CH672733A5 - - Google Patents

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Publication number
CH672733A5
CH672733A5 CH1991/87A CH199187A CH672733A5 CH 672733 A5 CH672733 A5 CH 672733A5 CH 1991/87 A CH1991/87 A CH 1991/87A CH 199187 A CH199187 A CH 199187A CH 672733 A5 CH672733 A5 CH 672733A5
Authority
CH
Switzerland
Prior art keywords
vesicles
iodine
liposomes
encapsulated
aqueous
Prior art date
Application number
CH1991/87A
Other languages
English (en)
French (fr)
Inventor
Michel Schneider
Herve Tournier
Bernard Lamy
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4223355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CH672733(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Priority to CH1991/87A priority Critical patent/CH672733A5/fr
Priority to DE3874485T priority patent/DE3874485T3/de
Priority to US07/302,690 priority patent/US5312615A/en
Priority to PCT/EP1988/000447 priority patent/WO1988009165A1/en
Priority to AU18054/88A priority patent/AU612371B2/en
Priority to AT88904952T priority patent/ATE80294T1/de
Priority to JP63504697A priority patent/JP2619037B2/ja
Priority to EP88904952A priority patent/EP0314764B2/en
Priority to ZA883449A priority patent/ZA883449B/xx
Priority to IL86409A priority patent/IL86409A/xx
Priority to CA000567314A priority patent/CA1303978C/en
Priority to ES8801604A priority patent/ES2009917A6/es
Publication of CH672733A5 publication Critical patent/CH672733A5/fr
Priority to MX9203271A priority patent/MX9203271A/es
Priority to US08/128,206 priority patent/US5445810A/en
Priority to US08/440,134 priority patent/US5626832A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH1991/87A 1987-05-22 1987-05-22 CH672733A5 (2)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CH1991/87A CH672733A5 (2) 1987-05-22 1987-05-22
US07/302,690 US5312615A (en) 1987-05-22 1988-05-16 Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations
JP63504697A JP2619037B2 (ja) 1987-05-22 1988-05-16 Ｘ線検査用の高封入容量のリポソームを含有する注射可能な不透明組成物
ZA883449A ZA883449B (en) 1987-05-22 1988-05-16 Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations
PCT/EP1988/000447 WO1988009165A1 (en) 1987-05-22 1988-05-16 Injectable opacifying liposome composition
AU18054/88A AU612371B2 (en) 1987-05-22 1988-05-16 Injectable opacifying liposome composition
AT88904952T ATE80294T1 (de) 1987-05-22 1988-05-16 Injizierbare, opazifizierende liposomzusammensetzung.
DE3874485T DE3874485T3 (de) 1987-05-22 1988-05-16 Injizierbare, opazifizierende liposomzusammensetzung.
EP88904952A EP0314764B2 (en) 1987-05-22 1988-05-16 Injectable opacifying liposome composition
IL86409A IL86409A (en) 1987-05-22 1988-05-17 Injectable x-ray opacifying liposome compositions
ES8801604A ES2009917A6 (es) 1987-05-22 1988-05-20 Composicion opacificante inyectable para examenes con rayos x, que contiene liposomas con elevada capacidad de encapsulado.
CA000567314A CA1303978C (en) 1987-05-22 1988-05-20 Injectable opacifying composition containing liposomes of high encapsulation capacity for x-ray examinations
MX9203271A MX9203271A (es) 1987-05-22 1992-06-24 Composicion opascificante inyectable para examenes con rayos x.
US08/128,206 US5445810A (en) 1987-05-22 1993-09-29 Injectable opacifying composition containing liposomes of high encapsulating capacity for X-ray examinations
US08/440,134 US5626832A (en) 1987-05-22 1995-05-12 Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1991/87A CH672733A5 (2) 1987-05-22 1987-05-22

Publications (1)

Publication Number Publication Date
CH672733A5 true CH672733A5 (2) 1989-12-29

Family

ID=4223355

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1991/87A CH672733A5 (2) 1987-05-22 1987-05-22

Country Status (13)

Country Link
US (3) US5312615A (2)
EP (1) EP0314764B2 (2)
JP (1) JP2619037B2 (2)
AT (1) ATE80294T1 (2)
AU (1) AU612371B2 (2)
CA (1) CA1303978C (2)
CH (1) CH672733A5 (2)
DE (1) DE3874485T3 (2)
ES (1) ES2009917A6 (2)
IL (1) IL86409A (2)
MX (1) MX9203271A (2)
WO (1) WO1988009165A1 (2)
ZA (1) ZA883449B (2)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672733A5 (2) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
MX9203504A (es) * 1988-04-20 1992-07-01 Liposome Co Inc Complejo agente: lipido activo de alta proporcion.
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) * 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
IN172208B (2) * 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
SE470086B (sv) * 1991-04-23 1993-11-08 Kabi Pharmacia Ab Organspecifik emulsion
SE9101709L (sv) * 1991-06-03 1992-12-04 Karlshamns Lipidteknik Ab Lipidderivat som diagnostikum eller kontrastmedel
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
JPH08505312A (ja) * 1992-10-16 1996-06-11 ザックセ，アンドレアス 液状分散系を製造する方法及び装置
EP0699068B1 (en) * 1993-05-21 2001-12-19 The Liposome Company, Inc. Reduction of liposome-induced adverse physiological reactions
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CN1068229C (zh) * 1993-12-15 2001-07-11 勃勒柯研究有限公司 超声对比介质、含该介质的对比剂及方法
WO1995026205A1 (en) * 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
JPH10500999A (ja) * 1995-02-24 1998-01-27 ブラッコ リサーチ ソシエテ アノニム 血液プール画像形成造影剤としてのリポソーム懸濁液
DE19518221A1 (de) * 1995-05-10 1996-11-14 Schering Ag Verwendung nichtsteroidaler Entzündungshemmer zur Verbesserung der physiologischen Verträglichkeit partikulärer pharmazeutischer Zubereitungen
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JP4109780B2 (ja) 1998-03-06 2008-07-02 株式会社東海理化電機製作所 ギヤ機構及びウエビング巻取装置
WO1999049849A1 (en) * 1998-03-31 1999-10-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal bupivacaine compositions and methods of preparation
US6706280B2 (en) * 1998-08-19 2004-03-16 Bracco Research S.A. Carboxylated phosphatidic acid esters
JP3980777B2 (ja) 1998-11-02 2007-09-26 株式会社東海理化電機製作所 ウエビング巻取装置
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
US7297344B1 (en) 1999-05-27 2007-11-20 Euro-Celtique, S.A. Preparations for the promotion of wound healing in the upper respiratory tract and/or ear
JP5616565B2 (ja) 1999-05-27 2014-10-29 ユーロ−セルティック エス． ア． 抗炎症剤を適用するための製剤
AU2001266696A1 (en) 2000-06-02 2001-12-11 Bracco Research Usa Compounds for targeting endothelial cells
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
US7713517B2 (en) * 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7588751B2 (en) * 2004-07-21 2009-09-15 Konica Minolta Medical & Graphic, Inc. Liposome-containing radiographic contrast medium and preparation method thereof
JP5176320B2 (ja) * 2004-08-11 2013-04-03 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法
TW200621306A (en) * 2004-10-22 2006-07-01 Dynamis Therapeutics Inc Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds
WO2007129311A2 (en) * 2006-05-04 2007-11-15 Pan Sci Tech S.A. Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct
JP2011506325A (ja) 2007-12-05 2011-03-03 マーバル バイオサイエンシーズ インコーポレイテッド ナノスケールのコントラスト剤及びその使用方法
US20090311191A1 (en) * 2008-06-13 2009-12-17 Ananth Annapragada Imaging of atherosclerotic plaques using liposomal imaging agents
WO2010107990A1 (en) * 2009-03-19 2010-09-23 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
IT1404011B1 (it) 2010-12-03 2013-11-08 Uni Degli Studi Magna Graecia Di Catanzaro Nanovettore coniugato con tsh per il trattamento del cancro della tiroide
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
EP3240579B1 (en) 2014-12-31 2022-07-27 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
MX2018013409A (es) 2016-05-04 2019-07-08 Lantheus Medical Imaging Inc Métodos y dispositivos para la preparación de agentes de contraste de ultrasonido.
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Citations (4)

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Publication number Priority date Publication date Assignee Title
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
FR2437831A1 (fr) * 1978-10-05 1980-04-30 Daeniker Felix Agent de contraste pour l'examen radiologique du foie et procede pour sa preparation
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media

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US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4519024A (en) * 1983-09-02 1985-05-21 At&T Bell Laboratories Two-terminal transistor rectifier circuit arrangement
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4567034A (en) * 1984-09-07 1986-01-28 E. R. Squibb & Sons, Inc. Esters of diatrizoic acid as X-ray contrast agents
CH672733A5 (2) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
FR2437831A1 (fr) * 1978-10-05 1980-04-30 Daeniker Felix Agent de contraste pour l'examen radiologique du foie et procede pour sa preparation
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth

Also Published As

Publication number Publication date
DE3874485T2 (de) 1993-03-11
EP0314764B2 (en) 2000-02-02
AU1805488A (en) 1988-12-21
MX9203271A (es) 1992-07-01
IL86409A0 (en) 1988-11-15
EP0314764A1 (en) 1989-05-10
IL86409A (en) 1991-12-12
CA1303978C (en) 1992-06-23
DE3874485T3 (de) 2000-09-14
JP2619037B2 (ja) 1997-06-11
ATE80294T1 (de) 1992-09-15
US5312615A (en) 1994-05-17
US5626832A (en) 1997-05-06
EP0314764B1 (en) 1992-09-09
ES2009917A6 (es) 1989-10-16
WO1988009165A1 (en) 1988-12-01
AU612371B2 (en) 1991-07-11
US5445810A (en) 1995-08-29
ZA883449B (en) 1988-11-16
JPH02500192A (ja) 1990-01-25
DE3874485D1 (de) 1992-10-15

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