CH242523A - Process for the preparation of an acylated sulfonamide. - Google Patents

Process for the preparation of an acylated sulfonamide.

Info

Publication number
CH242523A
CH242523A CH242523DA CH242523A CH 242523 A CH242523 A CH 242523A CH 242523D A CH242523D A CH 242523DA CH 242523 A CH242523 A CH 242523A
Authority
CH
Switzerland
Prior art keywords
amino
sulfonamide
methyl
preparation
benzene
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242523A publication Critical patent/CH242523A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

  Verfahren zur     Bierstellung    eines     acylerten    Sulfonamides.    Gegenstand vorliegenden Patentes ist     ein          Verfahren    zur     Herstellung    eines     acylierten     Sulfonamides.

   Das Verfahren ist dadurch  gekennzeichnet, dass man ein     substituiertes          4-Amino-benzolsuHonamid    der Formel -  
EMI0001.0009     
         in    der R einen durch     hydrolysierende        Mittel          abspaltbaren    Rest bedeutet, durch     Verseifung     in 4     -Amino    - Benzol -     N1-        (3'-        methyl    -     inden-          earboyl-[2'])-sulfonamid    überführt.  



  Die neue     Verbindung    bildet farblose Kri  stalle vom     Zersetzungspunkt    233 . Sie soll als  Arzneimittel     Verwendung    finden.  



  <I>Beispiel:</I>  10     Teile        N-(4'-Amino-benzolsulfonyl)-3-          methyl-indencarbonsäureamidin-(2)        von,    der  Formel  
EMI0001.0028     
    werden mit 100 Teilen 3,5 %     iger    Salzsäure       1A    Stunde auf 90-100  erhitzt. Nach     dem.     Erkalten     wird        sodaalkalisch    gestellt, filtriert  und mit Essigsäure angesäuert.

   Man erhält  das     4-Amino-benzol-Nl-(3'-methyl-inden-          carboyl-[2'])-sulfonamid.    Aus Alkohol um  kristallisiert     bildet    es. farblose Kristalle vom       Zersetzungspunkt    233 .



  Process for making beer from an acylated sulfonamide. The present patent relates to a process for the preparation of an acylated sulfonamide.

   The process is characterized in that a substituted 4-amino-benzenesu-monamide of the formula -
EMI0001.0009
         in which R denotes a radical which can be split off by hydrolyzing agents, converted by saponification into 4-amino-benzene-N1- (3'-methyl-indene-earboyl- [2 ']) -sulfonamide.



  The new compound forms colorless crystals from the decomposition point 233. It should be used as a medicine.



  <I> Example: </I> 10 parts of N- (4'-Amino-benzenesulfonyl) -3-methyl-indenecarboxamide- (2) of, of the formula
EMI0001.0028
    are heated to 90-100 for 1 hour with 100 parts of 3.5% hydrochloric acid. After this. Cooling is made alkaline with soda, filtered and acidified with acetic acid.

   The 4-amino-benzene-Nl- (3'-methyl-indene-carboyl- [2 ']) sulfonamide is obtained. Recrystallized from alcohol it forms. colorless crystals with decomposition point 233.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines acylier- ten Sulfonamides, dadurch gekennzeichnet, dass man ein substituiertes 4-Amino-benzol- sulfonamid der Formel EMI0001.0047 in der R einen durch hydrolysierende Mittel abspaltbaren Rest bedeutet, PATENT CLAIM: Process for the preparation of an acylated sulfonamide, characterized in that a substituted 4-amino-benzenesulfonamide of the formula EMI0001.0047 in which R is a residue that can be split off by hydrolyzing agents, durch Verseifung in 4 -Amino - benzol - N1-<B>W-</B> methyl - inden- carboyl-[2'] )-sulfonamid überführt. Die neue Verbindung bildet farblose Kri stalle vom Zersetzungspunkt 233 . Sie soll als Arzneimittel Verwendung finden. converted by saponification into 4-amino-benzene-N1- <B> W- </B> methyl - indene-carboyl- [2 ']) -sulfonamide. The new compound forms colorless crystals from the decomposition point 233. It should be used as a medicine. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man N - (4' -Amino- benzolsulfonyl) - 3 -methyl-indencärbonsäure- amidin-(2) durch hydrolytisöhe Spaltung in 4 - Amino - benzol - N1 -<B>(3'-</B> methyl - irden - carboyl-[2'])-sulfonamid überführt. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that N - (4 '-amino-benzenesulfonyl) -3-methyl-indenecarboxylic acid amidine- (2) by hydrolytic cleavage into 4-amino-benzene-N1 - <B> (3 '- </B> methyl - earthen - carboyl- [2']) - sulfonamide transferred.
CH242523D 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide. CH242523A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242523T 1943-05-21
CH239850T 1944-03-16

Publications (1)

Publication Number Publication Date
CH242523A true CH242523A (en) 1946-05-15

Family

ID=25728452

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242523D CH242523A (en) 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide.

Country Status (1)

Country Link
CH (1) CH242523A (en)

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