CH681960A5 - - Google Patents

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Info

Publication number: CH681960A5
Authority: CH; Switzerland
Prior art keywords: mass; derivatives; nifedipine; light; chlorophyll
Prior art date: 1990-07-20

Application number

CH2125/91A

Other languages

German (de)

English (en)

Inventor

Margit-Kricsfalussy Dr Nagy

Rita Balazs

Judit Marcisz

Katalin-Nagy Wagner

Eva Judit-Juhasz Tajthy

Attila Dr Mandi

Margit Dr Csoergo

Original Assignee

Egyt Gyogyszervegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-20

Filing date

1991-07-17

Publication date

1993-06-30

1991-07-17 Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar

1993-06-30 Publication of CH681960A5 publication Critical patent/CH681960A5/de

Links

239000002775 capsule Substances 0.000 claims description 41
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 35
229960001597 nifedipine Drugs 0.000 claims description 34
229930002875 chlorophyll Natural products 0.000 claims description 32
235000019804 chlorophyll Nutrition 0.000 claims description 32
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 32
238000011049 filling Methods 0.000 claims description 30
239000000975 dye Substances 0.000 claims description 29
239000004480 active ingredient Substances 0.000 claims description 27
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
238000000034 method Methods 0.000 claims description 22
235000013311 vegetables Nutrition 0.000 claims description 22
239000007903 gelatin capsule Substances 0.000 claims description 20
239000000825 pharmaceutical preparation Substances 0.000 claims description 13
239000007787 solid Substances 0.000 claims description 13
108010010803 Gelatin Proteins 0.000 claims description 11
229920000159 gelatin Polymers 0.000 claims description 11
239000008273 gelatin Substances 0.000 claims description 11
235000019322 gelatine Nutrition 0.000 claims description 11
235000011852 gelatine desserts Nutrition 0.000 claims description 11
239000000969 carrier Substances 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 9
239000000126 substance Substances 0.000 claims description 7
239000013543 active substance Substances 0.000 claims description 6
125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 claims description 6
-1 mirudipine Chemical compound 0.000 claims description 6
235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
239000008158 vegetable oil Substances 0.000 claims description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
239000003755 preservative agent Substances 0.000 claims description 5
239000000600 sorbitol Substances 0.000 claims description 5
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 4
239000000006 Nitroglycerin Substances 0.000 claims description 4
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 4
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
230000000340 anti-metabolite Effects 0.000 claims description 4
229940100197 antimetabolite Drugs 0.000 claims description 4
239000002256 antimetabolite Substances 0.000 claims description 4
229940085304 dihydropyridine derivative selective calcium channel blockers with mainly vascular effects Drugs 0.000 claims description 4
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 4
229960003711 glyceryl trinitrate Drugs 0.000 claims description 4
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 4
235000019155 vitamin A Nutrition 0.000 claims description 4
239000011719 vitamin A Substances 0.000 claims description 4
229940045997 vitamin a Drugs 0.000 claims description 4
PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 claims description 3
UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 claims description 3
VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 claims description 3
229960000715 nimodipine Drugs 0.000 claims description 3
229960000227 nisoldipine Drugs 0.000 claims description 3
229960005425 nitrendipine Drugs 0.000 claims description 3
239000004014 plasticizer Substances 0.000 claims description 3
JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims description 2
QHZUABXEBRGBLP-LKWYKXIFSA-N (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-4-benzyl-9b-hydroxy-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-9b-hydroxy-3,5-dioxo-2,4-di(propan-2-yl)-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,10aR)-N-[(2S,4S,9bS)-9b-hydroxy-4-(2-methylpropyl)-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)C4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2CC(CN(C)[C@@H]2C2)C(=O)N[C@@]3(C(=O)C4[C@@H](C(N5CCCC5[C@@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(C21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 QHZUABXEBRGBLP-LKWYKXIFSA-N 0.000 claims description 2
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims description 2
UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 claims description 2
FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 claims description 2
MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims description 2
FEBOTPHFXYHVPL-UHFFFAOYSA-N 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC(N2C(NC3=CC=CC=C32)=O)CC1 FEBOTPHFXYHVPL-UHFFFAOYSA-N 0.000 claims description 2
VCCNKWWXYVWTLT-CYZBKYQRSA-N 7-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 VCCNKWWXYVWTLT-CYZBKYQRSA-N 0.000 claims description 2
108010001478 Bacitracin Proteins 0.000 claims description 2
235000016068 Berberis vulgaris Nutrition 0.000 claims description 2
241000335053 Beta vulgaris Species 0.000 claims description 2
244000056139 Brassica cretica Species 0.000 claims description 2
235000003351 Brassica cretica Nutrition 0.000 claims description 2
235000003343 Brassica rupestris Nutrition 0.000 claims description 2
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical class CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 2
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
229930192392 Mitomycin Natural products 0.000 claims description 2
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 2
229940123445 Tricyclic antidepressant Drugs 0.000 claims description 2
UFLGIAIHIAPJJC-UHFFFAOYSA-N Tripelennamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 UFLGIAIHIAPJJC-UHFFFAOYSA-N 0.000 claims description 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
229930013930 alkaloid Natural products 0.000 claims description 2
BIVUUOPIAYRCAP-UHFFFAOYSA-N aminoazanium;chloride Chemical compound Cl.NN BIVUUOPIAYRCAP-UHFFFAOYSA-N 0.000 claims description 2
150000005010 aminoquinolines Chemical class 0.000 claims description 2
239000003263 anabolic agent Substances 0.000 claims description 2
229940070021 anabolic steroids Drugs 0.000 claims description 2
239000003242 anti bacterial agent Substances 0.000 claims description 2
230000000259 anti-tumor effect Effects 0.000 claims description 2
229940088710 antibiotic agent Drugs 0.000 claims description 2
229940054053 antipsychotics butyrophenone derivative Drugs 0.000 claims description 2
229940027988 antiseptic and disinfectant nitrofuran derivative Drugs 0.000 claims description 2
YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 claims description 2
229960002170 azathioprine Drugs 0.000 claims description 2
LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims description 2
229960003071 bacitracin Drugs 0.000 claims description 2
229930184125 bacitracin Natural products 0.000 claims description 2
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims description 2
229960002507 benperidol Drugs 0.000 claims description 2
UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 2
229960002537 betamethasone Drugs 0.000 claims description 2
QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims description 2
FFSAXUULYPJSKH-UHFFFAOYSA-N butyrophenone Chemical class CCCC(=O)C1=CC=CC=C1 FFSAXUULYPJSKH-UHFFFAOYSA-N 0.000 claims description 2
235000013736 caramel Nutrition 0.000 claims description 2
FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims description 2
229960000623 carbamazepine Drugs 0.000 claims description 2
150000003943 catecholamines Chemical class 0.000 claims description 2
229960003677 chloroquine Drugs 0.000 claims description 2
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 claims description 2
ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 2
229960003771 cocaine hydrochloride Drugs 0.000 claims description 2
PIQVDUKEQYOJNR-VZXSFKIWSA-N cocaine hydrochloride Chemical compound [Cl-].O([C@H]1C[C@@H]2CC[C@@H]([NH+]2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 PIQVDUKEQYOJNR-VZXSFKIWSA-N 0.000 claims description 2
239000003246 corticosteroid Substances 0.000 claims description 2
229960001334 corticosteroids Drugs 0.000 claims description 2
229960003638 dopamine Drugs 0.000 claims description 2
239000008298 dragée Substances 0.000 claims description 2
229960000394 droperidol Drugs 0.000 claims description 2
RMEDXOLNCUSCGS-UHFFFAOYSA-N droperidol Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CC=C(N2C(NC3=CC=CC=C32)=O)CC1 RMEDXOLNCUSCGS-UHFFFAOYSA-N 0.000 claims description 2
229960001903 ergotamine tartrate Drugs 0.000 claims description 2
229940011871 estrogen Drugs 0.000 claims description 2
239000000262 estrogen Substances 0.000 claims description 2
125000003916 ethylene diamine group Chemical class 0.000 claims description 2
229960003878 haloperidol Drugs 0.000 claims description 2
239000005556 hormone Substances 0.000 claims description 2
229940088597 hormone Drugs 0.000 claims description 2
150000002462 imidazolines Chemical class 0.000 claims description 2
229930005303 indole alkaloid Natural products 0.000 claims description 2
150000002475 indoles Chemical class 0.000 claims description 2
229960001317 isoprenaline Drugs 0.000 claims description 2
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 2
229960000991 ketoprofen Drugs 0.000 claims description 2
229960000485 methotrexate Drugs 0.000 claims description 2
229960004857 mitomycin Drugs 0.000 claims description 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 2
229960004715 morphine sulfate Drugs 0.000 claims description 2
GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 claims description 2
235000010460 mustard Nutrition 0.000 claims description 2
IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims description 2
NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 claims description 2
229960000564 nitrofurantoin Drugs 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
229960002460 nitroprusside Drugs 0.000 claims description 2
239000002736 nonionic surfactant Substances 0.000 claims description 2
229960003207 papaverine hydrochloride Drugs 0.000 claims description 2
229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 claims description 2
150000004885 piperazines Chemical class 0.000 claims description 2
CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 claims description 2
229960000624 procarbazine Drugs 0.000 claims description 2
SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 claims description 2
229960004306 sulfadiazine Drugs 0.000 claims description 2
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 claims description 2
239000003029 tricyclic antidepressant agent Substances 0.000 claims description 2
ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 claims description 2
229960002324 trifluoperazine Drugs 0.000 claims description 2
229960003223 tripelennamine Drugs 0.000 claims description 2
CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 claims description 2
229960001128 triprolidine Drugs 0.000 claims description 2
239000011782 vitamin Substances 0.000 claims description 2
229940088594 vitamin Drugs 0.000 claims description 2
229930003231 vitamin Natural products 0.000 claims description 2
235000013343 vitamin Nutrition 0.000 claims description 2
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
235000005282 vitamin D3 Nutrition 0.000 claims description 2
239000011647 vitamin D3 Substances 0.000 claims description 2
229940021056 vitamin d3 Drugs 0.000 claims description 2
239000003826 tablet Substances 0.000 claims 1
239000000243 solution Substances 0.000 description 15
238000004519 manufacturing process Methods 0.000 description 13
239000000203 mixture Substances 0.000 description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
238000000354 decomposition reaction Methods 0.000 description 12
235000011187 glycerol Nutrition 0.000 description 10
229920001223 polyethylene glycol Polymers 0.000 description 10
235000019501 Lemon oil Nutrition 0.000 description 8
239000010501 lemon oil Substances 0.000 description 8
229920000036 polyvinylpyrrolidone Polymers 0.000 description 8
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 8
239000001267 polyvinylpyrrolidone Substances 0.000 description 8
229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
239000000463 material Substances 0.000 description 6
239000008171 pumpkin seed oil Substances 0.000 description 6
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000002904 solvent Substances 0.000 description 5
239000001593 sorbitan monooleate Substances 0.000 description 5
235000011069 sorbitan monooleate Nutrition 0.000 description 5
229940035049 sorbitan monooleate Drugs 0.000 description 5
229920002472 Starch Polymers 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
235000010980 cellulose Nutrition 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
239000003814 drug Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000004006 olive oil Substances 0.000 description 4
235000008390 olive oil Nutrition 0.000 description 4
239000008107 starch Substances 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
238000003756 stirring Methods 0.000 description 4
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
229940079593 drug Drugs 0.000 description 3
235000010445 lecithin Nutrition 0.000 description 3
239000000787 lecithin Substances 0.000 description 3
229940067606 lecithin Drugs 0.000 description 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
150000002832 nitroso derivatives Chemical class 0.000 description 3
229920003023 plastic Polymers 0.000 description 3
239000004033 plastic Substances 0.000 description 3
230000002335 preservative effect Effects 0.000 description 3
239000000979 synthetic dye Substances 0.000 description 3
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000000576 coating method Methods 0.000 description 2
229940075614 colloidal silicon dioxide Drugs 0.000 description 2
238000004040 coloring Methods 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
239000008101 lactose Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000003921 oil Substances 0.000 description 2
235000019198 oils Nutrition 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
239000000341 volatile oil Substances 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 description 1
235000021537 Beetroot Nutrition 0.000 description 1
229940127291 Calcium channel antagonist Drugs 0.000 description 1
240000006685 Carthamus lanatus Species 0.000 description 1
235000006007 Carthamus lanatus subsp baeticus Nutrition 0.000 description 1
244000020518 Carthamus tinctorius Species 0.000 description 1
235000003255 Carthamus tinctorius Nutrition 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
239000004606 Fillers/Extenders Substances 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
239000004368 Modified starch Substances 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
206010034972 Photosensitivity reaction Diseases 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
235000009108 Urtica dioica Nutrition 0.000 description 1
241000218215 Urticaceae Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000008186 active pharmaceutical agent Substances 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
238000007664 blowing Methods 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
229960001338 colchicine Drugs 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 1
239000004174 erythrosine Substances 0.000 description 1
235000012732 erythrosine Nutrition 0.000 description 1
229940011411 erythrosine Drugs 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
229960003580 felodipine Drugs 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
XPFVYQJUAUNWIW-UHFFFAOYSA-N furfuryl alcohol Chemical compound OCC1=CC=CO1 XPFVYQJUAUNWIW-UHFFFAOYSA-N 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000001046 green dye Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000001034 iron oxide pigment Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
VZWXXKDFACOXNT-UHFFFAOYSA-N niludipine Chemical compound CCCOCCOC(=O)C1=C(C)NC(C)=C(C(=O)OCCOCCC)C1C1=CC=CC([N+]([O-])=O)=C1 VZWXXKDFACOXNT-UHFFFAOYSA-N 0.000 description 1
229950000109 niludipine Drugs 0.000 description 1
150000002828 nitro derivatives Chemical class 0.000 description 1
125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000036211 photosensitivity Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000009419 refurbishment Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000005204 segregation Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Medicines Containing Plant Substances (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CH2125/91A 1990-07-20 1991-07-17 CH681960A5 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU904564A HUT59592A (en)	1990-07-20	1990-07-20	Process for the preparation of solid medical products

Publications (1)

Publication Number	Publication Date
CH681960A5 true CH681960A5 (fr)	1993-06-30

Family

ID=10968329

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH2125/91A CH681960A5 (fr)	1990-07-20	1991-07-17

Country Status (22)

Country	Link
JP (1)	JPH04253924A (fr)
KR (1)	KR920002162A (fr)
BE (1)	BE1006829A3 (fr)
CA (1)	CA2047482A1 (fr)
CH (1)	CH681960A5 (fr)
CY (1)	CY1840A (fr)
CZ (1)	CZ280064B6 (fr)
DE (1)	DE4124081A1 (fr)
DK (1)	DK137591A (fr)
ES (1)	ES2039177B1 (fr)
FI (1)	FI913493L (fr)
FR (1)	FR2664814B1 (fr)
GB (1)	GB2246072B (fr)
GR (1)	GR1002175B (fr)
HU (1)	HUT59592A (fr)
IL (1)	IL98894A0 (fr)
IT (1)	IT1250681B (fr)
NL (1)	NL9101268A (fr)
SE (1)	SE9102160L (fr)
TW (1)	TW203012B (fr)
YU (1)	YU47573B (fr)
ZA (1)	ZA915677B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9411115D0 (en) *	1994-06-03	1994-07-27	Secr Defence	Stabilisation of photosensitive material
EP0827399A1 (fr) *	1995-04-24	1998-03-11	Pfizer Inc.	Inhibition de la photodecomposition des 2-oxindoles-3-substitues
DE19912623A1 (de) *	1999-03-20	2000-09-28	Lohmann Therapie Syst Lts	Verfahren zur Erhöhung der Stabilität bei Lagerung und/oder Anwendung lichtempfindlicher therapeutischer Systeme oder deren Bestandteile
JP3549522B1 (ja) *	2003-10-24	2004-08-04	日清ファルマ株式会社	コエンザイムｑ１０含有カプセル剤
CN102164606B (zh) *	2008-09-30	2014-04-16	电气化学工业株式会社	光稳定化药物组合物
CA2968861C (fr)	2017-05-30	2022-10-11	University Of Saskatchewan	Formulations de nifedipine topiques et utilisations associees
KR200489660Y1 (ko) *	2018-02-09	2019-07-19	김순희	퍼팅연습기

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55127448A (en) *	1979-03-23	1980-10-02	Chugai Pharmaceut Co Ltd	Gelatin coating
JPS6043046B2 (ja) *	1979-04-24	1985-09-26	パ−ク・デ−ビス・エンド・コンパニ−	ゼラチンカプセル
JPS55161863A (en) *	1979-06-06	1980-12-16	Paaku Deebisu Kk	Colored gelatin capsule
EP0143857B1 (fr) *	1983-11-30	1988-04-06	Siegfried Aktiengesellschaft	Composition thérapeutique coronaire sous forme de capsule molle de gélatine
JPS61225109A (ja) *	1985-03-29	1986-10-06	Shiseido Co Ltd	カラメル含有組成物
DE3526546A1 (de) *	1985-07-25	1987-01-29	Scherer Gmbh R P	Lichtbestaendige opakisierte gelatinekapseln und verfahren zur herstellung derselben
DE3532129A1 (de) *	1985-09-10	1987-03-12	Bayer Ag	Ss-carotin enthaltende gelatine
US4689233A (en) *	1986-01-06	1987-08-25	Siegfried Aktiengesellschaft	Coronary therapeutic agent in the form of soft gelatin capsules
EP0272336B1 (fr) *	1986-12-18	1991-10-23	Kurt H. Prof. Dr. Bauer	Concentré de nifédipine stabilisé contre l'influence de la lumière et mode de préparation
JPS63215641A (ja) *	1987-03-05	1988-09-08	Toyo Jozo Co Ltd	ゼラチン皮膜組成物
JPH01218573A (ja) *	1988-02-25	1989-08-31	Yoshio Tanaka	ドナリエラ藻体含有固形状食品の製造法

1990
- 1990-07-20 HU HU904564A patent/HUT59592A/hu unknown
1991
- 1991-07-10 SE SE9102160A patent/SE9102160L/ not_active Application Discontinuation
- 1991-07-17 CH CH2125/91A patent/CH681960A5/de not_active IP Right Cessation
- 1991-07-17 CZ CS912222A patent/CZ280064B6/cs unknown
- 1991-07-18 KR KR1019910012224A patent/KR920002162A/ko not_active Withdrawn
- 1991-07-19 NL NL9101268A patent/NL9101268A/nl not_active Application Discontinuation
- 1991-07-19 FR FR9109183A patent/FR2664814B1/fr not_active Expired - Fee Related
- 1991-07-19 ZA ZA915677A patent/ZA915677B/xx unknown
- 1991-07-19 DK DK137591A patent/DK137591A/da not_active Application Discontinuation
- 1991-07-19 IL IL98894A patent/IL98894A0/xx unknown
- 1991-07-19 CA CA002047482A patent/CA2047482A1/fr not_active Abandoned
- 1991-07-19 FI FI913493A patent/FI913493L/fi not_active Application Discontinuation
- 1991-07-19 TW TW080105605A patent/TW203012B/zh active
- 1991-07-19 GR GR910100319A patent/GR1002175B/el unknown
- 1991-07-19 BE BE9100683A patent/BE1006829A3/fr not_active IP Right Cessation
- 1991-07-19 IT ITMI912002A patent/IT1250681B/it active IP Right Grant
- 1991-07-19 DE DE4124081A patent/DE4124081A1/de not_active Withdrawn
- 1991-07-19 ES ES9101701A patent/ES2039177B1/es not_active Expired - Fee Related
- 1991-07-19 JP JP3203542A patent/JPH04253924A/ja active Pending
- 1991-07-19 GB GB9115693A patent/GB2246072B/en not_active Expired - Fee Related
- 1991-07-19 YU YU127191A patent/YU47573B/sh unknown
1996
- 1996-03-08 CY CY184096A patent/CY1840A/en unknown

Also Published As

Publication number	Publication date
DK137591D0 (da)	1991-07-19
GB2246072A (en)	1992-01-22
YU47573B (sh)	1995-10-03
GR910100319A (el)	1992-08-26
ES2039177A1 (es)	1993-09-01
ES2039177B1 (es)	1994-03-16
IL98894A0 (en)	1992-07-15
ITMI912002A1 (it)	1993-01-19
CS222291A3 (en)	1992-02-19
NL9101268A (nl)	1992-02-17
SE9102160L (sv)	1992-01-21
KR920002162A (ko)	1992-02-28
ZA915677B (en)	1993-03-31
GR1002175B (en)	1996-03-07
GB2246072B (en)	1994-06-15
FR2664814B1 (fr)	1995-05-24
FI913493A7 (fi)	1992-01-21
CZ280064B6 (cs)	1995-10-18
DE4124081A1 (de)	1992-01-23
JPH04253924A (ja)	1992-09-09
FI913493A0 (fi)	1991-07-19
CY1840A (en)	1996-03-08
FI913493L (fi)	1992-01-21
TW203012B (fr)	1993-04-01
GB9115693D0 (en)	1991-09-04
YU127191A (sh)	1994-05-10
CA2047482A1 (fr)	1992-01-21
BE1006829A3 (fr)	1995-01-03
IT1250681B (it)	1995-04-21
HUT59592A (en)	1992-06-29
ITMI912002A0 (it)	1991-07-19
FR2664814A1 (fr)	1992-01-24
SE9102160D0 (sv)	1991-07-10
DK137591A (da)	1992-01-21
HU904564D0 (en)	1990-12-28

Legal Events

Date	Code	Title	Description
1997-03-14	PL	Patent ceased

Publication	Publication Date	Title
EP0277459B1 (fr)	1993-04-07	Médicament à libération controlée
DE69808670T2 (de)	2003-07-03	Herstellungsverfahren und zusammensetzung einer oralen zubereitung von itraconazol
DE69925740T2 (de)	2006-05-11	Neue stabile mehreinheitliche substituierte Benzimidazole enthaltende pharmazeutische Präparate
EP0265848B1 (fr)	1991-09-25	Préparations médicamentaires pour l'administration orale contenant à dose unitaire de 10 à 240 mg d'une dihydropyridine
DE69723248T2 (de)	2004-05-27	Vergällungsstoffe für sympathomimetische aminsalze
DE3420283A1 (de)	1985-12-05	Nifedipin-trockenpraeparate und verfahren zu ihrer herstellung
EP0272336B1 (fr)	1991-10-23	Concentré de nifédipine stabilisé contre l'influence de la lumière et mode de préparation
DE3318649A1 (de)	1984-11-22	Zweiphasenformulierung
AT391806B (de)	1990-12-10	Verfahren zur herstellung einer festen dispersion eines pharmakologischen wirkstoffes in einer polymeren matrix
EP1509201B1 (fr)	2009-03-25	Preparations contenant des substances actives, sous forme de film, a stabilite chimique amelioree et procedes de production desdites preparations
DE60036014T2 (de)	2008-04-30	Methode zur stabilisierung von benzimidazol-verbindungen
DE2822882A1 (de)	1978-12-21	Nifedipine-enthaltende feste praeparatzusammensetzung, verfahren zu ihrer herstellung und ihre verwendung
EP0117888A1 (fr)	1984-09-12	Compositions liquides de dihydropyridines, leur préparation et application thérapeutique
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DE3738236A1 (de)	1989-05-24	Beisskapsel
EP0240484A1 (fr)	1987-10-07	Composition pharmaceutique et son mode de préparation
DE19929647A1 (de)	2000-09-07	Oral verabreichbares Nifedipinpellet sowie Verfahren zur Herstellung desselben
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DE68914683T2 (de)	1994-10-27	Arzneimittelzusammensetzung für die schnelle verabreichung des aktiven bestandteils, der aus einer festen dispersion und einem oberflächenaktiven mittel besteht.
EP0143857B1 (fr)	1988-04-06	Composition thérapeutique coronaire sous forme de capsule molle de gélatine
CH681960A5 (fr)	1993-06-30
EP0164588A2 (fr)	1985-12-18	Préparations de dihydropyridine et procédé pour leur obtention
DE10392718T5 (de)	2005-07-07	Pharmazeutische Formulierung in einem Medikamentenfreisetzungssystem und Verfahren zur Herstellung derselben
EP0163984A2 (fr)	1985-12-11	Associations de dihydropyridine et procédé pour leur préparation
DE3442065A1 (de)	1985-05-30	Nifedipin-zusammensetzung und verfahren zu ihrer herstellung