CL2016002105A1 - Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3. - Google Patents

Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3.

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Publication number
CL2016002105A1
CL2016002105A1 CL2016002105A CL2016002105A CL2016002105A1 CL 2016002105 A1 CL2016002105 A1 CL 2016002105A1 CL 2016002105 A CL2016002105 A CL 2016002105A CL 2016002105 A CL2016002105 A CL 2016002105A CL 2016002105 A1 CL2016002105 A1 CL 2016002105A1
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Chile
Prior art keywords
sample
dll3
melanoma
patient
ligand
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CL2016002105A
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English (en)
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Laura Saunders
Samuel Williams
Kathryn Loving
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Abbvie Stemcentrx Llc
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Publication of CL2016002105A1 publication Critical patent/CL2016002105A1/es

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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Abstract

Se describe un método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende las etapas de: (a) detectar el nivel de expresión de un ligando similar a Delta 3 (DLL3) en una muestra biológica obtenida del paciente que tiene melanoma, donde la detección comprende poner en contacto la muestra biológica con un anticuerpo anti-DLL3 que comprende tres regiones de complementariedad (CDR) de una secuencia de aminoácidos de la región variable de cadena ligera de SEC ID Nº 173 y tres CDR de una secuencia de aminoácidos de la región variable de cadena pesada de la SEC ID Nº 175.
CL2016002105A 2014-02-21 2016-08-19 Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3. CL2016002105A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461942796P 2014-02-21 2014-02-21

Publications (1)

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CL2016002105A1 true CL2016002105A1 (es) 2017-03-31

Family

ID=53879125

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2016002105A CL2016002105A1 (es) 2014-02-21 2016-08-19 Método in vitro para determinar un pronóstico pobre en un paciente que tiene melanoma que comprende: (a) detectar el nivel de expresión de un ligando similar a delta 3 (dll3) en una muestra, donde la detección comprende poner en contacto la muestra con un anticuerpo anti-dll3.
CL2018001646A CL2018001646A1 (es) 2014-02-21 2018-06-18 Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma. (divisional solicitud 201602105)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2018001646A CL2018001646A1 (es) 2014-02-21 2018-06-18 Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma. (divisional solicitud 201602105)

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US (1) US10308721B2 (es)
EP (1) EP3107576A4 (es)
JP (1) JP2017514143A (es)
KR (1) KR20170008202A (es)
CN (1) CN106550593A (es)
AU (1) AU2015218633A1 (es)
BR (1) BR112016018891A2 (es)
CA (1) CA2939941A1 (es)
CL (2) CL2016002105A1 (es)
CR (1) CR20160437A (es)
DO (1) DOP2016000214A (es)
EA (1) EA201691683A1 (es)
EC (1) ECSP16075472A (es)
GT (1) GT201600168A (es)
IL (1) IL247248A0 (es)
MX (1) MX2016010677A (es)
PE (1) PE20161209A1 (es)
PH (1) PH12016501618A1 (es)
SG (1) SG11201606898TA (es)
WO (1) WO2015127407A1 (es)

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JP2017514143A (ja) 2017-06-01
CN106550593A (zh) 2017-03-29
US20170137533A1 (en) 2017-05-18
MX2016010677A (es) 2017-04-10
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GT201600168A (es) 2018-12-20
EA201691683A1 (ru) 2017-04-28
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CA2939941A1 (en) 2015-08-27
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BR112016018891A2 (pt) 2017-10-10
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