CU20180130A7 - Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida - Google Patents

Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida

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Publication number
CU20180130A7
CU20180130A7 CU2018000130A CU20180130A CU20180130A7 CU 20180130 A7 CU20180130 A7 CU 20180130A7 CU 2018000130 A CU2018000130 A CU 2018000130A CU 20180130 A CU20180130 A CU 20180130A CU 20180130 A7 CU20180130 A7 CU 20180130A7
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CU
Cuba
Prior art keywords
indazol
carboxamide
hydroxipropan
trifluorometil
methylbuty
Prior art date
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CU2018000130A
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English (en)
Other versions
CU24593B1 (es
Inventor
Dr Nicolas Guimond
Dr Johannes Platzek
Dr Tobias Thaler
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Bayer Pharma AG
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Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20180130A7 publication Critical patent/CU20180130A7/es
Publication of CU24593B1 publication Critical patent/CU24593B1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

<p>La presente invención se refiere a las formas de N-[2-(3-Hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2H-indazol-5-il]-6-(trifluorometil)piridin-2-carboxamida, a los procesos para su preparación, a las composiciones farmacéuticas que las comprenden y a su uso en el control de trastornos.</p>
CU2018000130A 2016-04-29 2017-04-25 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida CU24593B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16167649 2016-04-29
EP16167650 2016-04-29
PCT/EP2017/059764 WO2017186700A1 (en) 2016-04-29 2017-04-25 Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide

Publications (2)

Publication Number Publication Date
CU20180130A7 true CU20180130A7 (es) 2019-06-04
CU24593B1 CU24593B1 (es) 2022-05-11

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CU2018000130A CU24593B1 (es) 2016-04-29 2017-04-25 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida

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US (2) US10501437B2 (es)
EP (2) EP3448849B1 (es)
JP (2) JP6821701B2 (es)
KR (2) KR102409105B1 (es)
CN (4) CN112898269A (es)
AU (2) AU2017257208B2 (es)
BR (1) BR112018072247A2 (es)
CA (1) CA3022327C (es)
CL (2) CL2018003097A1 (es)
CO (2) CO2018011655A2 (es)
CU (1) CU24593B1 (es)
DK (1) DK3448849T3 (es)
DO (1) DOP2018000236A (es)
EA (1) EA038103B1 (es)
EC (1) ECSP18081451A (es)
ES (1) ES2801800T3 (es)
GE (1) GEP20217230B (es)
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IL (2) IL262391B (es)
JO (2) JOP20170101B1 (es)
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MX (2) MX380550B (es)
NI (1) NI201800111A (es)
NZ (1) NZ746868A (es)
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PH (1) PH12018502288B1 (es)
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HUE064389T2 (hu) 2016-04-29 2024-03-28 Bayer Pharma AG Az N-{6-(2-hidroxipropán-2-il)-2-[2-(metilszulfonil)etil]-2h-indazol-5-il}-6- (trifluormetil)piridin-2-karboxamid polimorf formája
NZ748907A (en) 2016-06-01 2023-04-28 Bayer Pharma AG Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
UA124237C2 (uk) 2016-06-01 2021-08-11 Байєр Енімал Хелс Гмбх Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин

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EP3448847A1 (en) 2019-03-06
SV2018005776A (es) 2019-03-18
BR112018072247A2 (pt) 2019-02-12
KR20180137498A (ko) 2018-12-27
EP3448849A1 (en) 2019-03-06
LT3448849T (lt) 2020-09-25
JOP20170101B1 (ar) 2022-03-14
MA44758A (fr) 2019-03-06
TW201936599A (zh) 2019-09-16
US10633365B2 (en) 2020-04-28
SG11201808686VA (en) 2018-11-29
DOP2018000236A (es) 2019-01-15
TW201738233A (zh) 2017-11-01
JP6821701B2 (ja) 2021-01-27
US10501437B2 (en) 2019-12-10
UA122882C2 (uk) 2021-01-13
PT3448849T (pt) 2020-06-30
PH12018502288A1 (en) 2019-07-15
CN109415339A (zh) 2019-03-01
RS60419B1 (sr) 2020-07-31
KR102409105B1 (ko) 2022-06-16
AU2017257208B2 (en) 2022-01-20
SG11201809172WA (en) 2018-11-29
IL262391A (en) 2018-12-31
CO2018011655A2 (es) 2018-11-13
JOP20170102B1 (ar) 2023-09-17
CL2018003085A1 (es) 2019-02-15
IL262391B (en) 2022-03-01
HUE049331T2 (hu) 2020-09-28
CN112898269A (zh) 2021-06-04
CA3022327C (en) 2025-05-06
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US20190144420A1 (en) 2019-05-16
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UY37217A (es) 2017-11-30
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