CN1522701A - 环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰 - Google Patents

环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰 Download PDF

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Publication number
CN1522701A
CN1522701A CNA2004100027960A CN200410002796A CN1522701A CN 1522701 A CN1522701 A CN 1522701A CN A2004100027960 A CNA2004100027960 A CN A2004100027960A CN 200410002796 A CN200410002796 A CN 200410002796A CN 1522701 A CN1522701 A CN 1522701A
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CN
China
Prior art keywords
alkyl
chemical compound
epoxy
angiotension
base
Prior art date
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Pending
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CNA2004100027960A
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English (en)
Chinese (zh)
Inventor
J��C������ɣ�¶�
J·C·阿勒桑德尔
J·R·舒
R·J·高尔茨斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
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GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN1522701A publication Critical patent/CN1522701A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA2004100027960A 1995-06-07 1996-06-05 环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰 Pending CN1522701A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48645695A 1995-06-07 1995-06-07
US486456 1995-06-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB961961554A Division CN1142793C (zh) 1995-06-07 1996-06-05 环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰

Publications (1)

Publication Number Publication Date
CN1522701A true CN1522701A (zh) 2004-08-25

Family

ID=23931955

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2004100027960A Pending CN1522701A (zh) 1995-06-07 1996-06-05 环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰
CNB961961554A Expired - Fee Related CN1142793C (zh) 1995-06-07 1996-06-05 环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB961961554A Expired - Fee Related CN1142793C (zh) 1995-06-07 1996-06-05 环氧-甾族化合物醛甾酮拮抗剂和血管紧张肽ⅱ拮抗剂联合治疗用于治疗充血性心衰

Country Status (21)

Country Link
US (1) US6653306B1 (2)
EP (1) EP0831910B1 (2)
JP (1) JPH11507627A (2)
KR (1) KR100618466B1 (2)
CN (2) CN1522701A (2)
AT (1) ATE209047T1 (2)
AU (1) AU725689B2 (2)
BR (1) BR9609066A (2)
CA (1) CA2224079A1 (2)
CZ (1) CZ297975B6 (2)
DE (1) DE69617235T2 (2)
DK (1) DK0831910T3 (2)
ES (1) ES2167571T3 (2)
IL (1) IL122242A (2)
NO (1) NO318184B1 (2)
NZ (1) NZ310730A (2)
PL (1) PL185150B1 (2)
PT (1) PT831910E (2)
RO (1) RO118046B1 (2)
RU (1) RU2166330C2 (2)
WO (1) WO1996040257A1 (2)

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Also Published As

Publication number Publication date
BR9609066A (pt) 1999-01-26
DE69617235T2 (de) 2002-07-25
ATE209047T1 (de) 2001-12-15
CN1142793C (zh) 2004-03-24
ES2167571T3 (es) 2002-05-16
US6653306B1 (en) 2003-11-25
IL122242A0 (en) 1998-04-05
DE69617235D1 (de) 2002-01-03
KR100618466B1 (ko) 2006-12-13
PL185150B1 (pl) 2003-03-31
JPH11507627A (ja) 1999-07-06
CA2224079A1 (en) 1996-12-19
NO975741L (no) 1998-01-29
NO318184B1 (no) 2005-02-14
WO1996040257A1 (en) 1996-12-19
EP0831910A1 (en) 1998-04-01
CN1192697A (zh) 1998-09-09
RU2166330C2 (ru) 2001-05-10
NZ310730A (en) 2001-01-26
PT831910E (pt) 2002-05-31
NO975741D0 (no) 1997-12-05
EP0831910B1 (en) 2001-11-21
CZ385097A3 (cs) 1998-06-17
KR19990022548A (ko) 1999-03-25
AU725689B2 (en) 2000-10-19
CZ297975B6 (cs) 2007-05-09
IL122242A (en) 2001-07-24
PL324001A1 (en) 1998-04-27
AU6157796A (en) 1996-12-30
RO118046B1 (ro) 2003-01-30
DK0831910T3 (da) 2002-05-21

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