CL2014000181A1 - Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11). - Google Patents

Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11).

Info

Publication number: CL2014000181A1
Authority: CL; Chile
Prior art keywords: antibody; divisional; met; vector; nucleic acid
Prior art date: 2008-12-02

Application number

CL2014000181A

Other languages

English (en)

Inventor

Liliane Goetsh

Thierry Wurch

Cedric Bes

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-02

Filing date

2014-01-24

Publication date

2014-07-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014000181(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-12-02 Priority claimed from PCT/IB2008/055663 external-priority patent/WO2010064089A1/en

2014-01-24 Application filed by Pf Medicament filed Critical Pf Medicament

2014-07-25 Publication of CL2014000181A1 publication Critical patent/CL2014000181A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Connection Of Motors, Electrical Generators, Mechanical Devices, And The Like (AREA)
Medicinal Preparation (AREA)

CL2014000181A 2008-12-02 2014-01-24 Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11). CL2014000181A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/IB2008/055663 WO2010064089A1 (en)	2008-12-02	2008-12-02	Novel anti-cmet antibody
US18450209P	2009-06-05	2009-06-05

Publications (1)

Publication Number	Publication Date
CL2014000181A1 true CL2014000181A1 (es)	2014-07-25

Family

ID=41693124

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CL2011001296A CL2011001296A1 (es)	2008-12-02	2011-06-01	Anticuerpo monoclonal capaz de inhibir la dimerizacion de cmet; acido nucleico, vector y celula huesped que comprenden las secuencias que codifican el anticuerpo; composicion que comprende el anticuerpo; uso del anticuerpo para inhibir el crecimiento y/o proliferacion de celulas tumorales.
CL2014000181A CL2014000181A1 (es)	2008-12-02	2014-01-24	Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11).

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CL2011001296A CL2011001296A1 (es)	2008-12-02	2011-06-01	Anticuerpo monoclonal capaz de inhibir la dimerizacion de cmet; acido nucleico, vector y celula huesped que comprenden las secuencias que codifican el anticuerpo; composicion que comprende el anticuerpo; uso del anticuerpo para inhibir el crecimiento y/o proliferacion de celulas tumorales.

Country Status (38)

Country	Link
US (4)	US8741290B2 (es)
EP (4)	EP3431502B1 (es)
JP (3)	JP5863458B2 (es)
KR (1)	KR101838299B1 (es)
CN (2)	CN103351438B (es)
AR (1)	AR074439A1 (es)
AU (3)	AU2009328318C1 (es)
BR (2)	BR122019023930B1 (es)
CA (1)	CA2743433C (es)
CL (2)	CL2011001296A1 (es)
CO (1)	CO6382139A2 (es)
CR (1)	CR20110324A (es)
CY (2)	CY1119172T1 (es)
DK (2)	DK3135691T3 (es)
EC (1)	ECSP11011127A (es)
ES (3)	ES2827277T3 (es)
GE (2)	GEP20135930B (es)
HR (2)	HRP20171011T8 (es)
HU (3)	HUE040553T2 (es)
IL (2)	IL213273A0 (es)
LT (2)	LT2370468T (es)
MA (1)	MA32892B1 (es)
MX (2)	MX2011005677A (es)
MY (2)	MY185200A (es)
NZ (1)	NZ593853A (es)
PE (1)	PE20120343A1 (es)
PH (1)	PH12015501515A1 (es)
PL (3)	PL2370468T3 (es)
PT (3)	PT2370468T (es)
RS (2)	RS56204B1 (es)
RU (2)	RU2015127471A (es)
SA (2)	SA109300720B1 (es)
SG (2)	SG171851A1 (es)
SI (3)	SI3431502T1 (es)
TN (1)	TN2011000216A1 (es)
TW (2)	TWI523866B (es)
WO (1)	WO2010069765A1 (es)
ZA (1)	ZA201105164B (es)

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2009
- 2009-12-01 AR ARP090104624A patent/AR074439A1/es active IP Right Grant
- 2009-12-02 LT LTEP09771324.2T patent/LT2370468T/lt unknown
- 2009-12-02 MX MX2011005677A patent/MX2011005677A/es active IP Right Grant
- 2009-12-02 HU HUE16192250A patent/HUE040553T2/hu unknown
- 2009-12-02 HU HUE18188726A patent/HUE051288T2/hu unknown
- 2009-12-02 PT PT97713242T patent/PT2370468T/pt unknown
- 2009-12-02 EP EP18188726.6A patent/EP3431502B1/en active Active
- 2009-12-02 ES ES18188726T patent/ES2827277T3/es active Active
- 2009-12-02 PL PL09771324T patent/PL2370468T3/pl unknown
- 2009-12-02 BR BR122019023930-4A patent/BR122019023930B1/pt active IP Right Grant
- 2009-12-02 RS RS20170671A patent/RS56204B1/sr unknown
- 2009-12-02 CA CA2743433A patent/CA2743433C/en active Active
- 2009-12-02 SG SG2011038817A patent/SG171851A1/en unknown
- 2009-12-02 BR BRPI0923231A patent/BRPI0923231B8/pt active IP Right Grant
- 2009-12-02 ES ES09771324.2T patent/ES2629855T3/es active Active
- 2009-12-02 JP JP2011539008A patent/JP5863458B2/ja active Active
- 2009-12-02 GE GEAP200912279A patent/GEP20135930B/en unknown
- 2009-12-02 EP EP16192250.5A patent/EP3135691B1/en active Active
- 2009-12-02 HU HUE09771324A patent/HUE035047T2/en unknown
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Also Published As

Publication number	Publication date
US8765128B2 (en)	2014-07-01
HK1162536A1 (zh)	2012-08-31
PT2370468T (pt)	2017-07-13
HUE035047T2 (en)	2018-05-02
US8747850B2 (en)	2014-06-10
US20110239316A1 (en)	2011-09-29
RU2011124751A (ru)	2013-01-10
SG187518A1 (en)	2013-02-28
US20130109844A1 (en)	2013-05-02
JP6074018B2 (ja)	2017-02-01
AU2016200725C1 (en)	2017-10-19
ES2827277T3 (es)	2021-05-20
EP3135691B1 (en)	2018-08-15
PL2370468T3 (pl)	2017-09-29
DK3135691T3 (en)	2018-11-19
CA2743433A1 (en)	2010-06-24
JP6309657B2 (ja)	2018-04-11
LT2370468T (lt)	2017-07-10
CN102227446B (zh)	2015-10-21
PL3135691T3 (pl)	2019-02-28
ES2697098T3 (es)	2019-01-22
BR122019023930B1 (pt)	2021-05-04
US8729249B2 (en)	2014-05-20
CA2743433C (en)	2019-06-11
BRPI0923231A2 (pt)	2016-01-26
JP5863458B2 (ja)	2016-02-16
PT3135691T (pt)	2018-11-27
JP2012510280A (ja)	2012-05-10
HRP20171011T8 (hr)	2019-01-25
IL213273A0 (en)	2011-07-31
JP2016117721A (ja)	2016-06-30
PE20120343A1 (es)	2012-04-16
US8741290B2 (en)	2014-06-03
TWI523866B (zh)	2016-03-01
AR074439A1 (es)	2011-01-19
TW201446805A (zh)	2014-12-16
US20130109841A1 (en)	2013-05-02
CY1121025T1 (el)	2019-12-11
MY185200A (en)	2021-04-30
DK2370468T3 (en)	2017-06-19
RU2015127471A (ru)	2018-12-21
HRP20171011T1 (hr)	2017-09-22
CN103351438B (zh)	2016-04-20
AU2009328318C1 (en)	2017-11-02
SI3431502T1 (sl)	2021-01-29
ECSP11011127A (es)	2011-07-29
TWI459964B (zh)	2014-11-11
MX341014B (es)	2016-08-03
CN102227446A (zh)	2011-10-26
AU2016200725A1 (en)	2016-02-25
SG171851A1 (en)	2011-07-28
TW201023892A (en)	2010-07-01
SI2370468T1 (sl)	2017-08-31
BRPI0923231B8 (pt)	2021-05-25
EP3431502A1 (en)	2019-01-23
TN2011000216A1 (en)	2012-12-17
CY1119172T1 (el)	2018-02-14
RU2560257C2 (ru)	2015-08-20
PT3431502T (pt)	2020-10-29
MX2011005677A (es)	2011-06-30
SA109300720B1 (ar)	2013-05-25
EP2370468A1 (en)	2011-10-05
EP3135691A1 (en)	2017-03-01
EP3757132A1 (en)	2020-12-30
LT3135691T (lt)	2018-11-12
KR20110097839A (ko)	2011-08-31
EP3431502B1 (en)	2020-07-22
CN103351438A (zh)	2013-10-16
RS58018B1 (sr)	2019-02-28
AU2009328318B2 (en)	2015-11-05
AU2017203929A1 (en)	2017-07-06
ZA201105164B (en)	2012-03-28
GEP20135930B (en)	2013-10-10
HRP20181868T1 (hr)	2019-01-11
SI3135691T1 (sl)	2018-12-31
CL2011001296A1 (es)	2011-08-26
JP2017099392A (ja)	2017-06-08
WO2010069765A1 (en)	2010-06-24
PH12015501515A1 (en)	2015-12-14
GEP20146207B (en)	2014-12-10
HK1190414A1 (zh)	2014-07-04
HUE040553T2 (hu)	2019-03-28
RS56204B1 (sr)	2017-11-30
KR101838299B1 (ko)	2018-03-14
MY192567A (en)	2022-08-29
CO6382139A2 (es)	2012-02-15
ES2629855T3 (es)	2017-08-16
AU2017203929B2 (en)	2019-03-28
IL231525B (en)	2019-07-31
CR20110324A (es)	2011-07-28
PL3431502T3 (pl)	2020-12-28
BRPI0923231B1 (pt)	2020-04-28
US20130109840A1 (en)	2013-05-02
EP2370468B1 (en)	2017-04-05
AU2009328318A1 (en)	2011-07-28
AU2016200725B2 (en)	2017-05-25
SA112331005B1 (ar)	2015-09-13
MA32892B1 (fr)	2011-12-01
HUE051288T2 (hu)	2021-03-01
IL231525A0 (en)	2014-04-30
NZ593853A (en)	2013-03-28

Publication	Publication Date	Title
CL2014000181A1 (es)	2014-07-25	Anticuerpo monoclonal capaz de inhibir la dimerización de receptor para el factor del crecimiento de hepatocitos (c-met); acido nucleico aislado que lo codifica; vector y célula huesped que lo comprenden; proceso para la produccion del anticuerpo; uso del anticuerpo para tratar cancer (divisional de la solicitud 1296-11).
CL2015001356A1 (es)	2015-11-06	Anticuerpos bioespecificos egfr/c-met
CL2015001353A1 (es)	2015-10-02	Molécula que contiene el dominio de fibronectina de tipo iii (fn3) biespecífico, donde el primer dominio se une al receptor del factor de crecimiento epidérmico (egrf) y el segundo al factor de crecimiento de hepatocitos (c-met); dominio de fn3; polinucleótido que la codifica; vector; célula huésped; método de producción; composición farmacéutica que la comprende; y uso para tratar el cáncer.
CL2007002835A1 (es)	2008-05-30	Anticuerpo monoclonal especifico para el receptor cxcr4; acido nucleico que lo codifica; vector y celula que lo comprenden; metodo de produccion; inmunoconjugado y composicion que lo comprende; y su uso para tratar cancer, trastornos inflamatorios y
CL2016002116A1 (es)	2017-05-12	Anticuerpos anti-fap y métodos de utilización (divisional sol. n°369-13).
CL2015003090A1 (es)	2016-07-22	Proteínas de unión específicas y sus usos.
CL2008002015A1 (es)	2008-11-21	Anticuerpo anti-receptor del factor de creciemiento de hepatocito (hgf)/receptor c-met; hibridoma que lo produce; acido nucleico que lo codifica; vector y celula huesped que los comprende; procedimiento de produccion; composicion que los comprende; su uso para tratar cancer; y metodo de diagnostico in vitro
CL2013000930A1 (es)	2014-03-28	Anticuerpo para interleuquina 17 (il-17); uso de dicho anticuerpo para tratar soriasis usando antagonistas de il-17.
CL2015000094A1 (es)	2015-06-19	Compuestos derivados de imidazotriazincarbonitrilos, inhibidores de la proteina cinasa; composicion farmaceutica que los comprende; y su uso para tratar el cancer, psoriasis y artritis reumatoide.
CL2011000730A1 (es)	2012-02-03	Procedimiento de selección de anticuerpos anti-cxcr4 y anticuerpos seleccionados; ácido nucleico que codifica los anticuerpos; vector; célula huésped; procedimiento de producción; hibridoma que produce los anticuerpos; composición; uso de los anticuerpos seleccionados para preparar un medicamento para tratar cáncer.
CL2015002526A1 (es)	2016-06-10	Anticuerpos anti-ox40 y métodos de uso de los mismos.(divisional de 545-13).
CL2011002784A1 (es)	2012-08-31	Anticuerpo anti-egfl7; acido nucleico que lo codifica; vector; celula huesped; metodo de preparacion; composicion que lo comprende, y su uso para tratar un tumor, cancer o un trastorno proliferativo.
MX2014005728A (es)	2014-05-30	Anticuerpos especificos para antigeno de la superficie celular de trofoblasto-2 y sus usos.
CL2009000379A1 (es)	2012-02-24	Anticuerpo monoclonal aislado especifico contra los ligandos angiopoyetina 1 y 2 del receptor tie 2; fragmento del mismo; molecula de acido nucleico que lo codifica; vector; celula huesped; metodo de preparacion; composicion farmaceutica que lo comprende; y su uso para inhibir la angiogenesis no deseada tal como cancer.
CL2014003465A1 (es)	2015-02-27	Anticuerpo que se une al receptor del factor de crecimiento epidérmico humano dimérico (hegfr) ; composición farmacéutica que lo comprende; y uso para tratar el cáncer.
CL2008002083A1 (es)	2008-11-21	Anticuerpo humanizado anti-cd79b/igbeta/b29; inmunoconjugado; metodo in vitro para determinar presencia de cd79b, inhibir crecimiento de celula con cd79b, o para detectara celula b; metodo para elaborar dicho anticyerpo humanizado; acido nucleico; celula huesped; composicion; metodo de elaboracion de inmunoconjugado; uso medico
BR112016027585A2 (pt)	2018-01-30	construções de anticorpo multiespecíficas
CL2007003357A1 (es)	2008-04-04	Anticuerpo o fragmento funcional del mismo capaz de inhibir la proliferacion de celulas tumorales in vitro y/o in vivo; acido nucleico que lo codifica; metodo de produccion; composicion que lo comprende; y su uso para tratar el cancer.
CL2011002417A1 (es)	2012-03-30	Anticuerpo especifico para fcrh5, receptor de superficie celular con homologia con las familias del receptor fc; anticuerpo anti-fcrh5 humanizado; polinucleotido que lo codifica; vector; celular huesped; metodo de obtencion; inmunoconjugado; composicion farmaceutica; y su uso para tratar cancer.
CL2017002244A1 (es)	2018-04-13	Anticuerpos biespecíficos específicos para fap y dr5, anticuerpos específicos para dr5 y métodos de utilización. (divisional de solicitud 2829-2015).
CL2013002044A1 (es)	2014-05-09	Anticuerpo que une il-17a humano e il-17f humano; secuencia de adn que lo codifica; vector; celula huesped; proceso de produccion; composicion farmaceutica que lo comprende; y su uso para el tratamiento profilaxis de un trastorno patologico mediado por il-17a y/o il-17f.
CL2013003296A1 (es)	2014-07-25	Uso de un agonista del receptor 1 del factor de crecimiento anti-fibroblastos (fgfr1) para tratar enfermedades tales como sindrome de ovario poliquístico (pcos), sindrome metabólico, obesidad, estrato hepatitis no alcohólica (nash), entre otras; anticuerpo que se une con fgfr1; acido nucleico aislado; célula huesped.
CL2011002039A1 (es)	2012-03-30	Anticuerpo humanizado que se une al cd19 humano; acido nucleico aislado que codifica dicho anticuerpo; vector y celula huesped; composicion e inmunoconjugado; metodo para inhibir el crecimiento de celulas de tumor que expresan cd19.
CL2013001290A1 (es)	2013-11-15	Anticuerpo aislado, o su fragmento, que se une a beta secretasa (bace1); acido nucleico que codifica el anticuerpo; celula huesped que comprende el acido nucleico; metodo para producir un anticuerpo; inmunoconjugado que comprende el anticuerpo; formulacion farmaceutica; uso del anticuerpo para tratar enfermedad o trastorno neurológico.
CL2011002304A1 (es)	2012-04-09	Anticuerpo multiespecifico que comprende un dominio de union al antigeno que se une a egfr y a her3; acido nucleico que lo codifica; celula huesped; metodo de produccion; inmunoconjugado; formulacion farmaceutica que comprende el anticuerpo; y su uso para tratar el cancer.