DK591488A - 1-acyl-3-oe4-(2-pyrimidinyl)-1-piperazinylaapropan-forbindelser, deres anvendelse til fremstilling af et angstdaempende laegemiddel og farmaceutiske praeparater indeholdende disse forbindelser - Google Patents

1-acyl-3-oe4-(2-pyrimidinyl)-1-piperazinylaapropan-forbindelser, deres anvendelse til fremstilling af et angstdaempende laegemiddel og farmaceutiske praeparater indeholdende disse forbindelser

Info

Publication number: DK591488A
Authority: DK; Denmark
Prior art keywords: pyrimidinyl; piperazinylaapropan; anxicative; acyl; medicine
Prior art date: 1987-10-26

Application number

DK591488A

Other languages

English (en)

Other versions

DK591488D0 (da

DK171788B1 (da

Inventor

Jr Willard Mckowan Welch

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-26

Filing date

1988-10-25

Publication date

1989-04-27

1988-10-25 Application filed by Pfizer filed Critical Pfizer

1988-10-25 Publication of DK591488D0 publication Critical patent/DK591488D0/da

1989-04-27 Publication of DK591488A publication Critical patent/DK591488A/da

1997-05-26 Application granted granted Critical

1997-05-26 Publication of DK171788B1 publication Critical patent/DK171788B1/da

Links

AFNJMVYFZNHDRX-UHFFFAOYSA-N [C]1=NC=CC=N1 Chemical class [C]1=NC=CC=N1 AFNJMVYFZNHDRX-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Graft Or Block Polymers (AREA)

DK591488A 1987-10-26 1988-10-25 1-Acyl-3-[4-(2-pyrimidinyl)-1-piperazinyl]propan-forbindelser, og deres anvendelse til fremstilling af angstdæmpende lægemidler og farmaceutiske præparater indeholdende disse forbindelser DK171788B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1987/002855 WO1989003831A1 (en)	1987-10-26	1987-10-26	Anti-anxiety agents
US8702855		1987-10-26

Publications (3)

Publication Number	Publication Date
DK591488D0 DK591488D0 (da)	1988-10-25
DK591488A true DK591488A (da)	1989-04-27
DK171788B1 DK171788B1 (da)	1997-05-26

Family

ID=22202642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK591488A DK171788B1 (da)	1987-10-26	1988-10-25	1-Acyl-3-[4-(2-pyrimidinyl)-1-piperazinyl]propan-forbindelser, og deres anvendelse til fremstilling af angstdæmpende lægemidler og farmaceutiske præparater indeholdende disse forbindelser

Country Status (28)

Country	Link
US (1)	US4994455A (da)
EP (1)	EP0314363B1 (da)
JP (1)	JPH0643406B2 (da)
KR (1)	KR900006722B1 (da)
CN (1)	CN1022246C (da)
AT (1)	ATE87919T1 (da)
AU (1)	AU598161B2 (da)
CA (1)	CA1314881C (da)
CS (2)	CS274441B2 (da)
DD (2)	DD298397A5 (da)
DE (1)	DE3880077T2 (da)
DK (1)	DK171788B1 (da)
ES (1)	ES2054823T3 (da)
FI (1)	FI94638C (da)
HU (2)	HU208690B (da)
IE (1)	IE63285B1 (da)
IL (1)	IL88085A (da)
MX (1)	MX173180B (da)
MY (1)	MY103435A (da)
NO (2)	NO901652L (da)
NZ (1)	NZ226691A (da)
PH (1)	PH25106A (da)
PL (2)	PL153184B1 (da)
PT (1)	PT88835B (da)
RU (1)	RU2029768C1 (da)
WO (1)	WO1989003831A1 (da)
YU (1)	YU46592B (da)
ZA (1)	ZA887925B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR242678A1 (es) *	1986-03-05	1993-04-30	Gonzalez Jorge Alberto	Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) *	1987-04-03	1989-01-10	American Home Products Corporation	Psychotropic polycyclic imides
SE8803429D0 (sv) *	1988-09-28	1988-09-28	Pharmacia Ab	Novel pyridyl- and pyrimidyl derivatives
EP0376633B1 (en) *	1988-12-28	1994-10-12	Suntory Limited	Benzoxazepine derivatives
US5114936A (en) *	1990-08-23	1992-05-19	Hoechst-Roussel Pharmaceuticals Incorporated	6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
ES2099031B1 (es) *	1995-05-31	1997-12-01	Esteve Labor Dr	Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
PT1056725E (pt) *	1997-12-22	2006-09-29	Bayer Pharmaceuticals Corp	Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo
AU747815B2 (en) *	1998-02-19	2002-05-23	Kowa Co., Ltd.	Cyclic amide compounds
GB9902989D0 (en) *	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
UA77526C2 (en) *	2002-06-07	2006-12-15	Sanofi Aventis	Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862967B1 (fr) *	2003-12-01	2006-08-04	Sanofi Synthelabo	Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
FR2862968B1 (fr) *	2003-12-01	2006-08-04	Sanofi Synthelabo	Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
EP2318388A2 (en) *	2008-07-23	2011-05-11	Schering Corporation	Tricyclic spirocycle derivatives and methods of use thereof
US8617801B2 (en) *	2009-06-03	2013-12-31	Carestream Health, Inc.	Film with blue dye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US466691A (en) *		1892-01-05		Egg-crate
US2672460A (en) *	1952-06-24	1954-03-16	American Cyanamid Co	Disubstituted piperazines and methods of preparing the same
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4666911A (en) *	1981-07-14	1987-05-19	Taiho Pharmaceutical Company Limited	Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4605655A (en) *	1984-03-06	1986-08-12	Bristol-Myers Company	Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
JPS6175A (ja) *	1984-03-06	1986-01-06	ブリストル−マイア−ズ　コムパニ−	神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
US4562255A (en) *	1984-03-30	1985-12-31	American Home Products Corporation	Substituted bi-alicyclic imides
US4668687A (en) *	1984-07-23	1987-05-26	Bristol-Myers Company	Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
AR242678A1 (es) *	1986-03-05	1993-04-30	Gonzalez Jorge Alberto	Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) *	1987-04-03	1989-01-10	American Home Products Corporation	Psychotropic polycyclic imides

1987
- 1987-10-26 MX MX013562A patent/MX173180B/es unknown
- 1987-10-26 HU HU913849A patent/HU208690B/hu not_active IP Right Cessation
- 1987-10-26 WO PCT/US1987/002855 patent/WO1989003831A1/en not_active Ceased
- 1987-10-26 US US07/477,835 patent/US4994455A/en not_active Expired - Lifetime
- 1987-10-26 HU HU876036A patent/HU206109B/hu not_active IP Right Cessation
1988
- 1988-10-17 AT AT88309725T patent/ATE87919T1/de not_active IP Right Cessation
- 1988-10-17 EP EP88309725A patent/EP0314363B1/en not_active Expired - Lifetime
- 1988-10-17 DE DE8888309725T patent/DE3880077T2/de not_active Expired - Fee Related
- 1988-10-17 ES ES88309725T patent/ES2054823T3/es not_active Expired - Lifetime
- 1988-10-19 IL IL88085A patent/IL88085A/xx not_active IP Right Cessation
- 1988-10-21 MY MYPI88001197A patent/MY103435A/en unknown
- 1988-10-24 DD DD88337989A patent/DD298397A5/de not_active IP Right Cessation
- 1988-10-24 CN CN88107386A patent/CN1022246C/zh not_active Expired - Fee Related
- 1988-10-24 ZA ZA887925A patent/ZA887925B/xx unknown
- 1988-10-24 CA CA000581091A patent/CA1314881C/en not_active Expired - Fee Related
- 1988-10-24 JP JP63268008A patent/JPH0643406B2/ja not_active Expired - Lifetime
- 1988-10-24 DD DD88321032A patent/DD283388A5/de not_active IP Right Cessation
- 1988-10-24 PT PT88835A patent/PT88835B/pt not_active IP Right Cessation
- 1988-10-25 KR KR1019880013911A patent/KR900006722B1/ko not_active Expired
- 1988-10-25 PL PL1988279558A patent/PL153184B1/pl unknown
- 1988-10-25 DK DK591488A patent/DK171788B1/da active
- 1988-10-25 PL PL1988275476A patent/PL152117B1/pl unknown
- 1988-10-25 IE IE321888A patent/IE63285B1/en not_active IP Right Cessation
- 1988-10-25 NZ NZ226691A patent/NZ226691A/en unknown
- 1988-10-25 AU AU24327/88A patent/AU598161B2/en not_active Ceased
- 1988-10-25 YU YU198988A patent/YU46592B/sh unknown
- 1988-10-26 CS CS708088A patent/CS274441B2/cs not_active IP Right Cessation
- 1988-10-26 PH PH37726A patent/PH25106A/en unknown
1989
- 1989-03-02 CS CS135189A patent/CS274446B2/cs not_active IP Right Cessation
1990
- 1990-04-11 NO NO90901652A patent/NO901652L/no unknown
- 1990-04-25 FI FI902070A patent/FI94638C/fi not_active IP Right Cessation
- 1990-04-25 RU SU904743942A patent/RU2029768C1/ru active
- 1990-04-25 NO NO1990901826A patent/NO901826D0/no unknown

Also Published As

Publication number	Publication date
CS274441B2 (en)	1991-04-11
HU913849D0 (en)	1992-03-30
FI902070A0 (fi)	1990-04-25
MY103435A (en)	1993-06-30
HU208690B (en)	1993-12-28
PL153184B1 (en)	1991-03-29
DE3880077T2 (de)	1993-07-22
DK591488D0 (da)	1988-10-25
IE883218L (en)	1989-04-26
ES2054823T3 (es)	1994-08-16
JPH0643406B2 (ja)	1994-06-08
JPH01157979A (ja)	1989-06-21
YU46592B (sh)	1993-11-16
FI94638C (fi)	1995-10-10
KR890006621A (ko)	1989-06-14
CS708088A2 (en)	1990-08-14
ZA887925B (en)	1990-06-27
EP0314363B1 (en)	1993-04-07
NO901826D0 (no)	1990-04-25
DE3880077D1 (de)	1993-05-13
CA1314881C (en)	1993-03-23
CS135189A2 (en)	1990-08-14
CS274446B2 (en)	1991-04-11
EP0314363A2 (en)	1989-05-03
ATE87919T1 (de)	1993-04-15
KR900006722B1 (ko)	1990-09-20
HU206109B (en)	1992-08-28
NO901652D0 (no)	1990-04-11
PL152117B1 (en)	1990-11-30
HUT58724A (en)	1992-03-30
NO901652L (no)	1990-04-11
MX173180B (es)	1994-02-07
DD298397A5 (de)	1992-02-20
IL88085A (en)	1993-02-21
PH25106A (en)	1991-02-19
NZ226691A (en)	1990-04-26
AU598161B2 (en)	1990-06-14
PL275476A1 (en)	1989-09-18
DD283388A5 (de)	1990-10-10
RU2029768C1 (ru)	1995-02-27
CN1022246C (zh)	1993-09-29
DK171788B1 (da)	1997-05-26
FI94638B (fi)	1995-06-30
PL279558A1 (en)	1990-01-08
US4994455A (en)	1991-02-19
MX13562A (es)	1993-04-01
YU198988A (en)	1990-06-30
PT88835B (pt)	1993-01-29
WO1989003831A1 (en)	1989-05-05
EP0314363A3 (en)	1990-07-11
IE63285B1 (en)	1995-04-05
CN1042148A (zh)	1990-05-16
AU2432788A (en)	1989-04-27
HUT59393A (en)	1992-05-28

Publication	Publication Date	Title
DK591488A (da)	1989-04-27	1-acyl-3-oe4-(2-pyrimidinyl)-1-piperazinylaapropan-forbindelser, deres anvendelse til fremstilling af et angstdaempende laegemiddel og farmaceutiske praeparater indeholdende disse forbindelser
DK158838C (da)	1991-01-14	Quinazolinderivater, en fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende derivater samt anvendelse af derivaterne til fremstilling af medikamenter
NO984414D0 (no)	1998-09-22	Nye 5-ring-heterocykler, deres fremstilling, deres anvendelse og farmas°ytiske preparater inneholdende disse
DK154385A (da)	1985-10-07	Tetrahydrothienopyridiner eller farmaceutisk uskadelige salte deraf, deres fremstilling og anvendelse som laegemidler
NO162821C (no)	1990-02-21	Fremgangsmaate for fremstilling av terapeutisk aktive furo-pyridinderivater.
DK474288D0 (da)	1988-08-25	Benzimidazolderivater og fremgangsmaade til fremstilling deraf samt laegemiddel indeholdende benzimidazolderivaterne
DK114286A (da)	1986-09-14	Pyridylmethylnaphthylderivater eller fysiologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse som laegemidler
DK73289D0 (da)	1989-02-17	Basisk substituerede 5-halogen-thienoisothiazol-3(2h)-on-1,1-dioxider, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse
DK222588D0 (da)	1988-04-22	5-quinoxalyl-imidazolidin-2,4-dioner, deres fremstilling og anvendelse som laegemidler
DK456389A (da)	1990-03-17	Broforbundne bicycliske imider med en 4-oe4-(3-benzisothiazolyl)-1-piperazinylaabutylgruppe knyttet til imidnitrogenatomer og antipsykotisk farmaceutiske praeparater indeholdende disse
DK118988A (da)	1988-09-07	1-(1-aryl-2-hydroxy-ethyl)-imidazoler og deres salte, deres fremstilling og anvendelse i laegemidler
NO881554L (no)	1988-10-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-((1,1-difenyl)-1-alkenyl)piperazin-derivater og farmasoeytisk aksepterbare salter av disse derivater.
DK0586344T3 (da)	1999-06-07	Oxazolidinforbindelser og deres anvendelse som lægemidler
FI841293A0 (fi)	1984-03-30	Iminosulfonamider och foerfarande foer deras framstaellning, dessa foereningar innehaollande farmaceutiska prepara preparat samt deras anvaendning.
DK222886D0 (da)	1986-05-14	Propionylanilider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse forbindelser