CS390091A3 - N-/1,4-benzodiazepin-3-yl/amide of 1,7-annellated 1h-indole-2-carboxylic acids, process of its p[reparation and pharmaceutical comprising thereof - Google Patents

N-/1,4-benzodiazepin-3-yl/amide of 1,7-annellated 1h-indole-2-carboxylic acids, process of its p[reparation and pharmaceutical comprising thereof

Info

Publication number
CS390091A3
CS390091A3 CS913900A CS390091A CS390091A3 CS 390091 A3 CS390091 A3 CS 390091A3 CS 913900 A CS913900 A CS 913900A CS 390091 A CS390091 A CS 390091A CS 390091 A3 CS390091 A3 CS 390091A3
Authority
CS
Czechoslovakia
Prior art keywords
lower alkyl
represents hydrogen
halogen
carbon atoms
annellated
Prior art date
Application number
CS913900A
Other languages
Czech (cs)
English (en)
Inventor
Harald Waldeck
Werner Benson
Horst Zeugner
Klaus-Ullrich Wolf
Peter-Colin Gregory
Derk Hamminga
Wijngaarden Ineke Van
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3907389A external-priority patent/DE3907389A1/de
Priority claimed from DE3907390A external-priority patent/DE3907390A1/de
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of CS390091A3 publication Critical patent/CS390091A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
CS913900A 1989-03-08 1991-12-19 N-/1,4-benzodiazepin-3-yl/amide of 1,7-annellated 1h-indole-2-carboxylic acids, process of its p[reparation and pharmaceutical comprising thereof CS390091A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3907389A DE3907389A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-carbonsaeure-n-(5-alkyl-1,4-benzodiazepin-3-yl)amide
DE3907390A DE3907390A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-2-carbonsaeure-n-(5-phenyl-1,4-benzodiazepin-3-yl)amide

Publications (1)

Publication Number Publication Date
CS390091A3 true CS390091A3 (en) 1992-06-17

Family

ID=25878542

Family Applications (1)

Application Number Title Priority Date Filing Date
CS913900A CS390091A3 (en) 1989-03-08 1991-12-19 N-/1,4-benzodiazepin-3-yl/amide of 1,7-annellated 1h-indole-2-carboxylic acids, process of its p[reparation and pharmaceutical comprising thereof

Country Status (20)

Country Link
US (1) US5010076A (fr)
EP (1) EP0387618B1 (fr)
JP (1) JP3010558B2 (fr)
KR (1) KR920003627B1 (fr)
CN (1) CN1032208C (fr)
AT (1) ATE109146T1 (fr)
AU (1) AU616835B2 (fr)
CS (1) CS390091A3 (fr)
DE (1) DE59006544D1 (fr)
DK (1) DK0387618T3 (fr)
ES (1) ES2057216T3 (fr)
FI (1) FI92486C (fr)
HK (1) HK1006570A1 (fr)
HU (2) HU207317B (fr)
IE (1) IE65030B1 (fr)
IL (1) IL93401A (fr)
NO (1) NO173869C (fr)
NZ (1) NZ232774A (fr)
PH (1) PH26955A (fr)
PT (1) PT93360B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
CA2068355A1 (fr) * 1991-05-14 1992-11-15 Mark S. Chambers Derives de benzodiazepines, compositions les contenant et leur utilisation therapeutique
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
DE4304806A1 (de) * 1993-02-17 1994-08-18 Kali Chemie Pharma Gmbh 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
WO2000018391A1 (fr) * 1998-09-30 2000-04-06 Takeda Chemical Industries, Ltd. Medicaments qui ameliorent le pouvoir de vidange de la vessie
CA2446696A1 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
JP2006509832A (ja) * 2002-10-30 2006-03-23 ニューロ３デー サイクリックヌクレオチドホスホジエステラーゼ阻害剤、その調製及び使用
FR2846653B1 (fr) * 2002-10-30 2007-04-20 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
WO2014098000A1 (fr) * 2012-12-17 2014-06-26 Daiichi Sankyo Company, Limited Procédé de préparation d'un hétérocycle tricyclique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139584B1 (fr) * 1983-10-17 1988-05-18 Synthelabo Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
CA1332410C (fr) * 1984-06-26 1994-10-11 Roger M. Freidinger Analogues de benzodiazepines
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
FR2567126B1 (fr) * 1984-07-06 1986-12-12 Synthelabo Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
NZ227229A (en) * 1987-12-10 1991-03-26 Duphar Int Res Indole derivatives and pharmaceutical compositions
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

Also Published As

Publication number Publication date
IE900813L (en) 1990-09-08
KR900014391A (ko) 1990-10-23
KR920003627B1 (ko) 1992-05-04
ATE109146T1 (de) 1994-08-15
HUT53641A (en) 1990-11-28
AU616835B2 (en) 1991-11-07
HU210354A9 (en) 1995-03-28
EP0387618B1 (fr) 1994-07-27
US5010076A (en) 1991-04-23
NO901083L (no) 1990-09-10
DE59006544D1 (de) 1994-09-01
PT93360B (pt) 1996-02-29
HU901333D0 (en) 1990-05-28
DK0387618T3 (da) 1994-08-22
NO901083D0 (no) 1990-03-07
ES2057216T3 (es) 1994-10-16
FI92486C (fi) 1994-11-25
PH26955A (en) 1992-12-03
CN1032208C (zh) 1996-07-03
JP3010558B2 (ja) 2000-02-21
IL93401A (en) 1994-08-26
NO173869B (no) 1993-11-08
HU207317B (en) 1993-03-29
CN1045392A (zh) 1990-09-19
FI901154A0 (fi) 1990-03-07
EP0387618A1 (fr) 1990-09-19
IE65030B1 (en) 1995-10-04
NO173869C (no) 1994-02-16
NZ232774A (en) 1991-04-26
HK1006570A1 (en) 1999-03-05
FI92486B (fi) 1994-08-15
IL93401A0 (en) 1990-11-29
PT93360A (pt) 1990-11-07
AU5075390A (en) 1990-09-13
JPH02273678A (ja) 1990-11-08

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic