DD202307A5 - Verfahren zur herstellung eines polypeptids - Google Patents

Verfahren zur herstellung eines polypeptids Download PDF

Info

Publication number
DD202307A5
DD202307A5 DD81231371A DD23137181A DD202307A5 DD 202307 A5 DD202307 A5 DD 202307A5 DD 81231371 A DD81231371 A DD 81231371A DD 23137181 A DD23137181 A DD 23137181A DD 202307 A5 DD202307 A5 DD 202307A5
Authority
DD
German Democratic Republic
Prior art keywords
leif
fragment
interferon
item
polypeptide
Prior art date
Application number
DD81231371A
Other languages
German (de)
English (en)
Inventor
Goeddel David Van Norman
Sidney Pestka
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD202307(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of DD202307A5 publication Critical patent/DD202307A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DD81231371A 1980-07-01 1981-07-01 Verfahren zur herstellung eines polypeptids DD202307A5 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number Publication Date
DD202307A5 true DD202307A5 (de) 1983-09-07

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
DD81231371A DD202307A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines polypeptids
DD81255300A DD210305A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung von mikroorganismen
DD81255299A DD210304A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines replikablen vektors

Family Applications After (2)

Application Number Title Priority Date Filing Date
DD81255300A DD210305A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung von mikroorganismen
DD81255299A DD210304A5 (de) 1980-07-01 1981-07-01 Verfahren zur herstellung eines replikablen vektors

Country Status (36)

Country Link
EP (2) EP0211148B2 (cs)
AR (1) AR242833A1 (cs)
AT (3) AT380272B (cs)
AU (1) AU552004B2 (cs)
BG (1) BG42189A3 (cs)
BR (1) BR8104189A (cs)
CH (2) CH657141A5 (cs)
CS (1) CS273152B2 (cs)
DD (3) DD202307A5 (cs)
DE (3) DE3177288T3 (cs)
DK (1) DK173543B1 (cs)
DZ (1) DZ312A1 (cs)
ES (1) ES8207514A1 (cs)
FI (1) FI82712C (cs)
FR (1) FR2486098B1 (cs)
GB (1) GB2079291B (cs)
GE (1) GEP19960519B (cs)
GR (1) GR75714B (cs)
HK (1) HK49285A (cs)
HU (1) HU196457B (cs)
IE (1) IE49255B1 (cs)
IT (1) IT1137272B (cs)
KE (1) KE3534A (cs)
LU (1) LU83461A1 (cs)
MC (1) MC1396A1 (cs)
MY (1) MY8700711A (cs)
NL (1) NL8103151A (cs)
NO (1) NO159392C (cs)
NZ (1) NZ197572A (cs)
PH (1) PH18036A (cs)
PL (3) PL148261B1 (cs)
PT (1) PT73289B (cs)
RO (1) RO87590A (cs)
SE (2) SE8104093L (cs)
SU (1) SU1414319A3 (cs)
YU (1) YU47700B (cs)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
JP2687995B2 (ja) 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
DE3382317D1 (de) * 1982-03-15 1991-07-25 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4751287A (en) * 1983-02-24 1988-06-14 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr Human leukocyte interferon N and a method of producing same in bacterial cells
EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
ATE227133T1 (de) * 1994-03-07 2002-11-15 Imperial College Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber
DE69522492T2 (de) * 1994-04-09 2002-05-23 F. Hoffmann-La Roche Ag, Basel Verfahren zur Herstellung von Alpha-Interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
JP2001526033A (ja) 1997-12-08 2001-12-18 ジェネンテク・インコーポレイテッド ヒトインターフェロン−イプシロンというｉ型インターフェロン
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
CA2338665C (en) 1998-08-06 2011-01-18 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP2292652A2 (en) * 2000-11-03 2011-03-09 Pestka Biomedical Laboratories, Inc. Interferons uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
US8188224B2 (en) 2005-04-11 2012-05-29 Savient Pharmaceuticals, Inc. Variant forms of urate oxidase and use thereof
EP2245044A2 (en) * 2008-01-18 2010-11-03 F. Hoffmann-La Roche AG Purification of non-glycosylated proteins
EP4635567A3 (en) 2009-06-25 2025-12-03 Horizon Therapeutics USA, Inc. Methods and kits for preventing infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
CN110234340A (zh) 2016-11-11 2019-09-13 好利恩风湿病制药有限责任公司 泼尼松和尿酸酶分子的组合疗法及其用途
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (cs) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
EP0032134B2 (en) * 1980-01-08 1993-10-13 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Also Published As

Publication number Publication date
BG42189A3 (en) 1987-10-15
EP0211148B2 (en) 1999-11-24
IE49255B1 (en) 1985-09-04
DE3177288T3 (de) 2000-03-16
DE3125706C2 (de) 1995-05-24
FR2486098B1 (fr) 1985-12-27
FI82712C (fi) 1991-04-10
GB2079291B (en) 1984-06-13
ES503528A0 (es) 1982-10-01
SE465223C5 (sv) 1998-02-10
EP0043980B1 (en) 1987-09-16
DD210304A5 (de) 1984-06-06
IE811463L (en) 1982-01-01
SU1414319A3 (ru) 1988-07-30
YU162281A (en) 1984-02-29
ATA290981A (de) 1985-09-15
FI82712B (fi) 1990-12-31
ATE29727T1 (de) 1987-10-15
GEP19960519B (en) 1996-07-02
PL148276B1 (en) 1989-09-30
NO159392B (no) 1988-09-12
CH651308A5 (de) 1985-09-13
IT1137272B (it) 1986-09-03
AR242833A1 (es) 1993-05-31
AU552004B2 (en) 1986-05-22
YU47700B (sh) 1996-01-08
EP0211148B1 (en) 1992-08-26
PL148260B1 (en) 1989-09-30
DE3176448D1 (en) 1987-10-22
DZ312A1 (fr) 2004-09-13
DD210305A5 (de) 1984-06-06
PT73289B (en) 1983-05-11
DE3125706A1 (de) 1982-04-15
PL231940A1 (en) 1983-07-18
EP0211148A1 (en) 1987-02-25
BR8104189A (pt) 1982-03-16
NO159392C (no) 1988-12-21
DK173543B1 (da) 2001-02-05
MY8700711A (en) 1987-12-31
GB2079291A (en) 1982-01-20
ES8207514A1 (es) 1982-10-01
CH657141A5 (de) 1986-08-15
DE3177288D1 (de) 1992-10-01
KE3534A (en) 1985-06-07
SE465223B (sv) 1991-08-12
DE3177288T2 (de) 1992-12-10
RO87590A (ro) 1986-07-30
FR2486098A1 (fr) 1982-01-08
PL148261B1 (en) 1989-09-30
PT73289A (en) 1981-07-01
HU196457B (en) 1988-11-28
SE8104093L (sv) 1982-01-02
AT380272B (de) 1986-05-12
IT8122682A0 (it) 1981-07-01
NL8103151A (nl) 1982-02-01
FI812067L (fi) 1982-01-02
NZ197572A (en) 1985-07-31
HK49285A (en) 1985-07-05
GR75714B (cs) 1984-08-02
EP0043980A2 (en) 1982-01-20
DK291081A (da) 1982-01-02
AU7246281A (en) 1982-01-07
EP0043980A3 (en) 1982-09-15
MC1396A1 (fr) 1982-04-27
ATE79901T1 (de) 1992-09-15
PH18036A (en) 1985-03-06
CS273152B2 (en) 1991-03-12
CS503781A2 (en) 1990-07-12
NO812247L (no) 1982-01-04
LU83461A1 (de) 1983-04-06

Similar Documents

Publication Publication Date Title
DE3177288T3 (de) Reife menschliche Leukozyten-Interferone, Verfahren zu ihrer bacteriellen Herstellung, Zwischenprodukte hierfür und Zusammensetzungen diese enthaltend.
DE3238554C2 (cs)
EP0099084B1 (de) Verfahren zur Herstellung von Interferon und Expressionsvektoren dafür
DE3687763T2 (de) Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns-sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.
DE3685996T2 (de) Hybrid-interferone.
EP0147819B1 (de) Reinigung von rekombinanten Interleukin-2
DE3587605T2 (de) Interleukin-1 und dessen Derivat.
DD202085A5 (de) Verfahren zur herstellung von human-fibroblasten-interferon
DD203330A5 (de) Verfahren zur herstellung hybrider human-leukozyten-interferone
DD297188A5 (de) Gm-csf und il-3 umfassende fusionsproteine
DE3144469A1 (de) Hybride human-leukozyten-interferone
DE3586972T2 (de) Gereinigtes interleukin-1.
DD219505A5 (de) Verfahren zur herstellung von schweine-wachstumshormonaehnlichen polypeptiden
DE3642096A1 (de) Pferde-(gamma)-interferon
AT394209B (de) Verfahren zur herstellung neuer mikroorganismen zur produktion von hybriden human-leukozyten-interferonen
AT394208B (de) Verfahren zur herstelluung von vektoren
AT394207B (de) Verfahren zur herstellung von human-leukozyteninterferonen
DE69026440T2 (de) Für M-CSF kodierendes Gen und dazu gehörende rekombinante Systeme
AT394210B (de) Verfahren zur herstellung von doppelstraengiger dna kodierend fuer hybride human-leukozyten-interferone
FI82713B (fi) Plasmid, som foermaor expressera humant moget leukocytinterferon, foerfarande foer dess framstaellning samt dess anvaendning vid framstaellning av humant leukocytinterferon.

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee