CN1207730A - 喹啉衍生物 - Google Patents

喹啉衍生物 Download PDF

Info

Publication number
CN1207730A
CN1207730A CN96199753A CN96199753A CN1207730A CN 1207730 A CN1207730 A CN 1207730A CN 96199753 A CN96199753 A CN 96199753A CN 96199753 A CN96199753 A CN 96199753A CN 1207730 A CN1207730 A CN 1207730A
Authority
CN
China
Prior art keywords
formula
alkyl
compound
group
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96199753A
Other languages
English (en)
Chinese (zh)
Inventor
G·A·M·吉尔迪纳
M·格鲁尼
L·F·拉维格利
C·法利纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
SmithKline Beecham SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI952461 external-priority patent/IT1276170B1/it
Priority claimed from IT96MI001689 external-priority patent/IT1307331B1/it
Application filed by SmithKline Beecham SpA filed Critical SmithKline Beecham SpA
Publication of CN1207730A publication Critical patent/CN1207730A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN96199753A 1995-11-24 1996-11-22 喹啉衍生物 Pending CN1207730A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI952461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
ITMI95A002461 1995-11-24
IT96MI001689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici
ITMI96A01689 1996-08-02

Publications (1)

Publication Number Publication Date
CN1207730A true CN1207730A (zh) 1999-02-10

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96199753A Pending CN1207730A (zh) 1995-11-24 1996-11-22 喹啉衍生物

Country Status (26)

Country Link
US (1) US6277862B1 (2)
EP (1) EP0876347B1 (2)
JP (1) JP2000501104A (2)
KR (1) KR19990071597A (2)
CN (1) CN1207730A (2)
AP (1) AP9801237A0 (2)
AR (1) AR004972A1 (2)
AT (1) ATE289994T1 (2)
BG (1) BG102558A (2)
BR (1) BR9611820A (2)
CA (1) CA2238298A1 (2)
CZ (1) CZ157998A3 (2)
DE (1) DE69634416T2 (2)
EA (1) EA002124B1 (2)
ES (1) ES2236757T3 (2)
IL (1) IL124522A0 (2)
MX (1) MX9804107A (2)
NO (1) NO311212B1 (2)
NZ (1) NZ323387A (2)
OA (1) OA11010A (2)
PL (1) PL326967A1 (2)
SK (1) SK66798A3 (2)
TR (1) TR199800924T2 (2)
TW (1) TW353066B (2)
UY (1) UY24733A1 (2)
WO (1) WO1997021680A1 (2)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU219131B (hu) * 1991-10-18 2001-02-28 Monsanto Co. Módszer és fungicid készítmény növények torsgombabetegségének gátlására és a hatóanyagok
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
ATE247652T1 (de) 1999-03-29 2003-09-15 Neurogen Corp 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
WO2000064877A1 (en) * 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
EP1385839B1 (en) * 2001-04-11 2006-02-22 GlaxoSmithKline S.p.A. 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
WO2002089802A2 (en) * 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
BR122018074353B8 (pt) 2003-01-28 2023-05-02 Ironwood Pharmaceuticals Inc composição farmacêutica, polipeptídeo e métodos para a produção dos mesmos
GB0303086D0 (en) * 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
WO2006052722A1 (en) * 2004-11-09 2006-05-18 Smithkline Beecham Corporation Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
CN101282961A (zh) * 2005-08-11 2008-10-08 阿斯利康(瑞典)有限公司 作为nk3受体调节剂的烷基吡啶基喹啉
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW201018662A (en) * 2005-12-12 2010-05-16 Astrazeneca Ab Alkylsulphonamide quinolines
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100305207A1 (en) * 2007-09-28 2010-12-02 Pierette Banker Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof
CN101861303A (zh) * 2007-09-28 2010-10-13 葛兰素史密丝克莱恩有限责任公司 糖原磷酸化酶抑制剂化合物和其药物组合物
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
CN103819403B (zh) 2008-12-31 2017-01-04 阿德利克斯公司 用于治疗与体液潴留或盐超负荷有关的病症和胃肠道病症的化合物和方法
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
RU2015107019A (ru) 2012-08-21 2016-10-10 Эрделикс Инк. Соединения и способы для ингибирования nhe-опосредованного антипорта в лечении расстройств, ассоциированных с задержкой жидкости или солевой перегрузкой и заболеваний желудочно-кишечного тракта
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
BR112015026519A2 (pt) 2013-04-19 2017-07-25 Astrazeneca Ab composto antagonista do receptor nk3 (nk3ra) para uso em um método destinado ao tratamento de síndrome do ovário policístico (sop)
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
KR20240090875A (ko) 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS63119455A (ja) * 1986-06-27 1988-05-24 Nippon Shinyaku Co Ltd グリシン誘導体
DE69531458T2 (de) * 1994-05-27 2004-08-05 Glaxosmithkline S.P.A. Chinolinderivate als tachykinin nk3 rezeptor antagonisten
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
AP9801237A0 (en) 1998-06-30
DE69634416T2 (de) 2005-12-29
JP2000501104A (ja) 2000-02-02
NO311212B1 (no) 2001-10-29
NO982331D0 (no) 1998-05-22
PL326967A1 (en) 1998-11-09
OA11010A (en) 2003-03-06
DE69634416D1 (de) 2005-04-07
WO1997021680A1 (en) 1997-06-19
TR199800924T2 (xx) 1998-08-21
TW353066B (en) 1999-02-21
EA199800477A1 (ru) 1998-12-24
UY24733A1 (es) 2001-08-27
IL124522A0 (en) 1998-12-06
ES2236757T3 (es) 2005-07-16
AR004972A1 (es) 1999-04-07
BG102558A (bg) 1999-03-31
BR9611820A (pt) 1999-07-13
SK66798A3 (en) 1999-01-11
KR19990071597A (ko) 1999-09-27
ATE289994T1 (de) 2005-03-15
NO982331L (no) 1998-07-22
NZ323387A (en) 2000-02-28
MX9804107A (es) 1998-09-30
EP0876347B1 (en) 2005-03-02
CZ157998A3 (cs) 1998-12-16
EP0876347A1 (en) 1998-11-11
US6277862B1 (en) 2001-08-21
CA2238298A1 (en) 1997-06-19
EA002124B1 (ru) 2001-12-24

Similar Documents

Publication Publication Date Title
CN1078889C (zh) 非肽类速激肽受体拮抗剂
CN1072220C (zh) 作为神经激肽受体拮抗剂的1－苯甲酰基－2－(吲哚基－3－烷基)－哌嗪衍生物
CN1158264C (zh) 用于治疗中枢神经系统疾病的代谢性谷氨酸受体拮抗剂
CN1263755C (zh) 作为选择性cox－2抑制剂的吡唑并吡啶衍生物
CN1156451A (zh) 用作速激肽nk3受体拮抗剂的喹啉衍生物
US6277862B1 (en) Quinoline derivatives
CN1207729A (zh) 喹啉－4－酰胺衍生物,它们的制备以及它们作为神经激肽3(nk－3)和神经激肽2(nk－2)受体拮抗剂的应用
CN1305464A (zh) 杂环化合物和治疗心力衰竭及其它疾病的方法
CN1446218A (zh) 苯并咪唑衍生物,它们的制备方法以及它们的治疗应用
CN1906189A (zh) 用于治疗呼吸系统疾病的1－乙酸－吲哚、－吲唑和－苯并咪唑衍生物
CN1344249A (zh) 酰胺衍生物
CN1344160A (zh) 用作生长激素促分泌剂的杂环芳族化合物
CN1050187A (zh) 新的喹啉化合物及其制备方法
CN1098098A (zh) 哌嗪衍生物
CN1142226A (zh) 新的杂环化合物
CN1072219C (zh) 二氮杂䓬酮、其生产和用途
CN1406225A (zh) 用作nk－3和nk－2受体拮抗剂的喹啉－4－甲酰胺衍生物
CN1511151A (zh) 3-喹啉-2(1h)-亚基二氢吲哚-2-酮衍生物
CN1829694A (zh) 喹啉衍生物和它们在治疗中的用途
CN1496257A (zh) 调控免疫球蛋白e及抑制细胞增殖的苯并咪唑化合物
CN1264378A (zh) 作为nk－2和nk－3受体拮抗剂的喹啉－4－甲酰胺衍生物
CN1130346C (zh) 作为nmda拮抗剂的四氢喹啉类化合物
CN1589261A (zh) 哌啶衍生物及其作为趋化因子受体(尤其是ccr5)活性调节剂的用途
CN1022322C (zh) 稠合吡唑3-氧代-丙腈衍生物的制备方法
CN1323306A (zh) 萘啶衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication