CS274640B2 - Method of mevinic acids and their analogues lactonization - Google Patents

Method of mevinic acids and their analogues lactonization

Info

Publication number
CS274640B2
CS274640B2 CS435489A CS435489A CS274640B2 CS 274640 B2 CS274640 B2 CS 274640B2 CS 435489 A CS435489 A CS 435489A CS 435489 A CS435489 A CS 435489A CS 274640 B2 CS274640 B2 CS 274640B2
Authority
CS
Czechoslovakia
Prior art keywords
lactonization
analogues
mevinic
acids
mevinic acids
Prior art date
Application number
CS435489A
Other languages
Czech (cs)
English (en)
Other versions
CS435489A2 (en
Inventor
Laszlo R Treiber
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22827965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS274640(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CS435489A2 publication Critical patent/CS435489A2/cs
Publication of CS274640B2 publication Critical patent/CS274640B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS435489A 1988-07-19 1989-07-17 Method of mevinic acids and their analogues lactonization CS274640B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/221,475 US4916239A (en) 1988-07-19 1988-07-19 Process for the lactonization of mevinic acids and analogs thereof

Publications (2)

Publication Number Publication Date
CS435489A2 CS435489A2 (en) 1990-12-13
CS274640B2 true CS274640B2 (en) 1991-09-15

Family

ID=22827965

Family Applications (1)

Application Number Title Priority Date Filing Date
CS435489A CS274640B2 (en) 1988-07-19 1989-07-17 Method of mevinic acids and their analogues lactonization

Country Status (26)

Country Link
US (1) US4916239A (fr)
EP (1) EP0351918B1 (fr)
JP (3) JPH0273078A (fr)
KR (1) KR970011286B1 (fr)
CN (1) CN1022831C (fr)
AT (1) ATE111459T1 (fr)
AU (1) AU609319B2 (fr)
CA (1) CA1287639C (fr)
CS (1) CS274640B2 (fr)
CY (1) CY1813A (fr)
DE (1) DE68918191C5 (fr)
DK (1) DK173115B1 (fr)
ES (1) ES2058475T3 (fr)
FI (1) FI92695C (fr)
HK (1) HK136894A (fr)
HR (1) HRP930685B2 (fr)
HU (2) HU202511B (fr)
IE (1) IE64304B1 (fr)
IL (1) IL90925A (fr)
LV (1) LV11033B (fr)
NO (1) NO172800C (fr)
NZ (1) NZ229879A (fr)
PT (1) PT91191B (fr)
SI (1) SI8911362A (fr)
YU (1) YU47492B (fr)
ZA (1) ZA895458B (fr)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
GB9007738D0 (en) * 1990-04-05 1990-06-06 British Bio Technology Compounds
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
AU660132B2 (en) * 1992-12-21 1995-06-08 Bayer Aktiengesellschaft Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridine
WO1994016693A1 (fr) * 1993-01-19 1994-08-04 Warner-Lambert Company Formulation ci-981, orale, stable et son procede de preparation
IN186879B (fr) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186880B (fr) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
CA2240983A1 (fr) 1998-06-18 1999-12-18 Yong Tao Processus de fabrication de simvastatine et de produits intermediaires
HUP0103021A3 (en) * 1998-12-10 2002-04-29 Kaneka Corp Process for producing simvastatin derivatives
SK282679B6 (sk) * 1999-04-16 2002-11-06 Biotika, A. S. Spôsob izolácie lovastatínu z vyfermentovanej pôdy
AU5705000A (en) * 1999-06-29 2001-01-31 Kaneka Corporation Process for selective lactonization
CA2388182A1 (fr) 1999-10-27 2001-05-03 Merck & Co., Inc. Procede de lactonisation
TR200403001T3 (tr) 2000-03-03 2005-02-21 Plus Chemical, S.A. Lovastatin ve simvastatinin, azaltılmış dimerik katışkı seviyelerine sahip olacak şekilde arıtılması için bir işlem
NL1017548C2 (nl) * 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
US6797831B2 (en) * 2001-05-18 2004-09-28 Aurobindo Pharma Limited Process for lactonization to produce simvastatin
KR100407758B1 (ko) 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
US20050113577A1 (en) * 2002-04-16 2005-05-26 Karki Shyam B. Solid forms of slats with tyrosine kinase activity
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
ATE407670T1 (de) 2002-12-20 2008-09-15 Pfizer Prod Inc Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
CA2515179A1 (fr) 2003-02-11 2004-08-26 Ferenc Korodi Procede de preparation de simvastatine ayant des gammes regulees de contenu de dimere de simvastatine
AU2004266740B2 (en) 2003-08-21 2010-08-26 Merck Frosst Canada Ltd Cathepsin cysteine protease inhibitors
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
ATE414071T1 (de) * 2004-03-30 2008-11-15 Lupin Ltd Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten
AU2004323102A1 (en) * 2004-09-08 2006-03-16 Jubilant Organosys Limited An improved process for lactonization in the preparation of statins
EP1807070A1 (fr) * 2004-09-29 2007-07-18 Schering Corporation Combinaisons d'azetidinones substituees et d'antagonistes cb1
WO2006059346A2 (fr) * 2004-12-01 2006-06-08 Morepen Laboratories Limited Procede de lactonisation ameliore permettant de produire des statines hautement purifiees
EP1827421B1 (fr) 2004-12-09 2017-09-27 Merck Sharp & Dohme Corp. Modulateurs du recepteur de l'oestrogene
SI1855674T1 (sl) 2005-03-02 2014-10-30 Merck Sharp & Dohme Corp. Sestavek za inhibicijo katepsina k
EP1888050B1 (fr) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. Acide cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl) cyclohexanepropanoique pour le traitement du cancer
EP1741427A1 (fr) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Composition pharmaceutique comprenant la simvastatin et l'ezetimibe
WO2007020079A2 (fr) * 2005-08-17 2007-02-22 Synthon B.V. Comprimes de simvastatine a desintegration orale
PE20070427A1 (es) 2005-08-30 2007-04-21 Novartis Ag Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
US20070117996A1 (en) * 2005-11-21 2007-05-24 Srinivasulu Gudipati Process for preparing simvastatin
US20070161578A1 (en) * 2005-12-21 2007-07-12 Hwa Joyce J Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist
JP2009521445A (ja) * 2005-12-21 2009-06-04 シェーリング コーポレイション Ｈ３アンタゴニスト／逆アゴニストと食欲抑制剤との組み合わせ
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
PL2010528T3 (pl) 2006-04-19 2018-03-30 Novartis Ag 6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r
WO2008030382A1 (fr) * 2006-09-05 2008-03-13 Schering Corporation Compositions pharmaceutiques pour un traitement des lipides et dans le traitement de l'athérosclérose et de la stéatose hépatique
EP2698157B1 (fr) 2006-09-22 2015-05-20 Merck Sharp & Dohme Corp. Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2805945B1 (fr) 2007-01-10 2019-04-03 MSD Italia S.r.l. Indazoles substitués d'amide en tant qu'inhibiteurs PARP de poly(ADP-ribose)polymérase
ES2431163T3 (es) 2007-03-01 2013-11-25 Novartis Ag Inhibidores de PIM quinasa y métodos para su uso
ES2452349T3 (es) 2007-05-21 2014-04-01 Novartis Ag Inhibidores de CSF-1R, composiciones, y métodos de uso
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US20090048335A1 (en) * 2007-08-17 2009-02-19 Venkata Naga Mandava Process for preparing simvastatin
PT2222636E (pt) 2007-12-21 2013-07-16 Ligand Pharm Inc Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações
US8414958B2 (en) * 2008-02-27 2013-04-09 Thommen Medical Ag Implant and method for the manufacture thereof
EP2204170A1 (fr) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Composition pharmaceutique comprenant ézétimide et simvastatine
EP2216016A1 (fr) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Procédé pour la préparation d'une composition pharmaceutique comprenant de l'ézétimibe
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
EP2488028B1 (fr) 2009-10-14 2020-08-19 Merck Sharp & Dohme Corp. Pipéridines substituées qui accroissent l'activité de p53 et utilisations de ces composés
CN104098537A (zh) * 2009-11-20 2014-10-15 北大医药股份有限公司 制备他汀类化合物的内酯化方法
CN101704808A (zh) 2009-11-20 2010-05-12 西南合成制药股份有限公司 制备他汀类化合物的内酯化方法
EP2368543A1 (fr) 2010-03-25 2011-09-28 KRKA, tovarna zdravil, d.d., Novo mesto Procédé de préparation de composition pharmaceutique granulée comprenant de la simvastatine et/ou ézétimibe
WO2011163330A1 (fr) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
CN107090456B (zh) 2010-08-02 2022-01-18 瑟纳治疗公司 使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
JP2013537423A (ja) 2010-08-17 2013-10-03 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (fr) 2010-09-01 2012-03-08 Schering Corporation Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
EP2615916B1 (fr) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
CA139852S (en) 2010-10-15 2011-11-23 Reno de Medici SpA Christmas tree
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (fr) 2010-12-21 2012-06-28 Schering Corporation Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
WO2012112363A1 (fr) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Inhibiteurs de cystéine protéases, les cathepsines
EP2699568A1 (fr) 2011-04-21 2014-02-26 Piramal Enterprises Limited Forme cristalline d'un sel d'un dérivé de morpholinosulfonylindole et son procédé de préparation
WO2013031729A1 (fr) 2011-08-26 2013-03-07 国立大学法人大阪大学 Agent prophylactique/thérapeutique pour les complications vasculaires du diabète
WO2013063214A1 (fr) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Nouveaux composés qui sont des inhibiteurs d'erk
EP2597092A1 (fr) 2011-11-24 2013-05-29 Sterling Biotech Limited Procédé de purification de la lovastatine
EP2844261B1 (fr) 2012-05-02 2018-10-17 Sirna Therapeutics, Inc. Compositions de petit acide nucléique interférent (sina)
CN105050598B (zh) 2012-09-28 2018-04-27 默沙东公司 作为erk抑制剂的新型化合物
RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
US8846657B2 (en) 2012-12-20 2014-09-30 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
WO2014120748A1 (fr) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
EP3041938A1 (fr) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Polynucléotides circulaires
EP3055314B1 (fr) 2013-10-08 2018-09-12 Merck Sharp & Dohme Corp. Inhibiteurs de cysteine protease de type cathepsine
WO2015051479A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Inhibiteurs de cystéine-protéases de type cathepsines
US10441567B2 (en) 2014-01-17 2019-10-15 Ligand Pharmaceuticals Incorporated Methods and compositions for modulating hormone levels
WO2015120580A1 (fr) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Inhibiteurs de protéases à cystéine de type cathépsines
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
EP3706742B1 (fr) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3833667B1 (fr) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
EP3833668B1 (fr) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
WO2020033285A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
CA3108388A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
MX2021012690A (es) 2019-04-19 2022-01-31 Ligand Pharm Inc Formas cristalinas y metodos para producir formas cristalinas de un compuesto.
EP4076460B1 (fr) 2019-12-17 2026-01-21 Merck Sharp & Dohme LLC Dérivés de 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine] en tant qu'inhibiteurs de prmt5 pour le traitement du cancer
JP7589247B2 (ja) 2019-12-17 2024-11-25 メルク・シャープ・アンド・ドーム・エルエルシー Ｐｒｍｔ５阻害剤
WO2021126728A1 (fr) 2019-12-17 2021-06-24 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
WO2024180169A1 (fr) 2023-03-02 2024-09-06 Carcimun Biotech Gmbh Moyens et procédés de diagnostic du cancer et/ou d'une maladie inflammatoire aiguë
WO2025147589A1 (fr) 2024-01-05 2025-07-10 Osanni Bio, Inc. Implants, compositions et méthodes de traitement de maladies et de troubles de la rétine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes
JPS5948418A (ja) * 1982-09-10 1984-03-19 Sankyo Co Ltd 高血清過酸化脂質血症治療剤
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4611068A (en) * 1984-11-19 1986-09-09 Merck Frosst Canada, Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
US4611067A (en) * 1985-01-31 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
US4772626A (en) * 1986-01-31 1988-09-20 Merck & Co., Inc. Antihypercholesterolemic compounds
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
US4857546A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof

Also Published As

Publication number Publication date
NO172800C (no) 1993-09-08
FI92695B (fi) 1994-09-15
HUT50804A (en) 1990-03-28
IL90925A (en) 1993-04-04
SI8911362A (en) 1997-02-28
HK136894A (en) 1994-12-09
ES2058475T3 (es) 1994-11-01
KR910002828A (ko) 1991-02-26
IE892324L (en) 1990-01-19
HRP930685B1 (en) 1999-06-30
NO892938D0 (no) 1989-07-17
AU3824089A (en) 1990-01-25
PT91191A (pt) 1990-02-08
PT91191B (pt) 1995-03-01
AU609319B2 (en) 1991-04-26
EP0351918A1 (fr) 1990-01-24
LV11033B (en) 1996-06-20
CY1813A (en) 1995-10-20
DK354189A (da) 1990-01-22
LV11033A (lv) 1996-02-20
US4916239A (en) 1990-04-10
NO892938L (no) 1990-01-22
HU210533A9 (en) 1995-04-28
DK173115B1 (da) 2000-01-31
NZ229879A (en) 1991-12-23
CS435489A2 (en) 1990-12-13
FI893363A7 (fi) 1990-01-20
JPH07196642A (ja) 1995-08-01
NO172800B (no) 1993-06-01
JPH09188672A (ja) 1997-07-22
HRP930685A2 (en) 1998-06-30
ZA895458B (en) 1990-03-28
JPH0575752B2 (fr) 1993-10-21
DE68918191D1 (de) 1994-10-20
DE68918191T2 (de) 1995-03-02
ATE111459T1 (de) 1994-09-15
YU47492B (sh) 1995-10-03
IE64304B1 (en) 1995-07-26
HRP930685B2 (hr) 2006-11-30
JP2718422B2 (ja) 1998-02-25
YU136289A (en) 1991-02-28
DE68918191C5 (de) 2005-06-09
FI893363A0 (fi) 1989-07-11
KR970011286B1 (ko) 1997-07-09
IE892324A1 (en) 1991-06-19
FI92695C (fi) 1994-12-27
IL90925A0 (en) 1990-02-09
DK354189D0 (da) 1989-07-18
EP0351918B1 (fr) 1994-09-14
CN1039420A (zh) 1990-02-07
CN1022831C (zh) 1993-11-24
CA1287639C (fr) 1991-08-13
JPH0273078A (ja) 1990-03-13
HU202511B (en) 1991-03-28

Similar Documents

Publication Publication Date Title
CS435489A2 (en) Method of mevinic acids and their analogues lactonization
HUT63419A (en) Process for producing mercaptoacetamide derivatives of pyrrolo-, pyrido- and oxazinobenzazepine having encephalinase- and angiotensin-converting enzyme-inhibiting activity
PT83077A (en) Process for preparing compactin and mevinolin analogs useful as hmg-coa reductase inhibitors
GB8811929D0 (en) Phosphorus-containing hmg-coa reductase inhibitors new intermediates & method
EP0326151A3 (fr) Formulations perfectionnées à libération contrôlée
HUT42077A (en) Process for producing diesters of 2-tioxo- or 2-oxo-pyrimidine-1,5-dicarboxylic acid and 1-acyl-pyrimidine-5-carboxylic acids and esters
ZA893107B (en) Process for obtaining enantiomers of 2-arylpropionic acids
EP0430336A3 (en) Process for the preparation of 4-o-phosphates of dopamine and dopamine derivatives
GR3030718T3 (en) Novel prostaglandin analogue.
HK112693A (en) Immunogenic recombinant yeast expression product and method for purifying it
EP0266691A3 (en) Method for the production of alkene carboxylic acid esters
IL81318A (en) Method of working up the solution from the enzymatic resolution of a racemate of an n-acetyl-dl-amino carboxylic acid
PL279491A1 (en) Method for manufacturing spiro-substituted glutaramid derivatives
EP0210589A3 (en) Process for preparing optically active carboxylic acids and relative intermediates
EP0282221A3 (en) Method for racemization of optically active chrysanthemic acid or its ester
GR3007199T3 (fr)
IL104135A0 (en) Process for the manufacture of halomaleic and halofumaric esters
GR3007115T3 (fr)
PL271008A1 (en) Method of obtaining piperazine carboxylic acid
BG43676A1 (en) Method for indication of moving objects coordinates

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20070717