RS56204B1 - Antitelo na cmet - Google Patents

Antitelo na cmet

Info

Publication number
RS56204B1
RS56204B1 RS20170671A RSP20170671A RS56204B1 RS 56204 B1 RS56204 B1 RS 56204B1 RS 20170671 A RS20170671 A RS 20170671A RS P20170671 A RSP20170671 A RS P20170671A RS 56204 B1 RS56204 B1 RS 56204B1
Authority
RS
Serbia
Prior art keywords
permanent magnet
gear
housing
force
shaft
Prior art date
Application number
RS20170671A
Other languages
English (en)
Inventor
Liliane Goetsch
Thierry Wurch
Cédric Bes
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS56204(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/IB2008/055663 external-priority patent/WO2010064089A1/en
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of RS56204B1 publication Critical patent/RS56204B1/sr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Connection Of Motors, Electrical Generators, Mechanical Devices, And The Like (AREA)

Description

PERMANENTNI MAGNETNI MOTOR
"PERMMAG"
OBLAST TEHNIKE NA KOJU SE PRONALAZAK ODNOSI
Pronalazak pripada oblasti tehnike koja se bavi korisccnjem elcklromagnetne i magnetne energije u obrtnim mašinama.
Prema Mcdjunarodnoj klasifikaciji patenata (MKP) oznaka je:HO2Nl l/00.
TEHNIČKI PROBLEM
Pronalazak resava problem transformacije magnetne energije u mehaničku energiju primenom permanentnih magneta u uredjaju koristeći energiju istih.
STANJE TEHNIKE
Kako je opisano u osnovnoj prijavi br. 158/99 motori jednosmerne i naizmenicne struje imaju široku primenu u svim granama privrede.Koristeći opste zakone elektrotehnilke, nove materijale u izradi i razvoja elektronike elektromotori spadaju u mašine sa najvećim stepenom korisnog dejstva (SKD).
Samim tim ostvarene su uspesne konstrukcije motora kombinacijom stalnih magneta i elektromagneta ali ne i motora koji bi koristio energiju stalnih magneta ne koristeći druga sredstva.
IZLAGANJE SUŠTINE PROIZVODA
Permanentni magnetni motor "Permmag" ima prednost u tome da koristi energiju permanentnih magneta (odredjenih oblika; magnetisanja i karakteristika materijala) tako da se njihovi medjusobnim dejstvom magnetne sile akcije i rackcije dovode na krajeve dvokrake poluge učvršćene na pogonsko vratilo.Tako dobijeni momenti sila suprotnog su smera i nejednakog inleziteta sto daje rezultujuci moment sile u smeru većeg momenta sile uzrokujući time obrtanje pogonskog vratila.
KRATAK OPIS SLIKA NACRTA
Pronalazak je detaljno opisan na primeru načina izvodjenja prikazanom na nacrtu u kome: Slika 1 - prikazuje uzdužni presck "Permmag" motora (iz osnovne prijave 158/99) Slika 4 - daje grafički i računski prikaz vektorskih sila "Permmag" motora (iz osnovne prijave 158/99)
Slika 5a - prikazuje način magnetisanja permanentnog magneta 9 i magnetnih segmenata 20a i 20b.
Slika 5b - prikazuje izmenu sklopa "Permmag"motora i način izvodjenjai
DETALJAN OPIS PRONALASKA
Slika 1 prikazuje konstrukciju permanentnog magnetnog motora "Permmag"— reakciono dejstva.
Rad permanentnog magnetnog motora se zasniva na osobini privlačnih i odbojnih sila magneta i zakona dvokrake. polude.
Opis uredjaja i način rada prikazan je(sIikom 4) u prijavi 158/99.Ovom dopunskom prijavom prikazana je konstrukciona izmena:
a) energetske grupe
b) sklop
a) Permanentni magnet 9 dijametralno magnetisan, izradjen od materijala "Remag 25", "Remag 30" (BHmax =170 - 250 KJ/m3) umeće se odstojno
izmedju dva magnetna segmenta 20a I 20b radijalno magnetisana(npr. unutra S - pol, spolja N - pol), izradjena od materijala "Remag 25", "Remag 30" - kako je prikazano slikom 5a.
b) Na vratilu.21 nosač 19 zupčanika Z2 se oslanja na radiaksijalno ležište 6c i time omogućuje obrtanje zupčanika Z2 u oba smera.Unutar nosača 19 nalazi
se kućište 30 magnetnih segmenata 20a i 20b.Kućište 30 je čvrstom vezom spojeno za vratilo 21 - kako je prikazano slikom 5b.
Rotaciju oko svoje ose vrsi zupčanik Z2 a magnetni segmenti 20a i 20b zauzimaju stalan položaj u odnosu na magnet 9 i na taj način vrse translatorno kretanje. Izmena je vezana za zakon pretvaranja potencijalne (magnetne) energije u kinetičku energiju translatornog kretanja i kinetičku energiju rotacionog kretanja. Prednosti:
1. manja masa sklopa (50%)
2. manja masa rolirajuceg dela sklopa (rotira zupčanik Z2 ali ne i magnetni segmenti 20a i 20b)
3. manja inertnost
4. veća brzina rotacije
5. koriscenje istog materijala "Remag 25","Remag 30" za sve magnete cime se uvećava energetska vrednost motora a time i pogonska sila.
NAČIN INDUSTRIJSKE ILI DRUGE PRIMENE PRONALASKA
Način primene dat je u osnovnoj prijavi 158/99.

Claims (2)

1. Permanentni magnetni motor "Permmag", omogućuje transformaciju energije permanentnog magneta (9) i magnetnih segmenata (20a i 20b) u obrtno kretanje pogonskog vratila (7), NAZNAČEN TIME, sto na vratilu (21) naleze nosač (19) u kom je postavljeno kućište (30) permanentnih magnetnih segmenata (20a i 20b), i na kome je ucvrsccn zupčanik (Z2) naspramno ozubljen zupčanikom (Zl), učvršćenim na kućište (la), i zupčanikom (Z3), nasadjcnim na slobodno vratilo (16), koje na drugom kraju nosi zupčanik (Z4), ozubljen zupčanikom (Z5), postavljenim na kućište (lb) i sto je na pogonsko vratilo (7) učvršćena dvokraka poluga (8) tako da je na njenom dužem kraku oslonjeno slobodno vratilo (16) preko kućišta (18a i 18b) a na kraćem kraku učvršćena je krilna pumpa (14) i servo motor (11) koji omogućuje ugaono kretanje nosača (10) dijametralno magnetisanog permanentnog magneta (9) odstojno umetnutog u radijalno magnetisane segmente (20a i 20b).
2. Permanentni magnetni motor "Permmag", prema zahtevu 1, NAZNAČEN TIME, sto se sila (FB) permanentnog magneta (9) prenosi preko nosača (10) na kraci krak poluge (8) u napadnu tacku (B), a sila (FZ3) magnetnih segmenata (20a i 20b) se preko zupčanika (Z3, Z4) i slobodnog vratila (16) prenosi na duzi krak poluge (8) u napadnu tacku (A) pri tom menjajuci smer i intenzitet tako da razlika nejednakih momenata sila suprotnog smera rezultuje obrtanje pogonskog vratila (7) u smeru delovanja većeg momenta sile (Ms) odnosno u smeru sile (FA).
RS20170671A 2008-12-02 2009-12-02 Antitelo na cmet RS56204B1 (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/IB2008/055663 WO2010064089A1 (en) 2008-12-02 2008-12-02 Novel anti-cmet antibody
US18450209P 2009-06-05 2009-06-05
PCT/EP2009/066201 WO2010069765A1 (en) 2008-12-02 2009-12-02 ANTI-cMET ANTIBODY
EP09771324.2A EP2370468B1 (en) 2008-12-02 2009-12-02 ANTI-cMET ANTIBODY

Publications (1)

Publication Number Publication Date
RS56204B1 true RS56204B1 (sr) 2017-11-30

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ID=41693124

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Application Number Title Priority Date Filing Date
RS20170671A RS56204B1 (sr) 2008-12-02 2009-12-02 Antitelo na cmet
RS20181344A RS58018B1 (sr) 2008-12-02 2009-12-02 Antitelo na c-met

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RS20181344A RS58018B1 (sr) 2008-12-02 2009-12-02 Antitelo na c-met

Country Status (38)

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US (4) US8741290B2 (sr)
EP (4) EP2370468B1 (sr)
JP (3) JP5863458B2 (sr)
KR (1) KR101838299B1 (sr)
CN (2) CN103351438B (sr)
AR (1) AR074439A1 (sr)
AU (3) AU2009328318C1 (sr)
BR (2) BR122019023930B1 (sr)
CA (1) CA2743433C (sr)
CL (2) CL2011001296A1 (sr)
CO (1) CO6382139A2 (sr)
CR (1) CR20110324A (sr)
CY (2) CY1119172T1 (sr)
DK (2) DK3135691T3 (sr)
EC (1) ECSP11011127A (sr)
ES (3) ES2697098T3 (sr)
GE (2) GEP20135930B (sr)
HR (2) HRP20171011T8 (sr)
HU (3) HUE051288T2 (sr)
IL (2) IL213273A0 (sr)
LT (2) LT2370468T (sr)
MA (1) MA32892B1 (sr)
MX (2) MX2011005677A (sr)
MY (2) MY192567A (sr)
NZ (1) NZ593853A (sr)
PE (1) PE20120343A1 (sr)
PH (1) PH12015501515A1 (sr)
PL (3) PL3431502T3 (sr)
PT (3) PT2370468T (sr)
RS (2) RS56204B1 (sr)
RU (2) RU2560257C2 (sr)
SA (2) SA112331005B1 (sr)
SG (2) SG171851A1 (sr)
SI (3) SI3135691T1 (sr)
TN (1) TN2011000216A1 (sr)
TW (2) TWI523866B (sr)
WO (1) WO2010069765A1 (sr)
ZA (1) ZA201105164B (sr)

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