CN102666541B - 用于治疗特别是病毒感染的嘌呤或脱氮嘌呤的衍生物 - Google Patents

用于治疗特别是病毒感染的嘌呤或脱氮嘌呤的衍生物 Download PDF

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CN102666541B
CN102666541B CN201080047895.4A CN201080047895A CN102666541B CN 102666541 B CN102666541 B CN 102666541B CN 201080047895 A CN201080047895 A CN 201080047895A CN 102666541 B CN102666541 B CN 102666541B
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CN102666541A (zh
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R·L·哈克布
P·A·罗伊德勒
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Gilead Sciences Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P31/12—Antivirals
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080047895.4A 2009-10-22 2010-10-15 用于治疗特别是病毒感染的嘌呤或脱氮嘌呤的衍生物 Active CN102666541B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25410309P 2009-10-22 2009-10-22
US61/254,103 2009-10-22
US36679010P 2010-07-22 2010-07-22
US61/366,790 2010-07-22
PCT/US2010/052802 WO2011049825A1 (en) 2009-10-22 2010-10-15 Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections

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CN102666541A CN102666541A (zh) 2012-09-12
CN102666541B true CN102666541B (zh) 2015-11-25

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US (3) US8507507B2 (2)
EP (1) EP2491035B1 (2)
JP (1) JP5694345B2 (2)
KR (1) KR101793300B1 (2)
CN (1) CN102666541B (2)
AP (1) AP3103A (2)
AU (1) AU2010310813B2 (2)
BR (1) BR112012009329A2 (2)
CA (1) CA2777824C (2)
CL (1) CL2012000988A1 (2)
CO (1) CO6531469A2 (2)
CR (1) CR20120255A (2)
EA (1) EA020488B1 (2)
EC (1) ECSP12011915A (2)
ES (1) ES2644286T3 (2)
IL (1) IL218747A (2)
IN (1) IN2012DN02984A (2)
MX (1) MX2012004706A (2)
NO (1) NO2491035T3 (2)
NZ (1) NZ598933A (2)
PE (1) PE20121091A1 (2)
PL (1) PL2491035T3 (2)
PT (1) PT2491035T (2)
SG (1) SG10201406813RA (2)
SI (1) SI2491035T1 (2)
WO (1) WO2011049825A1 (2)
ZA (1) ZA201202858B (2)

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TWI704916B (zh) 2018-05-25 2020-09-21 大陸商江蘇恒瑞醫藥股份有限公司 一種吡唑并雜芳基類衍生物鹽酸鹽的晶型及製備方法

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ES2644286T3 (es) 2017-11-28
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AU2010310813A1 (en) 2012-05-03
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