CH242517A - Process for the preparation of an acylated sulfonamide. - Google Patents

Process for the preparation of an acylated sulfonamide.

Info

Publication number
CH242517A
CH242517A CH242517DA CH242517A CH 242517 A CH242517 A CH 242517A CH 242517D A CH242517D A CH 242517DA CH 242517 A CH242517 A CH 242517A
Authority
CH
Switzerland
Prior art keywords
sulfonamide
nitro
acetyl
benzene
preparation
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242517A publication Critical patent/CH242517A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

      Verfahren    zur Herstellung eines     aeylierten    Sulfonamides.    Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung des     bekannten          4-Nitro-benzol-N-acetyl-sulfonamids.    Das.

    Verfahren ist dadurch     gekennzeichnet,        dass.     man     ein    substituiertes     4-Nitrö-benzol-sulfon-          amid    der Formel  
EMI0001.0010     
    in der     Reinen    durch     hydrolysierende        Mittel          abspaltbaren    Rest bedeutet, durch     Verseifung.          in        4-Nitro-benzol-N-acetyl-sulfonamid    über  führt.  



  Die     Verbindung    bildet farblose     Kristalle     vom Schmelzpunkt 194 . Sie soll als Arznei  mittel Verwendung     finden.     



  <I>Beispiel:</I>  10 Teile     N-(4-Nitro-benzolsulfonyl-)-acet-          amidin    vom     Schmelzpunkt    190  und der  Formel  
EMI0001.0024     
    werden mit 100 Teilen     3,5%iger    Salzsäure  4     Stunden    auf 90-100  erhitzt. Nach dem  Erkalten     wird        sodaalkalisch    gestellt, filtriert  und mit Essigsäure angesäuert. Man erhält  das     4-Nitro-benzol-N-acetyl-sulfonamid.    Aus  Alkohol     umkristallisiert    bildet es farblose       Kristalle    vom     Schmelzpunkt    194 .



      Process for the preparation of an alkylated sulfonamide. The subject of the present patent is a process for the production of the known 4-nitro-benzene-N-acetyl-sulfonamide. The.

    The process is characterized in that a substituted 4-nitrobenzenesulfonamide of the formula
EMI0001.0010
    in the pure means radical which can be split off by hydrolyzing agents by saponification. in 4-nitro-benzene-N-acetyl-sulfonamide leads over.



  The compound forms colorless crystals with a melting point of 194. It should be used as a medicament.



  <I> Example: </I> 10 parts of N- (4-nitro-benzenesulfonyl -) - acetamidine with a melting point of 190 and the formula
EMI0001.0024
    are heated to 90-100 for 4 hours with 100 parts of 3.5% hydrochloric acid. After cooling, it is made alkaline with soda, filtered and acidified with acetic acid. The 4-nitro-benzene-N-acetyl-sulfonamide is obtained. Recrystallized from alcohol, it forms colorless crystals with a melting point of 194.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von 4-Nitro- benzol-N-acetyl-sulfo.namid, dadurch gekenn zeichnet, dass man ein substituiertes 4-Nitro- benzol-sulfonamid der Formel EMI0001.0040 in der R einen durch hydroly sierende Mittel äbspaltbaren Rest bedeutet, durch Verseifung in 4-Nitro-benzol-N-acetyl-sulfonamid über führt. PATENT CLAIM: Process for the preparation of 4-nitrobenzene-N-acetyl-sulfo.namid, characterized in that a substituted 4-nitrobenzene-sulfonamide of the formula EMI0001.0040 in which R denotes a radical which can be split off by hydrolyzing agents, leads to 4-nitro-benzene-N-acetyl-sulfonamide by saponification. Die Verbindung bildet farblose Kristalle vom Schmelzpunkt 194 ._ Sie soll als Arznei mittel Verwendung finden. UNTERANSPRUCII Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man N-(4-N itro-benzol- sulfonyl)-acetamidin durch hydrolytische Spaltung in 4-Nitro-benzol-N-acetyl-sulfon- amid überführt. The compound forms colorless crystals with a melting point of 194._ It is said to be used as a medicinal product. SUBSTITUTE SHEET A method according to claim, characterized in that N- (4-nitro-benzene-sulfonyl) -acetamidine is converted into 4-nitro-benzene-N-acetyl-sulfonamide by hydrolytic cleavage.
CH242517D 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide. CH242517A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242517T 1943-05-21
CH239850T 1944-03-16

Publications (1)

Publication Number Publication Date
CH242517A true CH242517A (en) 1946-05-15

Family

ID=25728446

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242517D CH242517A (en) 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide.

Country Status (1)

Country Link
CH (1) CH242517A (en)

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