CH242526A - Process for the preparation of an acylated sulfonamide. - Google Patents

Process for the preparation of an acylated sulfonamide.

Info

Publication number
CH242526A
CH242526A CH242526DA CH242526A CH 242526 A CH242526 A CH 242526A CH 242526D A CH242526D A CH 242526DA CH 242526 A CH242526 A CH 242526A
Authority
CH
Switzerland
Prior art keywords
naphthalene
sulfonamide
preparation
naphthoyl
converted
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH242526A publication Critical patent/CH242526A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung eines     aeylierten    Sulfonamides.    Gegenstand vorliegenden Patentes ist ein  Verfahren zur Herstellung     eines-        acylierten          Sulfonamides.    Das Verfahren ist dadurch       gekennzeichnet,    dass man ein substituiertes       2-Naphthalin-sulfonamid    der Formel  
EMI0001.0007     
    in der R einen durch     hydrolysierende        Mittel          abspaltbaren    Rest bedeutet, durch     Verseifung     in 2-N     aphthalin-N-(a-naphthoyl)-sulfonamid     überführt.

   '  Das     Natriumsalz    der neuen Verbindung  stellt     ein    weisses, in Wasser mässig lösliches       Pulver    dar. Die     Verbindung    soll als Arznei  mittel     Verwendung    finden.  



  <I>Beispiel:</I>  10 Teile     -N-(2-Naphthalin-sulfonyl)-.a-          naphthoesäureamidin.    vom     Schmelzpunkt    und  der Formel  
EMI0001.0021     
    werden mit 100 Teilen 15     %        iger    Salzsäure  4     Stunden    auf<I>90-100 </I> erhitzt. Nach dem  Erkalten     wird        s.odaalkalisch    gestellt, filtriert  und     mit        Essigsäure    angesäuert. Man erhält  das. 2     -Naphthalin    - N - (u -     naphthoyl)-sulfon-          amid.  



  Process for the preparation of an alkylated sulfonamide. The subject of the present patent is a process for the preparation of an acylated sulfonamide. The process is characterized in that a substituted 2-naphthalene sulfonamide of the formula
EMI0001.0007
    in which R denotes a radical which can be split off by hydrolyzing agents, converted by saponification into 2-naphthalene-N- (a-naphthoyl) sulfonamide.

   The sodium salt of the new compound is a white powder that is moderately soluble in water. The compound is said to be used as a medicinal product.



  <I> Example: </I> 10 parts -N- (2-naphthalene-sulfonyl) -. A-naphthoic acid amidine. on the melting point and the formula
EMI0001.0021
    are heated to <I> 90-100 </I> for 4 hours with 100 parts of 15% hydrochloric acid. After cooling, it is made soda-alkaline, filtered and acidified with acetic acid. The 2-naphthalene-N- (u-naphthoyl) -sulphonamide is obtained.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines acylier- ten Sulfonamides, dadurch gekennzeichnet, dass man ein. PATENT CLAIM: Process for the production of an acylated sulfonamide, characterized in that one. substituiertes 2-Naphthalin-sul- fonamid der Formel EMI0001.0042 in der R einen durch hydrolysierende Mittel abspaltbaren Rest bedeutet, durch Verseifung in 2-Naphthalin-N-(u-naphthoyl)-sulfona.mid überführt. Das Natriumsalz der neuen Verbindung stellt ein weisses, in Wasser mässig lösliches Pulver dar. substituted 2-naphthalene-sulphonamide of the formula EMI0001.0042 in which R is a residue that can be split off by hydrolyzing agents, converted into 2-naphthalene-N- (u-naphthoyl) -sulfona.mid by saponification. The sodium salt of the new compound is a white powder that is moderately soluble in water. Die Verbindung soll als Arznei mittel Verwendung finden. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man N-(2-Naphthalin- sulfonyl)-u-naphthoesäureamidin durch hy- drolytische Spaltung in 2-Naphthalin-N-(a- näphthoyl)-sulfonamid überführt. The compound is said to be used as a medicament. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that N- (2-naphthalenesulfonyl) -u-naphthoic acid amidine is converted into 2-naphthalene-N- (a-naphthoyl) -sulfonamide by hydrolytic cleavage.
CH242526D 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide. CH242526A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH242526T 1943-05-21
CH239850T 1944-03-16

Publications (1)

Publication Number Publication Date
CH242526A true CH242526A (en) 1946-05-15

Family

ID=25728455

Family Applications (1)

Application Number Title Priority Date Filing Date
CH242526D CH242526A (en) 1943-05-21 1943-05-21 Process for the preparation of an acylated sulfonamide.

Country Status (1)

Country Link
CH (1) CH242526A (en)

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