CH242521A - Process for the preparation of an acylated sulfonamide. - Google Patents

Process for the preparation of an acylated sulfonamide.

Info

Publication number
CH242521A
CH242521A CH242521DA CH242521A CH 242521 A CH242521 A CH 242521A CH 242521D A CH242521D A CH 242521DA CH 242521 A CH242521 A CH 242521A
Authority
CH
Switzerland
Prior art keywords
sulfonamide
amino
preparation
propogy
isobutyroyl
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242521A publication Critical patent/CH242521A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines     acylierten    Sulfonamides.    Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung eines     acylierten     Sulfonamides. Das Verfahren ist dadurch  gekennzeichnet, dass man ein     substituiertes          4-Amine-benzolsulfonamid    der Formel  
EMI0001.0005     
    in der R     einen    durch     hydrolysierende    Mittel       abspaltbaren    Rest bedeutet, durch     Verseifung          in    4 -     Amino    -     benzol    -     N,

  .    - (a -     propogy    -     iso-          butyroyl)-sulfonamid    überführt.  



  Die neue     Verbindung    bildet farblose Kri  stalle vom Schmelzpunkt 135-136 . Sie soll  als Arzneimittel     Verwendung    finden.  



  <I>Beispiel:</I>  10 Teile     N-(4-Amino-benzolsulfonyl)-a-          propogy-isobuttersäureamidin    von der Formel  
EMI0001.0021     
    werden mit 100 Teilen 3,5 %     iger    Salzsäure  2     Stunden    auf 90-100  erhitzt.

   Nach dem  Erkalten wird     sodaalkalisch    gestellt,     filtriert     und mit Essigsäure angesäuert.     Klan    erhält  das 4 -     Aminö    -     benzol    -     N,    - (a -     propogy    -     iso-          butyroyl)-sulfonamid.    Aus Alkohol umkri  stallisiert bildet es farblose Kristalle vom  Schmelzpunkt     135-136 .  



  Process for the preparation of an acylated sulfonamide. The present patent relates to a process for the preparation of an acylated sulfonamide. The process is characterized in that a substituted 4-amine-benzenesulfonamide of the formula
EMI0001.0005
    in which R denotes a residue that can be split off by hydrolyzing agents, by saponification in 4 - amino - benzene - N,

  . - (a - propogy - isobutyroyl) sulfonamide transferred.



  The new compound forms colorless crystals with a melting point of 135-136. It should be used as a medicine.



  <I> Example: </I> 10 parts of N- (4-amino-benzenesulfonyl) -a propogy-isobutyric acid amidine of the formula
EMI0001.0021
    are heated to 90-100 for 2 hours with 100 parts of 3.5% hydrochloric acid.

   After cooling, it is made alkaline with soda, filtered and acidified with acetic acid. Klan receives the 4 - amino - benzene - N, - (a - propogy - isobutyroyl) sulfonamide. Umkri crystallized from alcohol, it forms colorless crystals with a melting point of 135-136.

Claims (1)

PATENTANSPRUCH: Verfahren, zur Herstellung eines acylier- ten Sulfonamides, dadurch gekennzeichnet, dass man ein substituiertes 4-Amino-benzol- sulf onamid der Formel EMI0001.0041 in der R einen durch hydrolysierende Mittel abspaltbaren Rest bedeutet, PATENT CLAIM: Process for the preparation of an acylated sulfonamide, characterized in that a substituted 4-amino-benzenesulfonamide of the formula EMI0001.0041 in which R is a residue that can be split off by hydrolyzing agents, durch Verseifung in 4 - Amino - benzol - Nl - (a - propogy - iso- butyroyl)-sulfonamid überführt. Die neue Verbindung bildet farblose Kri stalle vom Schmelzpunkt 135-136 . Sie soll als Arzneimittel Verwendung finden. converted by saponification into 4 - amino - benzene - Nl - (a - propogy - isobutyroyl) sulfonamide. The new compound forms colorless crystals with a melting point of 135-136. It should be used as a medicine. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, da3 man N-(4-Amino-benzol- i sulfonyl) - a - propogy - isobuttersäureamidin durch hydrolytische Spaltung in 4-Amino- Nl-(a-propogy-isobutyroyl)-sulfonamid über führt. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that N- (4-amino-benzene-sulfonyl) -a-propogy-isobutyric acid amidine is converted into 4-amino-Nl- (a-propogy-isobutyroyl) -sulfonamide by hydrolytic cleavage .
CH242521D 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide. CH242521A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242521T 1943-05-21
CH239850T 1944-03-16

Publications (1)

Publication Number Publication Date
CH242521A true CH242521A (en) 1946-05-15

Family

ID=25728450

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242521D CH242521A (en) 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide.

Country Status (1)

Country Link
CH (1) CH242521A (en)

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