CU20120139A7 - Derivado de piridina y pirazina para el tratamiento de fibrosis quística(cf) - Google Patents

Derivado de piridina y pirazina para el tratamiento de fibrosis quística(cf)

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Publication number
CU20120139A7
CU20120139A7 CU2012000139A CU20120139A CU20120139A7 CU 20120139 A7 CU20120139 A7 CU 20120139A7 CU 2012000139 A CU2012000139 A CU 2012000139A CU 20120139 A CU20120139 A CU 20120139A CU 20120139 A7 CU20120139 A7 CU 20120139A7
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CU
Cuba
Prior art keywords
compounds
treatment
pharmaceutically acceptable
acceptable salts
general formula
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Application number
CU2012000139A
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English (en)
Other versions
CU24149B1 (es
Inventor
Urs Baettig
Kamlesh Jagdis Bala
Emma Budd
Lee Edwards
Catherine Howsham
Glyn Hughes
Darren Mark Legrand
Katrin Spiegel
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20120139A7 publication Critical patent/CU20120139A7/es
Publication of CU24149B1 publication Critical patent/CU24149B1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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  • General Health & Medical Sciences (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención proporciona derivados de piridina y pirazina, de la siguiente fórmula general (I): ESPACIO PARA LA FÓRMULA y sales farmacéuticamente aceptables de tales compuestos. Dichos compuestos restablecen o mejoran la función del regulador de conductancia transmembrana de fibrosis quística (CFTR) mutante y/o de tipo silvestre, para el tratamiento de fibrosis quística, dipielesia ciliar primaria, bronquitis crónica, enfermedad pulmonar obstructiva crónica, asma, infecciones del tracto respiratorio, carcinoma pulmonar, xerostomia y queraconjuntivitis sire, o estreñimiento (sindrome de intestino irritable(IBS),enfermedad de intestino irritable (IBD), inducido por opioide). En esta invención también se abarcan composiciones farmacéuticas que comprenden los derivados de piridina y pirazina de la fórmula general (I) o las sales farmacéuticamente aceptables de tales compuestos.
CUP2012000139A 2010-03-19 2011-03-17 Derivado de piridina y pirazina para el tratamiento de fibrosis quística(cf) CU24149B1 (es)

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US10117858B2 (en) 2018-11-06
EP2845593B1 (en) 2017-01-25
EP2547656A1 (en) 2013-01-23
TW201139427A (en) 2011-11-16
ZA201206775B (en) 2013-05-29
CN102892758B (zh) 2015-01-07
TWI515190B (zh) 2016-01-01
CR20120468A (es) 2012-10-31
ES2623848T3 (es) 2017-07-12
DK2845593T3 (en) 2017-04-24
SG184018A1 (en) 2012-10-30
MY158621A (en) 2016-10-31
CU24149B1 (es) 2016-02-29
PL2845593T3 (pl) 2017-07-31
PE20130343A1 (es) 2013-04-09
US20110230483A1 (en) 2011-09-22
MA34938B1 (fr) 2014-03-01
KR101473546B1 (ko) 2014-12-16
JP5643349B2 (ja) 2014-12-17

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