CY2277B1 - Process for the preparation of a tetrazole derivative in two crystalline forms and a new crystallineform of this derivative - Google Patents

Process for the preparation of a tetrazole derivative in two crystalline forms and a new crystallineform of this derivative

Info

Publication number: CY2277B1
Authority: CY; Cyprus
Prior art keywords: derivative; water; new; ray diffraction; diffraction pattern
Prior art date: 1994-10-19

Application number

CY0200030A

Other languages

English (en)

Inventor

Antoine Caron

Dominique Chantreux

Colette Bouloumie

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-19

Filing date

2002-05-15

Publication date

2003-07-04

2002-05-15 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2003-07-04 Publication of CY2277B1 publication Critical patent/CY2277B1/xx

Links

238000000034 method Methods 0.000 title abstract 2
150000003536 tetrazoles Chemical class 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
238000002441 X-ray diffraction Methods 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
KWEQEHOPDHARIA-UHFFFAOYSA-N 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]phenyl]benzonitrile Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C#N)C(CCCC)=NC21CCCC2 KWEQEHOPDHARIA-UHFFFAOYSA-N 0.000 abstract 2
238000010521 absorption reaction Methods 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
150000001540 azides Chemical class 0.000 abstract 1
159000000011 group IA salts Chemical class 0.000 abstract 1
YOSHYTLCDANDAN-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2NN=NN=2)C(CCCC)=NC21CCCC2 YOSHYTLCDANDAN-UHFFFAOYSA-N 0.000 abstract 1
230000003472 neutralizing effect Effects 0.000 abstract 1
ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Photoreceptors In Electrophotography (AREA)

CY0200030A 1994-10-19 2002-05-15 Process for the preparation of a tetrazole derivative in two crystalline forms and a new crystallineform of this derivative CY2277B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9412459A FR2725987B1 (fr)	1994-10-19	1994-10-19	Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive

Publications (1)

Publication Number	Publication Date
CY2277B1 true CY2277B1 (en)	2003-07-04

Family

ID=9467986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0200030A CY2277B1 (en)	1994-10-19	2002-05-15	Process for the preparation of a tetrazole derivative in two crystalline forms and a new crystallineform of this derivative

Country Status (26)

Country	Link
US (1)	US5629331A (de)
EP (1)	EP0708103B1 (de)
JP (1)	JP3366786B2 (de)
KR (1)	KR100251222B1 (de)
CN (1)	CN1061656C (de)
AT (1)	ATE198478T1 (de)
AU (1)	AU698041B2 (de)
CA (1)	CA2160725C (de)
CY (1)	CY2277B1 (de)
CZ (2)	CZ288629B6 (de)
DE (1)	DE69519788T2 (de)
DK (1)	DK0708103T3 (de)
ES (1)	ES2155115T3 (de)
FI (1)	FI114156B (de)
FR (1)	FR2725987B1 (de)
GR (1)	GR3035503T3 (de)
HU (1)	HU226461B1 (de)
IL (1)	IL115688A (de)
NO (1)	NO307516B1 (de)
NZ (1)	NZ280293A (de)
PL (1)	PL184193B1 (de)
PT (1)	PT708103E (de)
RU (1)	RU2144536C1 (de)
SI (1)	SI0708103T1 (de)
TW (1)	TW357147B (de)
ZA (1)	ZA958850B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW442301B (en) *	1995-06-07	2001-06-23	Sanofi Synthelabo	Pharmaceutical compositions containing irbesartan
US5994348A (en) *	1995-06-07	1999-11-30	Sanofi	Pharmaceutical compositions containing irbesartan
FR2780403B3 (fr) *	1998-06-24	2000-07-21	Sanofi Sa	Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
PT1094816E (pt)	1998-07-06	2009-03-10	Bristol Myers Squibb Co	Sulfonamidas bifenílicas duplamente antagonistas receptores de angiotensina e endotelina
BR0112665A (pt) *	2000-07-19	2003-06-24	Novartis Ag	Sais
US20050176793A1 (en) *	2001-12-10	2005-08-11	Reddy Reguri B.	Amorphous form of 2-n-butyl-3-((2-(1h-tetrazol-5-yl)([1,1'-biphenyl)-4-yl)methyl)-1, 3-diazaspiro(4,4')non-1-en-4-one
DE60308708T2 (de) *	2002-07-16	2007-08-23	Teva Pharmaceutical Industries Ltd.	Neue synthese von irbesartan
WO2004065383A2 (en) *	2003-01-16	2004-08-05	Teva Pharmaceutical Industries Ltd.	Novel synthesis of irbesartan
DE602004015071D1 (de) *	2003-02-05	2008-08-28	Teva Pharma	Synthese von 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro-4,4 -nonen-4-on
AU2003242984A1 (en) *	2003-04-07	2004-11-01	Hetero Drugs Limited	A novel crystalline form of irbesartan
PL379420A1 (pl) *	2003-07-31	2006-09-04	Nicox S.A.	Pochodne blokerów receptora angiotensyny II
TW200526638A (en) *	2003-10-22	2005-08-16	Smithkline Beecham Corp	2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005051943A1 (en) *	2003-11-28	2005-06-09	Ranbaxy Laboratories Limited	Processes for the preparation of highly pure irbesartan
CA2568640C (en)	2004-06-04	2011-08-09	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing irbesartan
WO2006001026A1 (en) *	2004-06-23	2006-01-05	Hetero Drugs Limited	Irbesartan polymorphs
SI21849A (sl) *	2004-07-29	2006-02-28	Krka, Tovarna Zdravil, D.D., Novo Mesto	Priprava hidrokloridnih soli tetrazolskega derivata
TWI346108B (en) *	2004-08-23	2011-08-01	Bristol Myers Squibb Co	A method for preparing irbesartan and intermediates thereof
GB2419592A (en) *	2004-10-26	2006-05-03	Cipla Ltd	Process for the preparation of irbesartan hydrochloride
WO2006050923A1 (en) *	2004-11-11	2006-05-18	Lek Pharmaceuticals D.D.	Polymorph form of irbesartan
ES2259909B1 (es) *	2005-02-28	2007-06-16	Inke, S.A.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de su intermedio de sintesis.
WO2007013101A1 (en) *	2005-07-27	2007-02-01	Jubilant Organosys Limited	PROCESS FOR PRODUCING 2-(N-BUTYL)-3-[[2'-(TETRAZOL-5-YL)BIPHENYL- 4-YL]METHYL]-l,3-DIAZASPIRO[4.4] NON-1-EN-4-ONE
PL1806130T3 (pl)	2006-01-09	2010-08-31	Krka D D Novo Mesto	Kompozycja farmaceutyczna w postaci stałej zawierająca irbesartan
WO2008041957A1 (en) *	2006-10-03	2008-04-10	Ulkar Kimya Sanayi Ve Ticaret As	Method for producing pure crystalline form of 2-n-butyl-3-((2-(1h-tetrazole-5-yl) (1,1'-biphenyl)-4-methyl)-1,3-diazapspiro (4,4') non -1- en-4-one
EP1918288A1 (de)	2006-11-02	2008-05-07	Cadila Pharmaceuticals Limited	Neues und verbessertes Verfahren für die Zubereitung von Irbesartan, einem Angiotensin-II Rezeptorantagonisten für die Behandlung von Bluthochdruck
PT2065035E (pt)	2007-11-28	2010-10-04	Lesvi Laboratorios Sl	Formulações farmacêuticas contendo irbesartan
EP2215083A2 (de) *	2007-12-07	2010-08-11	Hetero Drugs Limited	Verfahren für reines irbesartan
KR101009383B1 (ko) *	2008-04-30	2011-01-19	켐젠주식회사	고순도의2-부틸-3-[[2'-(1에이취-테트라졸-5-일)[1,1'-비페닐]-4-일]메틸]-1,3-디아자스피로[4.4]논-1-엔-4-온 화합물의제조방법
EP2417110B1 (de) *	2009-04-08	2014-05-07	CTX Life Sciences Pvt. Ltd.	Eintopfverfahren zur herstellung von 2-butyl-3-[[2'-(1h-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4] non-1-en-4-on (irbesartan)
AR078107A1 (es) *	2009-08-31	2011-10-12	Sanofi Aventis	Uso de irbesartan para la preparacion de un medicamento para la prevencion de la hospitalizacion por insuficiencia cardiaca
US8080670B2 (en)	2010-05-04	2011-12-20	Divi's Laboratories, Ltd.	Process for the preparation of irbesartan
FR2977253B1 (fr)	2011-06-30	2013-08-09	Centre Nat Rech Scient	Reactif organostannique alcoxyle supporte, preparation et utilisation pour la synthese de tetrazoles en phase heterogene
WO2018002673A1 (en)	2016-07-01	2018-01-04	N4 Pharma Uk Limited	Novel formulations of angiotensin ii receptor antagonists
US11655220B2 (en)	2020-10-22	2023-05-23	Hetero Labs Limited	Process for the preparation of angiotensin II receptor blockers
EP4408836A1 (de)	2021-10-01	2024-08-07	Sanofi	Verfahren zur herstellung von sartan-aktiven verbindungen mit einem tetrazolring

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2697919B2 (ja) *	1989-09-29	1998-01-19	キヤノン株式会社	信号内挿回路及び該回路を備えた変位測定装置
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5104891A (en) *	1989-12-11	1992-04-14	G. D. Searle & Co.	Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
PT97078B (pt) *	1990-03-20	1997-07-31	Sanofi Sa	Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem
IL99372A0 (en) *	1990-09-10	1992-08-18	Ciba Geigy Ag	Azacyclic compounds
FR2673427B1 (fr) *	1991-03-01	1993-06-18	Sanofi Elf	Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.

1994
- 1994-10-19 FR FR9412459A patent/FR2725987B1/fr not_active Expired - Fee Related
1995
- 1995-10-17 CA CA002160725A patent/CA2160725C/en not_active Expired - Fee Related
- 1995-10-17 CZ CZ19952710A patent/CZ288629B6/cs not_active IP Right Cessation
- 1995-10-17 US US08/544,027 patent/US5629331A/en not_active Expired - Lifetime
- 1995-10-18 EP EP95402322A patent/EP0708103B1/de not_active Expired - Lifetime
- 1995-10-18 RU RU95118109/04A patent/RU2144536C1/ru active
- 1995-10-18 AT AT95402322T patent/ATE198478T1/de active
- 1995-10-18 NO NO954154A patent/NO307516B1/no not_active IP Right Cessation
- 1995-10-18 PL PL95311012A patent/PL184193B1/pl not_active IP Right Cessation
- 1995-10-18 TW TW084110953A patent/TW357147B/zh not_active IP Right Cessation
- 1995-10-18 DK DK95402322T patent/DK0708103T3/da active
- 1995-10-18 ES ES95402322T patent/ES2155115T3/es not_active Expired - Lifetime
- 1995-10-18 DE DE69519788T patent/DE69519788T2/de not_active Expired - Lifetime
- 1995-10-18 CN CN95118711A patent/CN1061656C/zh not_active Expired - Lifetime
- 1995-10-18 SI SI9530469T patent/SI0708103T1/xx unknown
- 1995-10-18 PT PT95402322T patent/PT708103E/pt unknown
- 1995-10-19 FI FI954992A patent/FI114156B/fi not_active IP Right Cessation
- 1995-10-19 IL IL11568895A patent/IL115688A/xx not_active IP Right Cessation
- 1995-10-19 JP JP27151295A patent/JP3366786B2/ja not_active Expired - Lifetime
- 1995-10-19 HU HU9503016A patent/HU226461B1/hu unknown
- 1995-10-19 NZ NZ280293A patent/NZ280293A/en not_active IP Right Cessation
- 1995-10-19 AU AU34335/95A patent/AU698041B2/en not_active Ceased
- 1995-10-19 KR KR1019950036285A patent/KR100251222B1/ko not_active Expired - Fee Related
- 1995-10-19 ZA ZA958850A patent/ZA958850B/xx unknown
2000
- 2000-07-07 CZ CZ20002544A patent/CZ288624B6/cs not_active IP Right Cessation
2001
- 2001-03-05 GR GR20010400343T patent/GR3035503T3/el unknown
2002
- 2002-05-15 CY CY0200030A patent/CY2277B1/xx unknown

Also Published As

Publication number	Publication date
NZ280293A (en)	1997-10-24
FR2725987A1 (fr)	1996-04-26
CZ271095A3 (en)	1996-05-15
SI0708103T1 (en)	2001-04-30
CZ288624B6 (cs)	2001-08-15
US5629331A (en)	1997-05-13
NO954154L (no)	1996-04-22
CN1061656C (zh)	2001-02-07
HUT73179A (en)	1996-06-28
NO307516B1 (no)	2000-04-17
FI114156B (fi)	2004-08-31
ATE198478T1 (de)	2001-01-15
PL184193B1 (pl)	2002-09-30
CZ288629B6 (cs)	2001-08-15
EP0708103B1 (de)	2001-01-03
HU9503016D0 (en)	1995-12-28
EP0708103A1 (de)	1996-04-24
FI954992L (fi)	1996-04-20
GR3035503T3 (en)	2001-06-29
AU698041B2 (en)	1998-10-22
IL115688A (en)	1999-09-22
RU2144536C1 (ru)	2000-01-20
JPH08208642A (ja)	1996-08-13
PT708103E (pt)	2001-06-29
CA2160725A1 (en)	1996-04-20
KR100251222B1 (ko)	2000-05-01
HU226461B1 (en)	2008-12-29
NO954154D0 (no)	1995-10-18
IL115688A0 (en)	1996-01-19
CA2160725C (en)	2001-12-18
ES2155115T3 (es)	2001-05-01
FI954992A0 (fi)	1995-10-19
CN1128261A (zh)	1996-08-07
DE69519788D1 (de)	2001-02-08
HK1005135A1 (en)	1998-12-24
JP3366786B2 (ja)	2003-01-14
PL311012A1 (en)	1996-04-29
ZA958850B (en)	1996-05-27
DE69519788T2 (de)	2001-08-30
KR960014122A (ko)	1996-05-22
DK0708103T3 (da)	2001-04-23
FR2725987B1 (fr)	1997-01-10
TW357147B (en)	1999-05-01
AU3433595A (en)	1996-05-02

Publication	Publication Date	Title
SI0708103T1 (en)	2001-04-30	Process for the preparation of a tetrazole derivative in two crystalline forms and a new crystalline form of this derivative
RU95118109A (ru)	1997-09-20	Способ получения производного тетразола, способ получения формы b производного тетразола, форма b производного тетразола и фармацевтическая композиция на основе производного тетразола формы b
CA2229000A1 (en)	1992-08-22	1-biphenylimidazole derivatives, their preparation and their therapeutic use
NO973813D0 (no)	1997-08-19	Fremgangsmåte ved gjenvinning av xylose fra opplösninger
DK0793656T3 (da)	2003-07-21	Hidtil ukendte benzyl-pyrimidiner
CA2123900A1 (en)	1993-05-27	Tetrazolylphenylboronic Acid Intermediates for the Synthesis of AII Receptor Antagonists
CA2382406A1 (en)	2001-03-01	Substituted 2-arylbenzazole compounds and their use as antitumour agents
AU764260B2 (en)	2003-08-14	Method of producing cyclene
CA2144474A1 (en)	1995-09-15	Substituted n-ethylglycine derivatives for preparing pna and pna/dna hybrids
US6156890A (en)	2000-12-05	Process for the production of cyclene
ES2071135T3 (es)	1995-06-16	Procedimientos selectivos para polimorfos de fosinopril.
Pagoria	1994	Synthesis of pure RDX
KR20070110617A (ko)	2007-11-20	로사탄의 개선된 제조방법
US5625066A (en)	1997-04-29	Optically active hydroquinine (amino-3 phenyl)-1 ethanesulfonate, preparation and use thereof
CA2081135A1 (en)	1993-05-26	Method for precipitating an organic resin from an alkaline solution thereof
PT102061B (pt)	2000-06-30	Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime
RU99113400A (ru)	2001-06-10	Способ очистки сточных вод
JPH1059960A (ja)	1998-03-03	５−（アルコキシメチル）−２，３−ピリジンジカルボキシミド化合物の製造方法
Wakita et al.	2003	Decomposition of organic wastes by down flow supercritical water oxidation system
FR2808844B1 (fr)	2002-10-31	Systeme permettant la recuperation de l'energie de la mer (houle)
IDP000010651A (id)	2001-06-28	Sistem pengeboran berputar yang dapat dikemudikan yang terkendali secara aktif serta metode pengeboran sumur