CL2022000102A1 - Derivados de 6,7-dihidro-5h-pirido[2,3-c]piridazin-8-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos. - Google Patents
Derivados de 6,7-dihidro-5h-pirido[2,3-c]piridazin-8-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos.Info
- Publication number
- CL2022000102A1 CL2022000102A1 CL2022000102A CL2022000102A CL2022000102A1 CL 2022000102 A1 CL2022000102 A1 CL 2022000102A1 CL 2022000102 A CL2022000102 A CL 2022000102A CL 2022000102 A CL2022000102 A CL 2022000102A CL 2022000102 A1 CL2022000102 A1 CL 2022000102A1
- Authority
- CL
- Chile
- Prior art keywords
- pyridazin
- pyrido
- dihydro
- derivatives
- pharmaceutical compositions
- Prior art date
Links
- -1 6,7-Dihydro-5h-pyrido[2,3-c]pyridazin-8-yl Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000000861 pro-apoptotic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de fórmula (I): en donde Het, Het1, Het2, A4, A5, Z1, R1, R2 y R3 son como se definen en la descripción. Medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19188749 | 2019-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022000102A1 true CL2022000102A1 (es) | 2022-11-04 |
Family
ID=67514283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022000102A CL2022000102A1 (es) | 2019-07-29 | 2022-01-13 | Derivados de 6,7-dihidro-5h-pirido[2,3-c]piridazin-8-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos. |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US12570648B2 (es) |
| EP (1) | EP4003989B1 (es) |
| JP (1) | JP7805283B2 (es) |
| KR (1) | KR20220041132A (es) |
| CN (1) | CN114450284B (es) |
| AR (1) | AR119494A1 (es) |
| AU (1) | AU2020319652B2 (es) |
| BR (1) | BR112022001373A2 (es) |
| CL (1) | CL2022000102A1 (es) |
| CO (1) | CO2022000612A2 (es) |
| CR (1) | CR20220016A (es) |
| DK (1) | DK4003989T3 (es) |
| DO (1) | DOP2022000019A (es) |
| ES (1) | ES2975087T3 (es) |
| FI (1) | FI4003989T3 (es) |
| GE (2) | GEP20237581B (es) |
| HR (1) | HRP20240392T1 (es) |
| HU (1) | HUE065742T2 (es) |
| IL (1) | IL289933B2 (es) |
| JO (1) | JOP20220010A1 (es) |
| LT (1) | LT4003989T (es) |
| MA (1) | MA56649B1 (es) |
| MD (1) | MD4003989T2 (es) |
| MX (1) | MX2022001191A (es) |
| MY (1) | MY207131A (es) |
| PE (1) | PE20220705A1 (es) |
| PH (1) | PH12022550119A1 (es) |
| PL (1) | PL4003989T3 (es) |
| PT (1) | PT4003989T (es) |
| PY (1) | PY2039847A (es) |
| RS (1) | RS65248B1 (es) |
| SA (1) | SA522431522B1 (es) |
| SI (1) | SI4003989T1 (es) |
| TW (1) | TWI751629B (es) |
| UA (1) | UA130017C2 (es) |
| UY (1) | UY38810A (es) |
| WO (1) | WO2021018858A1 (es) |
| ZA (1) | ZA202200828B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202002032SA (en) | 2017-09-22 | 2020-04-29 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
| BR112020008851A2 (pt) | 2017-11-06 | 2020-10-20 | Jubilant Prodel LLC | composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas |
| PL3704120T3 (pl) | 2017-11-24 | 2024-09-16 | Jubilant Episcribe Llc | Związki heterocykliczne jako inhibitory prmt5 |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| AU2021386367A1 (en) * | 2020-11-24 | 2023-06-22 | Les Laboratoires Servier | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| KR20230170644A (ko) * | 2021-02-02 | 2023-12-19 | 르 라보레또레 쎄르비에르 | 선택적 bcl-xl protac 화합물 및 사용 방법 |
| CN114181039A (zh) * | 2021-12-23 | 2022-03-15 | 凯美克(上海)医药科技有限公司 | 一种4,4-二苯基-3-丁烯-1-醇的合成方法 |
| JP2025517430A (ja) | 2022-05-20 | 2025-06-05 | ノバルティス アーゲー | Ｅｐｈａ２ ｂｃｌ－ｘｌ阻害剤抗体－薬物コンジュゲートおよびその使用の方法 |
| PE20251072A1 (es) | 2022-05-20 | 2025-04-10 | Novartis Ag | Conjugados de anticuerpo-farmaco de compuestos antineoplasicos y metodos de uso de los mismos |
| EP4525926A1 (en) | 2022-05-20 | 2025-03-26 | Novartis AG | Met bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| JP2026508178A (ja) | 2023-02-14 | 2026-03-10 | シェンチェン ジョンジー バイオロジカル テクノロジー カンパニー， リミテッド | Ｎｌｒｐ３を阻害する化合物及びその製造方法と応用 |
| TW202540186A (zh) | 2023-11-22 | 2025-10-16 | 瑞士商諾華公司 | 抗ｃｄ７抗體藥物結合物及其使用方法 |
| PY24103486A (es) | 2023-11-22 | 2025-06-06 | Servier Lab | Conjugados de anticuerpo anti-cd74-fármaco y métodos de uso de los mismos |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200730527A (en) | 2005-12-02 | 2007-08-16 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
| NZ593537A (en) | 2008-12-19 | 2013-07-26 | Genentech Inc | Isoquinoline derivatives and methods of use |
| US8889675B2 (en) * | 2011-10-14 | 2014-11-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI571466B (zh) | 2011-10-14 | 2017-02-21 | 艾伯維有限公司 | 用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑 |
| TW201414737A (zh) * | 2012-07-13 | 2014-04-16 | 必治妥美雅史谷比公司 | 作爲激酶抑制劑之咪唑并三□甲腈 |
| FR3015483B1 (fr) | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2969908A1 (en) | 2014-12-09 | 2016-06-16 | Abbvie Inc. | Antibody drug conjugates with cell permeable bcl-xl inhibitors |
| CN111620861A (zh) | 2014-12-09 | 2020-09-04 | 艾伯维公司 | 具有低细胞渗透性的bcl-xl抑制性化合物以及包括它的抗体药物缀合物 |
| US20160158377A1 (en) | 2014-12-09 | 2016-06-09 | Abbvie Inc. | BCL-XL Inhibitory Compounds and Antibody Drug Conjugates Including the Same |
| TW201734002A (zh) * | 2015-12-11 | 2017-10-01 | 拜耳作物科學股份有限公司 | 作為殺蟲劑之經取代的丙二醯胺類 |
| JP2019521114A (ja) | 2016-06-08 | 2019-07-25 | アッヴィ・インコーポレイテッド | 抗ｅｇｆｒ抗体薬物コンジュゲート |
| WO2019037678A1 (zh) * | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用 |
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2020
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- 2020-07-28 PY PY202002039847A patent/PY2039847A/es unknown
- 2020-07-28 EP EP20751092.6A patent/EP4003989B1/en active Active
- 2020-07-28 GE GEAP202015865A patent/GEP20237581B/en unknown
- 2020-07-28 PH PH1/2022/550119A patent/PH12022550119A1/en unknown
- 2020-07-28 BR BR112022001373A patent/BR112022001373A2/pt unknown
- 2020-07-28 MY MYPI2022000310A patent/MY207131A/en unknown
- 2020-07-28 AU AU2020319652A patent/AU2020319652B2/en active Active
- 2020-07-28 MD MDE20220595T patent/MD4003989T2/ro unknown
- 2020-07-28 TW TW109125467A patent/TWI751629B/zh active
- 2020-07-28 GE GEAP202315865A patent/GEAP202315865A/en unknown
- 2020-07-28 CN CN202080068082.7A patent/CN114450284B/zh active Active
- 2020-07-28 PT PT207510926T patent/PT4003989T/pt unknown
- 2020-07-28 LT LTEPPCT/EP2020/071181T patent/LT4003989T/lt unknown
- 2020-07-28 PE PE2022000174A patent/PE20220705A1/es unknown
- 2020-07-28 HU HUE20751092A patent/HUE065742T2/hu unknown
- 2020-07-28 JP JP2022505554A patent/JP7805283B2/ja active Active
- 2020-07-28 JO JOP/2022/0010A patent/JOP20220010A1/ar unknown
- 2020-07-28 DK DK20751092.6T patent/DK4003989T3/da active
- 2020-07-28 RS RS20240257A patent/RS65248B1/sr unknown
- 2020-07-28 HR HRP20240392TT patent/HRP20240392T1/hr unknown
- 2020-07-28 MX MX2022001191A patent/MX2022001191A/es unknown
- 2020-07-28 US US17/630,673 patent/US12570648B2/en active Active
- 2020-07-28 IL IL289933A patent/IL289933B2/en unknown
- 2020-07-28 UA UAA202200297A patent/UA130017C2/uk unknown
- 2020-07-28 SI SI202030373T patent/SI4003989T1/sl unknown
- 2020-07-28 PL PL20751092.6T patent/PL4003989T3/pl unknown
- 2020-07-28 KR KR1020227005751A patent/KR20220041132A/ko active Pending
- 2020-07-28 ES ES20751092T patent/ES2975087T3/es active Active
- 2020-07-28 FI FIEP20751092.6T patent/FI4003989T3/fi active
- 2020-07-28 MA MA56649A patent/MA56649B1/fr unknown
- 2020-07-28 UY UY0001038810A patent/UY38810A/es active IP Right Grant
- 2020-07-28 CR CR20220016A patent/CR20220016A/es unknown
- 2020-07-28 WO PCT/EP2020/071181 patent/WO2021018858A1/en not_active Ceased
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2022
- 2022-01-13 CL CL2022000102A patent/CL2022000102A1/es unknown
- 2022-01-18 ZA ZA2022/00828A patent/ZA202200828B/en unknown
- 2022-01-25 CO CONC2022/0000612A patent/CO2022000612A2/es unknown
- 2022-01-27 DO DO2022000019A patent/DOP2022000019A/es unknown
- 2022-01-27 SA SA522431522A patent/SA522431522B1/ar unknown
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