CL2018000604A1 - Inhibidores marcados con 18f mejorados del antígeno de membrana específica de próstata (psma) y su uso como agentes de formación de imágenes para cáncer de próstata. - Google Patents
Inhibidores marcados con 18f mejorados del antígeno de membrana específica de próstata (psma) y su uso como agentes de formación de imágenes para cáncer de próstata.Info
- Publication number
- CL2018000604A1 CL2018000604A1 CL2018000604A CL2018000604A CL2018000604A1 CL 2018000604 A1 CL2018000604 A1 CL 2018000604A1 CL 2018000604 A CL2018000604 A CL 2018000604A CL 2018000604 A CL2018000604 A CL 2018000604A CL 2018000604 A1 CL2018000604 A1 CL 2018000604A1
- Authority
- CL
- Chile
- Prior art keywords
- prostate
- psma
- enhanced
- imaging agents
- specific membrane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15002800 | 2015-09-30 | ||
| EP16164090 | 2016-04-06 | ||
| EP16182764 | 2016-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018000604A1 true CL2018000604A1 (es) | 2019-03-29 |
Family
ID=57121178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018000604A CL2018000604A1 (es) | 2015-09-30 | 2018-03-08 | Inhibidores marcados con 18f mejorados del antígeno de membrana específica de próstata (psma) y su uso como agentes de formación de imágenes para cáncer de próstata. |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US10815200B2 (es) |
| EP (2) | EP3356385B1 (es) |
| JP (1) | JP6824971B2 (es) |
| KR (1) | KR102233726B1 (es) |
| CN (1) | CN108026144B (es) |
| AU (1) | AU2016333334B2 (es) |
| BR (1) | BR112018005899A2 (es) |
| CL (1) | CL2018000604A1 (es) |
| CO (1) | CO2018003726A2 (es) |
| CU (1) | CU24524B1 (es) |
| CY (1) | CY1123790T1 (es) |
| DK (1) | DK3356385T3 (es) |
| EA (1) | EA037512B1 (es) |
| ES (1) | ES2844586T3 (es) |
| GE (2) | GEAP202014748A (es) |
| HR (1) | HRP20210183T1 (es) |
| HU (1) | HUE053064T2 (es) |
| IL (1) | IL258378B (es) |
| LT (1) | LT3356385T (es) |
| MX (1) | MX390931B (es) |
| MY (1) | MY197061A (es) |
| NZ (1) | NZ739770A (es) |
| PE (1) | PE20181350A1 (es) |
| PH (1) | PH12018500701B1 (es) |
| PL (1) | PL3356385T3 (es) |
| RS (1) | RS61394B1 (es) |
| SA (1) | SA518391121B1 (es) |
| SI (1) | SI3356385T1 (es) |
| TN (1) | TN2018000089A1 (es) |
| WO (1) | WO2017054907A1 (es) |
| ZA (1) | ZA201801024B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3356385T1 (sl) * | 2015-09-30 | 2021-04-30 | Deutsches Krebsforschungszentrum | 18F-označeni inhibitorji prostatnih membranskih antigenov (PSMA) in njihova uporaba kot slikovno prikazna sredstva za rak prostate |
| WO2018031809A1 (en) | 2016-08-10 | 2018-02-15 | Cancer Targeted Technology Llc | Chelated psma inhibitors |
| US10340046B2 (en) | 2016-10-27 | 2019-07-02 | Progenics Pharmaceuticals, Inc. | Network for medical image analysis, decision support system, and related graphical user interface (GUI) applications |
| DE102016122273B4 (de) * | 2016-11-18 | 2018-06-21 | Abx Advanced Biochemical Compounds Gmbh | Präkursoren für die Radiofluorierung |
| US11147889B2 (en) * | 2016-11-23 | 2021-10-19 | Cancer Targeted Technology Llc | Albumin-binding PSMA inhibitors |
| US12602772B2 (en) | 2018-01-08 | 2026-04-14 | Progenics Pharmaceuticals, Inc. | Systems and methods for rapid neural network-based image segmentation and radiopharmaceutical uptake determination |
| CN113272859B (zh) | 2019-01-07 | 2025-04-04 | 西尼诊断公司 | 用于平台中立性全身图像分段的系统及方法 |
| TWI872062B (zh) | 2019-04-24 | 2025-02-11 | 美商普吉尼製藥公司 | 用於偵測轉移之骨掃描影像之自動及互動式分析系統、裝置及方法 |
| JP7729609B2 (ja) * | 2019-04-26 | 2025-08-26 | ファイブ イレブン ファーマ インコーポレイテッド | 診断および放射性核種治療剤としての前立腺特異的膜抗原（ｐｓｍａ）阻害剤 |
| CN110272468B (zh) * | 2019-05-14 | 2020-12-08 | 上海益泰医药科技有限公司 | 一种前列腺特异性膜抗原小分子抑制剂及其放射性核素配合物的制备及应用 |
| US12417533B2 (en) | 2019-09-27 | 2025-09-16 | Progenics Pharmaceuticals, Inc. | Systems and methods for artificial intelligence-based image analysis for cancer assessment |
| CN111253465A (zh) * | 2020-03-03 | 2020-06-09 | 复旦大学附属肿瘤医院 | 一种psma结合剂及其用途 |
| CA3206250A1 (en) | 2021-02-08 | 2022-08-11 | Mark RIJPKEMA | Psma-targeting ligands for multimodal applications |
| KR20240072996A (ko) | 2021-07-30 | 2024-05-24 | 오사카 유니버시티 | 방사성 표지된 화합물 및 이의 용도 |
| JP2024532475A (ja) * | 2021-09-01 | 2024-09-05 | 天津恒瑞医薬有限公司 | 前立腺特異的膜抗原の阻害剤及びその医薬的使用 |
| AU2022361659A1 (en) | 2021-10-08 | 2024-03-21 | Exini Diagnostics Ab | Systems and methods for automated identification and classification of lesions in local lymph and distant metastases |
| CN118344391A (zh) * | 2023-01-13 | 2024-07-16 | 浙江普利药业有限公司 | 一种新的用于硼中子捕获疗法的含硼化合物 |
| WO2025041103A1 (en) * | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Psma targeting ligands and methods of use |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479470B1 (en) | 1999-04-28 | 2002-11-12 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase |
| US20030031677A1 (en) | 2001-06-25 | 2003-02-13 | Drug Innovation & Design, Incorporated | Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications |
| ATE443260T1 (de) | 2002-01-10 | 2009-10-15 | Univ Johns Hopkins | Kontrastmittel und verfahren zum imaging von naaldase oder psma |
| WO2006093991A1 (en) | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
| US8685752B2 (en) | 2006-11-03 | 2014-04-01 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
| CA2669127C (en) | 2006-11-08 | 2016-09-13 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
| AU2007343600B2 (en) | 2007-01-11 | 2012-06-28 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| CA2926573C (en) | 2007-06-26 | 2018-08-28 | The Johns Hopkins University | Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents |
| US9193763B2 (en) * | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| SI2644192T1 (sl) | 2007-09-28 | 2017-08-31 | Pfizer Inc. | Ciljanje rakavih celic z uporabo nanodelcev |
| US9422234B2 (en) | 2007-11-30 | 2016-08-23 | The Johns Hopkins University | Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer |
| US8562945B2 (en) | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| AU2009204133B2 (en) | 2008-01-09 | 2014-04-10 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase IX |
| AU2009276423B2 (en) | 2008-08-01 | 2014-10-30 | The Johns Hopkins University | PSMA-binding agents and uses thereof |
| BRPI0922839A2 (pt) | 2008-12-05 | 2019-09-03 | Molecular Insight Pharmaceuticals, Inc. | radiofarmacêuticos específicos de ca-ix para tratamento e imageamento de câncer. |
| PL3222617T3 (pl) | 2009-03-19 | 2023-01-02 | The Johns Hopkins University | Związki do kierunkowania w psma i ich zastosowania |
| GB0905438D0 (en) * | 2009-03-30 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling reagents and methods |
| EP2338892A1 (en) * | 2009-12-18 | 2011-06-29 | Bayer Schering Pharma Aktiengesellschaft | Prostate specific membrane antigen inhibitors |
| GB201020314D0 (en) | 2010-12-01 | 2011-01-12 | Ge Healthcare Ltd | Apoptosis pet imaging agents |
| US9687572B2 (en) | 2010-12-06 | 2017-06-27 | Molecular Insight Pharmaceuticals, Inc. | PSMA-targeted dendrimers |
| US20140308363A1 (en) | 2011-05-31 | 2014-10-16 | Bind Therapeutics, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| PL2739316T3 (pl) | 2011-08-05 | 2019-09-30 | Molecular Insight Pharmaceuticals, Inc. | Radioznakowane inhibitory antygenu błonowego specyficznego dla prostaty |
| US10011632B2 (en) * | 2011-08-22 | 2018-07-03 | Siemens Medical Solutions Usa, Inc. | PSMA imaging agents |
| US20140187501A1 (en) | 2012-12-28 | 2014-07-03 | Blend Therapeutics, Inc. | Targeted Conjugates Encapsulated in Particles and Formulations Thereof |
| EP2958596B1 (en) | 2013-02-15 | 2019-12-04 | Case Western Reserve University | Psma ligands and uses thereof |
| WO2015004029A1 (en) | 2013-07-08 | 2015-01-15 | Technische Universität München | 18f-labeling of aromatic and heteroaromatic molecules with unprotected carboxylic acid groups |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| WO2015057250A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| CN105849568B (zh) | 2013-11-14 | 2018-05-04 | 恩多塞特公司 | 用于正电子发射断层术的化合物 |
| US11124845B2 (en) | 2014-03-18 | 2021-09-21 | The Johns Hopkins University | PSMA-based molecular-genetic reporter system |
| CA2950892C (en) | 2014-05-06 | 2023-10-24 | The Johns Hopkins University | Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy |
| ES2912753T3 (es) | 2014-08-24 | 2022-05-27 | Max Planck Gesellschaft Zur Foerderung Der Wss | Método para la producción de ésteres activos marcados con 18F y su aplicación ejemplificada por la preparación de un marcador de PET específico de PSMA |
| US9956305B2 (en) | 2014-09-08 | 2018-05-01 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in PSMA-targeted radionuclide therapy of prostate cancer |
| WO2016062370A1 (en) | 2014-10-20 | 2016-04-28 | Deutsches Krebsforschungszentrum | 18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP3011976A1 (en) | 2014-10-20 | 2016-04-27 | Deutsches Krebsforschungszentrum | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents |
| WO2016065142A2 (en) | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | New scaffolds and multifunctional intermediates for imaging psma and cancer therapy |
| SI3356385T1 (sl) * | 2015-09-30 | 2021-04-30 | Deutsches Krebsforschungszentrum | 18F-označeni inhibitorji prostatnih membranskih antigenov (PSMA) in njihova uporaba kot slikovno prikazna sredstva za rak prostate |
-
2016
- 2016-09-19 SI SI201631064T patent/SI3356385T1/sl unknown
- 2016-09-19 LT LTEP16778680.5T patent/LT3356385T/lt unknown
- 2016-09-19 MX MX2018004050A patent/MX390931B/es unknown
- 2016-09-19 NZ NZ739770A patent/NZ739770A/en unknown
- 2016-09-19 PH PH1/2018/500701A patent/PH12018500701B1/en unknown
- 2016-09-19 MY MYPI2018700586A patent/MY197061A/en unknown
- 2016-09-19 TN TNP/2018/000089A patent/TN2018000089A1/en unknown
- 2016-09-19 DK DK16778680.5T patent/DK3356385T3/da active
- 2016-09-19 PE PE2018000482A patent/PE20181350A1/es unknown
- 2016-09-19 PL PL16778680T patent/PL3356385T3/pl unknown
- 2016-09-19 KR KR1020187012228A patent/KR102233726B1/ko active Active
- 2016-09-19 CN CN201680054882.7A patent/CN108026144B/zh active Active
- 2016-09-19 ES ES16778680T patent/ES2844586T3/es active Active
- 2016-09-19 GE GEAP202014748A patent/GEAP202014748A/en unknown
- 2016-09-19 GE GEAP201614748A patent/GEP20207106B/en unknown
- 2016-09-19 HU HUE16778680A patent/HUE053064T2/hu unknown
- 2016-09-19 EA EA201890282A patent/EA037512B1/ru unknown
- 2016-09-19 WO PCT/EP2016/001573 patent/WO2017054907A1/en not_active Ceased
- 2016-09-19 AU AU2016333334A patent/AU2016333334B2/en active Active
- 2016-09-19 EP EP16778680.5A patent/EP3356385B1/en active Active
- 2016-09-19 BR BR112018005899-8A patent/BR112018005899A2/pt not_active Application Discontinuation
- 2016-09-19 RS RS20210120A patent/RS61394B1/sr unknown
- 2016-09-19 JP JP2018516512A patent/JP6824971B2/ja active Active
- 2016-09-19 HR HRP20210183TT patent/HRP20210183T1/hr unknown
- 2016-09-19 CU CU2018000030A patent/CU24524B1/es unknown
- 2016-09-19 EP EP20206516.5A patent/EP3805250A1/en active Pending
-
2018
- 2018-02-14 ZA ZA2018/01024A patent/ZA201801024B/en unknown
- 2018-03-08 CL CL2018000604A patent/CL2018000604A1/es unknown
- 2018-03-08 US US15/915,978 patent/US10815200B2/en active Active
- 2018-03-15 SA SA518391121A patent/SA518391121B1/ar unknown
- 2018-03-26 IL IL258378A patent/IL258378B/en active IP Right Grant
- 2018-04-06 CO CONC2018/0003726A patent/CO2018003726A2/es unknown
-
2020
- 2020-10-23 US US17/079,013 patent/US20210053922A1/en not_active Abandoned
-
2021
- 2021-02-01 CY CY20211100081T patent/CY1123790T1/el unknown
-
2023
- 2023-03-17 US US18/186,043 patent/US12054458B2/en active Active
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