CL2017002060A1 - Compuestos de benzoxaborol y usos de los mismos - Google Patents
Compuestos de benzoxaborol y usos de los mismosInfo
- Publication number
- CL2017002060A1 CL2017002060A1 CL2017002060A CL2017002060A CL2017002060A1 CL 2017002060 A1 CL2017002060 A1 CL 2017002060A1 CL 2017002060 A CL2017002060 A CL 2017002060A CL 2017002060 A CL2017002060 A CL 2017002060A CL 2017002060 A1 CL2017002060 A1 CL 2017002060A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- structure comprises
- whose structure
- formula iii
- formula
- Prior art date
Links
- GDMJXXLVTYSBBE-UHFFFAOYSA-N 1,2-benzoxaborole Chemical class C1=CC=C2OB=CC2=C1 GDMJXXLVTYSBBE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 239000003926 antimycobacterial agent Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
<p>Se proporcionan compuestos cuya estructura comprende la fórmula II: (Fórmula II) o un compuesto cuya estructura comprende la fórmula III: (Fórmula III) en donde X se selecciona a partir de cloro, flúor, bromo y yodo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, – CH2CH2CH3, o -CH(CH3)2; composiciones que los contienen, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.</p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382055 | 2015-02-12 | ||
| EP15382056 | 2015-02-12 | ||
| EP15382054 | 2015-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017002060A1 true CL2017002060A1 (es) | 2018-03-16 |
Family
ID=55409879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002060A CL2017002060A1 (es) | 2015-02-12 | 2017-08-11 | Compuestos de benzoxaborol y usos de los mismos |
| CL2017002059A CL2017002059A1 (es) | 2015-02-12 | 2017-08-11 | Compuestos 4- sustitutos de benzoxaborol y uso de los mismos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002059A CL2017002059A1 (es) | 2015-02-12 | 2017-08-11 | Compuestos 4- sustitutos de benzoxaborol y uso de los mismos |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US20180037595A1 (es) |
| EP (2) | EP3256480A1 (es) |
| JP (2) | JP2018506540A (es) |
| KR (2) | KR20170117158A (es) |
| CN (2) | CN107548398A (es) |
| AU (3) | AU2016217508A1 (es) |
| BR (2) | BR112017017211B1 (es) |
| CA (2) | CA2976030C (es) |
| CL (2) | CL2017002060A1 (es) |
| CO (2) | CO2017008816A2 (es) |
| CR (2) | CR20170371A (es) |
| CY (1) | CY1123687T1 (es) |
| DK (1) | DK3256479T3 (es) |
| DO (2) | DOP2017000189A (es) |
| EA (2) | EA036516B1 (es) |
| ES (1) | ES2821951T3 (es) |
| HR (1) | HRP20201597T1 (es) |
| HU (1) | HUE051113T2 (es) |
| IL (2) | IL253864B (es) |
| LT (1) | LT3256479T (es) |
| MA (2) | MA41495A (es) |
| MX (2) | MX379057B (es) |
| MY (1) | MY194004A (es) |
| NZ (1) | NZ734379A (es) |
| PE (2) | PE20171432A1 (es) |
| PH (2) | PH12017501427A1 (es) |
| PL (1) | PL3256479T3 (es) |
| PT (1) | PT3256479T (es) |
| RS (1) | RS60885B1 (es) |
| SG (2) | SG11201706511TA (es) |
| SI (1) | SI3256479T1 (es) |
| SM (1) | SMT202000565T1 (es) |
| TW (2) | TWI730953B (es) |
| UA (1) | UA120527C2 (es) |
| WO (2) | WO2016128949A1 (es) |
| ZA (1) | ZA201705456B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160251380A1 (en) * | 2013-08-09 | 2016-09-01 | Glaxosmithkline Intellectual Property (No.2) Limited | Tricyclic benzoxaborole compounds and uses thereof |
| DK3621609T3 (da) | 2017-05-08 | 2022-08-29 | Glaxosmithkline Ip Dev Ltd | Sanfetrinem eller et salt eller ester deraf til anvendelse i behandling af mykobakterieinfektion |
| MX2020005464A (es) | 2017-11-30 | 2020-12-03 | Boragen Inc | Compuestos de benzoxaborol y formulaciones de los mismos. |
| EP3836938A4 (en) | 2018-08-18 | 2022-05-11 | Boragen, Inc. | SOLID FORMS OF SUBSTITUTED BENZOXAZOLE AND COMPOSITIONS THEREOF |
| CN110441344B (zh) * | 2019-06-25 | 2020-09-29 | 北京大学 | 一种基于固体核磁共振技术检测rna结构的方法 |
| CA3239097A1 (en) | 2022-06-23 | 2023-12-28 | Shanghai Micurx Pharmaceutical Co., Ltd. | Prodrugs of boron compounds and their use in treating bacterial infections |
| JP2025520237A (ja) * | 2022-06-23 | 2025-07-03 | ミクウルク ファーマシューティカルズ， インコーポレイテッド | ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物 |
| KR20240150582A (ko) | 2023-04-08 | 2024-10-15 | 김태서 | 맥세이프 배터리팩을 포함한 아이폰 케이스 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| WO1998024753A1 (en) | 1996-12-02 | 1998-06-11 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same |
| US7446236B2 (en) | 2002-12-02 | 2008-11-04 | Solvias Ag | Catalytic hydrogenation of carbon-heteroatom double bonds |
| US7767657B2 (en) | 2005-02-16 | 2010-08-03 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| ES2872962T3 (es) | 2005-02-16 | 2021-11-03 | Anacor Pharmaceuticals Inc | Boronoftalidas para uso terapéutico |
| JP5084717B2 (ja) | 2005-03-08 | 2012-11-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | キラル・ビスオキサゾリン触媒 |
| TWM325238U (en) * | 2006-12-29 | 2008-01-11 | Universal Scient Ind Co Ltd | Voltage regulator and voltage regulating system |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| SG172040A1 (en) | 2008-12-17 | 2011-07-28 | Anacor Pharmaceuticals Inc | Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol |
| US20110124597A1 (en) * | 2009-09-25 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
| AU2011237681B2 (en) * | 2010-04-07 | 2015-01-22 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| DK2613788T3 (en) | 2010-09-07 | 2017-08-07 | Anacor Pharmaceuticals Inc | BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS |
| US8530452B2 (en) | 2011-12-22 | 2013-09-10 | Micurx Pharmaceuticals, Inc. | Tricyclic boron compounds for antimicrobial therapy |
| CN102739587B (zh) | 2012-06-16 | 2014-05-21 | 天地融科技股份有限公司 | 音频数据传输方法 |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| US20160251380A1 (en) * | 2013-08-09 | 2016-09-01 | Glaxosmithkline Intellectual Property (No.2) Limited | Tricyclic benzoxaborole compounds and uses thereof |
-
2016
- 2016-02-11 MA MA041495A patent/MA41495A/fr unknown
- 2016-02-11 MA MA41494A patent/MA41494B1/fr unknown
- 2016-02-12 SG SG11201706511TA patent/SG11201706511TA/en unknown
- 2016-02-12 CN CN201680021488.3A patent/CN107548398A/zh active Pending
- 2016-02-12 EA EA201791671A patent/EA036516B1/ru unknown
- 2016-02-12 PE PE2017001400A patent/PE20171432A1/es not_active Application Discontinuation
- 2016-02-12 WO PCT/IB2016/050776 patent/WO2016128949A1/en not_active Ceased
- 2016-02-12 PL PL16706002T patent/PL3256479T3/pl unknown
- 2016-02-12 AU AU2016217508A patent/AU2016217508A1/en not_active Abandoned
- 2016-02-12 MX MX2017010413A patent/MX379057B/es unknown
- 2016-02-12 KR KR1020177025539A patent/KR20170117158A/ko not_active Ceased
- 2016-02-12 PE PE2017001401A patent/PE20171348A1/es not_active Application Discontinuation
- 2016-02-12 SM SM20200565T patent/SMT202000565T1/it unknown
- 2016-02-12 LT LTEP16706002.9T patent/LT3256479T/lt unknown
- 2016-02-12 US US15/550,658 patent/US20180037595A1/en not_active Abandoned
- 2016-02-12 HR HRP20201597TT patent/HRP20201597T1/hr unknown
- 2016-02-12 CA CA2976030A patent/CA2976030C/en active Active
- 2016-02-12 WO PCT/IB2016/050775 patent/WO2016128948A1/en not_active Ceased
- 2016-02-12 US US15/550,693 patent/US10774096B2/en active Active
- 2016-02-12 CR CR20170371A patent/CR20170371A/es unknown
- 2016-02-12 PT PT167060029T patent/PT3256479T/pt unknown
- 2016-02-12 DK DK16706002.9T patent/DK3256479T3/da active
- 2016-02-12 CR CR20170372A patent/CR20170372A/es unknown
- 2016-02-12 NZ NZ734379A patent/NZ734379A/en not_active IP Right Cessation
- 2016-02-12 EA EA201791667A patent/EA201791667A1/ru unknown
- 2016-02-12 MY MYPI2017702943A patent/MY194004A/en unknown
- 2016-02-12 EP EP16706003.7A patent/EP3256480A1/en not_active Withdrawn
- 2016-02-12 BR BR112017017211-9A patent/BR112017017211B1/pt active IP Right Grant
- 2016-02-12 BR BR112017017213-5A patent/BR112017017213A2/pt not_active Application Discontinuation
- 2016-02-12 ES ES16706002T patent/ES2821951T3/es active Active
- 2016-02-12 KR KR1020177025535A patent/KR20170117156A/ko not_active Withdrawn
- 2016-02-12 SG SG11201706510YA patent/SG11201706510YA/en unknown
- 2016-02-12 EP EP16706002.9A patent/EP3256479B1/en active Active
- 2016-02-12 CN CN201680021538.8A patent/CN107531730B/zh active Active
- 2016-02-12 HU HUE16706002A patent/HUE051113T2/hu unknown
- 2016-02-12 MX MX2017010414A patent/MX2017010414A/es unknown
- 2016-02-12 AU AU2016217507A patent/AU2016217507B2/en not_active Ceased
- 2016-02-12 JP JP2017542053A patent/JP2018506540A/ja active Pending
- 2016-02-12 JP JP2017541999A patent/JP6771472B2/ja not_active Expired - Fee Related
- 2016-02-12 CA CA2976308A patent/CA2976308A1/en not_active Abandoned
- 2016-02-12 UA UAA201708405A patent/UA120527C2/uk unknown
- 2016-02-12 RS RS20201204A patent/RS60885B1/sr unknown
- 2016-02-12 SI SI201630941T patent/SI3256479T1/sl unknown
- 2016-02-15 TW TW105104376A patent/TWI730953B/zh not_active IP Right Cessation
- 2016-02-15 TW TW105104422A patent/TW201702250A/zh unknown
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2017
- 2017-08-07 IL IL253864A patent/IL253864B/en unknown
- 2017-08-07 IL IL253865A patent/IL253865A0/en unknown
- 2017-08-09 PH PH12017501427A patent/PH12017501427A1/en unknown
- 2017-08-09 PH PH12017501428A patent/PH12017501428A1/en unknown
- 2017-08-10 DO DO2017000189A patent/DOP2017000189A/es unknown
- 2017-08-10 DO DO2017000188A patent/DOP2017000188A/es unknown
- 2017-08-11 CL CL2017002060A patent/CL2017002060A1/es unknown
- 2017-08-11 ZA ZA201705456A patent/ZA201705456B/en unknown
- 2017-08-11 CL CL2017002059A patent/CL2017002059A1/es unknown
- 2017-08-29 CO CONC2017/0008816A patent/CO2017008816A2/es unknown
- 2017-08-29 CO CONC2017/0008809A patent/CO2017008809A2/es unknown
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2020
- 2020-09-11 US US17/018,301 patent/US11214582B2/en not_active Expired - Fee Related
- 2020-10-14 AU AU2020256369A patent/AU2020256369A1/en not_active Abandoned
- 2020-10-15 CY CY20201100978T patent/CY1123687T1/el unknown
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