CZ20004592A3 - Benzo(b)thiepin-1,1-dioxidové deriváty, způsob jejich přípravy, léčiva obsahující tyto sloučeniny a jejich použití - Google Patents

Benzo(b)thiepin-1,1-dioxidové deriváty, způsob jejich přípravy, léčiva obsahující tyto sloučeniny a jejich použití

Info

Publication number
CZ20004592A3
CZ20004592A3 CZ20004592A CZ20004592A CZ20004592A3 CZ 20004592 A3 CZ20004592 A3 CZ 20004592A3 CZ 20004592 A CZ20004592 A CZ 20004592A CZ 20004592 A CZ20004592 A CZ 20004592A CZ 20004592 A3 CZ20004592 A3 CZ 20004592A3
Authority
CZ
Czechia
Prior art keywords
thiepine
benzo
compounds
preparation
medicaments containing
Prior art date
Application number
CZ20004592A
Other languages
English (en)
Other versions
CZ297989B6 (cs
Inventor
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of CZ20004592A3 publication Critical patent/CZ20004592A3/cs
Publication of CZ297989B6 publication Critical patent/CZ297989B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CZ20004592A 1998-06-10 1999-05-28 Benzo(b)thiepin-1,1-dioxidové deriváty, zpusob jejich prípravy, léciva obsahující tyto deriváty a pouzití techto derivátu CZ297989B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
CZ20004592A3 true CZ20004592A3 (cs) 2001-04-11
CZ297989B6 CZ297989B6 (cs) 2007-05-16

Family

ID=7870440

Family Applications (2)

Application Number Title Priority Date Filing Date
CZ20004592A CZ297989B6 (cs) 1998-06-10 1999-05-28 Benzo(b)thiepin-1,1-dioxidové deriváty, zpusob jejich prípravy, léciva obsahující tyto deriváty a pouzití techto derivátu
CZ20004591A CZ297925B6 (cs) 1998-06-10 1999-05-29 Deriváty benzothiepin-1,1-dioxidu, zpusob jejich prípravy a léciva s jejich obsahem

Family Applications After (1)

Application Number Title Priority Date Filing Date
CZ20004591A CZ297925B6 (cs) 1998-06-10 1999-05-29 Deriváty benzothiepin-1,1-dioxidu, zpusob jejich prípravy a léciva s jejich obsahem

Country Status (25)

Country Link
US (1) US6387944B1 (cs)
EP (2) EP1086092B1 (cs)
JP (2) JP4374426B2 (cs)
KR (2) KR100681721B1 (cs)
CN (2) CN1127497C (cs)
AR (2) AR018633A1 (cs)
AT (2) ATE227715T1 (cs)
AU (2) AU753275B2 (cs)
BR (2) BR9912188B1 (cs)
CA (2) CA2334775C (cs)
CZ (2) CZ297989B6 (cs)
DE (3) DE19825804C2 (cs)
DK (2) DK1086092T3 (cs)
ES (2) ES2182535T3 (cs)
HU (2) HU229761B1 (cs)
ID (2) ID28695A (cs)
IL (1) IL140078A (cs)
NO (1) NO327075B1 (cs)
NZ (1) NZ508681A (cs)
PL (2) PL196074B1 (cs)
PT (2) PT1086092E (cs)
RU (2) RU2215001C2 (cs)
TR (2) TR200003634T2 (cs)
WO (2) WO1999064410A1 (cs)
ZA (2) ZA200007061B (cs)

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US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
IL156550A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
DE10064402A1 (de) * 2000-12-21 2002-06-27 Aventis Pharma Gmbh Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
WO2003018024A1 (de) * 2001-08-22 2003-03-06 Aventis Pharma Deutschland Gmbh Kombinationspräparate von 1,4- benzothiepin-1,1-dioxidderivaten mit weiteren wirkstoffen und deren verwendung
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
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MXPA04006255A (es) 2002-01-17 2004-09-27 Pharmacia Corp Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
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SE0201937D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
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DE102006053635B4 (de) * 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2155136T3 (es) * 1994-09-13 2001-05-01 Monsanto Co Nuevas benzotiepinas que tienen actividad como inhibidores del transporte de acido biliar iliaco y la captacion de taurocolato.
US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
DE04010088T1 (de) * 1996-03-11 2005-07-14 G.D. Searle Llc Neue Benzothiepine mit pharmazeutischer Wirkung.
US6221897B1 (en) * 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
EP1104416A2 (en) * 1998-08-20 2001-06-06 Takeda Chemical Industries, Ltd. Quaternary ammonium salts and their use as anti-hiv agents

Also Published As

Publication number Publication date
ATE227715T1 (de) 2002-11-15
BR9912188B1 (pt) 2010-12-14
EP1086092A1 (de) 2001-03-28
HU228570B1 (en) 2013-04-29
KR100681721B1 (ko) 2007-02-15
CN1127497C (zh) 2003-11-12
NO327075B1 (no) 2009-04-20
ATE259372T1 (de) 2004-02-15
AU753275B2 (en) 2002-10-10
JP2002517490A (ja) 2002-06-18
DK1086113T3 (da) 2004-05-24
TR200003634T2 (tr) 2001-06-21
BR9911123A (pt) 2006-01-03
AR018634A1 (es) 2001-11-28
DK1086092T3 (da) 2003-03-10
RU2215001C2 (ru) 2003-10-27
CZ297989B6 (cs) 2007-05-16
EP1086092B1 (de) 2002-11-13
NO20006251L (no) 2001-02-07
PL344827A1 (en) 2001-11-19
JP2002517491A (ja) 2002-06-18
PL196074B1 (pl) 2007-12-31
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
AU4503199A (en) 1999-12-30
ID26876A (id) 2001-02-15
DE59908522D1 (de) 2004-03-18
HUP0102554A1 (hu) 2001-10-28
CN1152039C (zh) 2004-06-02
WO1999064409A2 (de) 1999-12-16
WO1999064410A1 (de) 1999-12-16
HK1039490A1 (en) 2002-04-26
ZA200007060B (en) 2001-07-18
DE19825804C2 (de) 2000-08-24
HUP0102256A1 (hu) 2001-12-28
AU4501999A (en) 1999-12-30
KR20010052682A (ko) 2001-06-25
IL140078A (en) 2004-08-31
HK1036799A1 (en) 2002-01-18
BR9912188A (pt) 2001-04-10
AR018633A1 (es) 2001-11-28
NO20006251D0 (no) 2000-12-08
DE59903411D1 (de) 2002-12-19
JP3374129B2 (ja) 2003-02-04
ES2215387T3 (es) 2004-10-01
HUP0102256A3 (en) 2002-04-29
AU752633B2 (en) 2002-09-26
CA2334775A1 (en) 1999-12-16
ES2182535T3 (es) 2003-03-01
RU2220141C2 (ru) 2003-12-27
DE19825804A1 (de) 1999-12-16
ID28695A (id) 2001-06-28
HUP0102554A3 (en) 2002-12-28
EP1086113A2 (de) 2001-03-28
PT1086113E (pt) 2004-06-30
IL140078A0 (en) 2002-02-10
CA2334773C (en) 2009-05-26
NZ508681A (en) 2002-06-28
CN1305469A (zh) 2001-07-25
EP1086113B1 (de) 2004-02-11
ZA200007061B (en) 2001-07-18
HU229761B1 (hu) 2014-06-30
CA2334775C (en) 2009-10-13
CZ297925B6 (cs) 2007-05-02
JP4374426B2 (ja) 2009-12-02
US6387944B1 (en) 2002-05-14
TR200003632T2 (tr) 2001-04-20
KR20010052701A (ko) 2001-06-25
CA2334773A1 (en) 1999-12-16
WO1999064409A3 (de) 2000-03-02
CZ20004591A3 (cs) 2001-04-11
PT1086092E (pt) 2003-03-31
BR9911123B1 (pt) 2010-12-14
PL196057B1 (pl) 2007-11-30
CN1305487A (zh) 2001-07-25

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