CL2004000732A1 - Compuestos derivados de oximas sustituidas y sus sales farmaceuticamente aceptables; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los contiene; y uso de los compuestos para el tratamiento del cancer. - Google Patents
Compuestos derivados de oximas sustituidas y sus sales farmaceuticamente aceptables; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los contiene; y uso de los compuestos para el tratamiento del cancer.Info
- Publication number
- CL2004000732A1 CL2004000732A1 CL200400732A CL2004000732A CL2004000732A1 CL 2004000732 A1 CL2004000732 A1 CL 2004000732A1 CL 200400732 A CL200400732 A CL 200400732A CL 2004000732 A CL2004000732 A CL 2004000732A CL 2004000732 A1 CL2004000732 A1 CL 2004000732A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- pharmaceutically acceptable
- acceptable salts
- oximes
- cancer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000002923 oximes Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108010033040 Histones Proteins 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SON OBJETIVOS DE LA PRESENTE INVENCION LOS COMPUESTOS DE LA FORMULA I SUS SALES FARMACEUTICAMENTE ACEPTABLES COMO SUS FORMAS ENANTIOMERICAS, SUS DIASTEREOISOMEROS Y SUS RACEMATOS, LA OBTENCION DE LOS COMPUESTOS RECIEN MENCIONADOS, LOS MEDICAMENTOS QUE LOS CONTIENEN Y SU FABRICACION ASI COMO EL USO DE LOS COMPUESTOS RECIEN MENCIONADOS COMO INHIBIDORES DE DESACETILASA DE HISTONA (HDAC) Y POR LO TANTO PARA EL CONTROL O PREVENCION DE ENFERMEDADES Y TRANSTORNOS MENCIONADOS ANTERIORMENTE, O PARA LA FABRICACION DE LOS MEDICAMENTOS CORRESPONDIENTES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03007829 | 2003-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004000732A1 true CL2004000732A1 (es) | 2005-02-04 |
Family
ID=33104054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200400732A CL2004000732A1 (es) | 2003-04-04 | 2004-04-02 | Compuestos derivados de oximas sustituidas y sus sales farmaceuticamente aceptables; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los contiene; y uso de los compuestos para el tratamiento del cancer. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7173060B2 (es) |
| EP (1) | EP1613622A1 (es) |
| JP (1) | JP2006515345A (es) |
| KR (1) | KR100733757B1 (es) |
| CN (1) | CN1771247A (es) |
| AR (1) | AR043823A1 (es) |
| AU (1) | AU2004226215A1 (es) |
| BR (1) | BRPI0409182A (es) |
| CA (1) | CA2519301A1 (es) |
| CL (1) | CL2004000732A1 (es) |
| MX (1) | MXPA05010424A (es) |
| RU (1) | RU2005133994A (es) |
| TW (1) | TW200424187A (es) |
| WO (1) | WO2004087693A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04008797A (es) | 2002-03-13 | 2004-11-26 | Janssen Pharmaceutica Nv | Inhibidores de histona desacetilasa. |
| EA007099B1 (ru) | 2002-03-13 | 2006-06-30 | Янссен Фармацевтика Н. В. | Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы |
| CA2475766C (en) | 2002-03-13 | 2012-06-05 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
| HRP20040805A2 (en) | 2002-03-13 | 2005-04-30 | Janssen Pharmaceutica N.V. | Carbonylamino derivatives as novel inhibitors histone deacetylase |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7381825B2 (en) | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| KR101261305B1 (ko) | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP5156392B2 (ja) | 2005-02-03 | 2013-03-06 | トポターゲット ユーケー リミテッド | Hdac阻害剤を用いる併用療法 |
| EP1896436A2 (en) | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| ATE542527T1 (de) | 2005-05-13 | 2012-02-15 | Topotarget Uk Ltd | Pharmazeutische formulierungen von hdac-hemmern |
| ES2553178T3 (es) | 2005-05-18 | 2015-12-04 | Janssen Pharmaceutica N.V. | Derivados sustituidos de aminopropenil piperidina o morfolina como nuevos inhibidores de histona deacetilasa |
| EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| WO2007054719A2 (en) | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
| CA2631876C (en) | 2006-01-19 | 2014-05-27 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as inhibitors of histone deacetylase |
| WO2007082874A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US7888360B2 (en) | 2006-01-19 | 2011-02-15 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| EP1981875B1 (en) | 2006-01-19 | 2014-04-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| DK1981871T3 (da) | 2006-01-19 | 2012-02-13 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivater som hidtil ukendte inhibitorer af histondeacetylase |
| WO2007082876A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| JP2008266322A (ja) | 2007-03-28 | 2008-11-06 | Santen Pharmaceut Co Ltd | ヒストン脱アセチル化酵素阻害作用を有する化合物を有効成分として含有する眼圧下降剤 |
| US8642809B2 (en) | 2007-09-25 | 2014-02-04 | Topotarget Uk Ltd. | Methods of synthesis of certain hydroxamic acid compounds |
| US8426449B2 (en) * | 2008-04-02 | 2013-04-23 | Panmira Pharmaceuticals, Llc | Aminoalkylphenyl antagonists of prostaglandin D2 receptors |
| EP2695615A3 (en) | 2008-07-23 | 2014-04-30 | Novartis AG | Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| DK2970139T3 (en) | 2013-03-15 | 2018-08-13 | Biomarin Pharm Inc | HDAC inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1033046B (it) | 1970-10-31 | 1979-07-10 | Finotto Martino | Procedimento di fabbricazione di benzimidazoli sostituiti |
| DE2201062A1 (de) * | 1972-01-11 | 1973-07-26 | Bayer Ag | N-alkoxycarbonyl- bzw. n-alkylthiocarbonyl-2-(2'-thienyl)-benzimidazole, ein verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| NZ219974A (en) | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
| JPH0692398B2 (ja) * | 1987-07-07 | 1994-11-16 | 日本農薬株式会社 | ピラゾ−ルオキシム誘導体及び該化合物を含有する殺菌殺虫殺ダニ剤 |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| US20020103192A1 (en) | 2000-10-26 | 2002-08-01 | Curtin Michael L. | Inhibitors of histone deacetylase |
| US6784173B2 (en) | 2001-06-15 | 2004-08-31 | Hoffmann-La Roche Inc. | Aromatic dicarboxylic acid derivatives |
| JP4641670B2 (ja) * | 2001-06-28 | 2011-03-02 | 株式会社フジタ | 水浄化構造 |
| AR034897A1 (es) * | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
-
2004
- 2004-03-30 TW TW093108684A patent/TW200424187A/zh unknown
- 2004-03-31 US US10/814,410 patent/US7173060B2/en not_active Expired - Fee Related
- 2004-04-01 AR ARP040101103A patent/AR043823A1/es not_active Application Discontinuation
- 2004-04-02 AU AU2004226215A patent/AU2004226215A1/en not_active Abandoned
- 2004-04-02 CN CNA2004800092703A patent/CN1771247A/zh active Pending
- 2004-04-02 JP JP2006500084A patent/JP2006515345A/ja active Pending
- 2004-04-02 CA CA002519301A patent/CA2519301A1/en not_active Abandoned
- 2004-04-02 BR BRPI0409182-5A patent/BRPI0409182A/pt not_active IP Right Cessation
- 2004-04-02 EP EP04725309A patent/EP1613622A1/en not_active Withdrawn
- 2004-04-02 MX MXPA05010424A patent/MXPA05010424A/es active IP Right Grant
- 2004-04-02 KR KR1020057018818A patent/KR100733757B1/ko not_active Expired - Fee Related
- 2004-04-02 WO PCT/EP2004/003498 patent/WO2004087693A1/en not_active Ceased
- 2004-04-02 CL CL200400732A patent/CL2004000732A1/es unknown
- 2004-04-02 RU RU2005133994/04A patent/RU2005133994A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2519301A1 (en) | 2004-10-14 |
| JP2006515345A (ja) | 2006-05-25 |
| MXPA05010424A (es) | 2005-11-04 |
| AU2004226215A1 (en) | 2004-10-14 |
| US20040214880A1 (en) | 2004-10-28 |
| US7173060B2 (en) | 2007-02-06 |
| KR100733757B1 (ko) | 2007-06-29 |
| WO2004087693A1 (en) | 2004-10-14 |
| BRPI0409182A (pt) | 2006-04-11 |
| KR20060011947A (ko) | 2006-02-06 |
| EP1613622A1 (en) | 2006-01-11 |
| RU2005133994A (ru) | 2006-06-27 |
| CN1771247A (zh) | 2006-05-10 |
| AR043823A1 (es) | 2005-08-17 |
| TW200424187A (en) | 2004-11-16 |
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