TW353066B - Arylquinoline-carboxamide derivatives and pharmaceutical compositions containing them - Google Patents

Arylquinoline-carboxamide derivatives and pharmaceutical compositions containing them

Info

Publication number: TW353066B
Authority: TW; Taiwan
Prior art keywords: compound; formula; arylquinoline; pharmaceutical compositions; compositions containing
Prior art date: 1995-11-24

Application number

TW085114500A

Other languages

English (en)

Chinese (zh)

Inventor

Giuseppe Arnaldo M Giardina

Mario Grugni

Luca Francesco Raveglia

Carlo Farina

Original Assignee

Smithkline Beecham Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-24

Filing date

1996-11-23

Publication date

1999-02-21

1995-11-24 Priority claimed from IT95MI002461 external-priority patent/IT1276170B1/it

1996-08-02 Priority claimed from IT96MI001689 external-priority patent/IT1307331B1/it

1996-11-23 Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa

1999-02-21 Application granted granted Critical

1999-02-21 Publication of TW353066B publication Critical patent/TW353066B/zh

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
229940053202 antiepileptics carboxamide derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
-1 (2-carboxy)benzylcarbonyl Chemical group 0.000 abstract 3
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW085114500A 1995-11-24 1996-11-23 Arylquinoline-carboxamide derivatives and pharmaceutical compositions containing them TW353066B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95MI002461 IT1276170B1 (it)	1995-11-24	1995-11-24	Derivati chinolinici
IT96MI001689 IT1307331B1 (it)	1996-08-02	1996-08-02	Derivati chinolinici

Publications (1)

Publication Number	Publication Date
TW353066B true TW353066B (en)	1999-02-21

Family

ID=26331326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW085114500A TW353066B (en)	1995-11-24	1996-11-23	Arylquinoline-carboxamide derivatives and pharmaceutical compositions containing them

Country Status (26)

Country	Link
US (1)	US6277862B1 (2)
EP (1)	EP0876347B1 (2)
JP (1)	JP2000501104A (2)
KR (1)	KR19990071597A (2)
CN (1)	CN1207730A (2)
AP (1)	AP9801237A0 (2)
AR (1)	AR004972A1 (2)
AT (1)	ATE289994T1 (2)
BG (1)	BG102558A (2)
BR (1)	BR9611820A (2)
CA (1)	CA2238298A1 (2)
CZ (1)	CZ157998A3 (2)
DE (1)	DE69634416T2 (2)
EA (1)	EA002124B1 (2)
ES (1)	ES2236757T3 (2)
IL (1)	IL124522A0 (2)
MX (1)	MX9804107A (2)
NO (1)	NO311212B1 (2)
NZ (1)	NZ323387A (2)
OA (1)	OA11010A (2)
PL (1)	PL326967A1 (2)
SK (1)	SK66798A3 (2)
TR (1)	TR199800924T2 (2)
TW (1)	TW353066B (2)
UY (1)	UY24733A1 (2)
WO (1)	WO1997021680A1 (2)

Families Citing this family (38)

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CA2119155C (en) *	1991-10-18	1999-06-15	Dennis Paul Phillion	Fungicides for the control of take-all disease of plants
SE9703407D0 (sv) *	1997-09-19	1997-09-19	Astra Ab	New use
SE9802073D0 (sv)	1998-06-11	1998-06-11	Astra Ab	New use
GB9825554D0 (en) *	1998-11-20	1999-01-13	Smithkline Beecham Spa	Novel Compounds
US7037922B1 (en)	2000-03-10	2006-05-02	Neurogen Corporation	Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
JP2002540203A (ja)	1999-03-29	2002-11-26	ニューロゲンコーポレイション	Ｎｋ−３および／またはｇａｂａ（ａ）受容体リガンドとしての４−置換キノリン誘導体
WO2000064877A1 (en)	1999-04-26	2000-11-02	Neurogen Corporation	2-aminoquinolinecarboxamides: neurokinin receptor ligands
ES2254688T3 (es) *	2001-04-11	2006-06-16	Glaxosmithkline S.P.A.	Derivados de quinolina-4-carboxamida como antagonistas de los receptores nk-3 y nk-2.
AU2002259147A1 (en) *	2001-05-08	2002-11-18	Schering Corporation	Use of neurokinin receptor antagonists to treat androgen-dependent diseases
SG168407A1 (en)	2003-01-28	2011-02-28	Ironwood Pharmaceuticals Inc	Methods and compositions for the treatment of gastrointestinal disorders
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
GB0303086D0 (en)	2003-02-11	2003-03-19	Merck Sharp & Dohme	New compounds
GB0419192D0 (en)	2004-08-27	2004-09-29	Merck Sharp & Dohme	Therapeutic agents
AU2005304962B2 (en) *	2004-11-09	2009-11-19	Smithkline Beecham Corporation	Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof
GB0425077D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
JP2009504641A (ja) *	2005-08-11	2009-02-05	アストラゼネカ・アクチエボラーグ	Ｎｋ−３受容体の調節剤としてのアルキルピリジルキノリン
AR057130A1 (es)	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) *	2005-12-12	2008-01-16	Astrazeneca Ab	Alkylsulphonamide quinolines
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en)	2007-06-04	2015-10-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
KR20100075568A (ko) *	2007-09-28	2010-07-02	글락소스미스클라인 엘엘씨	글리코겐 포스포릴라아제 억제제 화합물 및 이의 약제 조성물
KR20100087300A (ko) *	2007-09-28	2010-08-04	글락소스미스클라인 엘엘씨	글리코겐 포스포릴라아제 억제제 화합물 및 이의 약학적 조성물
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2018129556A1 (en)	2017-01-09	2018-07-12	Ardelyx, Inc.	Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
SI2384318T1 (en)	2008-12-31	2018-03-30	Ardelyx, Inc.	MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
US10376481B2 (en)	2012-08-21	2019-08-13	Ardelyx, Inc.	Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
MX366293B (es)	2012-08-21	2019-07-04	Ardelyx Inc	Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal.
CA2905435A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
LT2983667T (lt)	2013-04-12	2019-07-10	Ardelyx, Inc.	Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai
CA2909752A1 (en)	2013-04-19	2014-10-23	Astrazeneca Ab	A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
SI3004138T1 (sl)	2013-06-05	2024-07-31	Bausch Health Ireland Limited	Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
WO2017072629A1 (en)	2015-10-29	2017-05-04	Cadila Healthcare Limited	Pharmaceutical combination of nk3 receptor antagonist and biguanides
EA201991676A1 (ru)	2017-01-09	2020-01-30	Арделикс, Инк.	Ингибиторы nhe-опосредованного антипорта
CA3049678A1 (en)	2017-01-09	2018-07-12	Ardelyx, Inc.	Compounds useful for treating gastrointestinal tract disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2538388B1 (fr) *	1982-12-24	1985-06-21	Pharmuka Lab	Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS6399057A (ja) *	1986-06-27	1988-04-30	Nippon Shinyaku Co Ltd	グリシン誘導体
DK0804419T3 (da) *	1994-05-27	2003-11-24	Glaxosmithkline Spa	Quinolinderivater som tachykinin NK 3-receptor-antagonister
IT1270615B (it) *	1994-07-14	1997-05-07	Smithkline Beecham Farma	Uso di derivati di chinolina

1996
- 1996-11-22 EA EA199800477A patent/EA002124B1/ru not_active IP Right Cessation
- 1996-11-22 DE DE69634416T patent/DE69634416T2/de not_active Expired - Fee Related
- 1996-11-22 AT AT96941023T patent/ATE289994T1/de not_active IP Right Cessation
- 1996-11-22 WO PCT/EP1996/005203 patent/WO1997021680A1/en not_active Ceased
- 1996-11-22 CA CA002238298A patent/CA2238298A1/en not_active Abandoned
- 1996-11-22 EP EP96941023A patent/EP0876347B1/en not_active Expired - Lifetime
- 1996-11-22 KR KR1019980703873A patent/KR19990071597A/ko not_active Withdrawn
- 1996-11-22 IL IL12452296A patent/IL124522A0/xx unknown
- 1996-11-22 NZ NZ323387A patent/NZ323387A/en unknown
- 1996-11-22 CN CN96199753A patent/CN1207730A/zh active Pending
- 1996-11-22 BR BR9611820A patent/BR9611820A/pt not_active Application Discontinuation
- 1996-11-22 SK SK667-98A patent/SK66798A3/sk unknown
- 1996-11-22 ES ES96941023T patent/ES2236757T3/es not_active Expired - Lifetime
- 1996-11-22 JP JP9521658A patent/JP2000501104A/ja active Pending
- 1996-11-22 PL PL96326967A patent/PL326967A1/xx unknown
- 1996-11-22 US US09/077,151 patent/US6277862B1/en not_active Expired - Fee Related
- 1996-11-22 TR TR1998/00924T patent/TR199800924T2/xx unknown
- 1996-11-22 AP APAP/P/1998/001237A patent/AP9801237A0/en unknown
- 1996-11-22 CZ CZ981579A patent/CZ157998A3/cs unknown
- 1996-11-23 TW TW085114500A patent/TW353066B/zh active
- 1996-11-25 AR ARP960105317A patent/AR004972A1/es not_active Application Discontinuation
1997
- 1997-09-30 UY UY24733A patent/UY24733A1/es not_active Application Discontinuation
1998
- 1998-05-22 NO NO19982331A patent/NO311212B1/no unknown
- 1998-05-22 OA OA9800061A patent/OA11010A/en unknown
- 1998-05-22 MX MX9804107A patent/MX9804107A/es unknown
- 1998-06-18 BG BG102558A patent/BG102558A/bg unknown

Also Published As

Publication number	Publication date
WO1997021680A1 (en)	1997-06-19
NO982331L (no)	1998-07-22
TR199800924T2 (xx)	1998-08-21
NO311212B1 (no)	2001-10-29
CN1207730A (zh)	1999-02-10
DE69634416D1 (de)	2005-04-07
IL124522A0 (en)	1998-12-06
DE69634416T2 (de)	2005-12-29
US6277862B1 (en)	2001-08-21
PL326967A1 (en)	1998-11-09
KR19990071597A (ko)	1999-09-27
EA199800477A1 (ru)	1998-12-24
NO982331D0 (no)	1998-05-22
EP0876347A1 (en)	1998-11-11
AR004972A1 (es)	1999-04-07
ATE289994T1 (de)	2005-03-15
MX9804107A (es)	1998-09-30
BR9611820A (pt)	1999-07-13
BG102558A (bg)	1999-03-31
JP2000501104A (ja)	2000-02-02
AP9801237A0 (en)	1998-06-30
OA11010A (en)	2003-03-06
SK66798A3 (en)	1999-01-11
NZ323387A (en)	2000-02-28
EP0876347B1 (en)	2005-03-02
ES2236757T3 (es)	2005-07-16
CA2238298A1 (en)	1997-06-19
EA002124B1 (ru)	2001-12-24
CZ157998A3 (cs)	1998-12-16
UY24733A1 (es)	2001-08-27

Publication	Publication Date	Title
TW353066B (en)	1999-02-21	Arylquinoline-carboxamide derivatives and pharmaceutical compositions containing them
IL63613A (en)	1984-10-31	Dihydrohalo oxo-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ES482134A1 (es)	1980-04-01	Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido.
HUP9802814A2 (hu)	1999-10-28	Szelektív béta3 adrenergiás agonista hatású vegyületek, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
ES8802220A1 (es)	1988-04-16	Procedimiento para la obtencion de amidas de acidos benzoheterociclilalcanoicos.
IL108259A0 (en)	1994-04-12	Piperazine derivates, their preparation and pharmaceutical compositions containing them
AU1085492A (en)	1992-08-13	New n-myristoyltransferase inhibitors, process for preparing these and pharmaceutical compositions containing them
IL66341A0 (en)	1982-11-30	Pyrrolidine derivatives,their manufacture and pharmaceutical compositions containing them
ATE59033T1 (de)	1990-12-15	N-enthaltende heterozyklische verbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel.
ATE48001T1 (de)	1989-12-15	Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
AU7414691A (en)	1991-10-10	New 3-aminochroman derivatives, process for preparing these and pharmaceutical compositions containing them
DE3170937D1 (en)	1985-07-18	2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them
DE3171074D1 (en)	1985-07-25	Phenylpiperazine derivatives of heterylphenols and hetarylanilines, their preparation and their pharmaceutical compositions
AU639154B2 (en)	1993-07-15	New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
ES8504190A1 (es)	1985-04-16	Procedimiento para la preparacion de nuevos derivados del acido quinolicincarboxilico.
ES8105738A1 (es)	1981-06-16	Procedimiento para la obtencion de derivados del amino-tia- diazolilo
HUT68258A (en)	1995-06-28	Fungicidal composition containing pyrimidinyl acrylic acid derivatives and process for their preparation
IL83725A0 (en)	1988-02-29	3-methylphthalimide derivatives,their preparation and their use as herbicides and plant growth regulants
DE3269533D1 (en)	1986-04-03	New quinolylacetic acid compounds and pharmaceutical compositions containing them
ES8206537A1 (es)	1982-08-16	Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina
ES8304973A1 (es)	1983-03-16	Un procedimiento para la preparacion de nuevos derivados de tiocarbapenem 3-sustituidos.
ES8307258A1 (es)	1983-06-16	"procedimiento para la preparacion de nuevas cefalosporinas".
IL115085A (en)	1999-06-20	Piperazine bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
ES8308565A1 (es)	1983-09-01	Procedimiento para la preparacion de compuestos de 1,4-benzodiazepina.
ES8201575A1 (es)	1981-12-16	Procedimiento de obtencion de nuevos 2-aminoetanoles