DK1050537T3 - Phosphinoxid-D- vitamin-precursorer - Google Patents

Phosphinoxid-D- vitamin-precursorer

Info

Publication number: DK1050537T3
Authority: DK; Denmark
Prior art keywords: compound; formula; phosphine oxide; chem; precursors
Prior art date: 1999-04-22

Application number

DK00108322T

Other languages

Danish (da)

English (en)

Inventor

Marek Michal Kabat

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-22

Filing date

2000-04-15

Publication date

2004-03-15

2000-04-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-03-15 Application granted granted Critical

2004-03-15 Publication of DK1050537T3 publication Critical patent/DK1050537T3/da

Links

-1 Phosphine oxide vitamin D Chemical class 0.000 title 1
229930003316 Vitamin D Natural products 0.000 title 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
239000002243 precursor Substances 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
YFPJFKYCVYXDJK-UHFFFAOYSA-N Diphenylphosphine oxide Chemical compound C=1C=CC=CC=1[P+](=O)C1=CC=CC=C1 YFPJFKYCVYXDJK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C4/00—Preparation of hydrocarbons from hydrocarbons containing a larger number of carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/532—Cycloaliphatic phosphine oxides or thioxides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicinal Preparation (AREA)

DK00108322T 1999-04-22 2000-04-15 Phosphinoxid-D- vitamin-precursorer DK1050537T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13045199P	1999-04-22	1999-04-22

Publications (1)

Publication Number	Publication Date
DK1050537T3 true DK1050537T3 (da)	2004-03-15

Family

ID=22444755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00108322T DK1050537T3 (da)	1999-04-22	2000-04-15	Phosphinoxid-D- vitamin-precursorer

Country Status (12)

Country	Link
US (1)	US6603030B1 (fr)
EP (1)	EP1050537B1 (fr)
JP (1)	JP2000319289A (fr)
KR (1)	KR100776102B1 (fr)
CN (1)	CN1176091C (fr)
AT (1)	ATE253585T1 (fr)
CA (1)	CA2306000A1 (fr)
DE (1)	DE60006311T2 (fr)
DK (1)	DK1050537T3 (fr)
ES (1)	ES2208171T3 (fr)
JO (1)	JO2197B1 (fr)
MX (1)	MXPA00003870A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG110107A1 (en)	2003-09-24	2005-04-28	Bioxell Spa	Compound and use in treatment
EP1924268A2 (fr) *	2005-08-18	2008-05-28	Bioxell S.p.a.	Synthese de 1alpha-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol
US20100009949A1 (en) *	2006-03-24	2010-01-14	Bioxell S.P.A.	Novel method
JP5480131B2 (ja) *	2007-05-30	2014-04-23	シトクロマインコーポレイテッド	ホスフィンオキシドビタミンｄ前駆物質の製造方法
CN102617302B (zh) *	2012-02-27	2014-05-07	浙江新赛科药业有限公司	一种合成三甲氧基二苯乙烯的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2472575B1 (fr) *	1979-12-28	1985-10-04	Poudres & Explosifs Ste Nale	Procede de synthese d'oxydes de phosphines tertiaires et nouveaux oxydes de phosphines tertiaires
AU650751B2 (en)	1991-05-28	1994-06-30	Wisconsin Alumni Research Foundation	Novel synthesis of 19-nor vitamin D compounds
US5086191A (en) *	1991-05-28	1992-02-04	Wisconsin Alumni Research Foundation	Intermediates for the synthesis of 19-nor vitamin D compounds
US5830885A (en)	1992-03-12	1998-11-03	The Johns Hopkins University	Antiproliferative vitamin D3 hybrids
US5403832A (en)	1992-03-12	1995-04-04	The Johns Hopkins University	Vitamin D3 analogues
JPH05279283A (ja)	1992-04-01	1993-10-26	Yuki Gosei Kogyo Co Ltd	シクロヘキシリデンエタノール誘導体の製造方法
IT1276165B1 (it) *	1995-11-24	1997-10-27	Caffaro Spa Ind Chim	Procedimento per la sintesi enantioselettiva di derivati chirali di s-3-(4'-tert-butil)-fenil-2-metil propilammina, fungicidi sistemici
SG70009A1 (en) *	1996-05-23	2000-01-25	Hoffmann La Roche	Vitamin d3 analogs
MA26481A1 (fr) *	1997-04-21	2004-12-20	Hoffmann La Roche	Derives d'arylsecocholadiene
AU7497798A (en)	1997-05-16	1998-12-08	F. Hoffmann-La Roche Ag	3-epi compounds of vitamin d3 and uses thereof
US6043385A (en)	1997-12-16	2000-03-28	Hoffman-La Roche Inc.	Vitamin D derivatives
KR101076979B1 (ko) *	2010-08-28	2011-10-26	이상원	방수 가능한 오디오 케이블 또는 비디오 케이블의 케이블 잭

2000
- 2000-03-29 US US09/537,209 patent/US6603030B1/en not_active Expired - Fee Related
- 2000-04-15 ES ES00108322T patent/ES2208171T3/es not_active Expired - Lifetime
- 2000-04-15 DK DK00108322T patent/DK1050537T3/da active
- 2000-04-15 EP EP00108322A patent/EP1050537B1/fr not_active Expired - Lifetime
- 2000-04-15 AT AT00108322T patent/ATE253585T1/de not_active IP Right Cessation
- 2000-04-15 DE DE60006311T patent/DE60006311T2/de not_active Expired - Lifetime
- 2000-04-17 JO JO200053A patent/JO2197B1/en active
- 2000-04-18 CA CA002306000A patent/CA2306000A1/fr not_active Abandoned
- 2000-04-19 JP JP2000117442A patent/JP2000319289A/ja active Pending
- 2000-04-19 MX MXPA00003870 patent/MXPA00003870A/es unknown
- 2000-04-20 CN CNB001060872A patent/CN1176091C/zh not_active Expired - Fee Related
- 2000-04-21 KR KR1020000021157A patent/KR100776102B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2306000A1 (fr)	2000-10-22
EP1050537A2 (fr)	2000-11-08
DE60006311D1 (de)	2003-12-11
EP1050537B1 (fr)	2003-11-05
JP2000319289A (ja)	2000-11-21
MX221790B (fr)	2004-07-27
ATE253585T1 (de)	2003-11-15
DE60006311T2 (de)	2004-09-09
CN1176091C (zh)	2004-11-17
KR100776102B1 (ko)	2007-11-16
KR20010014792A (ko)	2001-02-26
ES2208171T3 (es)	2004-06-16
EP1050537A3 (fr)	2001-03-07
MXPA00003870A (es)	2002-04-01
JO2197B1 (en)	2003-12-23
US6603030B1 (en)	2003-08-05
CN1276376A (zh)	2000-12-13

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