CH636012A5 - Pharmacologically acceptable bile acid sequestering agent composition and process for its preparation - Google Patents

Pharmacologically acceptable bile acid sequestering agent composition and process for its preparation Download PDF

Info

Publication number: CH636012A5
Authority: CH; Switzerland
Prior art keywords: poly; iminio; methyl; dichloride; water
Prior art date: 1977-02-17

Application number

CH162578A

Other languages

German (de)

English (en)

Inventor

Arthur Franklin Wagner

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-17

Filing date

1978-02-14

Publication date

1983-05-13

1978-02-14 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1983-05-13 Publication of CH636012A5 publication Critical patent/CH636012A5/de

Links

239000000203 mixture Substances 0.000 title claims description 45
238000000034 method Methods 0.000 title claims description 13
238000002360 preparation method Methods 0.000 title claims description 9
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title description 5
239000003613 bile acid Substances 0.000 title description 5
239000003352 sequestering agent Substances 0.000 title description 3
-1 3-trimethylammoniopropyl Chemical group 0.000 claims description 50
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 42
239000002156 adsorbate Substances 0.000 claims description 28
239000000725 suspension Substances 0.000 claims description 25
229910021485 fumed silica Inorganic materials 0.000 claims description 23
229920000642 polymer Polymers 0.000 claims description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
239000000377 silicon dioxide Substances 0.000 claims description 11
239000007864 aqueous solution Substances 0.000 claims description 9
229920000080 bile acid sequestrant Polymers 0.000 claims description 9
239000007787 solid Substances 0.000 claims description 9
238000003756 stirring Methods 0.000 claims description 8
239000002775 capsule Substances 0.000 claims description 7
235000012239 silicon dioxide Nutrition 0.000 claims description 7
239000000243 solution Substances 0.000 claims description 7
239000000853 adhesive Substances 0.000 claims description 6
230000001070 adhesive effect Effects 0.000 claims description 6
238000001704 evaporation Methods 0.000 claims description 5
230000008020 evaporation Effects 0.000 claims description 5
230000002035 prolonged effect Effects 0.000 claims description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
239000003463 adsorbent Substances 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 4
239000000843 powder Substances 0.000 description 4
229910021529 ammonia Inorganic materials 0.000 description 3
229940096699 bile acid sequestrants Drugs 0.000 description 3
239000000969 carrier Substances 0.000 description 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
229920001800 Shellac Polymers 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
150000001450 anions Chemical class 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000007580 dry-mixing Methods 0.000 description 2
239000010408 film Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
150000002500 ions Chemical group 0.000 description 2
239000000463 material Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
238000006116 polymerization reaction Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
230000009919 sequestration Effects 0.000 description 2
239000004208 shellac Substances 0.000 description 2
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 2
229940113147 shellac Drugs 0.000 description 2
235000013874 shellac Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000454 talc Substances 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
235000012222 talc Nutrition 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
VXEGSRKPIUDPQT-UHFFFAOYSA-N 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C=CC(N)=CC=2)CC1 VXEGSRKPIUDPQT-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
125000006231 alkoxy propyl group Chemical group 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
235000013361 beverage Nutrition 0.000 description 1
101150049912 bin3 gene Proteins 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000003312 cholesterol blood level Effects 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000007865 diluting Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000013766 direct food additive Nutrition 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
239000002702 enteric coating Substances 0.000 description 1
238000009505 enteric coating Methods 0.000 description 1
125000006232 ethoxy propyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000003925 fat Substances 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000015203 fruit juice Nutrition 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000001841 imino group Chemical group [H]N=* 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
238000002955 isolation Methods 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
125000005498 phthalate group Chemical class 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
239000002985 plastic film Substances 0.000 description 1
229920006254 polymer film Polymers 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000007789 sealing Methods 0.000 description 1
239000005049 silicon tetrachloride Substances 0.000 description 1
239000012798 spherical particle Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
239000013589 supplement Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
239000010409 thin film Substances 0.000 description 1
125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

CH162578A 1977-02-17 1978-02-14 Pharmacologically acceptable bile acid sequestering agent composition and process for its preparation CH636012A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US76949177A	1977-02-17	1977-02-17

Publications (1)

Publication Number	Publication Date
CH636012A5 true CH636012A5 (en)	1983-05-13

Family

ID=25085598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH162578A CH636012A5 (en)	1977-02-17	1978-02-14	Pharmacologically acceptable bile acid sequestering agent composition and process for its preparation

Country Status (26)

Country	Link
JP (1)	JPS53102958A (fr)
AT (1)	AT363173B (fr)
AU (1)	AU518127B2 (fr)
BE (1)	BE863930A (fr)
CA (1)	CA1109395A (fr)
CH (1)	CH636012A5 (fr)
DE (1)	DE2806707A1 (fr)
DK (1)	DK46578A (fr)
ES (1)	ES466892A1 (fr)
FI (1)	FI67483C (fr)
FR (1)	FR2381079A1 (fr)
GB (1)	GB1567294A (fr)
GR (1)	GR66100B (fr)
HU (1)	HU177685B (fr)
IE (1)	IE46408B1 (fr)
IL (1)	IL53978A (fr)
IT (1)	IT7848013A0 (fr)
LU (1)	LU79071A1 (fr)
NL (1)	NL7801240A (fr)
NO (1)	NO148838C (fr)
NZ (1)	NZ186399A (fr)
PH (1)	PH15263A (fr)
PL (1)	PL122299B1 (fr)
PT (1)	PT67663B (fr)
SE (1)	SE433170B (fr)
ZA (1)	ZA78913B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5618530A (en) *	1994-06-10	1997-04-08	Geltex Pharmaceuticals, Inc.	Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5929184A (en) *	1993-06-02	1999-07-27	Geltex Pharmaceuticals, Inc.	Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5703188A (en) *	1993-06-02	1997-12-30	Geltex Pharmaceuticals, Inc.	Process for removing bile salts from a patient and compositions therefor
US5624963A (en) *	1993-06-02	1997-04-29	Geltex Pharmaceuticals, Inc.	Process for removing bile salts from a patient and compositions therefor
US5900475A (en) *	1994-06-10	1999-05-04	Geltex Pharmaceuticals, Inc.	Hydrophobic sequestrant for cholesterol depletion
US5607669A (en) *	1994-06-10	1997-03-04	Geltex Pharmaceuticals, Inc.	Amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) *	1993-06-02	2000-10-10	Geltex Pharmaceuticals, Inc.	Water-insoluble noncrosslinked bile acid sequestrants
TW474813B (en) *	1994-06-10	2002-02-01	Geltex Pharma Inc	Alkylated composition for removing bile salts from a patient
US5709880A (en) *	1995-07-10	1998-01-20	Buckman Laboratories International, Inc.	Method of making tabletized ionene polymers
EP0778027A3 (fr)	1995-12-04	1998-04-01	Helmut Univ.-Prof. Dr. Wachter	Utilisation de silice pour la préparation de médicaments
JP4010585B2 (ja) *	1996-10-15	2007-11-21	久光製薬株式会社	陰イオン交換樹脂を含有する錠剤
US6203785B1 (en)	1996-12-30	2001-03-20	Geltex Pharmaceuticals, Inc.	Poly(diallylamine)-based bile acid sequestrants
US6423754B1 (en)	1997-06-18	2002-07-23	Geltex Pharmaceuticals, Inc.	Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en)	1997-11-05	2004-04-27	Genzyme Corporation	Poly (diallylamines)-based phosphate binders
CN116925354B (zh) *	2023-07-20	2025-09-23	黑龙江省科学院石油化学研究院	一种高强度的聚酰亚胺气凝胶褶皱纸及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR206115A1 (es) *	1973-06-11	1976-06-30	Merck & Co Inc	Procedimiento para preparar un polimero lineal no ramificado y no reticulado
US4027009A (en) *	1973-06-11	1977-05-31	Merck & Co., Inc.	Compositions and methods for depressing blood serum cholesterol

1978
- 1978-01-30 FI FI780296A patent/FI67483C/fi not_active IP Right Cessation
- 1978-02-01 DK DK46578A patent/DK46578A/da not_active Application Discontinuation
- 1978-02-02 SE SE7801242A patent/SE433170B/sv unknown
- 1978-02-02 NL NL7801240A patent/NL7801240A/xx not_active Application Discontinuation
- 1978-02-02 NO NO780367A patent/NO148838C/no unknown
- 1978-02-06 IL IL53978A patent/IL53978A/xx unknown
- 1978-02-06 PH PH20753A patent/PH15263A/en unknown
- 1978-02-06 GR GR55356A patent/GR66100B/el unknown
- 1978-02-07 NZ NZ186399A patent/NZ186399A/xx unknown
- 1978-02-08 AU AU33099/78A patent/AU518127B2/en not_active Expired
- 1978-02-08 AT AT0087978A patent/AT363173B/de not_active IP Right Cessation
- 1978-02-08 CA CA296,622A patent/CA1109395A/fr not_active Expired
- 1978-02-09 HU HU78ME2145A patent/HU177685B/hu unknown
- 1978-02-10 ES ES466892A patent/ES466892A1/es not_active Expired
- 1978-02-10 IT IT7848013A patent/IT7848013A0/it unknown
- 1978-02-14 BE BE185141A patent/BE863930A/fr not_active IP Right Cessation
- 1978-02-14 CH CH162578A patent/CH636012A5/de not_active IP Right Cessation
- 1978-02-15 LU LU79071A patent/LU79071A1/fr unknown
- 1978-02-15 FR FR7804268A patent/FR2381079A1/fr active Granted
- 1978-02-15 GB GB6014/78A patent/GB1567294A/en not_active Expired
- 1978-02-15 PL PL1978204642A patent/PL122299B1/pl unknown
- 1978-02-16 ZA ZA00780913A patent/ZA78913B/xx unknown
- 1978-02-16 PT PT67663A patent/PT67663B/pt unknown
- 1978-02-16 IE IE332/78A patent/IE46408B1/en unknown
- 1978-02-16 DE DE19782806707 patent/DE2806707A1/de not_active Withdrawn
- 1978-02-17 JP JP1666278A patent/JPS53102958A/ja active Pending

Also Published As

Publication number	Publication date
SE7801242L (sv)	1978-08-18
ATA87978A (de)	1980-12-15
ES466892A1 (es)	1979-08-16
GB1567294A (en)	1980-05-14
JPS53102958A (en)	1978-09-07
HU177685B (en)	1981-12-28
DE2806707A1 (de)	1978-08-24
NO780367L (no)	1978-08-18
SE433170B (sv)	1984-05-14
NL7801240A (nl)	1978-08-21
PH15263A (en)	1982-11-02
PT67663A (en)	1978-03-01
FR2381079B1 (fr)	1981-09-11
IL53978A0 (en)	1978-04-30
IE780332L (en)	1978-08-17
NO148838C (no)	1983-12-28
CA1109395A (fr)	1981-09-22
IT7848013A0 (it)	1978-02-10
PL204642A1 (pl)	1979-06-04
GR66100B (fr)	1981-01-16
BE863930A (fr)	1978-08-14
FR2381079A1 (fr)	1978-09-15
FI780296A7 (fi)	1978-08-18
AT363173B (de)	1981-07-10
PL122299B1 (en)	1982-07-31
FI67483C (fi)	1985-04-10
ZA78913B (en)	1979-09-26
AU3309978A (en)	1979-08-16
NZ186399A (en)	1980-11-28
DK46578A (da)	1978-08-18
IE46408B1 (en)	1983-06-01
IL53978A (en)	1981-03-31
FI67483B (fi)	1984-12-31
PT67663B (en)	1980-03-03
NO148838B (no)	1983-09-19
LU79071A1 (fr)	1978-09-28
AU518127B2 (en)	1981-09-17

Legal Events

Date	Code	Title	Description
1986-10-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
CH636012A5 (en)	1983-05-13	Pharmacologically acceptable bile acid sequestering agent composition and process for its preparation
EP0110170B1 (fr)	1987-05-13	Poudre de miel dans lequel les arômes naturels restent conservés et son procédé de production
DE69002198T2 (de)	1993-10-21	Schnellösliche Dosierungsformen.
LU84919A1 (de)	1984-03-22	Medizinisches praeparat enthaltend pirprofen
DD285720A5 (de)	1991-01-03	Verfahren zur herstellung einer saeurebindenden, aufschaeumenden zubereitung
EP0078820B1 (fr)	1987-12-09	Complexes d'inclusion de n-(1-phenylethyl) -3,3-diphenylpropylamine respectivement de son chlorhydrate avec cyclodextrine, un procede de preparation de ces complexes ainsi que des preparations pharmacetiques contenant ces complexes
US2879161A (en)	1959-03-24	Stable dry powder compositions containing choline chloride and methods of preparing same
DD221459A5 (de)	1985-04-24	Verfahren zur herstellung von omeprazolsalzen
DE3215844A1 (de)	1982-12-02	Mischsalz aus glucosaminsulfat und natriumchlorid
DE60026295T2 (de)	2006-10-12	Pflanzenmaterial enthaltendes granulat und verfahren zur herstellung
DE2246037A1 (de)	1974-04-11	Peroral anwendbares arzneimittel mit verstaerkter resorptionsverzoegerung
DE10254412A1 (de)	2003-06-12	Arzneimittel
DE2854651C2 (fr)	1987-10-29
US4185088A (en)	1980-01-22	Non-adhesive ionene quaternary polymer compositions useful as bile acid sequestrants
EP0116358B1 (fr)	1988-04-27	Complexes de prostaglandines
WO1993010797A1 (fr)	1993-06-10	Pastilles de dimeticon
DE2402413A1 (de)	1974-07-25	Stabilisiertes pulver
EP1058542A1 (fr)	2000-12-13	Procede de preparation de grains granulaires spheriques enrobes
AT368880B (de)	1982-11-25	Verfahren zur herstellung eines zur weiterverarbeitung zu einer waesserigen suspension dienenden wasserunloeslichen trockeninstantpr[parates
CH633164A5 (de)	1982-11-30	Verfahren zur herstellung einer als diaetetisches lebensmittel verwendbaren mischung.
EP0253293B1 (fr)	1990-02-28	Sels d'un acide aspartique avec des guanidines
US2871157A (en)	1959-01-27	Laxative powders containing di-n-octyl sulfosuccinates
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