NO20021811L - Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier - Google Patents

Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier

Info

Publication number
NO20021811L
NO20021811L NO20021811A NO20021811A NO20021811L NO 20021811 L NO20021811 L NO 20021811L NO 20021811 A NO20021811 A NO 20021811A NO 20021811 A NO20021811 A NO 20021811A NO 20021811 L NO20021811 L NO 20021811L
Authority
NO
Norway
Prior art keywords
treatment
oxabispidin
new
compounds useful
cardiac arrhythmias
Prior art date
Application number
NO20021811A
Other languages
English (en)
Other versions
NO327977B1 (no
NO20021811D0 (no
Inventor
Annika Bjoere
Magnus Bjoersne
David Cladingboel
Kurt-Juergen Hoffman
John Pavey
Fritiof Ponten
Gert Strandlund
Peder Svensson
Colin Thomson
Michael Wilstermann
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20021811D0 publication Critical patent/NO20021811D0/no
Publication of NO20021811L publication Critical patent/NO20021811L/no
Publication of NO327977B1 publication Critical patent/NO327977B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Oppfinnelsen tilveiebringer forbindelser med formel (I), hvori, R, R, Rtil R, A, B og G har de betydninger som er angitt i beskrivelsen, idet forbindelsene er nyttige ved profylakse og behandling av arytmier, spesielt atriale og ventrikulære arytmier.
NO20021811A 1999-10-18 2002-04-17 Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger som inkluderer nevnte forbindelser, samt mellomprodukter og fremgangsmater til fremstilling av mellomprodukter NO327977B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (3)

Publication Number Publication Date
NO20021811D0 NO20021811D0 (no) 2002-04-17
NO20021811L true NO20021811L (no) 2002-06-06
NO327977B1 NO327977B1 (no) 2009-11-02

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021811A NO327977B1 (no) 1999-10-18 2002-04-17 Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger som inkluderer nevnte forbindelser, samt mellomprodukter og fremgangsmater til fremstilling av mellomprodukter

Country Status (41)

Country Link
US (6) US6559143B1 (no)
EP (2) EP1559717A3 (no)
JP (3) JP3973906B2 (no)
KR (1) KR100796142B1 (no)
CN (2) CN100379743C (no)
AP (1) AP1536A (no)
AR (2) AR026064A1 (no)
AT (1) ATE292134T1 (no)
AU (1) AU769513B2 (no)
BG (1) BG65785B1 (no)
BR (1) BR0014804A (no)
CA (1) CA2386910A1 (no)
CO (1) CO5271655A1 (no)
CU (1) CU23210A3 (no)
CZ (1) CZ20021328A3 (no)
DE (1) DE60019158T2 (no)
DK (1) DK1235831T3 (no)
EA (1) EA005319B1 (no)
EE (1) EE04854B1 (no)
ES (1) ES2239047T3 (no)
HK (1) HK1049003B (no)
HR (1) HRP20020336B1 (no)
HU (1) HUP0204085A3 (no)
IL (5) IL149108A0 (no)
IS (2) IS2224B (no)
MX (1) MXPA02003848A (no)
MY (1) MY130661A (no)
NO (1) NO327977B1 (no)
NZ (2) NZ518156A (no)
OA (1) OA12067A (no)
PL (1) PL354970A1 (no)
PT (1) PT1235831E (no)
RS (1) RS50760B (no)
SE (1) SE9903759D0 (no)
SI (1) SI1235831T1 (no)
SK (1) SK286723B6 (no)
TR (1) TR200201059T2 (no)
TW (1) TWI283680B (no)
UA (1) UA75052C2 (no)
WO (1) WO2001028992A2 (no)
ZA (1) ZA200202575B (no)

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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
AU2002343067A1 (en) * 2001-11-22 2003-06-10 Astrazeneca Ab Process for the preparation of 2-or-9-oxa-3, 7-diazabicyclo (3.3.1) nonanes from 2-aminomethyl-2, 3-dihydrooxazines, intermediates therefore, and processes for preparing such intermediates
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
KR20080021114A (ko) * 2005-06-13 2008-03-06 아스트라제네카 아베 심부정맥의 치료를 위한 신규한 옥사비스피딘 화합물
AR054284A1 (es) * 2005-06-20 2007-06-13 Astrazeneca Ab Procedimiento para la preparacion de sales de acido sulfonico de oxabispidinas
KR20080028435A (ko) * 2005-06-20 2008-03-31 아스트라제네카 아베 Ｎ,ｎ’-이치환된 옥사비스피딘의 제조 방법
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
AU2006259936B2 (en) * 2005-06-20 2010-08-12 Astrazeneca Ab Process for the preparation of 3,7-dihydroxy-1,5-diazacyclooctanes
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation
JP7800143B2 (ja) * 2022-01-07 2026-01-16 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物
JP2023101256A (ja) * 2022-01-07 2023-07-20 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物

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US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
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JPS6284070A (ja) 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
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DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
TR200102911T2 (tr) 1999-04-09 2002-01-21 Astrazeneca Ab Adamantan türevleri.
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
US20070117799A1 (en) 2007-05-24
CZ20021328A3 (cs) 2002-09-11
US7164017B2 (en) 2007-01-16
US7772229B2 (en) 2010-08-10
SK5062002A3 (en) 2002-11-06
AU1069101A (en) 2001-04-30
CN101265262A (zh) 2008-09-17
JP3973906B2 (ja) 2007-09-12
HK1049003A1 (en) 2003-04-25
ES2239047T3 (es) 2005-09-16
CN1399639A (zh) 2003-02-26
IL183854A0 (en) 2009-02-11
JP2006342182A (ja) 2006-12-21
TWI283680B (en) 2007-07-11
WO2001028992A2 (en) 2001-04-26
AU769513B2 (en) 2004-01-29
IL149108A (en) 2009-12-24
EA200200390A1 (ru) 2002-10-31
IS6346A (is) 2002-04-17
HRP20020336B1 (en) 2006-02-28
OA12067A (en) 2006-05-04
BG106588A (en) 2003-01-31
US6559143B1 (en) 2003-05-06
ZA200202575B (en) 2003-09-23
AR039226A2 (es) 2005-02-09
AP1536A (en) 2006-01-09
MXPA02003848A (es) 2002-10-23
TR200201059T2 (tr) 2002-09-23
US20060166979A1 (en) 2006-07-27
EP1235831B1 (en) 2005-03-30
JP2003512352A (ja) 2003-04-02
PL354970A1 (en) 2004-03-22
UA75052C2 (en) 2006-03-15
HUP0204085A2 (hu) 2003-04-28
BR0014804A (pt) 2002-06-11
BG65785B1 (bg) 2009-11-30
IL149108A0 (en) 2002-11-10
CU23210A3 (es) 2007-06-20
KR20020038956A (ko) 2002-05-24
RS50760B (sr) 2010-08-31
NZ518156A (en) 2004-05-28
DE60019158D1 (de) 2005-05-04
EE200200203A (et) 2003-06-16
EP1235831A2 (en) 2002-09-04
US20090326221A1 (en) 2009-12-31
US7351821B2 (en) 2008-04-01
ATE292134T1 (de) 2005-04-15
SI1235831T1 (no) 2005-08-31
US20060166980A1 (en) 2006-07-27
SK286723B6 (sk) 2009-04-06
IS8586A (is) 2006-12-27
HRP20020336A2 (en) 2004-02-29
JP2007204486A (ja) 2007-08-16
IL183852A0 (en) 2009-02-11
CN100379743C (zh) 2008-04-09
IL183853A0 (en) 2009-02-11
KR100796142B1 (ko) 2008-01-21
EP1559717A2 (en) 2005-08-03
EP1559717A3 (en) 2009-04-29
EA005319B1 (ru) 2005-02-24
MY130661A (en) 2007-07-31
US20030153564A1 (en) 2003-08-14
DK1235831T3 (da) 2005-06-27
HK1049003B (en) 2005-09-09
HUP0204085A3 (en) 2006-01-30
AP2002002471A0 (en) 2002-06-30
CA2386910A1 (en) 2001-04-26
AR026064A1 (es) 2002-12-26
SE9903759D0 (sv) 1999-10-18
NO327977B1 (no) 2009-11-02
YU29402A (sh) 2004-12-31
PT1235831E (pt) 2005-06-30
IS2224B (is) 2007-04-15
WO2001028992A3 (en) 2001-09-13
NZ531260A (en) 2005-08-26
DE60019158T2 (de) 2006-02-02
CO5271655A1 (es) 2003-04-30
NO20021811D0 (no) 2002-04-17
EE04854B1 (et) 2007-06-15

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