CH235950A - Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Nicotinsäureamid. - Google Patents

Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Nicotinsäureamid.

Info

Publication number
CH235950A
CH235950A CH235950DA CH235950A CH 235950 A CH235950 A CH 235950A CH 235950D A CH235950D A CH 235950DA CH 235950 A CH235950 A CH 235950A
Authority
CH
Switzerland
Prior art keywords
sep
amino
pyridine
acid amide
nicotinic acid
Prior art date
Application number
Other languages
English (en)
Inventor
Dr. A. Wander Aktiengesellschaft
Original Assignee
Wander Ag Dr A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander Ag Dr A filed Critical Wander Ag Dr A
Publication of CH235950A publication Critical patent/CH235950A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
    • C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description


  Verfahren     zier    Herstellung von     p-amino-benzolsalfonyl-a-amino-pyridin-Bz-N-          methylettsttlfosaurem        Nieotinsäureamid.     
EMI0001.0005     
  
    Im <SEP> Hauptpatent <SEP> ist <SEP> ein <SEP> Verfahren <SEP> zur
<tb>  Herstellung <SEP> von <SEP> p-amino=benzo:lsulfonyl-a  amino <SEP> - <SEP> p:yridin <SEP> - <SEP> Bz <SEP> - <SEP> N <SEP> - <SEP> methylensulfosaurem
<tb>  Hegamethydentetramin <SEP> durch <SEP> Umsetzung <SEP> der
<tb>  freien <SEP> Säure <SEP> mit <SEP> Hexamethylentetramin <SEP> be  schrieben.
<tb>  



  Es <SEP> wurde <SEP> nun <SEP> gefunden, <SEP> .dass <SEP> man <SEP> thera  peutisch <SEP> ebenso <SEP> wertvolle <SEP> Salze <SEP> erhält, <SEP> wenn
<tb>  man <SEP> die <SEP> genannte <SEP> Säure <SEP> mit <SEP> einem <SEP> Säure  amid <SEP> umsetzt.
<tb>  



  Gegenstand <SEP> des <SEP> vorliegenden <SEP> Patentes. <SEP> ist
<tb>  ein <SEP> Verfahren <SEP> zur <SEP> Herstellung <SEP> von <SEP> p-amino  benzolsv,lfonyl <SEP> - <SEP> a <SEP> - <SEP> amino <SEP> - <SEP> pyridin <SEP> - <SEP> Bz <SEP> - <SEP> N  methyl & u;l.fosaurem <SEP> Nieotinsäureamid, <SEP> wel  ches <SEP> d!adurch <SEP> gekennzeichnet <SEP> ist, <SEP> dass <SEP> man:
<tb>  p-Amino-benzolenlfonyl <SEP> -a-amino-pyridin-B:z  N-rmethyiensufosäure <SEP> in <SEP> Gegenwart <SEP> eines
<tb>  Alkohols <SEP> auf <SEP> Nicotins#äureami:d <SEP> einwirken
<tb>  lässt.
<tb>  



  <I>Beispiel:</I>
<tb>  61 <SEP> g <SEP> Nicotinsäureamid <SEP> werden <SEP> in <SEP> einem
<tb>  Gemisch <SEP> von <SEP> 1500 <SEP> em3 <SEP> Wasser <SEP> und <SEP> 500 <SEP> em3
<tb>  Alkohol, <SEP> beispielsweise <SEP> Isopropylalkohol, <SEP> ge  löst <SEP> und <SEP> unter <SEP> Umrühren <SEP> hei <SEP> zirka <SEP> <B>50'C</B>     
EMI0001.0006     
  
    171 <SEP> g <SEP> p <SEP> - <SEP> Amino <SEP> - <SEP> benzolsulf <SEP> onyl <SEP> - <SEP> a <SEP> - <SEP> amino  pyridin-B:z-N-methylensulfosäure <SEP> eingetra  gen. <SEP> Bereits <SEP> in <SEP> der <SEP> Wärme <SEP> setzt <SEP> die <SEP> Kri  eta.ll2sation <SEP> ein. <SEP> Durch <SEP> Umkristallisieren <SEP> aus
<tb>  einem <SEP> Was:

  ser-Alkohol@Gemisch <SEP> erhält <SEP> man
<tb>  ,gelblichgrüne <SEP> Nädelch'en <SEP> vom <SEP> Schmelzpunkt
<tb>  173--175  <SEP> (unter <SEP> Zersetzung). <SEP> Das <SEP> p-amino  benzolsul'fonyl <SEP> - <SEP> a <SEP> - <SEP> amino <SEP> - <SEP> pyridin <SEP> - <SEP> Bz <SEP> - <SEP> N  methylens,u;lfosaure <SEP> Nicotineäureamid <SEP> soll
<tb>  therapeutische <SEP> Verwendung <SEP> finden.

Claims (1)

  1. EMI0001.0007 PATENTANSPRUCH: <tb> Verfahren <SEP> zur <SEP> Herstellung <SEP> von <SEP> p-amino benzolte,u.Lfonyl <SEP> - <SEP> a <SEP> - <SEP> amino <SEP> - <SEP> pyridin <SEP> - <SEP> Bz <SEP> - <SEP> N methylensuI,fosaurem <SEP> Nicotinsäureamid, <SEP> da durch <SEP> gekennzeichnet, <SEP> dass <SEP> man <SEP> p-Amino benzolsufon.yl <SEP> - <SEP> a <SEP> - <SEP> aunino <SEP> - <SEP> pyridin <SEP> - <SEP> Bz <SEP> - <SEP> N methylensulfosäure <SEP> in <SEP> Gegenwart <SEP> eines <SEP> Al kohole <SEP> auf <SEP> Nicotinsäureamd <SEP> einwirken <SEP> lässt. <tb> Das <SEP> neue <SEP> Produkt <SEP> bildet <SEP> gelblYChgrüne <tb> Nädelchen, <SEP> .die <SEP> bei <SEP> 173-175 C <SEP> unter <SEP> Zer setzung <SEP> schmelzen.
CH235950D 1942-05-02 1942-05-02 Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Nicotinsäureamid. CH235950A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH235950T 1942-05-02
CH228551T 1943-04-06

Publications (1)

Publication Number Publication Date
CH235950A true CH235950A (de) 1944-12-31

Family

ID=25727229

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235950D CH235950A (de) 1942-05-02 1942-05-02 Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Nicotinsäureamid.

Country Status (1)

Country Link
CH (1) CH235950A (de)

Similar Documents

Publication Publication Date Title
CH235950A (de) Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Nicotinsäureamid.
US2194201A (en) Organic compound and method of producing the same
US2411661A (en) 4-aminobenzene-sulfone-carbamic acid derivative
DE834989C (de) Verfahren zur Herstellung von 21-Jod-pregnen-(5)-ol-(3)-on-(20)
DE926248C (de) Verfahren zur Herstellung von Abkoemmlingen des Pyridin-4-carbonsaeurehydrazids
DE957841C (de) Verfahren zur Herstellung von Sulfonamiden
Kahn et al. 452. Some derivatives of 1: 3-dimethyl-2-azafluorenone
DE504248C (de) Verfahren zur Darstellung von Kuepenfarbstoffen der Thionaphthenreihe
DE848650C (de) Verfahren zur Herstellung von in 3-Stellung substituierten AEtiocholensaeurederivaten
DE496393C (de) Verfahren zur Darstellung von Anthrachinon und seinen Abkoemmlingen
DE895600C (de) Verfahren zur Herstellung von Diphenylsulfonen
CH235947A (de) Verfahren zur Herstellung von p-amino-benzolsulfonyl- -amino-pyridin-Bz-N-methylensulfosaurem Ephedrin.
AT152837B (de) Verfahren zur Darstellung von 2.4-Dioxo-3.3-dialkyl-1.2.3.4-tatrahydropyridinen.
DE845195C (de) Verfahren zur Herstellung neuer Thiosemicarbazone
DE835441C (de) Verfahren zur Herstellung von Xanthin
Hasselstrom et al. Lactone Formation in the Sulfonation of Heat Treated Rosin
CH221853A (de) Verfahren zur Herstellung eines Benzolsulfonsäureabkömmlings.
CH302076A (de) Verfahren zur Herstellung eines Thiosemicarbazons.
CH217346A (de) Verfahren zur Herstellung eines Benzolsulfonsäureabkömmlings.
CH297989A (de) Verfahren zur Herstellung einer mehrgliedrigen heterocyclischen Verbindung.
CH177848A (de) Verfahren zur Darstellung eines schwefel- und stickstoffhaltigen Anthrachinonderivates.
CH213144A (de) Verfahren zur Herstellung eines Benzolsulfonsäureabkömmlings.
CH220957A (de) Verfahren zur Herstellung eines Benzolsulfonsäureabkömmlings.
PL23743B3 (pl) Sposób wytwarzania podstawionych kwasów barbiturowych.
CH222077A (de) Verfahren zur Darstellung eines Kondensationsproduktes.