CL2018001484A1 - Dinucleotidas de purino ciclico como moduladores de estimulador de genes de interferon (sting). - Google Patents

Dinucleotidas de purino ciclico como moduladores de estimulador de genes de interferon (sting).

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Publication number
CL2018001484A1
CL2018001484A1 CL2018001484A CL2018001484A CL2018001484A1 CL 2018001484 A1 CL2018001484 A1 CL 2018001484A1 CL 2018001484 A CL2018001484 A CL 2018001484A CL 2018001484 A CL2018001484 A CL 2018001484A CL 2018001484 A1 CL2018001484 A1 CL 2018001484A1
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CL
Chile
Prior art keywords
sting
cyclin
modulators
interferon gene
gene stimulator
Prior art date
Application number
CL2018001484A
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English (en)
Inventor
Jerry Leroy Adams
Kevin J Duffy
Yiqian Lian
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Glaxosmithkline Ip Dev Ltd
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Publication of CL2018001484A1 publication Critical patent/CL2018001484A1/es

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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
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    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN COMPUESTO DE FÓRMULA (I), EN DONDE Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8 Y R9 SON COMO SE DEFINE EN LA PRESENTE; Y SALES Y TAUTÓMEROS FARMACÉUTICAMENTE ACEPTABLES DE ESTOS, COMPOSICIONES, COMBINACIONES Y MEDICAMENTOS QUE CONTIENEN DICHOS COMPUESTOS Y PROCESOS PARA SU PREPARACIÓN. LA INVENCIÓN TAMBIÉN SE REFIERE AL USO DE DICHOS COMPUESTOS, COMBINACIONES, COMPOSICIONES Y MEDICAMENTOS EN EL TRATAMIENTO DE ENFERMEDADES EN LAS CUALES LA MODULACIÓN DE STING (ESTIMULADOR DE LOS GENES DE INTERFERÓN) ES BENEFICIOSA, POR EJEMPLO INFLAMACIÓN, ENFERMEDADES ALÉRGICAS Y AUTOINMUNES, ENFERMEDADES INFECCIOSAS, CÁNCER, SÍNDROMES PRECANCEROSOS Y COMO ADYUVANTES DE VACUNAS.
CL2018001484A 2015-12-03 2018-06-01 Dinucleotidas de purino ciclico como moduladores de estimulador de genes de interferon (sting). CL2018001484A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562262668P 2015-12-03 2015-12-03
US201662299253P 2016-02-24 2016-02-24
US201662299704P 2016-02-25 2016-02-25
US201662327579P 2016-04-26 2016-04-26
US201662332517P 2016-05-06 2016-05-06

Publications (1)

Publication Number Publication Date
CL2018001484A1 true CL2018001484A1 (es) 2018-07-20

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CL2018001484A CL2018001484A1 (es) 2015-12-03 2018-06-01 Dinucleotidas de purino ciclico como moduladores de estimulador de genes de interferon (sting).

Country Status (23)

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US (4) US9718848B2 (es)
EP (2) EP3322713B1 (es)
JP (1) JP6411676B2 (es)
KR (1) KR101949108B1 (es)
CN (1) CN107849084B (es)
AU (1) AU2016362697B2 (es)
CA (1) CA3006930A1 (es)
CL (1) CL2018001484A1 (es)
CO (1) CO2017013310A2 (es)
CR (1) CR20180286A (es)
ES (1) ES2863225T3 (es)
HK (1) HK1250032A1 (es)
IL (1) IL255525B (es)
MA (1) MA52157A (es)
MX (1) MX363780B (es)
NZ (1) NZ738202A (es)
PE (1) PE20181297A1 (es)
PH (1) PH12017502332A1 (es)
RU (2) RU2722019C2 (es)
TW (1) TWI704154B (es)
UY (1) UY37007A (es)
WO (1) WO2017093933A1 (es)
ZA (1) ZA201801631B (es)

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