CU20190066A7 - Compuestos derivados de 6-cloro-n-(4,4-difluorociclohexil)-2-(3-metil-1h-pirazol-1-il)pirimidin-4-amina y 6-cloro-n-(4,4-difluorociclohexil)-2-(4-metiltiazol-2-il)pirimidin-4-amina como moduladores del canal de potasio - Google Patents

Compuestos derivados de 6-cloro-n-(4,4-difluorociclohexil)-2-(3-metil-1h-pirazol-1-il)pirimidin-4-amina y 6-cloro-n-(4,4-difluorociclohexil)-2-(4-metiltiazol-2-il)pirimidin-4-amina como moduladores del canal de potasio

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Publication number
CU20190066A7
CU20190066A7 CU2019000066A CU20190066A CU20190066A7 CU 20190066 A7 CU20190066 A7 CU 20190066A7 CU 2019000066 A CU2019000066 A CU 2019000066A CU 20190066 A CU20190066 A CU 20190066A CU 20190066 A7 CU20190066 A7 CU 20190066A7
Authority
CU
Cuba
Prior art keywords
pyrimidin
chloro
amine
difluorocyclohexyl
methylthiazol
Prior art date
Application number
CU2019000066A
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English (en)
Other versions
CU24560B1 (es
Inventor
Dipak Vasantrao Amrutkar
Kelly Foster
Thomas Amos Jacobsen
Martin R Jefson
Gregg F Keaney
Janus Schreiber Larsen
Karin Sandager Nielsen
Original Assignee
Cadent Therapeutics Inc
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Application filed by Cadent Therapeutics Inc filed Critical Cadent Therapeutics Inc
Publication of CU20190066A7 publication Critical patent/CU20190066A7/es
Publication of CU24560B1 publication Critical patent/CU24560B1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)

Abstract

<p>Se proporcionan compuestos derivados de 6-cloro-N-(4,4-difluorociclohexil)-2-(3-metil-1H-pirazol-1-il)pirimidin-4-amina y 6-cloro-N-(4,4-difluorociclohexil)-2-(4-metiltiazol-2-il)pirimidin-4-amina de fórmula:</p> <p>ESPACIO PARA FÓRMULA</p> <p>útiles para tratar una variedad de enfermedades, trastornos o condiciones, asociados con canales de potasio.</p>
CU2019000066A 2017-01-23 2018-01-23 N-(4,4-difluorociclohexil)-2-(3-metil-1h-pirazol-1-il)-6-morfolinopirimidin-4-amina útil como modulador de canales de potasio CU24560B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762449270P 2017-01-23 2017-01-23
PCT/US2018/014792 WO2018136917A1 (en) 2017-01-23 2018-01-23 Potassium channel modulators

Publications (2)

Publication Number Publication Date
CU20190066A7 true CU20190066A7 (es) 2020-03-04
CU24560B1 CU24560B1 (es) 2021-12-08

Family

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Family Applications (1)

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CU2019000066A CU24560B1 (es) 2017-01-23 2018-01-23 N-(4,4-difluorociclohexil)-2-(3-metil-1h-pirazol-1-il)-6-morfolinopirimidin-4-amina útil como modulador de canales de potasio

Country Status (30)

Country Link
US (4) US9975886B1 (es)
EP (1) EP3571193B1 (es)
JP (1) JP6997197B2 (es)
KR (1) KR102664772B1 (es)
CN (1) CN110198935B (es)
AR (1) AR110770A1 (es)
BR (1) BR112019014814B1 (es)
CL (1) CL2019002031A1 (es)
CO (1) CO2019009060A2 (es)
CU (1) CU24560B1 (es)
CY (1) CY1125463T1 (es)
DK (1) DK3571193T3 (es)
EA (1) EA036668B1 (es)
ES (1) ES2906078T3 (es)
HR (1) HRP20220079T1 (es)
HU (1) HUE057710T2 (es)
IL (1) IL267954B (es)
LT (1) LT3571193T (es)
MX (1) MX376080B (es)
MY (1) MY195123A (es)
PH (1) PH12019501678A1 (es)
PL (1) PL3571193T3 (es)
PT (1) PT3571193T (es)
RS (1) RS62899B1 (es)
SG (1) SG11201905893WA (es)
SI (1) SI3571193T1 (es)
TW (1) TWI751271B (es)
UA (1) UA123810C2 (es)
WO (1) WO2018136917A1 (es)
ZA (1) ZA201904458B (es)

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