CY2201B1 - Process of preparing etoposide phosphate and etoposide - Google Patents

Process of preparing etoposide phosphate and etoposide

Info

Publication number: CY2201B1
Authority: CY; Cyprus
Prior art keywords: etoposide; phosphate; etoposide phosphate; benzyl; preparing
Prior art date: 1993-11-04

Application number

CY0000053A

Other languages

English (en)

Inventor

Lee J Silverberg

Purushotham Vemishetti

John L Dillon Jr

John J Usher

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-04

Filing date

2000-11-02

Publication date

2002-11-08

2000-11-02 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2002-11-08 Publication of CY2201B1 publication Critical patent/CY2201B1/xx

Links

LIQODXNTTZAGID-OCBXBXKTSA-N etoposide phosphate Chemical compound COC1=C(OP(O)(O)=O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 LIQODXNTTZAGID-OCBXBXKTSA-N 0.000 title abstract 5
229960000752 etoposide phosphate Drugs 0.000 title abstract 5
229960005420 etoposide Drugs 0.000 title abstract 2
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 title abstract 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
QWUWMCYKGHVNAV-UHFFFAOYSA-N 1,2-dihydrostilbene Chemical group C=1C=CC=CC=1CCC1=CC=CC=C1 QWUWMCYKGHVNAV-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

CY0000053A 1993-11-04 2000-11-02 Process of preparing etoposide phosphate and etoposide CY2201B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/145,517 US5459248A (en)	1993-11-04	1993-11-04	Process of preparing etoposide phosphate and etoposide

Publications (1)

Publication Number	Publication Date
CY2201B1 true CY2201B1 (en)	2002-11-08

Family

ID=22513464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0000053A CY2201B1 (en)	1993-11-04	2000-11-02	Process of preparing etoposide phosphate and etoposide

Country Status (20)

Country	Link
US (2)	US5459248A (de)
EP (1)	EP0652226B1 (de)
JP (2)	JP2801152B2 (de)
KR (1)	KR100351325B1 (de)
CN (4)	CN1046290C (de)
AT (1)	ATE193018T1 (de)
AU (1)	AU692472B2 (de)
CA (1)	CA2133594C (de)
CY (1)	CY2201B1 (de)
DE (1)	DE69424504T2 (de)
DK (1)	DK0652226T3 (de)
ES (1)	ES2146247T3 (de)
FI (1)	FI115913B (de)
GR (1)	GR3034213T3 (de)
HK (1)	HK1003302A1 (de)
HU (1)	HU221969B1 (de)
IL (1)	IL111483A (de)
PT (1)	PT652226E (de)
SG (1)	SG50571A1 (de)
TW (1)	TW420687B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5459248A (en) *	1993-11-04	1995-10-17	Bristol-Myers Squibb Company	Process of preparing etoposide phosphate and etoposide
DE69627277T2 (de) *	1995-12-04	2004-03-04	Nippon Kayaku K.K.	Verfahren zur Herstellung von Etoposide
US6207673B1 (en)	1997-03-12	2001-03-27	The University Of North Carolina At Chapel Hill	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1998055491A1 (en) *	1997-06-02	1998-12-10	Bristol-Myers Squibb Company	Process for preparing etoposide
AU5612399A (en)	1998-09-10	2000-04-03	Phytogen Life Sciences Inc.	Synthetic method for the preparation of the antineoplastic agent etoposide
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
CN1198821C (zh) *	2000-04-19	2005-04-27	盐野义制药株式会社	磺酰胺衍生物的制备方法及其晶体
US20030082618A1 (en) *	2001-10-15	2003-05-01	Guangshan Li	Methods for detecting genetic aberrations
US20150246137A1 (en) *	2012-09-27	2015-09-03	The University Of North Carolina At Chapel Hill	Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
CN113121618A (zh) *	2021-04-07	2021-07-16	梯尔希（南京）药物研发有限公司	两种依托泊苷杂质的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2666778A (en) *	1950-05-10	1954-01-19	George M Steinberg	Method for the synthesis of organic phosphates
NL6613143A (de) *	1965-09-21	1967-03-22
EP0111058B1 (de) *	1982-11-26	1987-11-04	Nippon Kayaku Kabushiki Kaisha	Verfahren zur Herstellung von 4'-Demethyl-epipodophylotoxin-beta-D-ethyliden-glucosid und Acylderivate davon
JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
JPS62209089A (ja) *	1986-03-08	1987-09-14	Kuraray Co Ltd	ドリシルグリコピラノシルクロロホスフエイト誘導体およびその製造方法
NZ225599A (en) *	1987-08-04	1991-09-25	Bristol Myers Co	Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
US4904768A (en) *	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4888419A (en) *	1987-08-31	1989-12-19	Bristol-Myers Company	3'-demethoxyepipodophyllotoxin glucoside derivatives
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
US5066645A (en) *	1989-09-01	1991-11-19	Bristol-Myers Company	Epipodophyllotoxin altroside derivatives
US5081234A (en) *	1990-04-30	1992-01-14	Bristol-Myers Squibb Co.	4'-demethylepipodophyllotoxin glycosides
CA2041280A1 (en) *	1990-05-10	1991-11-11	Yosuke Sawada	Arylsulfatase
CN1025918C (zh) *	1990-06-07	1994-09-14	国家医药管理局上海医药工业研究院	抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
US4997931A (en) *	1990-06-11	1991-03-05	Bristol-Myers Squibb Company	Epipodophyllotoxin glycosides
TW260671B (de) *	1991-04-29	1995-10-21	Bristol Myers Squibb Co
US5648474A (en) *	1991-10-08	1997-07-15	Bristol-Myers Squibb	Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) *	1991-12-23	1996-07-16	Uday Shankar Gogate	Stable hexahydrate of etoposide 4'-phosphate disodium salt
JP3061476B2 (ja) *	1992-04-24	2000-07-10	日本化薬株式会社	エトポシド燐酸エステルの製造法
US5375555A (en) *	1992-10-06	1994-12-27	Dolan; George D.	Non-furling flag fasteners
US5459248A (en) *	1993-11-04	1995-10-17	Bristol-Myers Squibb Company	Process of preparing etoposide phosphate and etoposide

1993
- 1993-11-04 US US08/145,517 patent/US5459248A/en not_active Expired - Lifetime
1994
- 1994-10-03 TW TW083109134A patent/TW420687B/zh active
- 1994-10-04 CA CA002133594A patent/CA2133594C/en not_active Expired - Fee Related
- 1994-11-01 FI FI945149A patent/FI115913B/fi active IP Right Grant
- 1994-11-01 IL IL11148394A patent/IL111483A/en not_active IP Right Cessation
- 1994-11-02 KR KR1019940029032A patent/KR100351325B1/ko not_active Expired - Fee Related
- 1994-11-02 JP JP6269821A patent/JP2801152B2/ja not_active Expired - Fee Related
- 1994-11-03 EP EP94308115A patent/EP0652226B1/de not_active Expired - Lifetime
- 1994-11-03 DK DK94308115T patent/DK0652226T3/da active
- 1994-11-03 SG SG1996005289A patent/SG50571A1/en unknown
- 1994-11-03 AU AU77627/94A patent/AU692472B2/en not_active Ceased
- 1994-11-03 PT PT94308115T patent/PT652226E/pt unknown
- 1994-11-03 ES ES94308115T patent/ES2146247T3/es not_active Expired - Lifetime
- 1994-11-03 HU HU9403157A patent/HU221969B1/hu not_active IP Right Cessation
- 1994-11-03 AT AT94308115T patent/ATE193018T1/de not_active IP Right Cessation
- 1994-11-03 DE DE69424504T patent/DE69424504T2/de not_active Expired - Fee Related
- 1994-11-04 CN CN94118214A patent/CN1046290C/zh not_active Expired - Fee Related
1995
- 1995-06-07 US US08/483,429 patent/US5688926A/en not_active Expired - Lifetime
1997
- 1997-11-12 JP JP31075697A patent/JP3810906B2/ja not_active Expired - Fee Related
- 1997-11-27 CN CN97123033A patent/CN1058017C/zh not_active Expired - Fee Related
- 1997-11-27 CN CN97123031A patent/CN1061047C/zh not_active Expired - Fee Related
- 1997-11-27 CN CN97123032A patent/CN1056378C/zh not_active Expired - Fee Related
1998
- 1998-03-23 HK HK98102432D patent/HK1003302A1/en not_active IP Right Cessation
2000
- 2000-08-17 GR GR20000401898T patent/GR3034213T3/el not_active IP Right Cessation
- 2000-11-02 CY CY0000053A patent/CY2201B1/xx unknown

Also Published As

Publication number	Publication date
CN1189500A (zh)	1998-08-05
CN1056378C (zh)	2000-09-13
CN1061047C (zh)	2001-01-24
FI945149L (fi)	1995-05-05
CN1058017C (zh)	2000-11-01
US5459248A (en)	1995-10-17
TW420687B (en)	2001-02-01
DK0652226T3 (da)	2000-08-07
JPH07196680A (ja)	1995-08-01
JP2801152B2 (ja)	1998-09-21
FI115913B (fi)	2005-08-15
CN1189499A (zh)	1998-08-05
HU221969B1 (hu)	2003-03-28
IL111483A0 (en)	1995-01-24
KR950014128A (ko)	1995-06-15
US5688926A (en)	1997-11-18
CA2133594C (en)	1999-02-23
EP0652226A1 (de)	1995-05-10
ES2146247T3 (es)	2000-08-01
EP0652226B1 (de)	2000-05-17
AU7762794A (en)	1995-05-18
IL111483A (en)	1998-12-06
JPH10152499A (ja)	1998-06-09
GR3034213T3 (en)	2000-12-29
PT652226E (pt)	2000-09-29
KR100351325B1 (ko)	2002-10-31
HU9403157D0 (en)	1994-12-28
JP3810906B2 (ja)	2006-08-16
AU692472B2 (en)	1998-06-11
HUT72461A (en)	1996-04-29
CN1046290C (zh)	1999-11-10
FI945149A0 (fi)	1994-11-01
SG50571A1 (en)	1998-07-20
ATE193018T1 (de)	2000-06-15
CN1106016A (zh)	1995-08-02
CN1189497A (zh)	1998-08-05
HK1003302A1 (en)	1998-10-23
DE69424504D1 (de)	2000-06-21
CA2133594A1 (en)	1995-05-05
DE69424504T2 (de)	2000-09-21

Publication	Publication Date	Title
HUT75261A (en)	1997-05-28	Process for producing 1-hydroxy-alkylidene-1,1-bisphosphonic acids and intermediates thereof, trimers and tetramers of alkylpyrophosphonate and alkylpyrophosphate as intermediates
GR3034213T3 (en)	2000-12-29	Process of preparing etoposide phosphate and etoposide.
GB2211495B (en)	1991-04-24	Composting process for the production of mushroom cultivation substrates
CA2202487A1 (en)	1996-04-25	Fused pyrrolocarbazoles
AU7880494A (en)	1995-06-01	5-methyluridine process for large-scale preparation of 2',3'-didehydro-3'-deoxythymidine (d4T)
FI823072L (fi)	1983-03-09	Foerfarande foer framstaellning, isolation och rening av dipeptidsoetningsmedel
FR2701027B1 (fr)	1997-07-18	Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
ES8700655A1 (es)	1986-10-16	Un procedimiento para preparar derivados de pirrolidona
CA2100027A1 (en)	1994-01-09	Method of producing 5'-nucleotide
GB1211625A (en)	1970-11-11	Process for the production of n-carboxy anhydrides of amino acids and derivatives thereof
AU4532889A (en)	1990-05-31	A process for the preparation of tripeptides
GR920300049T1 (en)	1992-08-26	Improved process for the preparation of 2-amino(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
EP0751122A3 (de)	1997-06-25	Verfahren zur Herstellung von kristallinem O-Isopropylisoharnstoff-hydrochlorid
GB2194964B (en)	1991-01-02	Process for the production of a cooling or cooled element
EP0885879A4 (de)	2002-03-20	Verfahren zur erzeugung optisch aktiver cyanohydrine
EP0320484A3 (de)	1990-09-26	Reinigung von N-acetyl-aminophenolen
ES8306720A1 (es)	1983-06-01	"un procedimiento para preparar compuestos precursores de betalactama".
FR2595687B1 (fr)	1990-11-23	Procede de production d'engrais phosphates partiellement solubilises
JPS6463567A (en)	1989-03-09	Deprotection of 3-aminoazetidinones
BR9104328A (pt)	1992-06-09	Processo para a producao de nitrato de prata isento de po
HU902259D0 (en)	1990-08-28	Process for utilizing by-products, for supplying nutrients of soil
TW223122B (en)	1994-05-01	A process for preparing palatinose from sucrose
EP0416097A4 (en)	1991-08-07	Process for producing tropane alkaloids