CN1176091C - 氧化膦维生素d前体 - Google Patents

氧化膦维生素d前体 Download PDF

Info

Publication number
CN1176091C
CN1176091C CNB001060872A CN00106087A CN1176091C CN 1176091 C CN1176091 C CN 1176091C CN B001060872 A CNB001060872 A CN B001060872A CN 00106087 A CN00106087 A CN 00106087A CN 1176091 C CN1176091 C CN 1176091C
Authority
CN
China
Prior art keywords
compound
formula
carried out
protecting group
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB001060872A
Other languages
English (en)
Chinese (zh)
Other versions
CN1276376A (zh
Inventor
���׿ˡ��׹��ڡ�������
马雷克·米哈乌·卡巴特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1276376A publication Critical patent/CN1276376A/zh
Application granted granted Critical
Publication of CN1176091C publication Critical patent/CN1176091C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C4/00—Preparation of hydrocarbons from hydrocarbons containing a larger number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
CNB001060872A 1999-04-22 2000-04-20 氧化膦维生素d前体 Expired - Fee Related CN1176091C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13045199P 1999-04-22 1999-04-22
US60/130,451 1999-04-22

Publications (2)

Publication Number Publication Date
CN1276376A CN1276376A (zh) 2000-12-13
CN1176091C true CN1176091C (zh) 2004-11-17

Family

ID=22444755

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB001060872A Expired - Fee Related CN1176091C (zh) 1999-04-22 2000-04-20 氧化膦维生素d前体

Country Status (12)

Country Link
US (1) US6603030B1 (fr)
EP (1) EP1050537B1 (fr)
JP (1) JP2000319289A (fr)
KR (1) KR100776102B1 (fr)
CN (1) CN1176091C (fr)
AT (1) ATE253585T1 (fr)
CA (1) CA2306000A1 (fr)
DE (1) DE60006311T2 (fr)
DK (1) DK1050537T3 (fr)
ES (1) ES2208171T3 (fr)
JO (1) JO2197B1 (fr)
MX (1) MXPA00003870A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG110107A1 (en) 2003-09-24 2005-04-28 Bioxell Spa Compound and use in treatment
EP1924268A2 (fr) * 2005-08-18 2008-05-28 Bioxell S.p.a. Synthese de 1alpha-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
JP5480131B2 (ja) * 2007-05-30 2014-04-23 シトクロマ インコーポレイテッド ホスフィンオキシドビタミンｄ前駆物質の製造方法
CN102617302B (zh) * 2012-02-27 2014-05-07 浙江新赛科药业有限公司 一种合成三甲氧基二苯乙烯的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2472575B1 (fr) * 1979-12-28 1985-10-04 Poudres & Explosifs Ste Nale Procede de synthese d'oxydes de phosphines tertiaires et nouveaux oxydes de phosphines tertiaires
AU650751B2 (en) 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) * 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
US5830885A (en) 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
US5403832A (en) 1992-03-12 1995-04-04 The Johns Hopkins University Vitamin D3 analogues
JPH05279283A (ja) 1992-04-01 1993-10-26 Yuki Gosei Kogyo Co Ltd シクロヘキシリデンエタノール誘導体の製造方法
IT1276165B1 (it) * 1995-11-24 1997-10-27 Caffaro Spa Ind Chim Procedimento per la sintesi enantioselettiva di derivati chirali di s-3-(4'-tert-butil)-fenil-2-metil propilammina, fungicidi sistemici
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
MA26481A1 (fr) * 1997-04-21 2004-12-20 Hoffmann La Roche Derives d'arylsecocholadiene
AU7497798A (en) 1997-05-16 1998-12-08 F. Hoffmann-La Roche Ag 3-epi compounds of vitamin d3 and uses thereof
US6043385A (en) 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
KR101076979B1 (ko) * 2010-08-28 2011-10-26 이상원 방수 가능한 오디오 케이블 또는 비디오 케이블의 케이블 잭

Also Published As

Publication number Publication date
CA2306000A1 (fr) 2000-10-22
EP1050537A2 (fr) 2000-11-08
DE60006311D1 (de) 2003-12-11
EP1050537B1 (fr) 2003-11-05
JP2000319289A (ja) 2000-11-21
MX221790B (fr) 2004-07-27
ATE253585T1 (de) 2003-11-15
DK1050537T3 (da) 2004-03-15
DE60006311T2 (de) 2004-09-09
KR100776102B1 (ko) 2007-11-16
KR20010014792A (ko) 2001-02-26
ES2208171T3 (es) 2004-06-16
EP1050537A3 (fr) 2001-03-07
MXPA00003870A (es) 2002-04-01
JO2197B1 (en) 2003-12-23
US6603030B1 (en) 2003-08-05
CN1276376A (zh) 2000-12-13

Similar Documents

Publication Publication Date Title
CN1091088C (zh) α－卤代酮、α－卤代醇和环氧化物的制备方法
CN1144796C (zh) 新的中间体化合物和旋光活性辛酸衍生物的制备方法
CN1255425C (zh) 制备7－取代抗雌激素的方法及中间体
CN1845930A (zh) 制备硫代羧酸酯硅烷的方法
CN1298711C (zh) 制备环氧三唑衍生物及其使用的中间体的方法
CN1051907A (zh) 24-同-维生素-d-衍生物，其制备方法；含有该衍生物的药物制剂及其作为药物的应用
CN86101277A (zh) 三取代的苯甲酸中间体的制备方法
CN1324345A (zh) 含有多烯链结构的化合物和其制备方法
CN1882600A (zh) 双磷杂环戊烷配体的制备方法
CN1225084A (zh) 手性β－氨基酸的不对称合成
CN1038639A (zh) 旋光的萘并硫氮杂类的制备方法
CN1029400C (zh) 侧链系维生素d衍生物的制备方法
CN1158253C (zh) 制备番茄红素及其中间体的方法
CN100347155C (zh) 类胡萝卜素多烯链状化合物的制备方法和用于制备此类化合物的中间体
CN1922193A (zh) 化学方法
CN1616384A (zh) 二氟烷基芳香族化合物
CN1440376A (zh) 制备双环1,3－二酮的方法
CN87103668A (zh) 4-卤代-2-羟亚氨基-3-氧代丁酸
US6603030B1 (en) Process for producing phosphineoxide vitamin D precursors
CN1948283A (zh) 维生素d衍生物的制备方法
CN1100406A (zh) 环戊烯醇衍生物的制备方法
CN1215028C (zh) 外消旋的联二酚的光学拆分方法
CN1646468A (zh) 链状低聚乳酸酯的制备方法
CN1122030C (zh) 肌醇磷酸酯的新的合成方法
CN1179933C (zh) 用于制备烯烃聚合催化剂的γ-酰氧基取代醚化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20041117

Termination date: 20110420