DK1086092T3 - Benzo(b)thiepin-1,1-dioxidderivater, fremgangsmåder til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse - Google Patents

Benzo(b)thiepin-1,1-dioxidderivater, fremgangsmåder til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse

Info

Publication number
DK1086092T3
DK1086092T3 DK99927784T DK99927784T DK1086092T3 DK 1086092 T3 DK1086092 T3 DK 1086092T3 DK 99927784 T DK99927784 T DK 99927784T DK 99927784 T DK99927784 T DK 99927784T DK 1086092 T3 DK1086092 T3 DK 1086092T3
Authority
DK
Denmark
Prior art keywords
thiepin
benzo
compounds
processes
preparation
Prior art date
Application number
DK99927784T
Other languages
Danish (da)
English (en)
Inventor
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Application granted granted Critical
Publication of DK1086092T3 publication Critical patent/DK1086092T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99927784T 1998-06-10 1999-05-28 Benzo(b)thiepin-1,1-dioxidderivater, fremgangsmåder til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse DK1086092T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP1999/003701 WO1999064410A1 (de) 1998-06-10 1999-05-28 BENZO(b)THIEPIN-1,1-DIOXIDDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG

Publications (1)

Publication Number Publication Date
DK1086092T3 true DK1086092T3 (da) 2003-03-10

Family

ID=7870440

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99927784T DK1086092T3 (da) 1998-06-10 1999-05-28 Benzo(b)thiepin-1,1-dioxidderivater, fremgangsmåder til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse
DK99927802T DK1086113T3 (da) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivater, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99927802T DK1086113T3 (da) 1998-06-10 1999-05-29 Benzothiepin-1,1-dioxidderivater, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse

Country Status (25)

Country Link
US (1) US6387944B1 (cs)
EP (2) EP1086092B1 (cs)
JP (2) JP4374426B2 (cs)
KR (2) KR100681721B1 (cs)
CN (2) CN1127497C (cs)
AR (2) AR018633A1 (cs)
AT (2) ATE227715T1 (cs)
AU (2) AU753275B2 (cs)
BR (2) BR9912188B1 (cs)
CA (2) CA2334775C (cs)
CZ (2) CZ297989B6 (cs)
DE (3) DE19825804C2 (cs)
DK (2) DK1086092T3 (cs)
ES (2) ES2182535T3 (cs)
HU (2) HU229761B1 (cs)
ID (2) ID28695A (cs)
IL (1) IL140078A (cs)
NO (1) NO327075B1 (cs)
NZ (1) NZ508681A (cs)
PL (2) PL196074B1 (cs)
PT (2) PT1086092E (cs)
RU (2) RU2215001C2 (cs)
TR (2) TR200003634T2 (cs)
WO (2) WO1999064410A1 (cs)
ZA (2) ZA200007061B (cs)

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CN119343140A (zh) 2022-06-09 2025-01-21 阿尔比里奥公司 治疗肝炎
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CN120265290A (zh) 2022-12-09 2025-07-04 阿尔比里奥公司 治疗肾脏疾病的asbt抑制剂
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US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
BR9508916A (pt) * 1994-09-13 1997-12-30 Monsanto Co "Novas benzotiepinas tendo atividade como inibidores de transporte do ácido biliar ileal e absorção de taurocolato"
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AU5301599A (en) * 1998-08-20 2000-03-14 Takeda Chemical Industries Ltd. Quaternary ammonium salts and their use

Also Published As

Publication number Publication date
WO1999064410A1 (de) 1999-12-16
NO20006251L (no) 2001-02-07
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
HUP0102554A3 (en) 2002-12-28
ZA200007060B (en) 2001-07-18
NO20006251D0 (no) 2000-12-08
CA2334773A1 (en) 1999-12-16
HK1036799A1 (en) 2002-01-18
NO327075B1 (no) 2009-04-20
JP3374129B2 (ja) 2003-02-04
EP1086113A2 (de) 2001-03-28
PT1086113E (pt) 2004-06-30
WO1999064409A3 (de) 2000-03-02
HUP0102256A3 (en) 2002-04-29
DE19825804C2 (de) 2000-08-24
RU2215001C2 (ru) 2003-10-27
AU4501999A (en) 1999-12-30
IL140078A0 (en) 2002-02-10
BR9911123B1 (pt) 2010-12-14
PL196074B1 (pl) 2007-12-31
BR9911123A (pt) 2006-01-03
IL140078A (en) 2004-08-31
HU228570B1 (en) 2013-04-29
ES2215387T3 (es) 2004-10-01
DK1086113T3 (da) 2004-05-24
CZ20004591A3 (cs) 2001-04-11
CA2334773C (en) 2009-05-26
HK1039490A1 (en) 2002-04-26
PL196057B1 (pl) 2007-11-30
PL344827A1 (en) 2001-11-19
KR20010052701A (ko) 2001-06-25
HU229761B1 (hu) 2014-06-30
BR9912188A (pt) 2001-04-10
AR018634A1 (es) 2001-11-28
JP2002517491A (ja) 2002-06-18
CZ20004592A3 (cs) 2001-04-11
CA2334775C (en) 2009-10-13
TR200003632T2 (tr) 2001-04-20
CA2334775A1 (en) 1999-12-16
CN1152039C (zh) 2004-06-02
KR100681721B1 (ko) 2007-02-15
DE59908522D1 (de) 2004-03-18
EP1086092B1 (de) 2002-11-13
HUP0102256A1 (hu) 2001-12-28
CZ297989B6 (cs) 2007-05-16
DE59903411D1 (de) 2002-12-19
EP1086092A1 (de) 2001-03-28
DE19825804A1 (de) 1999-12-16
BR9912188B1 (pt) 2010-12-14
ZA200007061B (en) 2001-07-18
CN1305469A (zh) 2001-07-25
HUP0102554A1 (hu) 2001-10-28
CN1305487A (zh) 2001-07-25
AU4503199A (en) 1999-12-30
EP1086113B1 (de) 2004-02-11
ID26876A (id) 2001-02-15
US6387944B1 (en) 2002-05-14
ATE227715T1 (de) 2002-11-15
NZ508681A (en) 2002-06-28
TR200003634T2 (tr) 2001-06-21
RU2220141C2 (ru) 2003-12-27
ID28695A (id) 2001-06-28
CZ297925B6 (cs) 2007-05-02
PT1086092E (pt) 2003-03-31
AR018633A1 (es) 2001-11-28
KR20010052682A (ko) 2001-06-25
WO1999064409A2 (de) 1999-12-16
CN1127497C (zh) 2003-11-12
ATE259372T1 (de) 2004-02-15
JP2002517490A (ja) 2002-06-18
AU753275B2 (en) 2002-10-10
ES2182535T3 (es) 2003-03-01
JP4374426B2 (ja) 2009-12-02
AU752633B2 (en) 2002-09-26

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