DD141828A5 - Verfahren zur herstellung von 1-(p-methoxybenzoyl)-2-pyrolidinon - Google Patents

Verfahren zur herstellung von 1-(p-methoxybenzoyl)-2-pyrolidinon Download PDF

Info

Publication number: DD141828A5
Authority: DD; German Democratic Republic
Prior art keywords: pyrrolidinone; methoxybenzoyl; preparation; compound; mixture
Prior art date: 1978-02-10

Application number

DD79210944A

Other languages

German (de)

English (en)

Inventor

Emilio Kyburz

Werner Aschwanden

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-10

Filing date

1979-02-09

Publication date

1980-05-21

1979-02-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1980-05-21 Publication of DD141828A5 publication Critical patent/DD141828A5/de

Links

238000004519 manufacturing process Methods 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 33
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238000002360 preparation method Methods 0.000 claims description 27
239000000203 mixture Substances 0.000 claims description 26
238000000034 method Methods 0.000 claims description 20
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 18
MXMOTZIXVICDSD-UHFFFAOYSA-N anisoyl chloride Chemical compound COC1=CC=C(C(Cl)=O)C=C1 MXMOTZIXVICDSD-UHFFFAOYSA-N 0.000 claims description 16
230000008569 process Effects 0.000 claims description 9
VBEIIBKJHVIWOQ-UHFFFAOYSA-N 1-(4-hydroxybenzoyl)pyrrolidin-2-one Chemical compound C1=CC(O)=CC=C1C(=O)N1C(=O)CCC1 VBEIIBKJHVIWOQ-UHFFFAOYSA-N 0.000 claims description 5
YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
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125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000008012 organic excipient Substances 0.000 description 1
125000002524 organometallic group Chemical group 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920000137 polyphosphoric acid Polymers 0.000 description 1
235000008476 powdered milk Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003235 pyrrolidines Chemical class 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000011514 reflex Effects 0.000 description 1
238000007142 ring opening reaction Methods 0.000 description 1
238000004904 shortening Methods 0.000 description 1
210000003625 skull Anatomy 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000000859 sublimation Methods 0.000 description 1
230000008022 sublimation Effects 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
JFJZZMVDLULRGK-URLMMPGGSA-O tubocurarine Chemical compound C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 JFJZZMVDLULRGK-URLMMPGGSA-O 0.000 description 1
229960001844 tubocurarine Drugs 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229940072358 xylocaine Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)

DD79210944A 1978-02-10 1979-02-09 Verfahren zur herstellung von 1-(p-methoxybenzoyl)-2-pyrolidinon DD141828A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH140378		1978-02-10
CH1198178		1978-11-22

Publications (1)

Publication Number	Publication Date
DD141828A5 true DD141828A5 (de)	1980-05-21

Family

ID=25687541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79210944A DD141828A5 (de)	1978-02-10	1979-02-09	Verfahren zur herstellung von 1-(p-methoxybenzoyl)-2-pyrolidinon

Country Status (34)

Country	Link
US (1)	US4369139A (da)
EP (2)	EP0044088B1 (da)
JP (1)	JPS6059907B2 (da)
AR (1)	AR220739A1 (da)
AT (1)	AT374787B (da)
AU (1)	AU525514B2 (da)
BG (1)	BG29281A3 (da)
BR (1)	BR7900684A (da)
CA (1)	CA1100515A (da)
CS (1)	CS226182B2 (da)
CU (1)	CU21107A3 (da)
DD (1)	DD141828A5 (da)
DE (1)	DE2963321D1 (da)
DK (1)	DK155278C (da)
EG (1)	EG13873A (da)
ES (2)	ES477587A1 (da)
FI (1)	FI69063C (da)
GR (1)	GR71464B (da)
HK (1)	HK6185A (da)
HU (1)	HU177644B (da)
IE (1)	IE47831B1 (da)
IL (1)	IL56587A0 (da)
IN (1)	IN150106B (da)
MC (1)	MC1257A1 (da)
MY (1)	MY8500340A (da)
NO (1)	NO152046C (da)
NZ (1)	NZ189571A (da)
OA (1)	OA06180A (da)
PH (1)	PH15491A (da)
PL (1)	PL115958B1 (da)
PT (1)	PT69206A (da)
RO (1)	RO76615A (da)
SU (1)	SU931104A3 (da)
YU (1)	YU41330B (da)

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CA1124247A (en) *	1979-08-09	1982-05-25	Hoffmann-La Roche Limited	Pyrrolidine derivatives
CH646149A5 (de) *	1981-02-05	1984-11-15	Hoffmann La Roche	Pyrrolidin-derivat.
US4398938A (en) *	1982-05-20	1983-08-16	Velsicol Chemical Corporation	N-Acylated lactams and their herbicidal compositions and method of use
DE3326724A1 (de) *	1983-07-25	1985-02-07	Boehringer Ingelheim KG, 6507 Ingelheim	In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) *	1983-10-04	1985-04-18	Boehringer Ingelheim KG, 6507 Ingelheim	4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE3420193A1 (de) *	1984-05-30	1985-12-05	Boehringer Ingelheim KG, 6507 Ingelheim	Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
CH661174GA3 (da) *	1985-07-10	1987-07-15
US4691853A (en) *	1985-12-30	1987-09-08	Technalytics, Inc.	Surgical stapler
US5300642A (en) *	1986-04-10	1994-04-05	The Du Pont Merck Pharmaceutical Company	α, α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
US5173489A (en) *	1986-04-10	1992-12-22	The Dupont Merck Pharmaceutical Co.	α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4876259A (en) *	1987-01-05	1989-10-24	E. I. Du Pont De Nemours And Company	3,3-disubstituted indolines
IT1215587B (it) *	1987-06-26	1990-02-14	Roussel Maestretti Spa	Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale.
US5202345A (en) *	1987-08-19	1993-04-13	Shionogi & Co., Ltd.	Carbamoylpyrrolidone derivatives and drugs for senile dementia
CA1305148C (en) *	1987-08-19	1992-07-14	Hiromu Matsumura	Carbamoylpyrrolidone derivatives and drugs for senile dementia
JP2585086B2 (ja) *	1988-12-28	1997-02-26	大鵬薬品工業株式会社	ジアザビシクロアルカン誘導体
IT1231921B (it) *	1989-06-12	1992-01-15	Sigma Tau Ind Farmaceuti	1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
JP2803882B2 (ja) *	1990-02-20	1998-09-24	日清製粉株式会社	１―フエノキシカルボニル―２―ピロリジノン誘導体
JP3038032B2 (ja) *	1991-03-25	2000-05-08	日清製粉株式会社	血小板凝集抑制薬
DE69331761T2 (de) *	1992-07-24	2002-09-12	The Regents Of The University Of California, Oakland	Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
US5852008A (en) *	1995-01-24	1998-12-22	The Regents Of The University Of California	Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors
EP0811375B1 (en) *	1995-02-21	2001-01-03	Nippon Suisan Kaisha, Ltd.	Glutamic acid receptor agonist
IT1318490B1 (it) *	1999-04-27	2003-08-25	Hoffmann La Roche	Agente per fare aumentare la cessione di acetilcolina cerebrale.
KR100823668B1 (ko)	2000-12-28	2008-04-21	해밀턴 파마슈티컬스 인코포레이티드	신경성 통증 치료 및 예방약
US8858594B2 (en) *	2008-12-22	2014-10-14	Abbott Laboratories	Curved closure device
EP2604592B1 (en)	2011-12-12	2014-10-08	Zaklady Farmaceutyczne Polpharma SA	A process for the purification of aniracetam by crystallisation from aqueous solutions
CN109651222A (zh) *	2018-12-21	2019-04-19	上海昊航化工有限公司	一种阿尼西坦的催化合成方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3697563A (en) *	1970-06-29	1972-10-10	Inst Chemioterapico Italiano S	(3,4,5-trimethoxy-benzamido)-alkanoic acids for prophylaxis and treatment of cardiac disorders
DE2413935A1 (de) *	1974-03-20	1975-10-16	Schering Ag	4-(polyalkoxy-phenyl)-2-pyrrolidone

1978
- 1978-01-25 CU CU7835021A patent/CU21107A3/xx unknown
1979
- 1979-01-01 AR AR22073979D patent/AR220739A1/es active
- 1979-01-10 IN IN27/CAL/79A patent/IN150106B/en unknown
- 1979-01-11 CA CA319,509A patent/CA1100515A/en not_active Expired
- 1979-01-16 EG EG26/79A patent/EG13873A/xx active
- 1979-01-24 FI FI790226A patent/FI69063C/fi not_active IP Right Cessation
- 1979-01-25 PH PH22107A patent/PH15491A/en unknown
- 1979-02-05 NZ NZ189571A patent/NZ189571A/en unknown
- 1979-02-05 IL IL56587A patent/IL56587A0/xx not_active IP Right Cessation
- 1979-02-05 AU AU43916/79A patent/AU525514B2/en not_active Expired
- 1979-02-05 BR BR7900684A patent/BR7900684A/pt unknown
- 1979-02-07 HU HU79HO2135A patent/HU177644B/hu not_active IP Right Cessation
- 1979-02-08 CS CS79881A patent/CS226182B2/cs unknown
- 1979-02-08 RO RO7996556A patent/RO76615A/ro unknown
- 1979-02-08 BG BG042414A patent/BG29281A3/xx unknown
- 1979-02-08 GR GR58300A patent/GR71464B/el unknown
- 1979-02-08 SU SU792719854A patent/SU931104A3/ru active
- 1979-02-08 JP JP54012880A patent/JPS6059907B2/ja not_active Expired
- 1979-02-08 YU YU283/79A patent/YU41330B/xx unknown
- 1979-02-08 MC MC791362A patent/MC1257A1/fr unknown
- 1979-02-08 OA OA56728A patent/OA06180A/xx unknown
- 1979-02-09 EP EP81106674A patent/EP0044088B1/de not_active Expired
- 1979-02-09 DK DK056379A patent/DK155278C/da not_active Application Discontinuation
- 1979-02-09 DE DE7979100379T patent/DE2963321D1/de not_active Expired
- 1979-02-09 NO NO790434A patent/NO152046C/no unknown
- 1979-02-09 EP EP79100379A patent/EP0005143B1/de not_active Expired
- 1979-02-09 DD DD79210944A patent/DD141828A5/de unknown
- 1979-02-09 IE IE246/79A patent/IE47831B1/en not_active IP Right Cessation
- 1979-02-09 PT PT7969206A patent/PT69206A/pt unknown
- 1979-02-09 AT AT0099579A patent/AT374787B/de not_active IP Right Cessation
- 1979-02-09 ES ES477587A patent/ES477587A1/es not_active Expired
- 1979-02-10 PL PL1979213340A patent/PL115958B1/pl unknown
- 1979-08-31 ES ES483756A patent/ES483756A1/es not_active Expired
1980
- 1980-07-14 US US06/168,906 patent/US4369139A/en not_active Expired - Lifetime
1985
- 1985-01-24 HK HK61/85A patent/HK6185A/xx unknown
- 1985-12-30 MY MY340/85A patent/MY8500340A/xx unknown

Also Published As

Publication number	Publication date
ATA99579A (de)	1983-10-15
AU4391679A (en)	1979-08-16
GR71464B (da)	1983-05-30
NO152046B (no)	1985-04-15
AT374787B (de)	1984-05-25
YU41330B (en)	1987-02-28
BG29281A3 (bg)	1980-10-15
NO790434L (no)	1979-08-13
IE790246L (en)	1979-08-20
SU931104A3 (ru)	1982-05-23
YU28379A (en)	1983-02-28
JPS54117468A (en)	1979-09-12
EP0044088A3 (en)	1982-02-03
DK155278C (da)	1989-07-24
DK155278B (da)	1989-03-20
EP0044088B1 (de)	1984-02-22
PH15491A (en)	1983-01-31
CU21107A3 (es)	1988-02-01
CS226182B2 (en)	1984-03-19
NZ189571A (en)	1984-07-06
IN150106B (da)	1982-07-24
AU525514B2 (en)	1982-11-11
DK56379A (da)	1979-08-11
ES477587A1 (es)	1980-01-16
PT69206A (en)	1979-03-01
DE2963321D1 (en)	1982-09-02
EP0005143B1 (de)	1982-07-14
PL213340A1 (da)	1980-03-24
AR220739A1 (es)	1980-11-28
IE47831B1 (en)	1984-06-27
PL115958B1 (en)	1981-05-30
JPS6059907B2 (ja)	1985-12-27
FI69063C (fi)	1985-12-10
MY8500340A (en)	1985-12-31
IL56587A0 (en)	1979-05-31
US4369139A (en)	1983-01-18
EG13873A (en)	1982-12-31
EP0044088A2 (de)	1982-01-20
MC1257A1 (fr)	1980-01-14
OA06180A (fr)	1981-06-30
ES483756A1 (es)	1980-04-16
FI69063B (fi)	1985-08-30
HU177644B (en)	1981-11-28
CA1100515A (en)	1981-05-05
BR7900684A (pt)	1979-09-04
EP0005143A1 (de)	1979-11-14
HK6185A (en)	1985-02-01
NO152046C (no)	1985-07-24
FI790226A7 (fi)	1979-08-11
RO76615A (ro)	1981-04-30

Publication	Publication Date	Title
EP0005143B1 (de)	1982-07-14	1-Benzoyl-2-pyrrolidinonderivat, Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
DE3342164C2 (da)	1989-03-02
EP0136658A2 (de)	1985-04-10	1-Benzyl-aminoalkyl-pyrrolidinone und ihre Säureadditionssalze, Verfahren zu ihrer Herstellung und Arzneimittel
DE2952279A1 (de)	1981-06-25	Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DD263772A5 (de)	1989-01-11	Verfahren zur herstellung neuer 1h, 3h-pyrrolo[1,2-c]thiazolderivate
DE2918523A1 (de)	1979-11-15	Lactam-n-essigsaeuren und deren amide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DD149071A5 (de)	1981-06-24	Herstellung 2-substituierter trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido eckige klammer auf 4,3-b eckige klammer zu indole
DD235256A5 (de)	1986-04-30	Verfahren zur herstellung neuer substituierter pyrrolidinone
EP0057846B1 (de)	1985-06-05	Pyrrolidin-Derivat, Verfahren und Zwischenprodukte zu dessen Herstellung und dieses enthaltende Arzneimittel
DD264431A5 (de)	1989-02-01	Verfahren zur herstellung von benzazesin-derivaten
DE2362754C2 (de)	1985-11-21	Cyclopropylalkylaminoreste enthaltende Oxazolinverbindungen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0002672B1 (de)	1981-08-26	Substituierte Pyrrolidine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0024030B1 (de)	1983-03-30	Pyrrolidin-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
EP0496274B1 (de)	1996-07-03	Tricyclisches Pyridonderivat
DE3217236C2 (de)	1994-04-14	5,6-Dihydro-11H-dibenzo [b,e]- azepin-6-one, sowie diese enthaltende pharmazeutische Zusammensetzungen
DE2802306A1 (de)	1978-08-10	Azacycloalkane, azacycloalkene und ihre derivate
DE2605824C3 (de)	1981-04-23	N-Acylaniline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
EP0172526B1 (de)	1989-10-04	Neue Benzodiazepine, Verfahren zu ihrer Herstellung sowie ihre Verwendung
EP0073997A1 (de)	1983-03-16	Substituierte 2-Amino-3,4-dihydropyridinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
AT374792B (de)	1984-05-25	Verfahren zur herstellung eines neuen pyrrolidin -derivates
AT395852B (de)	1993-03-25	Imidazolyl-methyl-tetrahydrothiophenderivate
EP0025501A1 (de)	1981-03-25	Neue N-Aminoalkylindol-Derivate und ihre Salze; Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2519077B2 (de)	1979-07-26	3-Amino-4^,6,7-tetrahydroindazole, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE3439157C2 (da)	1992-10-08
EP0357043A2 (de)	1990-03-07	Imidazodiazepin-Derivate