JOP20170102B1 - أشكال بلورية منn- [2-(3-هيدروكسي-3-مثيل بيوتيل)-6-(2-هيدروكسي بروبان-2-يل)-2h-إندازول-5-يل]-6-(ثلاثي فلورومثيل) بيريدين-2-كربوكساميد - Google Patents

أشكال بلورية منn- [2-(3-هيدروكسي-3-مثيل بيوتيل)-6-(2-هيدروكسي بروبان-2-يل)-2h-إندازول-5-يل]-6-(ثلاثي فلورومثيل) بيريدين-2-كربوكساميد

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Publication number
JOP20170102B1
JOP20170102B1 JOP/2017/0102A JOP20170102A JOP20170102B1 JO P20170102 B1 JOP20170102 B1 JO P20170102B1 JO P20170102 A JOP20170102 A JO P20170102A JO P20170102 B1 JOP20170102 B1 JO P20170102B1
Authority
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Jordan
Prior art keywords
hydroxypropan
indazol
methylbutyl
carboxamide
trifluoromethyl
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JOP/2017/0102A
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English (en)
Inventor
Thaler Tobias
Platzek Johannes
GUIMOND Nicolas
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Bayer Pharma AG
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Publication date
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Publication of JOP20170102B1 publication Critical patent/JOP20170102B1/ar

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

يتعلق الاختراع الحالي بأشكال بلورية من N-[2-(3-Hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide، وبعمليات لتحضيرها، وبتركيبات صيدلية تشملها وباستخدامها في مكافحة الاضطرابات.
JOP/2017/0102A 2016-04-29 2017-04-27 أشكال بلورية منn- [2-(3-هيدروكسي-3-مثيل بيوتيل)-6-(2-هيدروكسي بروبان-2-يل)-2h-إندازول-5-يل]-6-(ثلاثي فلورومثيل) بيريدين-2-كربوكساميد JOP20170102B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16167649 2016-04-29
EP16167650 2016-04-29

Publications (1)

Publication Number Publication Date
JOP20170102B1 true JOP20170102B1 (ar) 2023-09-17

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ID=58579196

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Application Number Title Priority Date Filing Date
JOP/2017/0102A JOP20170102B1 (ar) 2016-04-29 2017-04-27 أشكال بلورية منn- [2-(3-هيدروكسي-3-مثيل بيوتيل)-6-(2-هيدروكسي بروبان-2-يل)-2h-إندازول-5-يل]-6-(ثلاثي فلورومثيل) بيريدين-2-كربوكساميد
JOP/2017/0101A JOP20170101B1 (ar) 2016-04-29 2017-04-27 توليف مركبات إندازول

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JOP/2017/0101A JOP20170101B1 (ar) 2016-04-29 2017-04-27 توليف مركبات إندازول

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JP (2) JP6821701B2 (ar)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
CN109071491B (zh) 2016-04-29 2020-08-21 拜耳医药股份有限公司 吲唑的合成
SI3448848T1 (sl) 2016-04-29 2024-01-31 Bayer Pharma Aktiengesellschaft Polimorfna oblika N-(6-(2-hidroksipropan-2-il)-2-(2-(metilsulfonil)etil)-2H-indazol-5-il) -6-(trifluormetil)piridin-2-karboksamida
WO2017207386A1 (de) 2016-06-01 2017-12-07 Bayer Pharma Aktiengesellschaft Verwendung von 2-substituierten indazolen zur behandlung und prophylaxe von autoimmunerkrankungen
SI3464266T1 (sl) 2016-06-01 2021-12-31 Bayer Animal Health Gmbh Substituirani indazoli, uporabni pri zdravljenju in preprečevanju alergijskih in/ali vnetnih bolezni pri živalih
CN112243438B (zh) 2018-06-25 2022-03-15 正大天晴药业集团股份有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
KR102392788B1 (ko) 2019-01-08 2022-04-28 주식회사 엘지에너지솔루션 폴더블 사이드 플레이트를 구비하는 배터리 모듈 및 그 제조 방법
CN111499612B (zh) * 2019-01-30 2022-12-30 上海美悦生物科技发展有限公司 一种作为irak抑制剂的化合物及其制备方法和用途
CN113521079A (zh) * 2020-04-20 2021-10-22 上海领泰生物医药科技有限公司 Irak4抑制剂在治疗ali/ards中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
BRPI0707718A2 (pt) 2006-02-10 2011-05-10 Summit Corp Plc uso de um composto
JP5258563B2 (ja) 2006-06-29 2013-08-07 日産化学工業株式会社 αアミノ酸誘導体及びそれを有効成分として含む医薬
NZ575410A (en) 2006-09-07 2012-03-30 Biogen Idec Inc 2-(1H-Indazol-3-ylamino)-1H-benzimidazole derivatives
JP5620393B2 (ja) 2009-10-09 2014-11-05 田辺三菱製薬株式会社 脳梗塞治療薬
WO2011153588A1 (en) 2010-06-10 2011-12-15 Biota Scientific Management Pty Ltd Viral polymerase inhibitors
HUE029617T2 (en) 2010-12-20 2017-03-28 Merck Serono Sa Indazolyl triazole derivatives as IRAK inhibitors
WO2013106254A1 (en) 2012-01-11 2013-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
JP6283862B2 (ja) * 2012-12-07 2018-02-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規インダニルオキシジヒドロベンゾフラニル酢酸
US9126984B2 (en) * 2013-11-08 2015-09-08 Iteos Therapeutics 4-(indol-3-yl)-pyrazole derivatives, pharmaceutical compositions and methods for use
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
HK1231480A1 (zh) 2014-01-10 2017-12-22 Aurigene Discovery Technologies Limited 作为irak4抑制剂的吲唑化合物
JO3705B1 (ar) * 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
WO2016174183A1 (en) * 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk
CA2992406A1 (en) 2015-07-15 2017-01-19 Aurigene Discovery Technologies Limited Indazole and azaindazole compounds as irak-4 inhibitors
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
EP3219329A1 (en) * 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
SI3448848T1 (sl) 2016-04-29 2024-01-31 Bayer Pharma Aktiengesellschaft Polimorfna oblika N-(6-(2-hidroksipropan-2-il)-2-(2-(metilsulfonil)etil)-2H-indazol-5-il) -6-(trifluormetil)piridin-2-karboksamida
CN109071491B (zh) 2016-04-29 2020-08-21 拜耳医药股份有限公司 吲唑的合成
WO2017207386A1 (de) 2016-06-01 2017-12-07 Bayer Pharma Aktiengesellschaft Verwendung von 2-substituierten indazolen zur behandlung und prophylaxe von autoimmunerkrankungen
SI3464266T1 (sl) 2016-06-01 2021-12-31 Bayer Animal Health Gmbh Substituirani indazoli, uporabni pri zdravljenju in preprečevanju alergijskih in/ali vnetnih bolezni pri živalih

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AU2017257208A1 (en) 2018-11-01
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CA3022329A1 (en) 2017-11-02
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WO2017186693A1 (en) 2017-11-02
LT3448849T (lt) 2020-09-25
PE20240651A1 (es) 2024-04-04
PE20190172A1 (es) 2019-02-01
CN112898269A (zh) 2021-06-04
CO2018011655A2 (es) 2018-11-13
KR102409105B1 (ko) 2022-06-16
CA3022327A1 (en) 2017-11-02
MA44758A (fr) 2019-03-06
CU24593B1 (es) 2022-05-11
TWI651316B (zh) 2019-02-21
DK3448849T3 (da) 2020-06-29
TW201738233A (zh) 2017-11-01
MX2018013232A (es) 2019-02-13
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WO2017186700A1 (en) 2017-11-02
ECSP18081451A (es) 2018-11-30
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HUE049331T2 (hu) 2020-09-28
US10633365B2 (en) 2020-04-28
ES2801800T3 (es) 2021-01-13
JOP20170101B1 (ar) 2022-03-14
UA123550C2 (uk) 2021-04-21
CN118184628A (zh) 2024-06-14
MX380550B (es) 2025-03-12
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