CN1541109B - Her3活性抑制剂 - Google Patents

Her3活性抑制剂 Download PDF

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Publication number
CN1541109B
CN1541109B CN028156153A CN02815615A CN1541109B CN 1541109 B CN1541109 B CN 1541109B CN 028156153 A CN028156153 A CN 028156153A CN 02815615 A CN02815615 A CN 02815615A CN 1541109 B CN1541109 B CN 1541109B
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CN
China
Prior art keywords
her3
antibody
purposes
her2
inhibitor
Prior art date
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Expired - Lifetime
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CN028156153A
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English (en)
Chinese (zh)
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CN1541109A (zh
Inventor
A·乌尔里克
E·赫顿-范德霍斯特
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Publication of CN1541109A publication Critical patent/CN1541109A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN028156153A 2001-08-09 2002-08-09 Her3活性抑制剂 Expired - Lifetime CN1541109B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01119260A EP1283053A1 (de) 2001-08-09 2001-08-09 Inhibitore der HER3 Aktivität
EP01119260.6 2001-08-09
PCT/EP2002/008938 WO2003013602A1 (en) 2001-08-09 2002-08-09 Inhibitors of her3 activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2010105512370A Division CN102078613A (zh) 2001-08-09 2002-08-09 Her3活性抑制剂

Publications (2)

Publication Number Publication Date
CN1541109A CN1541109A (zh) 2004-10-27
CN1541109B true CN1541109B (zh) 2013-07-10

Family

ID=8178284

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2010105512370A Pending CN102078613A (zh) 2001-08-09 2002-08-09 Her3活性抑制剂
CN028156153A Expired - Lifetime CN1541109B (zh) 2001-08-09 2002-08-09 Her3活性抑制剂

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2010105512370A Pending CN102078613A (zh) 2001-08-09 2002-08-09 Her3活性抑制剂

Country Status (13)

Country Link
US (1) US9011851B2 (de)
EP (3) EP1283053A1 (de)
JP (1) JP5226926B2 (de)
CN (2) CN102078613A (de)
AT (1) ATE424219T1 (de)
AU (1) AU2002333384B2 (de)
CA (1) CA2456723C (de)
CY (1) CY1110322T1 (de)
DE (1) DE60231407D1 (de)
DK (1) DK1414494T3 (de)
ES (1) ES2323772T3 (de)
PT (1) PT1414494E (de)
WO (1) WO2003013602A1 (de)

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Also Published As

Publication number Publication date
AU2002333384B2 (en) 2007-11-15
JP2005504044A (ja) 2005-02-10
EP1414494B1 (de) 2009-03-04
DE60231407D1 (de) 2009-04-16
JP5226926B2 (ja) 2013-07-03
US9011851B2 (en) 2015-04-21
CA2456723C (en) 2016-02-09
US20040197332A1 (en) 2004-10-07
PT1414494E (pt) 2009-06-12
CN102078613A (zh) 2011-06-01
EP1414494A1 (de) 2004-05-06
EP2067792A2 (de) 2009-06-10
CN1541109A (zh) 2004-10-27
CA2456723A1 (en) 2003-02-20
CY1110322T1 (el) 2015-01-14
ES2323772T3 (es) 2009-07-24
DK1414494T3 (da) 2009-07-06
WO2003013602A1 (en) 2003-02-20
EP1283053A1 (de) 2003-02-12
ATE424219T1 (de) 2009-03-15

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