RO118046B1 - Asociere farmaceutica - Google Patents

Asociere farmaceutica Download PDF

Info

Publication number: RO118046B1
Authority: RO; Romania
Prior art keywords: methyl; pub; biphenyl; acid; tetrazol
Prior art date: 1995-06-07

Application number

RO97-02272A

Other languages

English (en)

Romanian (ro)

Inventor

John Charles Alexander

Joseph R Schuh

Richard J Gorczynski

Original Assignee

Gd Searle & Co Chicago

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-05

Publication date

2003-01-30

1996-06-05 Application filed by Gd Searle & Co Chicago filed Critical Gd Searle & Co Chicago

2003-01-30 Publication of RO118046B1 publication Critical patent/RO118046B1/ro

Links

102000003979 Mineralocorticoid Receptors Human genes 0.000 claims abstract description 27
108090000375 Mineralocorticoid Receptors Proteins 0.000 claims abstract description 27
239000002333 angiotensin II receptor antagonist Substances 0.000 claims abstract description 25
229940126317 angiotensin II receptor antagonist Drugs 0.000 claims abstract description 15
239000004593 Epoxy Substances 0.000 claims abstract description 10
229940044551 receptor antagonist Drugs 0.000 claims abstract description 9
239000002464 receptor antagonist Substances 0.000 claims abstract description 9
150000001875 compounds Chemical class 0.000 claims description 197
-1 1H-tetrazol-5-yl Chemical group 0.000 claims description 110
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 53
239000005557 antagonist Substances 0.000 claims description 39
239000002253 acid Substances 0.000 claims description 37
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 26
125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 21
239000012634 fragment Substances 0.000 claims description 20
239000004305 biphenyl Substances 0.000 claims description 16
125000000457 gamma-lactone group Chemical group 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 14
235000010290 biphenyl Nutrition 0.000 claims description 13
HKYYMVLLLCHGTL-UNUXFHLRSA-N 3-[(8s,9s,10r,13r,14s,17r)-10,13-dimethyl-2,3,8,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]propanoic acid Chemical compound C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCC(O)=O)[C@@H]4[C@@H]3C=CC2=C1 HKYYMVLLLCHGTL-UNUXFHLRSA-N 0.000 claims description 12
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 12
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 11
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 10
150000004702 methyl esters Chemical class 0.000 claims description 8
150000002148 esters Chemical class 0.000 claims description 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 6
150000003431 steroids Chemical group 0.000 claims description 6
RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims description 6
NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims description 4
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
125000003700 epoxy group Chemical group 0.000 claims description 4
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
SUZXWXGJCOCMHU-UHFFFAOYSA-N n-sulfonylbenzamide Chemical compound O=S(=O)=NC(=O)C1=CC=CC=C1 SUZXWXGJCOCMHU-UHFFFAOYSA-N 0.000 claims description 4
ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical compound CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 claims description 4
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
HBNPHVRKFGNYAV-UHFFFAOYSA-N 1h-cyclohepta[d]imidazol-2-one Chemical compound C1=CC=CC=C2NC(=O)N=C21 HBNPHVRKFGNYAV-UHFFFAOYSA-N 0.000 claims description 3
UUPNFNCKGJOLQE-UHFFFAOYSA-N 2-[4-[[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]benzoic acid Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C(O)=O)C=C1 UUPNFNCKGJOLQE-UHFFFAOYSA-N 0.000 claims description 3
ZHWGRXBJGUEATA-UHFFFAOYSA-N 2-[[4-[[2-butyl-6-[methylcarbamoyl(pentyl)amino]benzimidazol-1-yl]methyl]phenyl]carbamoyl]-3,6-dichlorobenzoic acid Chemical compound C12=CC(N(C(=O)NC)CCCCC)=CC=C2N=C(CCCC)N1CC(C=C1)=CC=C1NC(=O)C1=C(Cl)C=CC(Cl)=C1C(O)=O ZHWGRXBJGUEATA-UHFFFAOYSA-N 0.000 claims description 3
PORJGKBQQFPVED-UNUXFHLRSA-N 3-[(8s,9s,10r,13r,14s,17r)-10,13-dimethyl-8,9,11,12,14,15,16,17-octahydro-3h-cyclopenta[a]phenanthren-17-yl]propanoic acid Chemical compound C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCC(O)=O)[C@@H]4[C@@H]3C=CC2=C1 PORJGKBQQFPVED-UNUXFHLRSA-N 0.000 claims description 3
FTDRSCZZEUAAIP-UHFFFAOYSA-N 3-methoxy-2,6-dimethyl-4-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methoxy]pyridine Chemical compound COC1=C(C)N=C(C)C=C1OCC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1 FTDRSCZZEUAAIP-UHFFFAOYSA-N 0.000 claims description 3
CICPLKAJEGYYGM-UHFFFAOYSA-N 3h-pyridazin-4-one Chemical compound O=C1CN=NC=C1 CICPLKAJEGYYGM-UHFFFAOYSA-N 0.000 claims description 3
PZKFSRWSQOQYNR-UHFFFAOYSA-N 5-methyl-1h-1,2,4-triazole Chemical compound CC1=NC=NN1 PZKFSRWSQOQYNR-UHFFFAOYSA-N 0.000 claims description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
239000002080 C09CA02 - Eprosartan Substances 0.000 claims description 3
239000004072 C09CA03 - Valsartan Substances 0.000 claims description 3
239000002947 C09CA04 - Irbesartan Substances 0.000 claims description 3
239000002081 C09CA05 - Tasosartan Substances 0.000 claims description 3
239000002053 C09CA06 - Candesartan Substances 0.000 claims description 3
239000005537 C09CA07 - Telmisartan Substances 0.000 claims description 3
FDKIDFYIEWFERB-UHFFFAOYSA-N [2-butyl-5-chloro-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;potassium Chemical compound [K].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 FDKIDFYIEWFERB-UHFFFAOYSA-N 0.000 claims description 3
229960000932 candesartan Drugs 0.000 claims description 3
229960004349 candesartan cilexetil Drugs 0.000 claims description 3
IDAWWPOAHPVPMY-UHFFFAOYSA-N elisartan Chemical compound CCCCC1=NC(Cl)=C(C(=O)OC(C)OC(=O)OCC)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1 IDAWWPOAHPVPMY-UHFFFAOYSA-N 0.000 claims description 3
229950000980 elisartan Drugs 0.000 claims description 3
229960004563 eprosartan Drugs 0.000 claims description 3
OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims description 3
125000004494 ethyl ester group Chemical group 0.000 claims description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
229960002198 irbesartan Drugs 0.000 claims description 3
YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims description 3
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
PZQSQRCNMZGWFT-QXMHVHEDSA-N propan-2-yl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(C)C PZQSQRCNMZGWFT-QXMHVHEDSA-N 0.000 claims description 3
159000000000 sodium salts Chemical class 0.000 claims description 3
229960000651 tasosartan Drugs 0.000 claims description 3
ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 claims description 3
229960005187 telmisartan Drugs 0.000 claims description 3
229960004699 valsartan Drugs 0.000 claims description 3
NWLPRJINWFMRHH-UHFFFAOYSA-N 1-methylpyrimidin-4-one Chemical compound CN1C=CC(=O)N=C1 NWLPRJINWFMRHH-UHFFFAOYSA-N 0.000 claims description 2
QCMJWOUBUKPNOA-UHFFFAOYSA-N 2-[[4-[[2-butyl-5-(carboxymethyl)-4-chloroimidazol-1-yl]methyl]phenyl]carbamoyl]benzoic acid Chemical compound CCCCC1=NC(Cl)=C(CC(O)=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C(O)=O QCMJWOUBUKPNOA-UHFFFAOYSA-N 0.000 claims description 2
PBEDVTDUVXFSMW-UHFFFAOYSA-N 3-methylimidazole-4-carboxylic acid Chemical compound CN1C=NC=C1C(O)=O PBEDVTDUVXFSMW-UHFFFAOYSA-N 0.000 claims description 2
239000005478 Saprisartan Substances 0.000 claims description 2
DUEWVPTZCSAMNB-UHFFFAOYSA-N Saprisartan Chemical compound NC(=O)C=1N(CC=2C=C3C(Br)=C(OC3=CC=2)C=2C(=CC=CC=2)NS(=O)(=O)C(F)(F)F)C(CC)=NC=1C1CC1 DUEWVPTZCSAMNB-UHFFFAOYSA-N 0.000 claims description 2
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 2
ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims description 2
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
239000012895 dilution Substances 0.000 claims description 2
238000010790 dilution Methods 0.000 claims description 2
JQXJNTQZCWEHKS-UHFFFAOYSA-N n-[4-oxo-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]-n-pentylbenzamide Chemical compound C=1C=C2N=C(CCC)N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(=O)C2=CC=1N(CCCCC)C(=O)C1=CC=CC=C1 JQXJNTQZCWEHKS-UHFFFAOYSA-N 0.000 claims description 2
229960003512 nicotinic acid Drugs 0.000 claims description 2
239000011664 nicotinic acid Substances 0.000 claims description 2
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims description 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
229950006241 saprisartan Drugs 0.000 claims description 2
DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 claims description 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 2
FIKYECRHLXONOX-UHFFFAOYSA-N zolasartan Chemical compound CCCCC1=NC(Cl)=C(C(O)=O)N1CC1=CC=C(OC(=C2Br)C=3C(=CC=CC=3)C3=NNN=N3)C2=C1 FIKYECRHLXONOX-UHFFFAOYSA-N 0.000 claims description 2
229950004433 zolasartan Drugs 0.000 claims description 2
WZHRJGWXUCLILI-UHFFFAOYSA-N sulfonylcarbamic acid Chemical compound OC(=O)N=S(=O)=O WZHRJGWXUCLILI-UHFFFAOYSA-N 0.000 claims 3
SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 2
ITOFPJRDSCGOSA-KZLRUDJFSA-N (2s)-2-[[(4r)-4-[(3r,5r,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H](CC[C@]13C)[C@@H]2[C@@H]3CC[C@@H]1[C@H](C)CCC(=O)N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12 ITOFPJRDSCGOSA-KZLRUDJFSA-N 0.000 claims 1
IYPXPGSELZFFMI-UHFFFAOYSA-N 1-phenyltetrazole Chemical compound C1=NN=NN1C1=CC=CC=C1 IYPXPGSELZFFMI-UHFFFAOYSA-N 0.000 claims 1
FQZSMTSTFMNWQF-UHFFFAOYSA-N 2-butyl-4-chloro-1-({4-[2-(1h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1h-imidazole-5-carbaldehyde Chemical compound CCCCC1=NC(Cl)=C(C=O)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1 FQZSMTSTFMNWQF-UHFFFAOYSA-N 0.000 claims 1
FZESPVBONPPRAW-UHFFFAOYSA-N 2-methyl-1h-imidazo[4,5-b]pyridine Chemical compound C1=CC=C2NC(C)=NC2=N1 FZESPVBONPPRAW-UHFFFAOYSA-N 0.000 claims 1
ILYSAKHOYBPSPC-UHFFFAOYSA-N 2-phenylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=CC=CC=C1 ILYSAKHOYBPSPC-UHFFFAOYSA-N 0.000 claims 1
BFVNEYDCFJNLGN-UHFFFAOYSA-N 5,7-diethyl-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3,4-dihydro-1,6-naphthyridin-2-one Chemical compound O=C1CCC=2C(CC)=NC(CC)=CC=2N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 BFVNEYDCFJNLGN-UHFFFAOYSA-N 0.000 claims 1
LYJUNKZCCWURDK-UHFFFAOYSA-N CCCCC1=NN(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=O)O)C4=CC=CC=C4C(F)(F)F Chemical compound CCCCC1=NN(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=O)O)C4=CC=CC=C4C(F)(F)F LYJUNKZCCWURDK-UHFFFAOYSA-N 0.000 claims 1
UDHXJZHVNHGCEC-UHFFFAOYSA-N Chlorophacinone Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)C(=O)C1C(=O)C2=CC=CC=C2C1=O UDHXJZHVNHGCEC-UHFFFAOYSA-N 0.000 claims 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
KLVDUSUYBDMJKR-UHFFFAOYSA-N PD 123177 Chemical compound C1=C(N)C(C)=CC(CN2C=3CC(N(CC=3N=C2)C(=O)C(C=2C=CC=CC=2)C=2C=CC=CC=2)C(O)=O)=C1 KLVDUSUYBDMJKR-UHFFFAOYSA-N 0.000 claims 1
229920006085 Remid® Polymers 0.000 claims 1
108010083387 Saralasin Proteins 0.000 claims 1
OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 1
229940125810 compound 20 Drugs 0.000 claims 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
125000004894 pentylamino group Chemical group C(CCCC)N* 0.000 claims 1
SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 1
PFGWGEPQIUAZME-NXSMLHPHSA-N saralasin Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)C1=CC=C(O)C=C1 PFGWGEPQIUAZME-NXSMLHPHSA-N 0.000 claims 1
229960004785 saralasin Drugs 0.000 claims 1
LENLQGBLVGGAMF-UHFFFAOYSA-N tributyl([1,2,4]triazolo[1,5-a]pyridin-6-yl)stannane Chemical compound C1=C([Sn](CCCC)(CCCC)CCCC)C=CC2=NC=NN21 LENLQGBLVGGAMF-UHFFFAOYSA-N 0.000 claims 1
206010020772 Hypertension Diseases 0.000 abstract description 17
206010019280 Heart failures Diseases 0.000 abstract description 16
206010007559 Cardiac failure congestive Diseases 0.000 abstract description 11
206010003445 Ascites Diseases 0.000 abstract description 5
230000007882 cirrhosis Effects 0.000 abstract description 5
206010007572 Cardiac hypertrophy Diseases 0.000 abstract description 4
208000006029 Cardiomegaly Diseases 0.000 abstract description 4
206010054936 Cardiac cirrhosis Diseases 0.000 abstract description 3
230000003637 steroidlike Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 description 29
PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 description 27
229960002478 aldosterone Drugs 0.000 description 27
PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 description 26
125000004432 carbon atom Chemical group C* 0.000 description 23
150000003254 radicals Chemical class 0.000 description 23
238000002648 combination therapy Methods 0.000 description 22
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 18
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 18
102000005862 Angiotensin II Human genes 0.000 description 17
101800000733 Angiotensin-2 Proteins 0.000 description 17
229950006323 angiotensin ii Drugs 0.000 description 16
229960002256 spironolactone Drugs 0.000 description 15
230000003042 antagnostic effect Effects 0.000 description 13
125000003118 aryl group Chemical group 0.000 description 13
239000003795 chemical substances by application Substances 0.000 description 13
230000000694 effects Effects 0.000 description 13
235000002639 sodium chloride Nutrition 0.000 description 13
230000005764 inhibitory process Effects 0.000 description 11
239000011734 sodium Substances 0.000 description 11
229910052717 sulfur Inorganic materials 0.000 description 11
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
230000027455 binding Effects 0.000 description 10
125000000623 heterocyclic group Chemical group 0.000 description 10
201000010099 disease Diseases 0.000 description 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
239000011777 magnesium Substances 0.000 description 9
229910052757 nitrogen Inorganic materials 0.000 description 9
102000005962 receptors Human genes 0.000 description 9
108020003175 receptors Proteins 0.000 description 9
239000005541 ACE inhibitor Substances 0.000 description 8
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125000004043 oxo group Chemical group O=* 0.000 description 1
UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 description 1
WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
229940055726 pantothenic acid Drugs 0.000 description 1
235000019161 pantothenic acid Nutrition 0.000 description 1
239000011713 pantothenic acid Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 description 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
125000004193 piperazinyl group Chemical group 0.000 description 1
229940037129 plain mineralocorticoids for systemic use Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000009090 positive inotropic effect Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940070017 potassium supplement Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000036584 pressor response Effects 0.000 description 1
238000009117 preventive therapy Methods 0.000 description 1
208000013846 primary aldosteronism Diseases 0.000 description 1
239000000047 product Substances 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
229960002429 proline Drugs 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
201000001474 proteinuria Diseases 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
125000003373 pyrazinyl group Chemical group 0.000 description 1
125000003226 pyrazolyl group Chemical group 0.000 description 1
125000002098 pyridazinyl group Chemical group 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
206010037844 rash Diseases 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
231100000046 skin rash Toxicity 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
OSDQJFVHDVAJSD-UHFFFAOYSA-M sodium;2-[2-butyl-3-[[4-[(2-carboxybenzoyl)amino]phenyl]methyl]-5-chloroimidazol-4-yl]propanoate Chemical compound [Na+].CCCCC1=NC(Cl)=C(C(C)C([O-])=O)N1CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C(O)=O OSDQJFVHDVAJSD-UHFFFAOYSA-M 0.000 description 1
UISHOHGMISMAQN-UHFFFAOYSA-M sodium;2-[2-butyl-5-chloro-3-[(2-chlorophenyl)methyl]imidazol-4-yl]acetate Chemical compound [Na+].CCCCC1=NC(Cl)=C(CC([O-])=O)N1CC1=CC=CC=C1Cl UISHOHGMISMAQN-UHFFFAOYSA-M 0.000 description 1
YFABTKCYNBWJHS-UHFFFAOYSA-N sodium;2-butyl-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine Chemical compound [Na+].CCCCC1=NC2=CC=CN=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N-]1 YFABTKCYNBWJHS-UHFFFAOYSA-N 0.000 description 1
125000006850 spacer group Chemical group 0.000 description 1
239000003270 steroid hormone Substances 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003457 sulfones Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
210000000106 sweat gland Anatomy 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000019270 symptomatic heart failure Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
230000024883 vasodilation Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
229960002769 zofenopril Drugs 0.000 description 1
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Organic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

RO97-02272A 1995-06-07 1996-06-05 Asociere farmaceutica RO118046B1 (ro)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48645695A	1995-06-07	1995-06-07
PCT/US1996/009335 WO1996040257A1 (en)	1995-06-07	1996-06-05	Epoxy-steroidal aldosterone antagonist and angiotensin ii antagonist combination therapy for treatment of congestive heart failure

Publications (1)

Publication Number	Publication Date
RO118046B1 true RO118046B1 (ro)	2003-01-30

Family

ID=23931955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RO97-02272A RO118046B1 (ro)	1995-06-07	1996-06-05	Asociere farmaceutica

Country Status (21)

Country	Link
US (1)	US6653306B1 (2)
EP (1)	EP0831910B1 (2)
JP (1)	JPH11507627A (2)
KR (1)	KR100618466B1 (2)
CN (2)	CN1522701A (2)
AT (1)	ATE209047T1 (2)
AU (1)	AU725689B2 (2)
BR (1)	BR9609066A (2)
CA (1)	CA2224079A1 (2)
CZ (1)	CZ297975B6 (2)
DE (1)	DE69617235T2 (2)
DK (1)	DK0831910T3 (2)
ES (1)	ES2167571T3 (2)
IL (1)	IL122242A (2)
NO (1)	NO318184B1 (2)
NZ (1)	NZ310730A (2)
PL (1)	PL185150B1 (2)
PT (1)	PT831910E (2)
RO (1)	RO118046B1 (2)
RU (1)	RU2166330C2 (2)
WO (1)	WO1996040257A1 (2)

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US6008210A (en) *	1992-04-21	1999-12-28	Weber; Karl T.	Use of aldosterone antagonists to inhibit myocardial fibrosis
US5529992A (en) *	1992-04-21	1996-06-25	Curators Of The University Of Missouri	Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors
AU5449194A (en) *	1992-10-26	1994-05-24	Merck & Co., Inc.	Combinations of angiotensin-ii receptor antagonists and diuretics
CA2125251C (en) *	1993-06-07	2005-04-26	Yoshiyuki Inada	A pharmaceutical composition for angiotensin ii-mediated diseases

1996
- 1996-06-05 DK DK96919170T patent/DK0831910T3/da active
- 1996-06-05 AT AT96919170T patent/ATE209047T1/de not_active IP Right Cessation
- 1996-06-05 NZ NZ310730A patent/NZ310730A/xx unknown
- 1996-06-05 RO RO97-02272A patent/RO118046B1/ro unknown
- 1996-06-05 CZ CZ0385097A patent/CZ297975B6/cs not_active IP Right Cessation
- 1996-06-05 AU AU61577/96A patent/AU725689B2/en not_active Ceased
- 1996-06-05 BR BR9609066A patent/BR9609066A/pt not_active Application Discontinuation
- 1996-06-05 CA CA002224079A patent/CA2224079A1/en not_active Abandoned
- 1996-06-05 JP JP9501678A patent/JPH11507627A/ja not_active Ceased
- 1996-06-05 EP EP96919170A patent/EP0831910B1/en not_active Expired - Lifetime
- 1996-06-05 WO PCT/US1996/009335 patent/WO1996040257A1/en not_active Ceased
- 1996-06-05 RU RU98100250/14A patent/RU2166330C2/ru not_active IP Right Cessation
- 1996-06-05 CN CNA2004100027960A patent/CN1522701A/zh active Pending
- 1996-06-05 IL IL12224296A patent/IL122242A/en not_active IP Right Cessation
- 1996-06-05 DE DE69617235T patent/DE69617235T2/de not_active Expired - Fee Related
- 1996-06-05 KR KR1019970709029A patent/KR100618466B1/ko not_active Expired - Fee Related
- 1996-06-05 ES ES96919170T patent/ES2167571T3/es not_active Expired - Lifetime
- 1996-06-05 CN CNB961961554A patent/CN1142793C/zh not_active Expired - Fee Related
- 1996-06-05 PT PT96919170T patent/PT831910E/pt unknown
- 1996-06-05 PL PL96324001A patent/PL185150B1/pl not_active IP Right Cessation
1997
- 1997-01-09 US US08/781,786 patent/US6653306B1/en not_active Expired - Fee Related
2004
- 2004-11-23 NO NO19975741A patent/NO318184B1/no unknown

Also Published As

Publication number	Publication date
BR9609066A (pt)	1999-01-26
DE69617235T2 (de)	2002-07-25
ATE209047T1 (de)	2001-12-15
CN1142793C (zh)	2004-03-24
ES2167571T3 (es)	2002-05-16
US6653306B1 (en)	2003-11-25
CN1522701A (zh)	2004-08-25
IL122242A0 (en)	1998-04-05
DE69617235D1 (de)	2002-01-03
KR100618466B1 (ko)	2006-12-13
PL185150B1 (pl)	2003-03-31
JPH11507627A (ja)	1999-07-06
CA2224079A1 (en)	1996-12-19
NO975741L (no)	1998-01-29
NO318184B1 (no)	2005-02-14
WO1996040257A1 (en)	1996-12-19
EP0831910A1 (en)	1998-04-01
CN1192697A (zh)	1998-09-09
RU2166330C2 (ru)	2001-05-10
NZ310730A (en)	2001-01-26
PT831910E (pt)	2002-05-31
NO975741D0 (no)	1997-12-05
EP0831910B1 (en)	2001-11-21
CZ385097A3 (cs)	1998-06-17
KR19990022548A (ko)	1999-03-25
AU725689B2 (en)	2000-10-19
CZ297975B6 (cs)	2007-05-09
IL122242A (en)	2001-07-24
PL324001A1 (en)	1998-04-27
AU6157796A (en)	1996-12-30
DK0831910T3 (da)	2002-05-21

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US20040067915A1 (en)	2004-04-08	Method to treat cardiofibrosis with a combination of an angiotensin II antagonist and spironolactone
US20020042405A1 (en)	2002-04-11	Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
US20030220312A1 (en)	2003-11-27	Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of cardiovascular disorders
US20030220310A1 (en)	2003-11-27	Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
ES2205023T3 (es)	2004-05-01	Combinacion de inhibidor de la enzima converitidora de angiotensina y antagonista de aldosterona para el tratamiento de la hipertrofia ventricular.
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AU2003202486B2 (en)	2005-06-16	Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for the treatment of congestive heart failure
US20030199483A1 (en)	2003-10-23	Aldosterone receptor antagonist and alpha-adrenergic modulating agent combination therapy for prevention or treatment of pathogenic conditions
AU4264200A (en)	2000-09-07	Spironolactone and angiotensin II antagonist combination therapy for treatment of congestive heart failure
JPH10513472A (ja)	1998-12-22	心臓血管疾患の治療を目的とするアンギオテンシン変換酵素抑制物質、副作用軽減量のアルドステロン拮抗物質および利尿剤のコンビネーション療法
AU2003214938A1 (en)	2003-09-02	Aldosterone receptor antagonist and alpha-adrenergic modulating agent combination therapy for prevention or treatment of cardiovascular conditions