CS135189A2 - Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production - Google Patents

Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production

Info

Publication number: CS135189A2
Authority: CS; Czechoslovakia
Prior art keywords: propanes; piperazinyl; pyrimidinyl; acyl; production
Prior art date: 1987-10-26

Application number

CS891351A

Other languages

English (en)

Other versions

CS274446B2 (en

Inventor

Willard Mckowan Welch Jr

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-26

Filing date

1989-03-02

Publication date

1990-08-14

1989-03-02 Application filed by Pfizer filed Critical Pfizer

1990-08-14 Publication of CS135189A2 publication Critical patent/CS135189A2/cs

1991-04-11 Publication of CS274446B2 publication Critical patent/CS274446B2/cs

Links

235000013849 propane Nutrition 0.000 title 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 title 1
125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Graft Or Block Polymers (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CS135189A 1987-10-26 1989-03-02 Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production CS274446B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1987/002855 WO1989003831A1 (en)	1987-10-26	1987-10-26	Anti-anxiety agents
CS708088A CS274441B2 (en)	1987-10-26	1988-10-26	Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production

Publications (2)

Publication Number	Publication Date
CS135189A2 true CS135189A2 (en)	1990-08-14
CS274446B2 CS274446B2 (en)	1991-04-11

Family

ID=22202642

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CS708088A CS274441B2 (en)	1987-10-26	1988-10-26	Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production
CS135189A CS274446B2 (en)	1987-10-26	1989-03-02	Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CS708088A CS274441B2 (en)	1987-10-26	1988-10-26	Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production

Country Status (28)

Country	Link
US (1)	US4994455A (cs)
EP (1)	EP0314363B1 (cs)
JP (1)	JPH0643406B2 (cs)
KR (1)	KR900006722B1 (cs)
CN (1)	CN1022246C (cs)
AT (1)	ATE87919T1 (cs)
AU (1)	AU598161B2 (cs)
CA (1)	CA1314881C (cs)
CS (2)	CS274441B2 (cs)
DD (2)	DD298397A5 (cs)
DE (1)	DE3880077T2 (cs)
DK (1)	DK171788B1 (cs)
ES (1)	ES2054823T3 (cs)
FI (1)	FI94638C (cs)
HU (2)	HU206109B (cs)
IE (1)	IE63285B1 (cs)
IL (1)	IL88085A (cs)
MX (1)	MX173180B (cs)
MY (1)	MY103435A (cs)
NO (2)	NO901652D0 (cs)
NZ (1)	NZ226691A (cs)
PH (1)	PH25106A (cs)
PL (2)	PL152117B1 (cs)
PT (1)	PT88835B (cs)
RU (1)	RU2029768C1 (cs)
WO (1)	WO1989003831A1 (cs)
YU (1)	YU46592B (cs)
ZA (1)	ZA887925B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR242678A1 (es) *	1986-03-05	1993-04-30	Gonzalez Jorge Alberto	Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) *	1987-04-03	1989-01-10	American Home Products Corporation	Psychotropic polycyclic imides
SE8803429D0 (sv) *	1988-09-28	1988-09-28	Pharmacia Ab	Novel pyridyl- and pyrimidyl derivatives
DE68918832T2 (de) *	1988-12-28	1995-02-09	Suntory Ltd	Benzoxazepinderivate.
US5114936A (en) *	1990-08-23	1992-05-19	Hoechst-Roussel Pharmaceuticals Incorporated	6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
ES2099031B1 (es) *	1995-05-31	1997-12-01	Esteve Labor Dr	Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
NZ505845A (en) *	1997-12-22	2003-10-31	Bayer Ag	Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
DE69937045T2 (de) *	1998-02-19	2008-05-29	Kowa Co., Ltd., Nagoya	Cyclische amidderivate
GB9902989D0 (en) *	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
UA77526C2 (en) *	2002-06-07	2006-12-15	Sanofi Aventis	Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862968B1 (fr) *	2003-12-01	2006-08-04	Sanofi Synthelabo	Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
FR2862967B1 (fr) *	2003-12-01	2006-08-04	Sanofi Synthelabo	Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
EP2318388A2 (en) *	2008-07-23	2011-05-11	Schering Corporation	Tricyclic spirocycle derivatives and methods of use thereof
US8617801B2 (en) *	2009-06-03	2013-12-31	Carestream Health, Inc.	Film with blue dye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US466691A (en) *		1892-01-05		Egg-crate
US2672460A (en) *	1952-06-24	1954-03-16	American Cyanamid Co	Disubstituted piperazines and methods of preparing the same
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4666911A (en) *	1981-07-14	1987-05-19	Taiho Pharmaceutical Company Limited	Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4605655A (en) *	1984-03-06	1986-08-12	Bristol-Myers Company	Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
JPS6175A (ja) *	1984-03-06	1986-01-06	ブリストル−マイア−ズ　コムパニ−	神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
US4562255A (en) *	1984-03-30	1985-12-31	American Home Products Corporation	Substituted bi-alicyclic imides
US4668687A (en) *	1984-07-23	1987-05-26	Bristol-Myers Company	Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
AR242678A1 (es) *	1986-03-05	1993-04-30	Gonzalez Jorge Alberto	Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) *	1987-04-03	1989-01-10	American Home Products Corporation	Psychotropic polycyclic imides

1987
- 1987-10-26 US US07/477,835 patent/US4994455A/en not_active Expired - Lifetime
- 1987-10-26 HU HU876036A patent/HU206109B/hu not_active IP Right Cessation
- 1987-10-26 HU HU913849A patent/HU208690B/hu not_active IP Right Cessation
- 1987-10-26 MX MX013562A patent/MX173180B/es unknown
- 1987-10-26 WO PCT/US1987/002855 patent/WO1989003831A1/en not_active Ceased
1988
- 1988-10-17 DE DE8888309725T patent/DE3880077T2/de not_active Expired - Fee Related
- 1988-10-17 EP EP88309725A patent/EP0314363B1/en not_active Expired - Lifetime
- 1988-10-17 ES ES88309725T patent/ES2054823T3/es not_active Expired - Lifetime
- 1988-10-17 AT AT88309725T patent/ATE87919T1/de not_active IP Right Cessation
- 1988-10-19 IL IL88085A patent/IL88085A/xx not_active IP Right Cessation
- 1988-10-21 MY MYPI88001197A patent/MY103435A/en unknown
- 1988-10-24 CN CN88107386A patent/CN1022246C/zh not_active Expired - Fee Related
- 1988-10-24 ZA ZA887925A patent/ZA887925B/xx unknown
- 1988-10-24 PT PT88835A patent/PT88835B/pt not_active IP Right Cessation
- 1988-10-24 JP JP63268008A patent/JPH0643406B2/ja not_active Expired - Lifetime
- 1988-10-24 DD DD88337989A patent/DD298397A5/de not_active IP Right Cessation
- 1988-10-24 CA CA000581091A patent/CA1314881C/en not_active Expired - Fee Related
- 1988-10-24 DD DD88321032A patent/DD283388A5/de not_active IP Right Cessation
- 1988-10-25 PL PL1988275476A patent/PL152117B1/pl unknown
- 1988-10-25 KR KR1019880013911A patent/KR900006722B1/ko not_active Expired
- 1988-10-25 DK DK591488A patent/DK171788B1/da active
- 1988-10-25 AU AU24327/88A patent/AU598161B2/en not_active Ceased
- 1988-10-25 PL PL1988279558A patent/PL153184B1/pl unknown
- 1988-10-25 IE IE321888A patent/IE63285B1/en not_active IP Right Cessation
- 1988-10-25 YU YU198988A patent/YU46592B/sh unknown
- 1988-10-25 NZ NZ226691A patent/NZ226691A/en unknown
- 1988-10-26 PH PH37726A patent/PH25106A/en unknown
- 1988-10-26 CS CS708088A patent/CS274441B2/cs not_active IP Right Cessation
1989
- 1989-03-02 CS CS135189A patent/CS274446B2/cs not_active IP Right Cessation
1990
- 1990-04-11 NO NO1990901652A patent/NO901652D0/no unknown
- 1990-04-25 RU SU904743942A patent/RU2029768C1/ru active
- 1990-04-25 FI FI902070A patent/FI94638C/fi not_active IP Right Cessation
- 1990-04-25 NO NO1990901826A patent/NO901826D0/no unknown

Also Published As

Publication number	Publication date
DK591488D0 (da)	1988-10-25
FI902070A0 (fi)	1990-04-25
PL275476A1 (en)	1989-09-18
AU598161B2 (en)	1990-06-14
HUT58724A (en)	1992-03-30
PH25106A (en)	1991-02-19
KR890006621A (ko)	1989-06-14
US4994455A (en)	1991-02-19
PL152117B1 (en)	1990-11-30
MX13562A (es)	1993-04-01
WO1989003831A1 (en)	1989-05-05
EP0314363B1 (en)	1993-04-07
CS274441B2 (en)	1991-04-11
HUT59393A (en)	1992-05-28
CN1042148A (zh)	1990-05-16
DK171788B1 (da)	1997-05-26
KR900006722B1 (ko)	1990-09-20
NO901652L (no)	1990-04-11
ZA887925B (en)	1990-06-27
PL279558A1 (en)	1990-01-08
CN1022246C (zh)	1993-09-29
DD283388A5 (de)	1990-10-10
NO901652D0 (no)	1990-04-11
FI94638B (fi)	1995-06-30
MX173180B (es)	1994-02-07
PT88835B (pt)	1993-01-29
DE3880077T2 (de)	1993-07-22
JPH01157979A (ja)	1989-06-21
IL88085A (en)	1993-02-21
DE3880077D1 (de)	1993-05-13
FI94638C (fi)	1995-10-10
YU46592B (sh)	1993-11-16
CA1314881C (en)	1993-03-23
HU913849D0 (en)	1992-03-30
NZ226691A (en)	1990-04-26
IE63285B1 (en)	1995-04-05
YU198988A (en)	1990-06-30
IE883218L (en)	1989-04-26
HU206109B (en)	1992-08-28
DD298397A5 (de)	1992-02-20
RU2029768C1 (ru)	1995-02-27
EP0314363A3 (en)	1990-07-11
EP0314363A2 (en)	1989-05-03
JPH0643406B2 (ja)	1994-06-08
ATE87919T1 (de)	1993-04-15
ES2054823T3 (es)	1994-08-16
DK591488A (da)	1989-04-27
HU208690B (en)	1993-12-28
CS708088A2 (en)	1990-08-14
MY103435A (en)	1993-06-30
PL153184B1 (en)	1991-03-29
AU2432788A (en)	1989-04-27
NO901826D0 (no)	1990-04-25
CS274446B2 (en)	1991-04-11

Legal Events

Date	Code	Title	Description
2000-06-30	IF00	In force as of 2000-06-30 in czech republic
2008-05-14	MM4A	Patent lapsed due to non-payment of fee	Effective date: 20071026

Publication	Publication Date	Title
CS708088A2 (en)	1990-08-14	Method of 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propanes production
DE69133406D1 (de)	2004-08-26	Herstellung von 1,3-disubstituierter imidazolsalzen
CO4900064A1 (es)	2000-03-27	Derivados de la 4-hidroxi-piperidina
IL74401A (en)	1988-11-30	1-(4-(haloalkyl thio)phenyl)-3-(2-halobenzoyl ureas,their production and use as insecticides and ovicides
HUT37797A (en)	1986-02-28	Process for production of tetrahydro-tieno-piridinderivatives and medical preparatives containing of such compounds
JPS6468359A (en)	1989-03-14	Novel benzimidazole derivative, manufacture and remedy for central nervous system disease
ATE40554T1 (de)	1989-02-15	Furo(3,2-c>pyridinderivate, ihre herstellung und ihre therapeutische verwendung.
NO864635L (no)	1987-06-15	Nye krystallinske salter av aryloksypropanolaminer, deres fremstilling og anvendelse.
ATE56713T1 (de)	1990-10-15	1,2,3,4,4a,9b-hexahydro-4aaminoalkyldibenzofurane, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE68911610D1 (de)	1994-02-03	Antigeschwür-Alkyldithio-Chinolin-Derivate.
ES2150564T3 (es)	2000-12-01	Proceso para la preparacion de derivados de 5,6-dihidroxi-2-amino-1,2,3,4-tetrahidronaftaleno.
NO911042D0 (no)	1991-03-15	Antipsykotiske 4-(4-(3-benzisotiazolyl)-1-piperazinyl)butyl brodannede bicykliske imider.
FI861001A0 (fi)	1986-03-11	Benzo/c/-1,5-naftyridiner, foerfarande foer deras framstaellning och i deras framstaellning anvaendbara mellanprodukter samt deras anvaendning saosom laekemedel.
ES8505517A2 (es)	1985-05-16	Mejoras en el objeto de la patente de invencion n 519.297 que se refiere a procedimiento de obtencion de nuevas 1,2-oxazetidinas
EP0110169A3 (en)	1985-04-17	4-(benzisothiazol-3-yl)phenoxyacetic-acid l',l'-dioxides, a process for preparing the same, intermediates thereof and their use as medicaments