프로덕츠 에스.에이. 흡입 가능한 니코틴 제형, 및 이의 제조 및 사용 방법
WO2018223109A1 (fr) 2017-06-02 2018-12-06 Csp Technologies, Inc. Inhalateur et ses méthodes d'utilisation et de fabrication
CN109200034A (zh) * 2017-06-30 2019-01-15 正大天晴药业集团股份有限公司 一种可吸入干粉形式的组合物及其制备方法
KR102681843B1 (ko) 2017-09-22 2024-07-05 벡추라 인코포레이티드 스테아르산마그네슘을 갖는 건조 분말 조성물
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
CN112451509B (zh) * 2020-12-19 2023-03-07 沈阳药科大学 一种川丁特罗吸入粉雾剂及其制备方法
WO2023069028A1 (fr) * 2021-10-20 2023-04-27 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Procédé de préparation de compositions de poudre sèche pour inhalation
IT202100031133A1 (it) * 2021-12-13 2023-06-13 Zambon Spa Composizione farmaceutica comprendente tigeciclina
US12005185B2 (en) * 2021-12-17 2024-06-11 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods
WO2023128913A1 (fr) * 2021-12-31 2023-07-06 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Procédé de préparation de compositions de poudre sèche pour inhalation
KR20250084912A (ko) 2022-07-04 2025-06-11 호비온 사이언티아 리미티드 흡입을 위한 코팅된 결정형 건조 분말의 건조 분말 흡입기 약학 조성물
CN115060832B (zh) * 2022-08-18 2022-11-29 上海奥科达生物医药科技有限公司 奥卡西平口服混悬液中奥卡西平及防腐剂含量检测方法
CN115770221A (zh) * 2022-12-29 2023-03-10 浙江上药九旭药业有限公司 银杏酮酯粉体、银杏酮酯滴丸剂及其制备方法
GB2633305B (en) 2023-08-30 2025-11-26 Envirohale Malta Holdings Ltd Nasal and pulmonary drug delivery
CN120678762A (zh) * 2024-03-20 2025-09-23 浙江萃泽医药科技有限公司 一种可吸入的药物粉末制剂及其制备方法
CN119055610A (zh) * 2024-08-27 2024-12-03 江苏谦仁生物科技有限公司 一种阿昔莫司胶囊及其制备方法
CN119371006B (zh) * 2024-11-06 2025-07-04 北京城市排水集团有限责任公司 一种长效缓释型污泥脱氮菌群调节药剂及制备方法和应用

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687773A (en) 1983-03-28 1987-08-18 Mclean Hospital (+)-N-N-propylnorapomorphine and selective limbic activity
WO1990013327A1 (fr) 1989-04-28 1990-11-15 Riker Laboratories, Inc. Dispositif d'inhalation de poudre seche
JPH05963A (ja) 1990-04-13 1993-01-08 Toray Ind Inc ポリペプチド類組成物
US5292520A (en) 1990-09-13 1994-03-08 Akzo N.V. Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
AR002009A1 (es) 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9515182D0 (en) * 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
FR2747311B1 (fr) 1996-04-10 1998-08-14 Pf Medicament Inhalateur a poudre et a air comprime
DE69732306T2 (de) 1997-01-16 2006-01-12 Massachusetts Institute Of Technology, Cambridge Zubereitung von partikelhaltigen arzneimitteln zur inhalation
US6051257A (en) 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
EP0931595A1 (fr) 1998-01-26 1999-07-28 Imra Europe S.A. Dispositif pour pulvériser un liquide
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
AU756852B2 (en) 1998-11-13 2003-01-23 Jagotec Ag Dry powder for inhalation
GB9827145D0 (en) 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
ES2286881T3 (es) 1999-03-05 2007-12-01 Chiesi Farmaceutici S.P.A. Composiciones farmaceuticas en polvo mejoradas para inhalacion.
CA2371836C (fr) 1999-05-27 2006-01-31 Acusphere, Inc. Matrices medicamenteuses poreuses et procedes de fabrication associes
US6858199B1 (en) 2000-06-09 2005-02-22 Advanced Inhalation Research, Inc. High efficient delivery of a large therapeutic mass aerosol
GB2353222B (en) 1999-06-23 2001-09-19 Cambridge Consultants Inhalers
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
US20010036481A1 (en) 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
JP2001072586A (ja) 1999-09-06 2001-03-21 Nikken Chem Co Ltd 吸入用粉末製剤及びその製造方法
JP2001151673A (ja) 1999-09-06 2001-06-05 Nikken Chem Co Ltd 吸入用粉末製剤の製造方法
EP1219609B1 (fr) 1999-09-16 2007-04-04 Tanabe Seiyaku Co., Ltd. Composes cycliques aromatiques azotes a six elements
FI20002217A7 (fi) 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
BR0109515A (pt) 2000-04-07 2004-08-10 Tap Pharmaceutical Prod Inc Derivados da apomorfina e métodos para seu uso
GB0008660D0 (en) 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
GB0009468D0 (en) * 2000-04-17 2000-06-07 Vectura Ltd Improvements in or relating to formulations for use in inhaler devices
DE60128902T2 (de) 2000-04-17 2008-02-14 Vectura Ltd., Chippenham Formulierungen zur verwendung in inhalationsvorrichtungen
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0009469D0 (en) * 2000-04-17 2000-06-07 Vectura Ltd Improvements in or relating to formalities for use in inhaler devices
GB0010709D0 (en) 2000-05-03 2000-06-28 Vectura Ltd Powders for use a in dry powder inhaler
PT1296651E (pt) * 2000-06-27 2008-02-12 Vectura Ltd Método para fazer partículas para serem usadas numa composição farmacêutica
GB2364919A (en) 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
WO2002009669A2 (fr) 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Appareil et procede de production de particules a distribution granulometrique etroite et particules ainsi obtenues
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US20020086876A1 (en) 2000-11-15 2002-07-04 Ruff Dustin D. Treatment of anti-depression drug-induced sexual dysfunction with apomorphine
US6528521B2 (en) 2000-11-15 2003-03-04 Tap Pharmaceutical Products, Inc. Treatment of anti-depression drug-induced sexual dysfunction with apomorphine
NZ526059A (en) 2000-11-30 2005-05-27 Vectura Ltd Method of making composite active particles in the presence of an additive material for use in a pharmaceutical composition
EP2168571B1 (fr) * 2000-11-30 2018-08-22 Vectura Limited Compositions pharmaceutiques pour inhalation
WO2002043693A2 (fr) 2000-11-30 2002-06-06 Vectura Limited Compositions pharmaceutiques a inhaler
EP2283818B1 (fr) * 2000-11-30 2017-08-02 Vectura Limited Procede de preparation de particules destinees a etre utilisees dans une composition pharmaceutique
PT2301524E (pt) 2000-12-27 2013-07-10 Gilead Sciences Inc Aztreonam inalável sem arginina para tratamento e prevenção de infecções bacterianas pulmonares
GB0109384D0 (en) * 2001-04-12 2001-05-30 Vectura Ltd Pharmaceutical products, preparation and uses thereof
CA2444729A1 (fr) 2001-05-10 2002-11-14 Vectura Delivery Devices Limited Inhalateurs
GB2375308A (en) 2001-05-10 2002-11-13 Cambridge Consultants Inhalers
CA2446904A1 (fr) 2001-05-24 2003-04-03 Alexza Pharmaceuticals, Inc. Administration d'esters medicamenteux par inhalation
US20040028613A1 (en) 2001-06-25 2004-02-12 Nastech Pharmaceutical Company Inc Dopamine agonist formulations for enhanced central nervous system delivery
US20050013862A1 (en) * 2001-09-05 2005-01-20 Vectura Limited Functional powders for oral delivery
WO2003074029A1 (fr) * 2002-03-07 2003-09-12 Vectura Limited Formulations a base de particules multiples a fusion rapide pour administration orale
US20040003341A1 (en) 2002-06-20 2004-01-01 Koninklijke Philips Electronics N.V. Method and apparatus for processing electronic forms for use with resource constrained devices
AU2003269284A1 (en) * 2002-10-11 2004-05-04 Pharmakodex Limited Pharmaceutical excipients comprising inorganic particles in association with an organic polymeric material and forming a solid reticulated matrix, compositions, manufacturing and use thereof
US20060147389A1 (en) * 2004-04-14 2006-07-06 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
JP2006522634A (ja) 2003-04-14 2006-10-05 ベクトゥラ・リミテッド 投与効率を向上させるデバイス及び製薬組成
US20040204439A1 (en) 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
RU2364400C2 (ru) 2003-04-14 2009-08-20 Вектура Лтд Фармацевтические композиции
EP1663164A2 (fr) * 2003-09-15 2006-06-07 Vectura Limited Procedes de preparation de compositions pharmaceutiques
GB0321607D0 (en) * 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
GB0330255D0 (en) 2003-12-31 2004-02-04 Vectura Ltd Multiparticulate formulations for oral delivery
GB0408308D0 (en) 2004-04-14 2004-05-19 Vectura Ltd Pharmaceutical compositions
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
GB0410399D0 (en) 2004-05-10 2004-06-16 Arakis Ltd The treatment of respiratory disease
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0426301D0 (en) 2004-11-30 2004-12-29 Vectura Ltd Pharmaceutical formulations

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