CS254978B2 - Agent for glucose,cholesterol and haemoglobin determination - Google Patents

Agent for glucose,cholesterol and haemoglobin determination Download PDF

Info

Publication number: CS254978B2
Authority: CS; Czechoslovakia
Prior art keywords: liter; mmol; glucose; cholesterol; concentration
Prior art date: 1983-09-02

Application number

CS846580A

Other languages

Czech (cs)

English (en)

Other versions

CS658084A2 (en

Inventor

Ferenc Farago

Tamas Jancso

Ivan Daroszi

Gabriella Zajka

Original Assignee

Reanal Finomvegyszergyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-02

Filing date

1984-08-31

Publication date

1988-02-15

1984-08-31 Application filed by Reanal Finomvegyszergyar filed Critical Reanal Finomvegyszergyar

1987-07-16 Publication of CS658084A2 publication Critical patent/CS658084A2/cs

1988-02-15 Publication of CS254978B2 publication Critical patent/CS254978B2/cs

Links

WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 24
239000008103 glucose Substances 0.000 title claims description 24
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims description 23
235000012000 cholesterol Nutrition 0.000 title claims description 11
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title claims description 9
239000003795 chemical substances by application Substances 0.000 title description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 claims description 18
239000003153 chemical reaction reagent Substances 0.000 claims description 13
102000001554 Hemoglobins Human genes 0.000 claims description 6
108010054147 Hemoglobins Proteins 0.000 claims description 6
239000012472 biological sample Substances 0.000 claims description 4
239000003599 detergent Substances 0.000 claims description 3
230000002255 enzymatic effect Effects 0.000 claims description 3
239000007853 buffer solution Substances 0.000 claims description 2
239000003054 catalyst Substances 0.000 claims description 2
239000003381 stabilizer Substances 0.000 claims description 2
IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 claims 2
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 30
230000008033 biological extinction Effects 0.000 description 19
238000000034 method Methods 0.000 description 18
239000000243 solution Substances 0.000 description 17
239000005844 Thymol Substances 0.000 description 15
229960000790 thymol Drugs 0.000 description 15
239000000126 substance Substances 0.000 description 9
238000005259 measurement Methods 0.000 description 8
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 7
238000006243 chemical reaction Methods 0.000 description 7
102000003992 Peroxidases Human genes 0.000 description 6
108040007629 peroxidase activity proteins Proteins 0.000 description 6
-1 polyethylethylene Polymers 0.000 description 6
210000002966 serum Anatomy 0.000 description 6
238000012360 testing method Methods 0.000 description 5
210000004369 blood Anatomy 0.000 description 4
239000008280 blood Substances 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000000523 sample Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 3
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
229940116269 uric acid Drugs 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000007836 KH2PO4 Substances 0.000 description 2
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
229920004890 Triton X-100 Polymers 0.000 description 2
239000013504 Triton X-100 Substances 0.000 description 2
235000013361 beverage Nutrition 0.000 description 2
238000001816 cooling Methods 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000006911 enzymatic reaction Methods 0.000 description 2
229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
238000005457 optimization Methods 0.000 description 2
238000007430 reference method Methods 0.000 description 2
WYXXLXHHWYNKJF-UHFFFAOYSA-N 2-methyl-4-propan-2-ylphenol Chemical compound CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
YFTNYASYRGXQAA-UHFFFAOYSA-N 5-amino-1,5-dimethyl-2-phenylpyrazolidin-3-one Chemical compound C1(=CC=CC=C1)N1N(C(CC1=O)(N)C)C YFTNYASYRGXQAA-UHFFFAOYSA-N 0.000 description 1
238000008620 Cholesterol Assay Methods 0.000 description 1
108010089254 Cholesterol oxidase Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004366 Glucosidases Human genes 0.000 description 1
108010056771 Glucosidases Proteins 0.000 description 1
102000005548 Hexokinase Human genes 0.000 description 1
108700040460 Hexokinases Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
108010055297 Sterol Esterase Proteins 0.000 description 1
102000000019 Sterol Esterase Human genes 0.000 description 1
108010092464 Urate Oxidase Proteins 0.000 description 1
235000013334 alcoholic beverage Nutrition 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
150000001558 benzoic acid derivatives Chemical class 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
239000012535 impurity Substances 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
230000031700 light absorption Effects 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
229960005222 phenazone Drugs 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
238000005375 photometry Methods 0.000 description 1
229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000000630 rising effect Effects 0.000 description 1
229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
150000003872 salicylic acid derivatives Chemical class 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
SPOMEWBVWWDQBC-UHFFFAOYSA-K tripotassium;dihydrogen phosphate;hydrogen phosphate Chemical compound [K+].[K+].[K+].OP(O)([O-])=O.OP([O-])([O-])=O SPOMEWBVWWDQBC-UHFFFAOYSA-K 0.000 description 1
JLEXUIVKURIPFI-UHFFFAOYSA-N tris phosphate Chemical compound OP(O)(O)=O.OCC(N)(CO)CO JLEXUIVKURIPFI-UHFFFAOYSA-N 0.000 description 1
PGUDRSADMCSYHV-UHFFFAOYSA-N trisodium borate hydrochloride Chemical compound [Na+].[Na+].[Na+].Cl.[O-]B([O-])[O-] PGUDRSADMCSYHV-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/62—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving uric acid
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/50—Phenols; Naphthols; Catechols
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
- C12Q2326/90—Developer
- C12Q2326/96—4-Amino-antipyrine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

CS846580A 1983-09-02 1984-08-31 Agent for glucose,cholesterol and haemoglobin determination CS254978B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU833059A HU188953B (en)	1983-09-02	1983-09-02	Reagent for determination of glucose, colestherin and carbamide

Publications (2)

Publication Number	Publication Date
CS658084A2 CS658084A2 (en)	1987-07-16
CS254978B2 true CS254978B2 (en)	1988-02-15

Family

ID=10962331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS846580A CS254978B2 (en)	1983-09-02	1984-08-31	Agent for glucose,cholesterol and haemoglobin determination

Country Status (9)

Country	Link
CH (1)	CH669673A5 (pl)
CS (1)	CS254978B2 (pl)
DD (1)	DD232558A5 (pl)
DE (1)	DE3432348A1 (pl)
FI (1)	FI77941C (pl)
HU (1)	HU188953B (pl)
IN (1)	IN163164B (pl)
PL (1)	PL141984B1 (pl)
SU (1)	SU1505444A3 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0218083A1 (en) *	1985-09-03	1987-04-15	Abbott Laboratories	Stabilized cholesterol reagent and method for determining total cholesterol using the reagent

1983
- 1983-09-02 HU HU833059A patent/HU188953B/hu not_active IP Right Cessation
1984
- 1984-08-31 SU SU843786908A patent/SU1505444A3/ru active
- 1984-08-31 CS CS846580A patent/CS254978B2/cs unknown
- 1984-08-31 FI FI843428A patent/FI77941C/fi not_active IP Right Cessation
- 1984-08-31 DD DD84266856A patent/DD232558A5/de not_active IP Right Cessation
- 1984-08-31 PL PL1984249428A patent/PL141984B1/pl unknown
- 1984-09-03 DE DE19843432348 patent/DE3432348A1/de not_active Withdrawn
1985
- 1985-02-18 IN IN134/DEL/85A patent/IN163164B/en unknown
- 1985-05-08 CH CH1983/85A patent/CH669673A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CS658084A2 (en)	1987-07-16
FI77941B (fi)	1989-01-31
IN163164B (pl)	1988-08-20
FI843428L (fi)	1985-03-03
HU188953B (en)	1986-05-28
FI843428A0 (fi)	1984-08-31
PL249428A1 (en)	1985-05-21
FI77941C (fi)	1989-05-10
DD232558A5 (de)	1986-01-29
DE3432348A1 (de)	1985-03-21
PL141984B1 (en)	1987-09-30
CH669673A5 (pl)	1989-03-31
SU1505444A3 (ru)	1989-08-30

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