CU22850A3 - Isobutilgaba y sus derivados para el tratamiento del dolor - Google Patents

Isobutilgaba y sus derivados para el tratamiento del dolor

Info

Publication number
CU22850A3
CU22850A3 CU1999008A CU1999008A CU22850A3 CU 22850 A3 CU22850 A3 CU 22850A3 CU 1999008 A CU1999008 A CU 1999008A CU 1999008 A CU1999008 A CU 1999008A CU 22850 A3 CU22850 A3 CU 22850A3
Authority
CU
Cuba
Prior art keywords
pain
hydrogen
formula
treatment
aminomethyl
Prior art date
Application number
CU1999008A
Other languages
English (en)
Inventor
Lakhbir Singh
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21809080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU22850(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CU22850A3 publication Critical patent/CU22850A3/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención es un método para usar un compuesto de la Fórmula I mostrada abajo en el tratamiento del dolor, especialmente para el tratamiento de trastornos de dolor crónicos. Tales trastornos incluyen, en forma no taxativa, dolor inflamatorio, dolor posoperatorio, dolor osteoartrítico asociado con cáncer metastático, neuralgia trigeminal, neuralgia herpética y posherpética aguda, neuropatía diabética, causalgia, avulsión del plexo braquial, neuralgia occipital, distrofia simpática refleja, fibromialgia, gota, dolor de miembro fantasma, dolor de quemadura, y otras formas de síndromes de dolor neurálgico, neuropático e idiopático. Un compuesto es aquel de la Fórmula I o una sal farmacéuticamente aceptable de él, donde R1 es un alquilo recto o ramificado de 1 a 6 átomos de carbono, fenilo, o cicloalquilo de 3 a 6 átomos de carbono; R2 es hidrógeno o metilo; y R3 es hidrógeno, metilo o carboxilo. Los diastereómeros y enantiómeros de compuestos de la Fórmula I están incluidos en la invención. Los compuestos preferidos de la invención son aquellos de 5 acuerdo con la reivindicación 1 donde R3 y R2 son hidrógeno, y R1 es - (CH2) 0-22-i C4H9 como un isómero (R) , (S) , o (R, S) . Los compuestos más preferidos de la invención son ácido (S)-3(aminometil)-5-metilhexanoico y ácido 3-aminometil-5-metil10 hexanoico.
CU1999008A 1996-07-24 1999-01-22 Isobutilgaba y sus derivados para el tratamiento del dolor CU22850A3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2233796P 1996-07-24 1996-07-24

Publications (1)

Publication Number Publication Date
CU22850A3 true CU22850A3 (es) 2003-04-28

Family

ID=21809080

Family Applications (1)

Application Number Title Priority Date Filing Date
CU1999008A CU22850A3 (es) 1996-07-24 1999-01-22 Isobutilgaba y sus derivados para el tratamiento del dolor

Country Status (22)

Country Link
US (2) US6001876A (es)
EP (1) EP0934061B3 (es)
JP (1) JP3693258B2 (es)
KR (1) KR100491282B1 (es)
CN (1) CN1094757C (es)
AT (1) ATE241351T1 (es)
AU (1) AU714980B2 (es)
BR (1) BR9710536A (es)
CU (1) CU22850A3 (es)
DE (1) DE69722426T3 (es)
DK (1) DK0934061T6 (es)
ES (1) ES2200184T7 (es)
HR (1) HRP970387A2 (es)
HU (2) HU228426B1 (es)
IL (1) IL126999A (es)
NO (2) NO325822B1 (es)
NZ (1) NZ332762A (es)
PL (1) PL189872B1 (es)
PT (1) PT934061E (es)
SI (1) SI0934061T1 (es)
WO (1) WO1998003167A1 (es)
ZA (1) ZA976562B (es)

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