DD208549A5 - Verfahren zur herstellung mit gamma-cyclodextrin gebildete einschlusskomplexe von steroidverbindungen - Google Patents

Verfahren zur herstellung mit gamma-cyclodextrin gebildete einschlusskomplexe von steroidverbindungen Download PDF

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Publication number
DD208549A5
DD208549A5 DD82244272A DD24427282A DD208549A5 DD 208549 A5 DD208549 A5 DD 208549A5 DD 82244272 A DD82244272 A DD 82244272A DD 24427282 A DD24427282 A DD 24427282A DD 208549 A5 DD208549 A5 DD 208549A5
Authority
DD
German Democratic Republic
Prior art keywords
cyclodextrin
complex
steroid
solubility
water
Prior art date
Application number
DD82244272A
Other languages
German (de)
English (en)
Inventor
Agnes Stadler
Jozsef Szejtli
Ilona Habon
Gyoezoe Hortobagyi
Ilona Kolbe
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of DD208549A5 publication Critical patent/DD208549A5/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001Lactones
    • C07J21/003Lactones at position 17
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD82244272A 1981-10-27 1982-10-26 Verfahren zur herstellung mit gamma-cyclodextrin gebildete einschlusskomplexe von steroidverbindungen DD208549A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU813147A HU190356B (en) 1981-10-27 1981-10-27 Process for preparing steroid-gamma-cyclodextrin inclusion complexes with high water-solubility

Publications (1)

Publication Number Publication Date
DD208549A5 true DD208549A5 (de) 1984-04-04

Family

ID=10962794

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82244272A DD208549A5 (de) 1981-10-27 1982-10-26 Verfahren zur herstellung mit gamma-cyclodextrin gebildete einschlusskomplexe von steroidverbindungen

Country Status (12)

Country Link
JP (1) JPS5883699A (fr)
BE (1) BE894825A (fr)
DD (1) DD208549A5 (fr)
DE (1) DE3238800A1 (fr)
DK (1) DK474782A (fr)
ES (1) ES516840A0 (fr)
FR (1) FR2515187A1 (fr)
GB (1) GB2109381A (fr)
HU (1) HU190356B (fr)
IT (1) IT1191049B (fr)
NL (1) NL8204122A (fr)
SE (1) SE8206055L (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196230B (en) * 1983-12-29 1988-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing water-soluble forms of polyene antibiotics and pharmaceutics comprising such active ingredient and plant protective with antifungal effect
GB2162529B (en) * 1984-06-08 1988-03-02 Nitrokemia Ipartelepek B-cyclodextrin complex of benzene sulphonyl urea derivatives
US5223295A (en) * 1988-01-22 1993-06-29 Asterol International Process for the elimination of steroid compounds contained in substance of biological origin
EP0381747A4 (en) * 1988-08-15 1991-09-11 American Maize-Products Company Water soluble branched beta cyclodextrin steroid complex
US5229370A (en) * 1988-08-15 1993-07-20 Ammeraal Robert N Water soluble branched beta cyclodextrin steroid complex
WO1992020699A1 (fr) * 1991-05-20 1992-11-26 Eisai Co., Ltd. Compose steroide combine avec du polysaccharide
US20040152664A1 (en) * 1998-09-02 2004-08-05 Allergan, Inc. Prednisolone compositions
US20040048830A1 (en) * 2000-11-02 2004-03-11 Mingqiang Zhang Use of cortisol-sequestering agents for the treatment of hypercortisolaemia related disorders
EP1216712A1 (fr) * 2000-12-20 2002-06-26 Schering Aktiengesellschaft Complexes d'inclusion de drospirenone et de cyclodextrines
AU2002222387A1 (en) * 2000-12-20 2002-07-01 Schering Aktiengesellschaft Cyclodextrin-drospirenone inclusion complexes
EP1216713A1 (fr) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions de complexes de estrogen-cyclodextrine
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
WO2013135248A2 (fr) * 2012-03-13 2013-09-19 Amphidex A/S Production de cristaux de cyclodextrine de type canal
WO2025068481A1 (fr) * 2023-09-29 2025-04-03 Institut National de la Santé et de la Recherche Médicale Formulations de gouttes oculaires de spironolactone

Also Published As

Publication number Publication date
ES8308571A1 (es) 1983-09-16
JPS5883699A (ja) 1983-05-19
SE8206055L (sv) 1983-04-28
HU190356B (en) 1986-08-28
IT8223942A1 (it) 1984-04-26
FR2515187A1 (fr) 1983-04-29
IT1191049B (it) 1988-02-24
SE8206055D0 (sv) 1982-10-25
ES516840A0 (es) 1983-09-16
BE894825A (fr) 1983-02-14
NL8204122A (nl) 1983-05-16
DK474782A (da) 1983-04-28
GB2109381A (en) 1983-06-02
IT8223942A0 (it) 1982-10-26
DE3238800A1 (de) 1983-05-05

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