CL2004000900A1 - Combinacion farmaceutica que comprende (i) un antagonista de la menos un receptor seleccionado de vegfr 1-3, pdgfr alfa y beta, fgfr1-3, egfr, her2, igf1r, hgfr o c-kit, y (ii) al menos un agente quimioterapeutico o terapeutico y su uso en el tratami - Google Patents

Combinacion farmaceutica que comprende (i) un antagonista de la menos un receptor seleccionado de vegfr 1-3, pdgfr alfa y beta, fgfr1-3, egfr, her2, igf1r, hgfr o c-kit, y (ii) al menos un agente quimioterapeutico o terapeutico y su uso en el tratami

Info

Publication number
CL2004000900A1
CL2004000900A1 CL200400900A CL2004000900A CL2004000900A1 CL 2004000900 A1 CL2004000900 A1 CL 2004000900A1 CL 200400900 A CL200400900 A CL 200400900A CL 2004000900 A CL2004000900 A CL 2004000900A CL 2004000900 A1 CL2004000900 A1 CL 2004000900A1
Authority
CL
Chile
Prior art keywords
treatment
hgfr
igf1r
fgfr1
pdgfr
Prior art date
Application number
CL200400900A
Other languages
English (en)
Inventor
Martin Friedrich Hilb Stefanic
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33424438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2004000900(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP03009587A external-priority patent/EP1473043A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2004000900A1 publication Critical patent/CL2004000900A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Radiation-Therapy Devices (AREA)
  • Indole Compounds (AREA)

Abstract

LA PRESENTE INVENCION DICE RELACION CON UNA COMPOSICION FARMACEUTICA PARA EL TRATAMIENTO DE ENFERMEDADES QUE IMPLIQUEN, MIGRACION O APOPTOSIS CELULARES DE CELULAS DE MIELOMA O ANGIOGENESIS. LA INVENCION TAMBIEN SE REFIERE A UN METODO PARA EL TRATAMIENTO DE DICHAS ENFERMEDADES QUE COMPRENDE LA COADMINISTRACION DE CANTIDADES EFECTIVAS DE COMPUESTOS ESPECIFICOS Y/O EL CO-TRATAMIENTO CON TERAPIA DE RADIACION, EN UNA RELACION QUE PROPORCIONA UN EFECTO ADITIVO O SINERGICO, Y AL USO COMBINADO DE ESTOS COMPUESTOS ESPECIFICOS Y/O RADIOTERAPIA PARA LA FABRICACION DE LAS PREPARACIONES DE COMBINACIONES FARMACEUTICAS CORRESPONDIENTES.
CL200400900A 2003-04-29 2004-04-28 Combinacion farmaceutica que comprende (i) un antagonista de la menos un receptor seleccionado de vegfr 1-3, pdgfr alfa y beta, fgfr1-3, egfr, her2, igf1r, hgfr o c-kit, y (ii) al menos un agente quimioterapeutico o terapeutico y su uso en el tratami CL2004000900A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03009587A EP1473043A1 (en) 2003-04-29 2003-04-29 Pharmaceutical combination for the treatment of diseases involving cell proliferation, migration or apotosis of myeloma cells, or angiogenesis
EP04000508 2004-01-13
EP04001171 2004-01-21

Publications (1)

Publication Number Publication Date
CL2004000900A1 true CL2004000900A1 (es) 2005-03-04

Family

ID=33424438

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400900A CL2004000900A1 (es) 2003-04-29 2004-04-28 Combinacion farmaceutica que comprende (i) un antagonista de la menos un receptor seleccionado de vegfr 1-3, pdgfr alfa y beta, fgfr1-3, egfr, her2, igf1r, hgfr o c-kit, y (ii) al menos un agente quimioterapeutico o terapeutico y su uso en el tratami

Country Status (30)

Country Link
US (7) US20050043233A1 (es)
EP (5) EP1622619B1 (es)
JP (2) JP4701159B2 (es)
KR (1) KR101150315B1 (es)
CN (1) CN1780627B (es)
AR (1) AR044114A1 (es)
AU (2) AU2004233576B2 (es)
BR (1) BRPI0409919A (es)
CA (1) CA2523868C (es)
CL (1) CL2004000900A1 (es)
CO (1) CO5640112A2 (es)
CY (1) CY1114622T1 (es)
DK (1) DK1622619T3 (es)
EA (2) EA011888B1 (es)
EC (1) ECSP056132A (es)
ES (1) ES2437841T3 (es)
IL (1) IL171579A (es)
ME (1) MEP46908A (es)
MX (1) MXPA05011656A (es)
MY (1) MY141119A (es)
NO (1) NO333994B1 (es)
NZ (1) NZ543774A (es)
PE (1) PE20050463A1 (es)
PL (1) PL1622619T4 (es)
PT (1) PT1622619E (es)
RS (1) RS52143B (es)
SI (1) SI1622619T1 (es)
TW (2) TWI442924B (es)
UY (1) UY28287A1 (es)
WO (1) WO2004096224A2 (es)

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