CL2018003097A1 - Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]- 6(trifluorometil)- piridin-2-carboxamida. - Google Patents
Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]- 6(trifluorometil)- piridin-2-carboxamida.Info
- Publication number
- CL2018003097A1 CL2018003097A1 CL2018003097A CL2018003097A CL2018003097A1 CL 2018003097 A1 CL2018003097 A1 CL 2018003097A1 CL 2018003097 A CL2018003097 A CL 2018003097A CL 2018003097 A CL2018003097 A CL 2018003097A CL 2018003097 A1 CL2018003097 A1 CL 2018003097A1
- Authority
- CL
- Chile
- Prior art keywords
- indazol
- carboxamide
- hydroxypropan
- methylbutyl
- pyridin
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes
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- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Medicinal Chemistry (AREA)
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- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
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- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A LAS FORMAS DE N-[2-(3-HIDROXI-3-METILBUTIL)-6-(2- HIDROXIPROPAN-2-IL)-2H-INDAZOL-5-IL]-6-(TRIFLUOROMETIL)PIRIDIN-2-CARBOXAMIDA, A LOS PROCESOS PARA SU PREPARACIÓN, A LAS COMPOSICIONES FARMACÉUTICAS QUE LAS COMPRENDEN Y A SU USO EN EL CONTROL DE TRASTORNOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16167649 | 2016-04-29 | ||
| EP16167650 | 2016-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018003097A1 true CL2018003097A1 (es) | 2019-02-15 |
Family
ID=58579196
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018003097A CL2018003097A1 (es) | 2016-04-29 | 2018-10-29 | Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]- 6(trifluorometil)- piridin-2-carboxamida. |
| CL2018003085A CL2018003085A1 (es) | 2016-04-29 | 2018-10-29 | Síntesis de indazoles |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018003085A CL2018003085A1 (es) | 2016-04-29 | 2018-10-29 | Síntesis de indazoles |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US10501437B2 (es) |
| EP (2) | EP3448849B1 (es) |
| JP (2) | JP6916207B2 (es) |
| KR (2) | KR102409105B1 (es) |
| CN (4) | CN118184628A (es) |
| AU (2) | AU2017256659B2 (es) |
| BR (1) | BR112018072247A2 (es) |
| CA (1) | CA3022327C (es) |
| CL (2) | CL2018003097A1 (es) |
| CO (2) | CO2018011655A2 (es) |
| CU (1) | CU24593B1 (es) |
| DK (1) | DK3448849T3 (es) |
| DO (1) | DOP2018000236A (es) |
| EA (1) | EA038103B1 (es) |
| EC (1) | ECSP18081451A (es) |
| ES (1) | ES2801800T3 (es) |
| GE (1) | GEP20217230B (es) |
| HU (1) | HUE049331T2 (es) |
| IL (2) | IL262391B (es) |
| JO (2) | JOP20170102B1 (es) |
| LT (1) | LT3448849T (es) |
| MA (1) | MA44758A (es) |
| MX (2) | MX385470B (es) |
| NI (1) | NI201800111A (es) |
| NZ (1) | NZ746868A (es) |
| PE (2) | PE20240651A1 (es) |
| PH (1) | PH12018502288B1 (es) |
| PL (1) | PL3448849T3 (es) |
| PT (1) | PT3448849T (es) |
| RS (1) | RS60419B1 (es) |
| SG (2) | SG11201809172WA (es) |
| SI (1) | SI3448849T1 (es) |
| SV (1) | SV2018005776A (es) |
| TN (1) | TN2018000359A1 (es) |
| TW (3) | TWI671291B (es) |
| UA (2) | UA123550C2 (es) |
| UY (2) | UY37217A (es) |
| WO (2) | WO2017186700A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| EP3423446B1 (de) | 2016-03-03 | 2020-09-16 | Bayer Pharma Aktiengesellschaft | Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| KR102409105B1 (ko) | 2016-04-29 | 2022-06-16 | 바이엘 파마 악티엔게젤샤프트 | 인다졸의 합성 |
| UA123169C2 (uk) | 2016-04-29 | 2021-02-24 | Байєр Фарма Акцієнгезелльшафт | Поліморфна форма n-{6-(2-гідроксипропан-2-іл)-2-[2-(метилсульфоніл)етил]-2н-індазол-5-іл}-6-(трифторметил)піридин-2-карбоксаміду |
| SG10202011653WA (en) * | 2016-06-01 | 2020-12-30 | Bayer Pharma AG | Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases |
| MY199070A (en) | 2016-06-01 | 2023-10-12 | Bayer Pharma AG | Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseaes in animals |
| CN112243438B (zh) | 2018-06-25 | 2022-03-15 | 正大天晴药业集团股份有限公司 | 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物 |
| KR102392788B1 (ko) | 2019-01-08 | 2022-04-28 | 주식회사 엘지에너지솔루션 | 폴더블 사이드 플레이트를 구비하는 배터리 모듈 및 그 제조 방법 |
| CN111499612B (zh) * | 2019-01-30 | 2022-12-30 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物及其制备方法和用途 |
| CN113521079A (zh) * | 2020-04-20 | 2021-10-22 | 上海领泰生物医药科技有限公司 | Irak4抑制剂在治疗ali/ards中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US20100048660A1 (en) | 2006-02-10 | 2010-02-25 | Graham Michael Wynne | Treatment of duchenne muscular dystrophy |
| US7879887B2 (en) | 2006-06-29 | 2011-02-01 | Nissan Chemical Industries, Ltd. | α-amino acid derivatives and medicaments containing the same as an active ingredient |
| KR20090049076A (ko) | 2006-09-07 | 2009-05-15 | 바이오겐 아이덱 엠에이 인코포레이티드 | 인터루킨-1 수용체-결합 키나제 조절물질로서 인다졸 유도체 |
| WO2011043479A1 (ja) | 2009-10-09 | 2011-04-14 | 田辺三菱製薬株式会社 | 脳梗塞治療薬 |
| WO2011153588A1 (en) | 2010-06-10 | 2011-12-15 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
| BR112013015460B1 (pt) | 2010-12-20 | 2022-01-25 | Merck Serono S.A. | Derivados de indazolil triazol, kit, e composição farmacêutica |
| WO2013106254A1 (en) | 2012-01-11 | 2013-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| JP6283862B2 (ja) * | 2012-12-07 | 2018-02-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規インダニルオキシジヒドロベンゾフラニル酢酸 |
| US9126984B2 (en) * | 2013-11-08 | 2015-09-08 | Iteos Therapeutics | 4-(indol-3-yl)-pyrazole derivatives, pharmaceutical compositions and methods for use |
| TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
| SG11201605408RA (en) | 2014-01-10 | 2016-07-28 | Aurigene Discovery Tech Ltd | Indazole compounds as irak4 inhibitors |
| JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| UY36660A (es) | 2015-04-30 | 2016-11-30 | Bayer Pharma AG | Combinaciones de inhibidores de irak4 |
| BR112018000624A2 (pt) | 2015-07-15 | 2018-09-18 | Aurigene Discovery Technologies Limited | compostos de indazol e azaindazol como inibidores de irak-4 |
| EP3423446B1 (de) | 2016-03-03 | 2020-09-16 | Bayer Pharma Aktiengesellschaft | Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| EP3219329A1 (en) * | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
| KR102409105B1 (ko) | 2016-04-29 | 2022-06-16 | 바이엘 파마 악티엔게젤샤프트 | 인다졸의 합성 |
| UA123169C2 (uk) | 2016-04-29 | 2021-02-24 | Байєр Фарма Акцієнгезелльшафт | Поліморфна форма n-{6-(2-гідроксипропан-2-іл)-2-[2-(метилсульфоніл)етил]-2н-індазол-5-іл}-6-(трифторметил)піридин-2-карбоксаміду |
| SG10202011653WA (en) | 2016-06-01 | 2020-12-30 | Bayer Pharma AG | Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases |
| MY199070A (en) | 2016-06-01 | 2023-10-12 | Bayer Pharma AG | Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseaes in animals |
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2017
- 2017-04-25 KR KR1020187030702A patent/KR102409105B1/ko not_active Expired - Fee Related
- 2017-04-25 CU CU2018000130A patent/CU24593B1/es unknown
- 2017-04-25 CN CN202410286070.1A patent/CN118184628A/zh active Pending
- 2017-04-25 US US16/097,506 patent/US10501437B2/en active Active
- 2017-04-25 PL PL17719256T patent/PL3448849T3/pl unknown
- 2017-04-25 EA EA201892407A patent/EA038103B1/ru unknown
- 2017-04-25 MX MX2018013227A patent/MX385470B/es unknown
- 2017-04-25 GE GEAP201714932A patent/GEP20217230B/en unknown
- 2017-04-25 RS RS20200749A patent/RS60419B1/sr unknown
- 2017-04-25 SG SG11201809172WA patent/SG11201809172WA/en unknown
- 2017-04-25 CA CA3022327A patent/CA3022327C/en active Active
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